Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional studyTracey E Toms
Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, West Midlands, UK
Arthritis Res Ther 10:R145. 2008
..We examined whether GC exposure associates with the presence of metabolic syndrome in patients with RA...
- Methotrexate therapy associates with reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60- more than just an anti-inflammatory effect? A cross sectional study
Tracey E Toms
Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, West Midlands, UK
Arthritis Res Ther 11:R110. 2009
..We aimed to: assess the prevalence of the MetS in RA; identify factors that associate with its presence; and assess their interaction with the potential influence of MTX...
- Microalbuminuria in rheumatoid arthritis in the post penicillamine/gold era: association with hypertension, but not therapy or inflammation
Dimitrios Daoussis
Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Pensnett Road, Dudley, West Midlands, DY1 2HQ, UK
Clin Rheumatol 30:477-84. 2011
..Given the association of MA with MetS, future prospective studies are needed to establish the use of MA as a screening tool for RA patients at increased CVD risk...
- Are lipid ratios less susceptible to change with systemic inflammation than individual lipid components in patients with rheumatoid arthritis?
Tracey E Toms
Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, West Midlands, UK
Angiology 62:167-75. 2011
..In summary, the effects of inflammation on individual lipid levels may underestimate lipid-associated cardiovascular disease (CVD) risk in RA, thus lipid ratios may be more appropriate for CVD risk stratification in RA...
- Prevalence of risk factors for statin-induced myopathy in rheumatoid arthritis patients
Tracey E Toms
Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, West Midlands, UK
Musculoskeletal Care 8:2-9. 2010
..We aimed to identify the frequency of risk factors for statin-induced myopathy and establish whether the rs4149056 genotype is more prevalent in RA...
- Target organ damage in patients with rheumatoid arthritis: the role of blood pressure and heart rate
Vasileios F Panoulas
Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, West Midlands, UK
Atherosclerosis 209:255-60. 2010
..Inflammation and sympathetic overdrive may also associate with TOD. We investigated the prevalence and associations of TOD in RA...
- Rheumatoid arthritis susceptibility genes associate with lipid levels in patients with rheumatoid arthritis
Tracey E Toms
Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, West Midlands DY1 2HQ, UK
Ann Rheum Dis 70:1025-32. 2011
..The authors assessed whether RA susceptibility genes associate with the presence of dyslipidaemia in RA patients...
- Association of mean platelet volume with hypertension in rheumatoid arthritis
Armen Yuri Gasparyan
Clinical Research Unit, Russell s Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust Teaching, Dudley, West Midlands, UK
Inflamm Allergy Drug Targets 9:45-50. 2010
..3-3.7; P=0.003). It is possible that MPV as a surrogate marker of platelet function reflects enhanced vascular risk. To further explore the role of MPV as a marker for cardiovascular risk in RA, prospective studies are warranted...
- Statin use in rheumatoid arthritis in relation to actual cardiovascular risk: evidence for substantial undertreatment of lipid-associated cardiovascular risk?
Tracey E Toms
Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Pensnett Road, Dudley, West Midlands, UK
Ann Rheum Dis 69:683-8. 2010
..We aimed to (a) identify the proportion of at risk patients with rheumatoid arthritis (RA) requiring statin therapy identified by conventional risk calculators, and (b) assess whether patients at risk were receiving statins...
- Disease activity and low physical activity associate with number of hospital admissions and length of hospitalisation in patients with rheumatoid arthritis
George S Metsios
Department of physical activity, Exercise and Health, University of Wolverhampton, Gorway Road, Walsall, WS13BD, West Midlands, UK
Arthritis Res Ther 13:R108. 2011
..We hypothesised that disease activity/severity and physical activity are major predictors for the need of hospitalisation in patients with RA...
- Apolipoprotein e gene polymorphisms are strong predictors of inflammation and dyslipidemia in rheumatoid arthritis
Tracey E Toms
Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Pensnett Road, Dudley, West Midlands, DY1 2HQ, UK
J Rheumatol 39:218-25. 2012
..We compared the frequency of 2 ApoE single-nucleotide polymorphisms (SNP) in patients with RA and controls, and studied the relationship of ApoE genotypes with lipids and inflammation in RA...
- The rationale for comparative studies of accelerated atherosclerosis in rheumatic diseases
Armen Yuri Gasparyan
Department of Rheumatology, Clinical Research Unit, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley DY1 2HQ, West Midlands, UK
Curr Vasc Pharmacol 8:437-49. 2010
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- Polymorphisms of the endothelin-1 gene associate with hypertension in patients with rheumatoid arthritis
Vasileios F Panoulas
Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, West Midlands, UK
Endothelium 15:203-12. 2008
..These findings, if replicated in future studies, could be used as a screening tool for RA patients at increased hypertension, and thus cardiovascular, risk...
- Dyslipidaemia in rheumatoid arthritis: the role of inflammation, drugs, lifestyle and genetic factors
Tracey E Toms
Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, West Midlands DY1 2HQ, UK
Curr Vasc Pharmacol 8:301-26. 2010
..In this review, we discuss lipid abnormalities specifically in the context of RA and highlight the potential impact of inflammation, genetic factors, lifestyle, and anti-rheumatic drugs on lipid metabolism...
- Rheumatoid arthritis: is it a coronary heart disease equivalent?
Holly John
Department of Rheumatology, Dudley Group of Hospitals NHS Foundation Trust, Dudley, UK
Curr Opin Cardiol 26:327-33. 2011
..This review examines current evidence to address the question whether rheumatoid arthritis (RA) is a coronary heart disease equivalent, similar to type 2 diabetes mellitus (DM2)...
- Dyslipidaemia in rheumatological autoimmune diseases
Tracey E Toms
Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, Dudley, West Midlands, UK
Open Cardiovasc Med J 5:64-75. 2011
..In this review, we discuss the association between several of the rheumatological autoimmune diseases and dyslipidaemia, and the potential cardiovascular impact this may confer...
