Isaac van der Waal

..Since osteonecrosis of the jaws is presenting relatively rare, it is understandable that guidelines with respect to prevention and treatment are not evidence-based...

..There are conflicting views in the literature on the survival rate of patients treated for a second primary in the head and neck region...

..Since no primary desmoplastic ameloblastomas were encountered in the present study no further comments can be made on this apparently rare entity...

..Computertomography (CT) and Magnetic Resonance Imaging (MRI) have become important imaging tools in disease processes in the bones and the soft tissues...

..Unless clearly indicated dental or medical treatment should be avoided, even if the patient insists on it, since such treatment is rarely effective...

..Dentists and physicians, and also oral hygienists and nurse practitioners, may play a valuable role in such screening programs...

..Our objective was to study the results of the medical workup in patients with amyloidosis of the oral cavity...

..At present, oral lichen planus is more or less accepted as being a potentially malignant disorder. There are no means to prevent such event. The efficacy of follow-up of oral lichen planus is questionable...

..To study patients with oral metastatic tumours for the distribution of sex and age, the oral site and histopathological type of the metastasis, the primary tumour site and length of follow-up...

..Finally, brief attention has been paid to oral submucous fibrosis, actinic cheilitis, some inherited cancer syndromes and immunodeficiency in relation to cancer predisposition...

..DNA aneuploidy in oral leukoplakia is associated with an increased risk of progression to OSCC. However, for the individual leukoplakia patient, DNA ploidy status as single biomarker has limited value to predict progression to cancer...

..The test characteristics of three genetic assays that were developed to detect pre-cancerous fields were investigated and compared to histology...

..SN identification (and thus biopsy) does not seem to be reliable in patients with tumors located in or close to the midline...

..This assay could therefore contribute to the secondary prevention of oral squamous cell carcinoma. The assay also shows promise for the detection of precancerous changes that are not macroscopically visible...

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..Furthermore, specific amplifications of a mucin and a Polycomb group gene imply these proteins in the tumorigenesis of carcinosarcomas...

..The objective of this study was to define different prognostic groups with regard to locoregional control (LRC) derived from recursive partitioning analysis (RPA)...

..5 years. The three patients who refused radical surgery all developed one or more new recurrences...

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..We specifically studied the differences in male-female ratio, age, TNM-stage, site distribution, and alcohol and tobacco use...

..Both unsupervised and supervised analysis of the genomic profiles revealed chromosome arm 8q to be involved in the malignant phenotype of salivary gland myoepitheliomas...

..CONCLUSIONS: Wait-and-see seems justified in case of negative USgFNAC. Strict follow-up with USgFNAC is required. SN identification and aspiration is feasible but did not improve lymph node selection...

..5 cm, but not into the deep surgical margin, does not necessarily seem to require additional treatment. The pattern of invasion and the presence or absence of perineural spread were not significantly related with local recurrence either...

..It has been suggested that patients with squamous cell carcinomas derived from oral leukoplakia have a better prognosis than patients with carcinomas that are not associated with oral leukoplakia...

..This study aimed at unraveling common genetic abnormalities associated with ACC. Additionally, chromosomal changes were correlated with patient characteristics and survival...

..Negative surgical margins are an important prognostic factor, but are difficult to obtain in head and neck sarcomas...

..Before treatment with polyacrylamide gel injection this complication should be disclosed to the patient...

..Different strategies are available for the management of patients with early (i.e. tumour stage one or two) oral or oropharyngeal carcinoma and a clinically negative neck...

..Bisphosphonate-associated osteonecrosis is very difficult to treat. Therefore, dental preventive measures and treatment of dental foci and other inflammations are recommended before starting bisphosphonate therapy...

..The condition can be divided into idiopathic and symptomatic trigeminal neuralgia. It is important to consider a possible trigeminal neuralgia in case of atypical pain in the oral region in order to prevent unnecessary dental procedures...

..To decipher the biological behaviour of ACC, and to identify patients at risk of developing metastases, additional markers are needed...

..Quality of life was significantly better for patients in groups A and B. These results demonstrate that compression after surgical removal of mandibular third molars is a valuable method for preventing pain...

..The first studies revealed a sensitivity of 94%. However, the sentinel node procedure is not yet a routinely performed procedure in oral cancer...

..5 cm of the surgical margins and by excluding patients who received postoperative radiotherapy, amongst others...

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..At present, there seems to be no justification to give a weighting factor to the oral subsite of leukoplakias...

..An overview of the clinical features, histopathology, differential diagnosis, management strategies and prognosis of cheilitis granulomatosa is presented and discussed with regard to the literature...

..With further insight into the biology of soft tissue sarcoma, modern imaging techniques and new treatment options, we will most certainly be able to improve clinical outcome in patients with soft tissue sarcoma in the upcoming years...

..Four years later, intestinal Crohn's disease was diagnosed. One year afterward, acute loss of visual acuity from optic neuropathy developed as another rare extraintestinal manifestation of Crohn's disease...

..The value of annual chest films or other tests for the presence of distant metastases during follow-up after surgical removal of an ACC seems rather questionable...

..To identify immunostaining patterns that are predictive for p53 mutations and to investigate whether p53 mutations are associated with established risk factors for oral squamous cell carcinoma (OSCC)...

..On inquiry, the patient admitted to having this filler injected into her nasolabial folds 3 years previously...

..In one of the patients with a recurrence a cervical lymph node metastasis was detected at the same time, resulting in a diagnosis of metastasizing ameloblastoma...

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..However, in contrast with previous findings, which show a significant difference between prevalences of leukoplakia for men and women, leukoplakia was equally distributed between both sexes...

..A set of clinical and histopathological diagnostic criteria with good interobserver and intraobserver agreements (kappa values > 0.8) is very important in enabling reproducible and reliable studies on OLP to be performed...

..This study re-evaluated the value of p53 immunoexpression to predict malignant transformation of PMOLs after discounting possible confounding factors...

..The results show that neither of the histological grading systems has a strong predictive value and that none is superior to the other...

..The aim of the present investigation was to study the correlation between the clinical and histopathologic assessment of OLP, and to propose diagnostic refinements, if appropriate...

..g. amalgam restoration associated. Such lesions are referred to as oral lichenoid lesions (OLLs). The management of OLP and the various OLLs may be different. Therefore, accurate diagnosis should be aimed at...

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..To perform a histopathologic analysis of condyles that were resected because of unilateral condylar hyperactivity and compare the results of the bone scan with the histopathologic findings...

..These malignancies will be briefly reviewed and discussed. The emphasis is on diagnosis and management...

..Intracutaneous injection of botulinum toxin A is an effective, long-lasting, and well-tolerated treatment of Frey syndrome. If recurrence occurs, the treatment can be repeated...

..Considering the etiologic differences of these lesions, we believe that an accurate molecular definition is essential to make headway with the clinical management of oral and oropharyngeal cancer...

..In view of the rarity of PE-NHL involving the oral region multicenter studies are needed for evaluation of the usefulness of the International Prognostic Index for non-Hodgkin lymphoma in this particular part of the body...

..Based upon the findings of the literature and the results of the present study, there seems insufficient proof to consider geographic stomatitis an oral manifestation of psoriasis...

..Regional and distant metastases are extremely rare. Here is presented a case of a 26-year-old woman with a recurrent ameloblastoma of the mandible and a metastatic lymph node in the homolateral neck...

..The system can easily be adjusted by replacing the histopathological criteria of epithelial dysplasia by a clinical subdivision in homogeneous and non-homogeneous leukoplakia for cases in which no biopsy is available...

..Furthermore, family doctors were much more used to refer patients with oral mucosal disease to medical specialists rather than to the dentist or the oral and maxillofacial surgeon...

..The clinical, histopathological, and molecular biological aspects of this uncommon disorder will be discussed. Furthermore, dental and surgical guidelines will be described...

..Cheilitis granulomatosa and optic neuropathy represent 2 rare manifestations of orofacial granulomatosis in Crohn's disease...

..An overview is presented of the various odontogenic and nonodontogenic diseases that may involve the maxillary sinus...

..Myoepithelial salivary gland tumours are uncommon and follow an unpredictable biological course. The aim was to examine their molecular background to acquire a better understanding of their clinical behaviour...

..To evaluate the possible value of chemotherapy in the treatment of craniofacial osteosarcoma (CFOS)...

..Only, when additional information about these variables will become available, a more precise and realistic calculation can be performed...

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..The conditions diagnosed most frequently were aphthous ulceration, oral candidiasis, and herpes simplex infection. Most oral conditions were minor ailments, and could be dealt with by the general practitioner alone...

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..The boy was diagnosed with a dentigerous cyst in the maxillary sinus and the man had a nasolabial cyst (Klestadt's cyst). Both patients were treated with trans-oral enucleation and fully recovered...

..Whether the simultaneous presence of a GCT and OLP in this particular case was based on a causal relationship or on coincidence still remains unknown...

..Sufficient knowledge of the nomenclature and clinical characteristics of oral white lesions may contribute to the prevention of malignancies and unnecessary referral to a medical specialist...

..001; OR = 0.22 and 0.12 for men and women, respectively). CONCLUSION: The present study suggests that the influence of tobacco on the development of leukoplakia varies by anatomical site...

..The prognosis of head and neck cancer in general depends largely on the stage at diagnosis. Small cancers carry a much better prognosis after surgical removal or radiotherapy than larger ones...

..This suggests that, in addition to its role in caries defense, SAG may serve as a potential tumor indicator and/or tumor suppressor in salivary gland tissue...

..Using a combination of history, examination and, when necessary, fine-needle aspiration and röntgenological examination, the diagnosis of submandibular lumps is usually straightforward...

..The patient underwent a stam cell transplantation. After one year follow-up the patient is still alive. There was no distinct regression of the macroglossia...

..The terminology presented in this report reflects our best understanding of multi-step carcinogenesis in the oral mucosa, and aspires to engender consistency in use...

..Apical endodontic surgery was performed and periapical tissue was examined histopathologically, showing an osteosarcoma. In retrospect, signs of malignancy were already present on the radiograph taken prior to the endodontic treatment...

..The important role of the dental profession in the recognition of this genetic disease is emphasized. In addition, a brief overview of the current literature is presented...

..However, because of changes in the health care system it has become possible for a dentist to refer patients directly to a dermatologist in case of the presence of a skin disease...

..Since many patients with oral diseases see their family doctor first, an extension of the numbers of hours on oral diseases in general and, more specific, in oral medicine, in the medical curriculum is recommended...

..In the majority of patients the burning mouth syndrome will disappear spontaneously, although this may take many years...

..Such a location is extremely rare. Treatment consisted of a partial maxillectomy. The defect was closed by a partial denture. During the 5 year follow-up period no signs of local recurrence or metastatic spread occurred...

..Therapeutic research is mainly aimed at treating symptoms, whereas innovative research tries to increase insight in development of a disorder or to prevent the development of that disorder or to reduce its progression...

..There seems to be no increased risk in patients with OLP. In view of our results we advise to monitor only the subgroup of OLL patients twice a year for early detection of possible malignant transformation...

..No differences in wound healing after simple tooth extractions were observed between healthy and medically compromised patients...

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