Research Topics
Genomes and GenesSpecies | C E TeunissenSummaryAffiliation: VU University Medical Center Country: The Netherlands Publications
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Detail Information
Publications
Classically and alternatively activated bone marrow derived macrophages differ in cytoskeletal functions and migration towards specific CNS cell typesElly J F Vereyken
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
J Neuroinflammation 8:58. 2011..The aim of this study was therefore to determine the characteristics of these phenotypically different macrophages in the context of the CNS in an in vitro setting...- Serum homocysteine levels in relation to clinical progression in multiple sclerosisC E Teunissen
Molecular Cell Biology and Immunology, VU University Medical Centre, FdG, PO Box 7057, 1007 MB Amsterdam, The Netherlands
J Neurol Neurosurg Psychiatry 79:1349-53. 2008..Homocysteine levels may be elevated in patients with multiple sclerosis (MS) but large studies are lacking and the relation with disease progression remains to be determined... - 24S-hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitisC E Teunissen
Department of Molecular Cell Biology, VU University Medical Center, Amsterdam, The Netherlands
J Neurosci Res 85:1499-505. 2007..The data indicate that changes in serum oxysterols occur early in EAE and can be formed by macrophages. These early changes indicate an important role for oxysterols in the development of EAE... - Combination of CSF N-acetylaspartate and neurofilaments in multiple sclerosisC E Teunissen
Molecular Cell Biology and Immunology, VU University Medical Center, FdG, P O Box 7057, 1007 MB Amsterdam, The Netherlands
Neurology 72:1322-9. 2009..Next, we wanted to know the additional value of measurement of NAA compared to other candidate markers for axonal damage, such as neurofilament subunits and tau protein... - Growth-associated protein 43 in lesions and cerebrospinal fluid in multiple sclerosisC E Teunissen
Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Amsterdam, The Netherlands
Neuropathol Appl Neurobiol 32:318-31. 2006..The increased levels of GAP-43 in remyelinated or nondemyelinated white matter close to MS lesions may reflect regenerative attempts by damaged axons... - Homocysteine in relation to cognitive performance in pathological and non-pathological conditionsCharlotte E Teunissen
Department of Molecular Cell Biology and Immunology, Amsterdam, and VUmc Medical Center Amsterdam, Amsterdam, The Netherlands
Clin Chem Lab Med 43:1089-95. 2005..The relationship between homocysteine and cognitive function in non-pathological and pathological situations indicates that changes in its levels may play a role in cognitive functioning in a broad spectrum of conditions... - A consensus protocol for the standardization of cerebrospinal fluid collection and biobankingC E Teunissen
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
Neurology 73:1914-22. 2009..We focus on CSF collection procedures, preanalytical factors, and high-quality clinical and paraclinical information. The biobanking protocols are applicable for CSF biobanks for research targeting any neurologic disease... - Biomarker research in multiple sclerosis: addressing axonal damage and heterogeneityCharlotte E Teunissen
VU University Medical Center, Department of Molecular Cell Biology and Immunology, MS Center Amsterdam, NeuroUnit Biomarkers for Inflammation and Neurodegneration Amsterdam, FdG, PO Box 7057, 1007 MB, Amsterdam, The Netherlands www bioms eu
Biomark Med 1:111-9. 2007..Such networks enhance the opportunities to obtain sufficient samples for in-depth studies on biomarkers in precious material, such as cerebrospinal fluid... - Biological markers in CSF and blood for axonal degeneration in multiple sclerosisCharlotte E Teunissen
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, Netherlands
Lancet Neurol 4:32-41. 2005..These concepts may be helpful for biomarker research in various neurodegenerative diseases... - Biomarkers for Alzheimer's disease. Which way to go?Charlotte E Teunissen
NeuroUnit Biomarkers for Inflammation and Neurodegeneration, Department of Molecular Cell Biology, Vrije Universiteit Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands
Neurobiol Aging 25:695-6. 2004 - Brain-specific fatty acid-binding protein is elevated in serum of patients with dementia-related diseasesC E Teunissen
Neurological laboratory, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
Eur J Neurol 18:865-71. 2011..The aim of this study was to measure the serum levels of brain-type fatty acid-binding protein (FABP) and heart-type FABP in patients with dementia-involving diseases... - Identification of biomarkers for diagnosis and progression of MS by MALDI-TOF mass spectrometryC E Teunissen
NUBIN, Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands
Mult Scler 17:838-50. 2011..Proteomics tools are optimal for the unbiased simultaneous detection of large series of peptides and proteins... - Cerebrospinal fluid anti-myelin antibodies are related to magnetic resonance measures of disease activity in multiple sclerosisM H J Vogt
Department of Molecular Cell Biology and Immunology, VU University Medical Centre, Amsterdam, The Netherlands
J Neurol Neurosurg Psychiatry 80:1110-5. 2009..Here, myelin particles were used to detect anti-myelin antibodies in the CSF of MS patients. Subsequently, their relation with MRI parameters was evaluated... - Cerebrospinal fluid markers for differential dementia diagnosis in a large memory clinic cohortN S M Schoonenboom
Departments of Neurology, VU University Medical Center, Alzheimer Center, Amsterdam, The Netherlands
Neurology 78:47-54. 2012..To determine how amyloid ? 42 (A?42), total tau (t-tau), and phosphorylated tau (p-tau) levels in CSF behave in a large cohort of patients with different types of dementia... - Decreased levels of the brain specific 24S-hydroxycholesterol and cholesterol precursors in serum of multiple sclerosis patientsC E Teunissen
Department of Molecular Cell Biology, Vrije Universiteit Medical Center, FdG, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
Neurosci Lett 347:159-62. 2003..The decreased levels of brain specific and peripheral sterols indicate a role for cholesterol homeostasis in relation to the pathology of multiple sclerosis, at least in the primary progressive clinical subtype... - N-acetylaspartic acid in cerebrospinal fluid of multiple sclerosis patients determined by gas-chromatography-mass spectrometryBas Jasperse
Dept of Neurology, VU University Medical Center, De Boelelaan 1117, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
J Neurol 254:631-7. 2007..To our knowledge there are no studies available that evaluated NAA in cerebrospinal fluid (CSF) as a possible marker for disease severity... - CSF neurofilaments in frontotemporal dementia compared with early onset Alzheimer's disease and controlsYolande A L Pijnenburg
Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, The Netherlands, and Chelsea and Westminster, Brompton and Charing Cross Hospitals, London, UK
Dement Geriatr Cogn Disord 23:225-30. 2007.... - Endogeneous peptide profiling of cerebrospinal fluid by MALDI-TOF mass spectrometry: Optimization of magnetic bead-based peptide capture and analysis of preanalytical variablesConnie R Jimenez
OncoProteomics Laboratory, Department of Medical Oncology, VU Medical Center, Amsterdam, The Netherlands
Proteomics Clin Appl 1:1385-92. 2007..01%). These peptides may be used for quality control in a MALDI-TOF-MS screening strategy to select high quality samples for in-depth proteomics analysis in disease studies... - In vivo detection of myelin proteins in cervical lymph nodes of MS patients using ultrasound-guided fine-needle aspiration cytologyBabs O Fabriek
Department of Molecular Cell Biology and Immunology, VU Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
J Neuroimmunol 161:190-4. 2005..This novel approach allows investigation of the first draining site of the brain for in vivo analysis of the immune regulation of MS... - Diagnostic cerebrospinal fluid biomarkers for Parkinson's disease: a pathogenetically based approachKarin D van Dijk
Department of Anatomy and Neurosciences, Neuroscience Campus Amsterdam, VU University Medical Center Amsterdam, Amsterdam, The Netherlands
Neurobiol Dis 39:229-41. 2010..Furthermore, identified candidate biomarkers will have to be thoroughly validated before they can be implemented as diagnostic aids... - Macrophages and neurodegenerationJerome J A Hendriks
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
Brain Res Brain Res Rev 48:185-95. 2005..Interference with the process of infiltration and migration of monocytes across the blood-brain barrier is one of the possibilities to reduce the damage by activated macrophages... - An in vitro model for de- and remyelination using lysophosphatidyl choline in rodent whole brain spheroid culturesE J F Vereyken
Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
Glia 57:1326-40. 2009..This model for demyelination with potential for remyelination offers possibilities for testing novel therapies and studying mechanisms of remyelination... - Proteolytic shedding of the macrophage scavenger receptor CD163 in multiple sclerosisBabs O Fabriek
Department of Molecular Cell Biology and Immunology, VU Medical Center, The Netherlands
J Neuroimmunol 187:179-86. 2007..Collectively, our results provide evidence for proteolytic shedding of CD163 in MS and suggest a possible link to cytokine production... - Myelin flow cytometry assay detects enhanced levels of antibodies to human whole myelin in a subpopulation of multiple sclerosis patientsEsther C W Breij
Department of Molecular Cell Biology and Immunology, VU Medical Center Amsterdam, FdG, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands
J Neuroimmunol 176:106-14. 2006..Anti-myelin IgG levels were not correlated with clinical parameters of disease. In the same population, serum antibody responses to recombinant myelin oligodendrocyte glycoprotein were comparable in MS patients and HD... - Evaluation of 3-nitrotyrosine as a marker for 3-nitropropionic acid-induced oxidative stress in Lewis and Wistar rats and strain-specific whole brain spheroid culturesCharlotte E Teunissen
European Graduate School of Neuroscience EURON, Universiteit Maastricht, Department of Psychiatry and Neuropsychology, P O Box 616, 6200 MD, Maastricht, The Netherlands
Brain Res 931:5-20. 2002..Finally, the similarities between the 3-NP spheroid model and the vivo model indicate that the spheroid cultures provide a good alternative for chronic exposure of animals to neurotoxins... - Use of proteomic approaches to identify disease biomarkersCharlotte E Teunissen
Lancet Neurol 6:1036-7. 2007