Marjolein Visser

..Behavioral influence on fat distribution is of importance because of the accumulation of abdominal fat with age and its associated health risks...

..05-5.28) based on muscle mass. The associations were similar in men and women. The results of this prospective, population-based study show that lower 25-OHD and higher PTH levels increase the risk of sarcopenia in older men and women...

..This study examined the association of (change in) physical activity and decline in mobility performance in older men and women...

..Our aim was to determine whether low leg muscle mass and greater fat infiltration in the muscle were associated with poor lower extremity performance (LEP)...

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..The most stringent test is an external validation: the application of the model to a new population. The usability of a predictive model can be evaluated using the receiver operating characteristic (ROC) curve...

..Hip fracture in elderly persons has a serious impact on long-term physical function. This study determines the change in muscle strength and muscle mass after a hip fracture, and the associations between these changes and mobility recovery...

..When LS and LM were modeled simultaneously, only LS remained independently associated with performance. In conclusion, muscle strength, but not muscle mass, is independently associated with lower-extremity performance...

..We tested the hypothesis that persons with lower muscle mass or muscle strength have poorer lower-extremity performance (LEP)...

..Human adipose tissue expresses and releases the proinflammatory cytokine interleukin 6, potentially inducing low-grade systemic inflammation in persons with excess body fat...

..86-0.96). MM by DEXA was higher than by CT in three regions. The results of this study suggest that fan-beam DEXA offers considerable promise for the measurement of total body FFM and leg MM in elderly persons...

..The main goal was to determine which tissue in the trunk and legs, fat or lean tissue, is associated with measures of glucose metabolism...

..This study aims to investigate whether low muscle mass, low muscle strength, and greater fat infiltration into the muscle predict incident mobility limitation...

..However, smaller hip or thigh circumference may also explain the predictive value of the WHR or WTR for type 2 diabetes...

..Despite the previously established differences in abdominal fat distribution across gender and race, visceral fat remained a significant predictor of inflammatory marker concentration across all four subgroups examined...

..To examine the association between physical activity and inflammatory markers, with consideration for body fatness and antioxidant use...

..We therefore examined the association of baseline total body fat with changes in leg lean mass, muscle strength, and muscle quality over 7 years of follow-up and whether this link was explained by adipocytokines and insulin resistance...

..To examine the association between physical fitness, assessed according to ability and time to complete a 400-m walk, on changes in body composition and muscle strength over a 7-year period...

..The aim of this study was to investigate the association between serum levels of inflammatory markers and loss of muscle mass and strength in older persons...

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..Low albumin concentrations in older persons increase the risk of poor health outcomes, including functional decline...

..Fat distribution has been shown to be a strong correlate of hypertension, independent of general obesity. However, population-based studies are lacking on the association of regional fat depots with hypertension...

..To estimate the relation of precisely measured regional body composition with peripheral and central arterial stiffness in the elderly...

..This study examines whether a three-year change in serum albumin concentration is associated with subsequent decline in functional status in older persons...

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..However, it is unclear if these factors coexist or are independent in elderly people, and if a relationship does exist, whether it varies by sex and/or race...

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..It is, however, unclear how the underlying body mass components (fat and muscle mass - FM and MM, respectively) are associated with mortality in old age...

..To investigate the association between different types of physical activity behavior and incident mobility limitation in older men and women and to examine whether muscle parameters mediate these associations...

..To identify levels of knee extensor strength that are associated with high and low risk of incident severe mobility limitation (SML) in initially well-functioning older adults...

..In conclusion, the prevalence of pain is higher among obese older men and women compared to their normal-weight peers. Furthermore, obese older adults are at increased odds to develop pain...

..This study explored the associations between various types of activities, their underlying physical components, and recurrent falling in community-dwelling older persons...

..Loss of ALST was greater in men compared with women, and greater in blacks compared with whites, suggesting that men and blacks may be more prone to muscle loss...

..The objective of this study was to assess the association of inflammation with hyperglycemia (impaired fasting glucose [IFG]/impaired glucose tolerance [IGT]) and diabetes in older individuals...

..To examine the association of serum concentrations of 25-hydroxyvitamin D [25(OH)D], interleukin-6 (IL-6), C-reactive protein (CRP) and IGF-1 with prevalent and incident frailty...

..Although both obesity and the metabolic syndrome (MetS) are known risk factors for decline in physical function, the joint association of obesity and metabolic alterations with risk of incident mobility limitation is unknown...

..This study evaluates standardized administration of an endurance walk test for identifying unrecognized and impending mobility limitation in community elders...

..To examine joint associations of physical activity and adiposity measures (body mass index (BMI), waist circumference, percentage body fat) with incident mobility limitation...

..The purpose of this study was to: (1) examine the role of adipocytokines in the association between obesity and the MetS and (2) to determine whether the association is different in obese and non-obese persons...

..Vitamin D deficiency is common among older people and can cause mineralization defects, bone loss, and muscle weakness...

..The aim of this study was to investigate predictors for achieving protein and energy requirements on the fourth day of admission in undernourished hospitalized patients...

..We examined whether levels of testosterone were associated with 3-year decline in physical performance and muscle strength in older men...

..16 (95% CI: 1.28-3.63) and 2.04 (95% CI: 1.12-3.67) respectively. CONCLUSION: RA is associated with an increased risk of CVD and this risk is similar to that associated with DM2...

..We prospectively assessed the incidence of CVD in patients with RA compared with patients with type 2 diabetes mellitus (DM) and the general population...

..Tantamount to this discussion is whether low muscle mass or, rather, muscle weakness should be used for the definition...

..Both serum albumin and total cholesterol are potential markers of frailty. A decline in functional status is one of the key components of frailty...

..The aim of this methodological study was to propose a method for distinguishing four components underlying self reported physical activity of older adults: intensity, muscle strength, turning actions and mechanical strain...

..The objective of this study was to examine whether low levels of oestradiol and testosterone are associated with impaired mobility, low muscle strength and the incidence of falls in a population-based sample of older men and women...

..To identify factors associated with falling in well-functioning older people...

..Exercise is associated with mortality benefits but simply expending energy through any activity in an individual's free-living environment may confer survival advantages...

..05). CONCLUSION: These results suggest that low serum albumin, even within the normal range, is independently associated with weaker muscle strength and future decline in muscle strength in older women and men...

..7 min, and 0.5% of the respondents had missing values. CONCLUSION: The LAPAQ appears to be a valid and reliable instrument for classifying physical activity in older people. The LAPAQ was easier to use than the 7-day diary and pedometer...

..To study the relationship between 4 components of physical activity and the 12-year incidence of clinical knee osteoarthritis (OA) among older adults...

..This finding supports the cognitive reserve hypothesis, and might suggest that early life physical activity may delay late-life cognitive deficits...

..For the prevention of functional decline, falls, and early mortality in older men and women a major focus on maintaining or increasing muscle strength instead of muscle size seems warranted...

..Our aim was to investigate this association in a variety of ethnic groups, some highly susceptible to type 2 diabetes...

..The purpose of this study was to assess the prevalence of undernutrition in hospital outpatients in the Netherlands, to determine high risk departments, and to determine the percentage of patients receiving dietetic treatment...

..Muscle mass might be better reflected by thigh circumference. The aim of this study was to investigate the contributions of thigh and hip circumferences, independent of waist circumference, to measures of glucose metabolism...

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..The effect of the recent obesity epidemic on body composition remains unknown. Furthermore, age-related changes in body composition are still unclear...

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..To determine whether lower lean mass and higher fat mass have independent effects on the loss of strength and muscle quality in older adults and might explain part of the effect of age...

..Falls frequently occur in the elderly and are a major cause of morbidity and mortality...

..These findings suggest that the current calibration of the fan-beam system of the Hologic QDR 4500A provides an overestimate of FFM and underestimate of FM compared with reference methods...

..CONCLUSION: Race differences in AT distribution extend to IMAT, a depot that may influence race-ethnicity differences in dysglycemia...

..Weight loss may contribute to the loss of lean mass with age...

..Therefore, the purpose of this study was to determine whether estrogen use is associated with enhanced muscle composition and, if so, whether this translates into improved strength and physical function...

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..Although muscle strength and mass are highly correlated, the relationship between direct measures of low muscle mass (sarcopenia) and strength in association with mortality has not been examined...

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..To study the levels of systemic markers for inflammation with parameters of periodontal diseases in older people...

..To define clinically relevant cutpoints for usual gait speed and to investigate their predictive value for health-related events in older persons...

..The prevalence of vitamin D deficiency in nursing home patients is high...

..The loss of muscle mass is considered to be a major determinant of strength loss in aging. However, large-scale longitudinal studies examining the association between the loss of mass and strength in older adults are lacking...

..Longitudinal studies are needed to determine the direction of causality in this relationship...

..To compare two methods for classifying an individual as sarcopenic for predicting decline in physical function in the Health, Aging and Body Composition Study...

..Dietary surveys suggest that many older, community-dwelling adults consume insufficient dietary protein, which may contribute to the age-related loss of lean mass (LM)...

..This study examines the association between incident mobility limitation and 4 lifestyle factors: smoking, alcohol intake, physical activity, and diet in well-functioning obese (n = 667) and non-obese (n = 2027) older adults...

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..We focus on the extent to which low and high ankle-arm index values as well as noncompressible arteries are associated with mortality and cardiovascular events, including stroke in older adults...

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..To examine the relationship between indicators of inflammation and the incidence of mobility limitation in older persons...

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