Detail Information
Publications
Tracking repeats using significance and transitivityRadek Szklarczyk
Centre for Integrative Bioinformatics IBIVU, Faculty of Sciences and Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1081a, Amsterdam, The Netherlands
Bioinformatics 20:i311-7. 2004..Identification of repeats is crucial to shed light on the function and structure of proteins, and explain their evolutionary past. The task is difficult because during the course of evolution many repeats diverged beyond recognition...
Rapid asymmetric evolution of a dual-coding tumor suppressor INK4a/ARF locus contradicts its functionRadek Szklarczyk
Centre for Integrative Bioinformatics, Vrije University, De Boelelaan 1081a, 1081 HV Amsterdam, The Netherlands
Proc Natl Acad Sci U S A 104:12807-12. 2007..Thus, the strong link between mutations in INK4a/ARF and cancer may be a direct consequence of the architecture of the locus...
AuberGene--a sensitive genome alignment toolRadek Szklarczyk
Centre for Integrative Bioinformatics VU (IBIVU, Faculty of Sciences and Faculty of Earth and Life Sciences, Vrije Universiteit De Boelelaan 1081A, 1081 HV Amsterdam, The Netherlands
Bioinformatics 22:1431-6. 2006..Our results suggest that, over the CFTR region, human shares 10% more sequence with mouse than previously thought ( approximately 50%, instead of 40% found with the pairwise alignment)...
