Joris C Verster

..Many people who use hypnotics are outpatients and are likely to drive a car the day after drug intake. The purpose of these meta-analyses was to determine whether or not this is safe...

..However, to ensure traffic safety higher dosages than recommended (10 mg) or allowing less than 8 hours between zolpidem intake and actual operation of a motor vehicle should be avoided...

..Future studies should elucidate the pathology of alcohol hangover. Until then, it is unlikely that an effective hangover cure will be developed...

..05%; after 3 h of driving impairment corresponds to a BAC of 0.08%. In conclusion, a maximum of two continuous nocturnal driving hours should be recommended...

..This review examined the prevalence and nature of stopped driving tests, and the relationship with Standard Deviation of Lateral Position (SDLP), i.e. the "weaving of the car"...

..There are various methods to examine driving ability. Comparisons between these methods and their relationship with actual on-road driving is often not determined...

..05 km/h, 95% CI = -0.4 to 0.2, P = 0.70). Among adults with ADHD, with a history of a positive clinical response to methylphenidate, methylphenidate significantly improves driving performance...

..The Dutch OISQ is a suitable tool to examine the occupational impact of sleep...

..Some studies have already used the DASS, but the magnitude of impairment is difficult to interpret because reference values are lacking...

..The International Council on Alcohol, Drugs and Traffic Safety (ICADTS) categorization can help physicians to make a choice between treatments when patients want to drive a car...

..The objective of this study was to examine the effects of methylphenidate on memory functioning of adults with ADHD...

..Adverse drug effects such as reduced alertness may cause drivers to be unaware that their driving is impaired...

..In conclusion, zopiclone (7.5 mg) is a reliable positive control, that consistently shows significant and meaningful impairment on the on-the-road driving test...

..The purpose of this study was to validate the Dutch version of the Brief Young Adult Alcohol Consequences Questionnaire (B-YAACQ)...

..Sedation following antihistamine use poses a danger to ambulant patients involved in daily activities such as driving...

..Disturbed body balance and standing steadiness are problematic for those who wake up at night or in the morning after using hypnotic drugs. As a result, falls and hip fractures are frequently reported in patients using sleep medication...

..The results show that zaleplon (10 and 20 mg) is a safe hypnotic devoid of next-morning residual impairment when used in the middle of the night...

..5 mg), and placebo on driving performance, memory functioning, psychomotor performance, and mood in healthy adult subjects following bedtime dosing and a middle of the night awakening...

..In contrast, after 2 weeks of treatment, no significant differences were found between amitriptyline and placebo, suggesting that tolerance had developed to the impairing effects of amitriptyline...

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..It is concluded that alcohol increases distractibility and interference from secondary task stimuli, as well as reduces attentional capacity and dual-task integrality...

..Vigilance performance was not significantly affected, indicating that this memory impairment does not reflect sedation...

..The purpose of this study was to examine if Red Bull® Energy Drink can counteract sleepiness and driving impairment during prolonged driving...

..These effects might interfere with memory functioning and psychomotor performance. Levocetirizine was recently introduced as a new antihistamine said to be free from sedative effects...

..Since the majority of alprazolam users are outpatients, this behavioral impairment limits the safe use of alprazolam in patients routinely engaged in potentially dangerous daily activities, such as driving a car...

..It is of concern that a substantial number of drug users are not aware that their driving is impaired...

..Future studies should more rigorously study these factors as well as biological correlates to further elucidate the pathology of alcohol hangover...

..All antihistamines are capable of crossing the blood-brain barrier and thus may cause sedation. Most antihistamine users are ambulatory patients and therefore presumably drive a car...

..4, p <.0001). Furthermore, alprazolam significantly impaired performance on the laboratory tests. In conclusion, alprazolam users must be warned not to drive an automobile or operate potentially dangerous machinery...

..Middle-of-the-night administration of zolpidem significantly impairs driving ability in a dose-dependent manner. In contrast, zaleplon did not affect driving ability 4 h after middle-of-the-night administration...

..g., congeners), and (7) develop effective hangover remedies...

..It is important that standard operation procedures are applied to conduct the test and analyze the data in order to allow comparisons between studies from different sites...

..To assess the clinical evidence on the effectiveness of any medical intervention for preventing or treating alcohol hangover...