J A Witjes

Summary

Affiliation: University Medical Centre
Country: The Netherlands

Publications

  1. ncbi Advances in the management of testicular cancer
    Cathy Balk
    University Medical Centre Nijmegen, Department of Urology, St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Expert Rev Anticancer Ther 4:669-77. 2004
  2. ncbi Comparison of hexaminolevulinate based flexible and rigid fluorescence cystoscopy with rigid white light cystoscopy in bladder cancer: results of a prospective Phase II study
    J Alfred Witjes
    Department of Urology, University Medical Centre, St Radboud, Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 47:319-22. 2005
  3. ncbi [Guidelines for follow-up of patients with prostate carcinoma]
    J A Witjes
    Universitair Medisch Centrum St Radboud, afd Urologie, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 146:360-2. 2002
  4. ncbi Urinary NMP22 and karyometry in the diagnosis and follow-up of patients with superficial bladder cancer
    J A Witjes
    Department of Urology, University Hospital Nijmegen, The Netherlands
    Eur Urol 33:387-91. 1998
  5. ncbi Prognostic factors in clinical stage 1 non-seminomatous testicular tumours
    J A Witjes
    Department of Urology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Curr Opin Urol 11:531-4. 2001
  6. ncbi Mycotic aneurysm of the popliteal artery as a complication of intravesical BCG therapy for superficial bladder cancer. Case report and literature review
    J A Witjes
    Department of Urology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Urol Int 71:430-2. 2003
  7. ncbi Targeting of renal cell carcinoma with iodine-131-labeled chimeric monoclonal antibody G250
    M G Steffens
    Department of Urology, University Hospital Nijmegen, The Netherlands
    J Clin Oncol 15:1529-37. 1997
  8. ncbi Does the tertiary Gleason pattern influence the PSA progression-free interval after retropubic radical prostatectomy for organ-confined prostate cancer?
    I M van Oort
    Department of Urology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 48:572-6. 2005
  9. ncbi Conventional bladder wash cytology performed by four experts versus quantitative image analysis
    H G van der Poel
    Department of Urology, University Hospital, Nijmegen, The Netherlands
    Mod Pathol 10:976-82. 1997
  10. ncbi Solitary skull recurrence from stage I seminomatous germ cell tumor of testis
    J R Spermon
    Department of Urology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Urology 64:377-9. 2004

Collaborators

Detail Information

Publications110 found, 100 shown here

  1. ncbi Advances in the management of testicular cancer
    Cathy Balk
    University Medical Centre Nijmegen, Department of Urology, St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Expert Rev Anticancer Ther 4:669-77. 2004
    ..Extensive research into the molecular biology of testicular cancer is ongoing and will hopefully offer new targets for the diagnosis, staging, and treatment of testicular cancer in the future...
  2. ncbi Comparison of hexaminolevulinate based flexible and rigid fluorescence cystoscopy with rigid white light cystoscopy in bladder cancer: results of a prospective Phase II study
    J Alfred Witjes
    Department of Urology, University Medical Centre, St Radboud, Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 47:319-22. 2005
    ..We carried out a study to evaluate whether the technique of fluorescence cystoscopy with HAL was also feasible with a specially designed flexible fluorescence cystoscope (FFC)...
  3. ncbi [Guidelines for follow-up of patients with prostate carcinoma]
    J A Witjes
    Universitair Medisch Centrum St Radboud, afd Urologie, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 146:360-2. 2002
    ..The frequency and duration of the follow-up investigation, as well as the consequences of the findings during this, depend on the stage of the disease, the patient's wishes and the possibilities of additional treatment...
  4. ncbi Urinary NMP22 and karyometry in the diagnosis and follow-up of patients with superficial bladder cancer
    J A Witjes
    Department of Urology, University Hospital Nijmegen, The Netherlands
    Eur Urol 33:387-91. 1998
    ..To study the value of two outpatient urine tests with regard to the diagnosis and recurrence of bladder tumors...
  5. ncbi Prognostic factors in clinical stage 1 non-seminomatous testicular tumours
    J A Witjes
    Department of Urology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Curr Opin Urol 11:531-4. 2001
    ..Several additional prognostic factors have been studied, but none is yet applicable in daily practice...
  6. ncbi Mycotic aneurysm of the popliteal artery as a complication of intravesical BCG therapy for superficial bladder cancer. Case report and literature review
    J A Witjes
    Department of Urology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Urol Int 71:430-2. 2003
    ..No vascular surgery was necessary. This case report again stresses the necessity to recognise complications of BCG treatment and to start adequate therapy as soon as possible...
  7. ncbi Targeting of renal cell carcinoma with iodine-131-labeled chimeric monoclonal antibody G250
    M G Steffens
    Department of Urology, University Hospital Nijmegen, The Netherlands
    J Clin Oncol 15:1529-37. 1997
    ....
  8. ncbi Does the tertiary Gleason pattern influence the PSA progression-free interval after retropubic radical prostatectomy for organ-confined prostate cancer?
    I M van Oort
    Department of Urology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 48:572-6. 2005
    ..This suggests that tumour multifocality, rather than the presence of a higher-grade tertiary Gleason pattern has prognostic value...
  9. ncbi Conventional bladder wash cytology performed by four experts versus quantitative image analysis
    H G van der Poel
    Department of Urology, University Hospital, Nijmegen, The Netherlands
    Mod Pathol 10:976-82. 1997
    ..Image analysis was superior to cytologic analysis for the prediction of tumor recurrence after normal findings at cystoscopic examination...
  10. ncbi Solitary skull recurrence from stage I seminomatous germ cell tumor of testis
    J R Spermon
    Department of Urology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Urology 64:377-9. 2004
    ..The patient had complete remission after combined cisplatin-based chemotherapy...
  11. ncbi Diagnostic efficacy of the ImmunoCyt test to detect superficial bladder cancer recurrence
    J L Vriesema
    Department of Urology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Urology 58:367-71. 2001
    ..The validity of ImmunoCyt was insufficient to justify the omission of cystoscopy in patients in follow-up for superficial UCC...
  12. ncbi The prognostic value of E-cadherin and the cadherin-associated molecules alpha-, beta-, gamma-catenin and p120ctn in prostate cancer specific survival: a long-term follow-up study
    I M van Oort
    Department of Urology, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands
    Prostate 67:1432-8. 2007
    ..To determine the value of loss of expression of E-cadherin and cadherin associated molecules as prognostic markers for prostate cancer patients in a long-term follow-up study...
  13. ncbi Sperm integrity pre- and post-chemotherapy in men with testicular germ cell cancer
    J R Spermon
    Department of Urology, Radboud University Nijmegen Medical Centre, The Netherlands
    Hum Reprod 21:1781-6. 2006
    ....
  14. ncbi Intravesical gemcitabine: a phase 1 and pharmacokinetic study
    J A Witjes
    Department of Urology, University Medical Center St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 45:182-6. 2004
    ..We investigated the use of three dose levels of gemcitabine when given intravesically in humans for safety and pharmacokinetic research...
  15. ncbi High-intensity focused ultrasound (HIFU) followed after one to two weeks by radical retropubic prostatectomy: results of a prospective study
    H P Beerlage
    Department of Urology, University Hospital Nijmegen, The Netherlands
    Prostate 39:41-6. 1999
    ..Experimental studies have shown clear damage of malignant tissue exposed to HIFU, but knowledge of in vivo effects is limited. We studied the safety and efficacy of HIFU in patients with a T1-2 N0) M0 prostate carcinoma...
  16. ncbi Difference in stage and morphology-adjusted survival between young and elderly patients with a testicular germ cell tumor
    J R Spermon
    Department of Urology, University Medical Centre, Nijmegen, Nijmegen, The Netherlands
    Urology 60:889-93. 2002
    ..This difference was more evident in metastasized disease. Whether the worse prognosis in testicular cancer can be explained by a lower tolerance to chemotherapy and/or to suboptimal treatment in the elderly has to be established...
  17. ncbi Maximum tumor diameter is not an independent prognostic factor in high-risk localized prostate cancer
    I M van Oort
    Department of Urology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 10, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    World J Urol 26:237-41. 2008
    ..This study investigates the prognostic value of MTD for biochemical recurrence (BCR) in patients with PC, after radical prostatectomy (RP), with emphasis on high-risk localized prostate cancer...
  18. ncbi Safety and side effects of immediate instillation of apaziquone following transurethral resection in patients with nonmuscle invasive bladder cancer
    K Hendricksen
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Urol 180:116-20. 2008
    ..We studied the safety, tolerability and pharmacokinetics of a single immediate post-transurethral resection intravesical instillation of apaziquone for patients with nonmuscle invasive bladder cancer...
  19. ncbi Comparison of surveillance and retroperitoneal lymph node dissection in Stage I nonseminomatous germ cell tumors
    J R Spermon
    Department of Urology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Urology 59:923-9. 2002
    ..Most complications after both treatment strategies are reversible. The choice of treatment should be based on balanced information and not on dogmatic principles...
  20. ncbi Urinary NMP22 BladderChek test in the diagnosis of superficial bladder cancer
    P M J Moonen
    Department of Urology, Radboud University Nijmegen Medical Centre, The Netherlands
    Eur Urol 48:951-6; discussion 956. 2005
    ..Furthermore it is an easy test with instant result. However, no extra tumours were detected by adjunction of the NMP22 BladderChek test...
  21. ncbi Evaluation of chemotherapy with magnetic resonance imaging in patients with regionally metastatic or unresectable bladder cancer
    B Ph Schrier
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, Geert Grooteplein 10, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 49:698-703. 2006
    ....
  22. ncbi Review pathology in a diagnostic bladder cancer trial: effect of patient risk category
    J A Witjes
    Department of Urology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Urology 67:751-5. 2006
    ..Review pathology might be an answer, but appears to be of limited value. We studied the effect of patients' risk profile on the value of review pathology...
  23. ncbi The Bard BTA test: its mode of action, sensitivity and specificity, compared to cytology of voided urine, in the diagnosis of superficial bladder cancer
    D H Schamhart
    Department of Urology, University of Amsterdam, Nijmegen, The Netherlands
    Eur Urol 34:99-106. 1998
    ..In this study, the mode of action, sensitivity and specificity of the Bard(R) BTA test, detecting a tumor-associated release of a basement membrane complex, was addressed and compared with voided urine cytology (VUC)...
  24. ncbi Superficial and metachronous invasive bladder carcinomas are clonally related
    J L Vriesema
    Department of Urology, University Medical Centre Nijmegen, The Netherlands
    Int J Cancer 93:699-702. 2001
    ..All tumors arose from the same progenitor cell. These results support the concept of a clonal origin of superficial and metachronous invasive bladder UCCs...
  25. ncbi Intratumoral distribution of two consecutive injections of chimeric antibody G250 in primary renal cell carcinoma: implications for fractionated dose radioimmunotherapy
    M G Steffens
    Department of Urology, University Hospital Nijmegen, The Netherlands
    Cancer Res 59:1615-9. 1999
    ....
  26. ncbi [Treatment of testicular cancer clinical stage I: watchful waiting, radiotherapy, chemotherapy or surgical intervention]
    J R Spermon
    Universitair Medisch Centrum St Radboud, afd. Urologie, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 150:2637-42. 2006
    ..Standard treatment in this case consists of watchful waiting or retroperitoneal lymph node dissection with chemotherapy, if necessary, in case of positive lymph nodes. Another option is primary chemotherapy...
  27. ncbi The role of (18)fluoro-2-deoxyglucose positron emission tomography in initial staging and re-staging after chemotherapy for testicular germ cell tumours
    J R Spermon
    Department of Urology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    BJU Int 89:549-56. 2002
    ....
  28. ncbi Survivin mRNA expression is elevated in malignant urothelial cell carcinomas and predicts time to recurrence
    I J Schultz
    Department of Clinical Chemistry 564, University Medical Center Nijmegen, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Anticancer Res 23:3327-31. 2003
    ..Expression of the inhibitor of apoptosis protein survivin is up-regulated in many tumors of epithelial origin and frequently shows a relationship with disease prognosis...
  29. ncbi Efficacy of routine follow-up after first-line treatment for testicular cancer
    J R Spermon
    Department of Urology, University Medical Centre St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    World J Urol 22:235-43. 2004
    ..Abdominal computed tomography does not appear necessary in routine follow-up of patients treated for low-stage testicular cancer...
  30. ncbi Risk of urothelial bladder cancer in Lynch syndrome is increased, in particular among MSH2 mutation carriers
    R S van der Post
    Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Med Genet 47:464-70. 2010
    ..The aim of the present study was to establish whether carriers of mutations in mismatch repair genes MLH1, MSH2 or MSH6 are at increased risk of urinary bladder cancer...
  31. ncbi Prognostic value of p53 for high risk superficial bladder cancer with long-term followup
    P M J Moonen
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Urol 177:80-3. 2007
    ..We determined the value of p53 mutation, as demonstrated by mutation analysis, in a clinically selected group of high risk patients with superficial bladder cancer...
  32. ncbi Preliminary European results of local microwave hyperthermia and chemotherapy treatment in intermediate or high risk superficial transitional cell carcinoma of the bladder
    A G van der Heijden
    Department of Urology, University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 46:65-71; discussion 71-2. 2004
    ..e. BCG, have failed...
  33. ncbi Cancer incidence in relatives of patients with testicular cancer in the eastern part of The Netherlands
    J R Spermon
    Department of Urology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Urology 57:747-52. 2001
    ..This study supports previous reports that families of patients with TC do not seem to be prone to nontesticular cancer. Additional investigations in families with TC are recommended to map candidate genes for TC...
  34. ncbi The effect of N-acetyl-L-cysteine on the viscosity of ileal neobladder mucus
    B P Schrier
    University Medical Centre, St Radboud, Nijmegen, The Netherlands
    World J Urol 20:64-7. 2002
    ..NAC was found to decrease the viscosity of ileal neobladder mucus, supporting the in vivo experience that NAC can be useful in patients with an ileal neobladder to facilitate the evacuation of mucus by decreasing viscosity...
  35. ncbi Important factors in the diagnosis and primary staging of testicular tumours
    J Roan Spermon
    Department of Urology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Curr Opin Urol 12:419-25. 2002
    ..In the present review we outline the use of different staging methods and highlight future possibilities in the management of testicular germ cell cancer...
  36. ncbi Fertility in men with testicular germ cell tumors
    J Roan Spermon
    Department of Urology, University Medical Center Nijmegen, The, Nijmegen, Netherlands
    Fertil Steril 79:1543-9. 2003
    ..To assess the prevalence of fertility or infertility in men before and after treatment for unilateral testicular cancer. The results were compared with the lifetime prevalence of infertility in the general population (20%-28%)...
  37. ncbi Phase 2 study of adjuvant intravesical instillations of apaziquone for high risk nonmuscle invasive bladder cancer
    K Hendricksen
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Urol 187:1195-9. 2012
    ..We studied the safety and efficacy of multiple adjuvant apaziquone instillations in patients with high risk nonmuscle invasive bladder cancer...
  38. ncbi Pharmacokinetics of intravesical gemcitabine: a preclinical study in pigs
    J A Witjes
    Department of Urology, University Medical Center St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 44:615-9. 2003
    ..It has been shown to be effective and well tolerated when given systemically. We investigated the use of this agent administered intravesically in pigs for histological studies of the bladder and pharmacokinetic research...
  39. ncbi [In favour of open versus laparoscopic prostatectomy]
    J A Witjes
    Universitair Medisch Centrum St Radboud, afd Urologie, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 150:139. 2006
    ..Postoperatively, many patients appear to have T3 tumours, which cannot be optimally detected with current imaging techniques. Therefore, an open operation remains preferable...
  40. ncbi Nuclear medicine techniques for the diagnosis and therapy of prostate carcinoma
    W J Oyen
    University Medical Center Nijmegen, Department of Nuclear Medicine, Nijmegen, The Netherlands
    Eur Urol 40:294-9. 2001
    ..The bone scan remains useful in well-defined stages of disease, and palliative therapeutic options are evolving. At present, monoclonal antibodies and PET are not very useful in daily clinical practice...
  41. ncbi Absence of karyotype abnormalities in patients with familial urothelial cell carcinoma
    K K Aben
    Department of Epidemiology, University Medical Centre, Nijmegen, The Netherlands
    Urology 57:266-9. 2001
    ..CONCLUSIONS: It is conceivable that genetic germline abnormalities do exist in the patients in our study but are below the detection limit of the explorative methods used in this study...
  42. ncbi Bladder carcinoma in situ in 2003: state of the art
    J A Witjes
    Department of Urology, University Medical Center St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 45:142-6. 2004
    ..Unfortunately, despite much research, this prediction is not yet possible with molecular markers in daily practice...
  43. ncbi A randomized study comparing epirubicin in a 4-weekly versus a weekly intravenous regimen in patients with metastatic, hormone resistant, prostatic carcinoma: effects on health related quality of life
    G van Andel
    Department of Urology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands
    World J Urol 21:177-82. 2003
    ..In this study, HRQOL was not improved which is in line with other studies using only epirubicine. Epirubicin as single agent therapy should not be used in future treatment of patients with HRPC...
  44. ncbi False-positive lesions detected by fluorescence cystoscopy: any association with p53 and p16 expression?
    K Hendricksen
    Department of Urology, Radboud University Nijmegen Medical Centre, intern mail 659, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands
    World J Urol 24:597-601. 2006
    ..False positive lesions of fluorescence cystoscopy did not differ from benign lesions detected by standard white light cystoscopy with regard to p53 and p16 immunoreactivity. Little evidence remains for these lesions to be pre-malignant...
  45. ncbi Predictive value of PCA3 in urinary sediments in determining clinico-pathological characteristics of prostate cancer
    Daphne Hessels
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Prostate 70:10-6. 2010
    ..In this study, PCA3 was correlated with clinical stage, biopsy Gleason score (GS), radical prostatectomy GS, tumor volume, and pathological stage to assess its potential as predictor of PCa aggressiveness...
  46. ncbi Detailed analysis of histopathological parameters in radical prostatectomy specimens and PCA3 urine test results
    Martijn P M Q van Gils
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Prostate 68:1215-22. 2008
    ..PCA3 has proven to be of value in the diagnosis of PCa. However, so far few attempts have been made to investigate the prognostic value of PCA3. Our objective was to further investigate the prognostic value of PCA3...
  47. ncbi Downstaging of TURBT-Based Muscle-Invasive Bladder Cancer by Radical Cystectomy Predicts Better Survival
    P R van Dijk
    Department of Urology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    ISRN Urol 2011:458930. 2011
    ..pT stage was pT1 in 20 patients and pTis in 17 patients. Patients with tumor downstaging have about a 30% higher RFS and RS compared to those without. Consequently, tumor downstaging is a favorable marker for prognosis after RC...
  48. ncbi A multicenter, double-blind, randomized, parallel group study comparing polyvinyl chloride and polyvinyl chloride-free catheter materials
    J A Witjes
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Urol 182:2794-8. 2009
    ....
  49. ncbi Bladder cancer in women
    H G van der Poel
    University Hospital, Nijmegen, The Netherlands
    Int Urogynecol J Pelvic Floor Dysfunct 10:207-12. 1999
    ..The treatment of superficial bladder cancer tumors is similar for men and women. In recent years orthotopic bladder replacement has improved quality of life after cystectomy in invasive disease...
  50. ncbi Evaluation of early pelvic floor physiotherapy on the duration and degree of urinary incontinence after radical retropubic prostatectomy in a non-teaching hospital
    E B Cornel
    Department of Urology, Twente Hospital Group location SMT, P O Box 546, 7550 Hengelo, The Netherlands
    World J Urol 23:353-5. 2005
    ..Comparison of our results with current literature suggest that the time period towards continence after a RRP can be shortened relevantly if pelvic floor re-education is started directly after catheter removal...
  51. ncbi alpha-Catenin expression pattern and DNA image-analysis cytometry have no additional value over primary histology in clinical stage I nonseminomatous testicular cancer
    J R Spermon
    Department of Urology, University Medical Centre Nijmegen, The Netherlands
    BJU Int 89:278-84. 2002
    ....
  52. ncbi Comparison of orthotopic sigmoid and ileal neobladders: continence and urodynamic parameters
    B Ph Schrier
    Department of Urology, University Medical Center, St Radboud, Geert Grooteplein 10, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 47:679-85. 2005
    ..The objective this of the study was to compare continence rates and urodynamic parameters among patients who had undergone orthotopic bladder substitution with sigmoid or ileal segments...
  53. ncbi Comparison of three schedules of intravesical epirubicin in patients with non-muscle-invasive bladder cancer
    Kees Hendricksen
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Urol 53:984-91. 2008
    ....
  54. ncbi Simultaneous proteomic and genomic analysis of primary Ta urothelial cell carcinomas for the prediction of tumor recurrence
    Iman J Schultz
    Departments of Clinical Chemistry, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Anticancer Res 27:1051-8. 2007
    ..The prediction of tumor recurrence in patients with Ta urothelial cell carcinoma is inaccurate and new prognostic markers are desirable...
  55. ncbi Urinary bladder cancer: preoperative nodal staging with ferumoxtran-10-enhanced MR imaging
    Willem M L L G Deserno
    Department of Radiology, University Medical Center Sint Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Radiology 233:449-56. 2004
    ..To prospectively evaluate ferumoxtran-10-enhanced magnetic resonance (MR) imaging for nodal staging in patients with urinary bladder cancer...
  56. ncbi Molecular markers for detection, surveillance and prognostication of bladder cancer
    Olaf P J Vrooman
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Urol 16:234-43. 2009
    ..Currently, there are not clinically usable molecular markers that can guide us in diagnosis or surveillance, nor guide us in lowering the frequency of urethrocystoscopy in bladder cancer...
  57. ncbi Prostate cancer: local staging at 3-T endorectal MR imaging--early experience
    Jurgen J Futterer
    Department of Radiology, University Medical Center Nijmegen, Geert Grooteplein zuid 10, NL 6500 HB, Nijmegen, The Netherlands
    Radiology 238:184-91. 2006
    ..To prospectively investigate the local staging accuracy of 3-T endorectal magnetic resonance (MR) imaging for prostate cancer by using whole-mount-section histopathologic analysis as the standard of reference...
  58. ncbi The role of hexaminolevulinate fluorescence cystoscopy in bladder cancer
    J Alfred Witjes
    Department of Urology, University Medical Centre, St Radboud, Nijmegen, The Netherlands
    Nat Clin Pract Urol 4:542-9. 2007
    ..Long-term studies in this area with HAL are ongoing. The technique is well tolerated and is a useful adjunct to white-light cystoscopy...
  59. ncbi Case report: the danger of postchemotherapy laparoscopic retroperitoneal lymph node dissection for nonseminomatous testicular carcinoma
    J Roan Spermon
    Department of Urology, University Medical Center, St Radboud, Nijmegen, The Netherlands
    J Endourol 22:1013-6. 2008
    ..We report a case of retroperitoneal recurrent disease including a port-site metastasis secondary to laparoscopic RPLND...
  60. ncbi Three-dimensional proton MR spectroscopy of human prostate at 3 T without endorectal coil: feasibility
    Tom W J Scheenen
    Department of Radiology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 10, 6525 GA, Nijmegen, The Netherlands
    Radiology 245:507-16. 2007
    ....
  61. ncbi Magnetic resonance imaging guided prostate biopsy in men with repeat negative biopsies and increased prostate specific antigen
    Thomas Hambrock
    University Medical Centre St Radboud, Nijmegen, The Netherlands
    J Urol 183:520-7. 2010
    ..We compared results to those in a matched transrectal ultrasound guided prostate biopsy population. Also, we determined the clinical significance of detected tumors...
  62. ncbi The prognostic role of the pathological T2 subclassification for prostate cancer in the 2002 Tumour-Nodes-Metastasis staging system
    Inge M van Oort
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BJU Int 102:438-41. 2008
    ..To evaluate the prognostic role of the 2002 Tumour-Nodes-Metastasis (TNM) pT2 subclassification for biochemical recurrence (BCR) after radical prostatectomy (RP) for prostate cancer...
  63. ncbi The time-resolved fluorescence-based PCA3 test on urinary sediments after digital rectal examination; a Dutch multicenter validation of the diagnostic performance
    Martijn P M Q van Gils
    Department of Urology, Radboud University Nijmegen Medical Centre, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Clin Cancer Res 13:939-43. 2007
    ..In a previous single institution study, the PCA3 urine test clearly proved to be of diagnostic value. Therefore, the diagnostic performance of the PCA3 urine test was validated in a multicenter study...
  64. ncbi Molecular PCA3 diagnostics on prostatic fluid
    Martijn P M Q van Gils
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Prostate 67:881-7. 2007
    ..In this study, we evaluated the PCA3 test on prostatic fluid and compared this with the PCA3 test on urine in a clinical research setting...
  65. ncbi Evaluation of an orthotopic rat bladder urothelial cell carcinoma model by cystoscopy
    Kees Hendricksen
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BJU Int 101:889-93. 2008
    ..To enable preclinical testing of intravesical therapies against non-muscle-invasive bladder cancer (NMIBC) in an orthotopic rat bladder tumour model, augmented by the use of serial cystoscopy for in vivo tumour assessment and follow-up...
  66. ncbi Prostate cancer: body-array versus endorectal coil MR imaging at 3 T--comparison of image quality, localization, and staging performance
    Stijn W T P J Heijmink
    Department of Radiology, Radboud University Nijmegen Medical Centre, Geert Grooteplein zuid 10, NL 6500 HB, Nijmegen, The Netherlands
    Radiology 244:184-95. 2007
    ....
  67. ncbi Urinary markers in bladder cancer
    Olaf P J Vrooman
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Urol 53:909-16. 2008
    ..Almost all urinary markers reported are better than cytology with regard to sensitivity, but they score lower in specificity. The purpose of this review is to highlight the most important urinary biomarkers studied and reported recently...
  68. ncbi Detection of TMPRSS2-ERG fusion transcripts and prostate cancer antigen 3 in urinary sediments may improve diagnosis of prostate cancer
    Daphne Hessels
    Experimental Urology, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Cancer Res 13:5103-8. 2007
    ..We studied the diagnostic usefulness of TMPRSS2-ERG fusion transcripts as well as the combination of prostate cancer antigen 3 (PCA3) RNA and TMPRSS2-ERG fusion transcripts in urinary sediments after digital rectal examination (DRE)...
  69. ncbi A single institution experience with biochemical recurrence after radical prostatectomy for tumors that on pathology are of small volume or "insignificant"
    I M van Oort
    Department of Urology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Urol Oncol 27:509-13. 2009
    ..5 cc and Gleason scores <7, InsigPC) are considered clinically insignificant by some investigators. The aim of this study is to determine the biochemical recurrence rate (BCR) of svPC and InsigPC in prostatectomy specimens...
  70. ncbi Feasibility of 3T dynamic contrast-enhanced magnetic resonance-guided biopsy in localizing local recurrence of prostate cancer after external beam radiation therapy
    Derya Yakar
    Department of Radiology, Nijmegen Medical Centre, Radboud University, Nijmegen, The Netherlands
    Invest Radiol 45:121-5. 2010
    ....
  71. ncbi Human papilloma virus DNA and p53 mutation analysis on bladder washes in relation to clinical outcome of bladder cancer
    Paula M J Moonen
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Urol 52:464-8. 2007
    ..We aimed to study the association between presence of (high-risk) HPV DNA, p53 status, and clinical outcome in bladder cancer patients. This study must be seen as a preliminary study to investigate this potentially important problem...
  72. ncbi Prostate cancer: comparison of local staging accuracy of pelvic phased-array coil alone versus integrated endorectal-pelvic phased-array coils. Local staging accuracy of prostate cancer using endorectal coil MR imaging
    Jurgen J Futterer
    Department of Radiology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Eur Radiol 17:1055-65. 2007
    ..Overstaging is reduced significantly with equal sensitivity when an endorectal-pelvic phased-array coil is used...
  73. ncbi CDC91L1 (PIG-U) mRNA expression in urothelial cell carcinomas
    Iman J Schultz
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Int J Cancer 116:282-4. 2005
    ..Our results suggest, in contrast to those of Guo et al. (Nat Med 2004;10:374-81), that the oncogene CDC91L1 is not overexpressed at the mRNA level in urothelial cell carcinomas and cannot be used to predict the course of the disease...
  74. ncbi Bladder cancer diagnosis and recurrence prognosis: comparison of markers with emphasis on survivin
    Iman J Schultz
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Clin Chim Acta 368:20-32. 2006
    ..Also, important requirements for a successful implementation of such markers in a hospital setting are discussed. Finally, future directions for the discovery of new diagnostic or prognostic candidate markers will be mentioned...
  75. ncbi Survivin mRNA copy number in bladder washings predicts tumor recurrence in patients with superficial urothelial cell carcinomas
    Iman J Schultz
    Department of Clinical Chemistry, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Clin Chem 50:1425-8. 2004
  76. ncbi Applicability of biomarkers in the early diagnosis of prostate cancer
    Daphne Hessels
    Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Expert Rev Mol Diagn 4:513-26. 2004
    ..This could subsequently lead to a reduction of the number of unnecessary biopsies...
  77. ncbi Gene expression analysis for the prediction of recurrence in patients with primary Ta urothelial cell carcinoma
    Iman J Schultz
    Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Urol 51:416-22; discussion 422-3. 2007
    ..This study aims at discriminating between patients with primary Ta UCC and long or short recurrence-free periods...
  78. ncbi Prognosis of muscle-invasive bladder cancer: difference between primary and progressive tumours and implications for therapy
    Barthold Ph Schrier
    Department of Urology 426, University Medical Centre, St Radboud, Geert Grooteplein 10, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 45:292-6. 2004
    ..To evaluate the difference in prognosis between progressive and primary muscle-invasive bladder cancer...
  79. ncbi The efficacy of different follow-up strategies in clinical stage I Non-seminomatous Germ Cell Cancer: a Markov simulation study
    Jesse Roan Spermon
    Department of Urology, Radboud University Nijmegen Medical Center, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 48:258-67; discussion 267-8. 2005
    ..In this study, we constructed a Markov model to evaluate the impact of different follow-up strategies on disease-specific mortality (DSM) and life expectancy (LE) of patients with CS I NSGCT...
  80. ncbi Future strategies in the diagnosis, staging and treatment of bladder cancer
    Antoine G van der Heijden
    Department of Urology, Medical Centre, St Radboud, Nijmegem, The Netherlands
    Curr Opin Urol 13:389-95. 2003
    ..Finally, radical radiotherapy should be considered a valid treatment in patients with invasive bladder cancer...
  81. ncbi DD3(PCA3)-based molecular urine analysis for the diagnosis of prostate cancer
    Daphne Hessels
    Department of Experimental Urology, Nijmegen Center for Molecular Life Sciences, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Eur Urol 44:8-15; discussion 15-6. 2003
    ..DD3(PCA3) is the most prostate cancer-specific gene described to date. To assess the clinical utility of DD3(PCA3) a time-resolved fluorescence-based, quantitative RT-PCR analysis for DD3(PCA3) was developed...
  82. ncbi UroVysion compared with cytology and quantitative cytology in the surveillance of non-muscle-invasive bladder cancer
    Paula M J Moonen
    Department of Urology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Eur Urol 51:1275-80; discussion 1280. 2007
    ..The results were compared with conventional cytology and quantitative cytology (Quanticyt). The aim of this study was to evaluate whether UroVysion is a better adjunct to urethrocystoscopy than cytology and quantitative cytology...
  83. ncbi Effect of hyperthermia on the cytotoxicity of 4 chemotherapeutic agents currently used for the treatment of transitional cell carcinoma of the bladder: an in vitro study
    Antoine G van der Heijden
    Department of Urology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    J Urol 173:1375-80. 2005
    ..Hyperthermia alone did not cause decreased cell proliferation. Synergism was most prominent with low drug doses and the most potent drug used in this in vitro study was EO9...
  84. ncbi What is the optimal BCG dose in non-muscle-invasive bladder cancer?
    J Alfred Witjes
    Eur Urol 52:1300-2. 2007
  85. ncbi Survivin and MKI67 mRNA expression in bladder washings of patients with superficial urothelial cell carcinoma correlate with tumor stage and grade but do not predict tumor recurrence
    Iman J Schultz
    Clin Chem 52:1440-2. 2006
  86. ncbi Bacillus calmette-guerin versus chemotherapy for the intravesical treatment of patients with carcinoma in situ of the bladder: a meta-analysis of the published results of randomized clinical trials
    Richard J Sylvester
    European Organization for the Research and Treatment of Cancer Data Center, Brussels, Belgium
    J Urol 174:86-91; discussion 91-2. 2005
    ..We determined the short-term and long-term efficacy of bacillus Calmette-Guerin (BCG) and chemotherapy in the treatment of patients with carcinoma in situ (CIS)...
  87. ncbi Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer
    Julius Gudmundsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nat Genet 40:281-3. 2008
    ..23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease...
  88. ncbi The effect of an endorectal balloon and off-line correction on the interfraction systematic and random prostate position variations: a comparative study
    Emile N J Th van Lin
    Department of Radiation Oncology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Int J Radiat Oncol Biol Phys 61:278-88. 2005
    ..To investigate the effect of an endorectal balloon (ERB) and an off-line correction protocol on the day-to-day, interfraction prostate gland motion, in patients receiving external beam radiotherapy for prostate cancer...
  89. ncbi Initial experience of 3 tesla endorectal coil magnetic resonance imaging and 1H-spectroscopic imaging of the prostate
    Jurgen J Futterer
    Department of Radiology, University Medical Center Nijmegen, Nijmegen The Netherlands
    Invest Radiol 39:671-80. 2004
    ..We sought to explore the feasibility of magnetic resonance imaging (MRI) of the prostate at 3T, with the knowledge of potential drawbacks of MRI at high field strengths...
  90. ncbi MRI with a lymph-node-specific contrast agent as an alternative to CT scan and lymph-node dissection in patients with prostate cancer: a prospective multicohort study
    Roel A M Heesakkers
    Department of Radiology, Radboud University Medical Centre, Nijmegen, Netherlands
    Lancet Oncol 9:850-6. 2008
    ..In this prospective, multicentre cohort study, we aimed to compare the diagnostic accuracy of MRL with up-to-date multidetector CT (MDCT), and test the hypothesis that a negative MRL finding obviates the need for a PLND...
  91. ncbi Site-specific familial aggregation of prostate cancer
    Bas A J Verhage
    Center for Prevention and Health Services Research PZO, National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Int J Cancer 109:611-7. 2004
    ..5; 95% CI = 1.7-3.6). Cancers at other sites did not coaggregate with PC. Our data suggest that familial PC, at least in this Western European population, is site-specific, not part of an inherited cancer syndrome...
  92. ncbi Familial aggregation of urothelial cell carcinoma
    Katja K H Aben
    Department of Epidemiology and Biostatistics, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Int J Cancer 98:274-8. 2002
    ..Future segregation analyses may indicate whether this clustering can be attributed to genetic susceptibility...
  93. ncbi Staging prostate cancer with dynamic contrast-enhanced endorectal MR imaging prior to radical prostatectomy: experienced versus less experienced readers
    Jurgen J Futterer
    Department of Radiology, University Medical Center Nijmegen, The Netherlands
    Radiology 237:541-9. 2005
    ....
  94. ncbi The schedule and duration of intravesical chemotherapy in patients with non-muscle-invasive bladder cancer: a systematic review of the published results of randomized clinical trials
    Richard J Sylvester
    EORTC Data Center, Brussels, Belgium
    Eur Urol 53:709-19. 2008
    ..The objective is to determine the effect of schedule and duration of intravesical chemotherapy on recurrence in patients with stage Ta T1 bladder cancer...
  95. ncbi Intravesical chemotherapy for superficial bladder cancer
    J Alfred Witjes
    Department of Urology at University Medical Center Nijmegen, The Netherlands
    Nat Clin Pract Urol 1:56-7. 2004
  96. ncbi Standardized threshold approach using three-dimensional proton magnetic resonance spectroscopic imaging in prostate cancer localization of the entire prostate
    Jurgen J Futterer
    Department of Radiology, Radboud University Nijmegen Medical Center, The Netherlands
    Invest Radiol 42:116-22. 2007
    ..We sought to determine the localization accuracy using 3-dimensional (3D) proton magnetic resonance spectroscopic imaging (MRSI) of the entire prostate with a standardized thresholds approach in prostate cancer patients...
  97. ncbi Prostate cancer localization with dynamic contrast-enhanced MR imaging and proton MR spectroscopic imaging
    Jurgen J Futterer
    Department of Radiology, Radboud University Nijmegen Medical Center, Geert Grooteplein zuid 10, NL 6500 HB, Nijmegen, The Netherlands
    Radiology 241:449-58. 2006
    ....
  98. ncbi Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
    Julius Gudmundsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:631-7. 2007
    ..The newly identified variant shows a stronger association with affected individuals who have an earlier age at diagnosis...
  99. ncbi Phase II marker lesion study with intravesical instillation of apaziquone for superficial bladder cancer: toxicity and marker response
    Antoine G van der Heijden
    University Medical Centre Nijmegen, Nijmegen, The Netherlands
    J Urol 176:1349-53; discussion 1353. 2006
    ..Local side effects were comparable to side effects due to other chemotherapy instillations...
  100. ncbi Intravesical gemcitabine: an update of clinical results
    Kees Hendricksen
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Curr Opin Urol 16:361-6. 2006
    ..Exploring phase-II and comparative randomized phase-III studies should provide additional information on gemcitabine and its benefit to clinical practice...
  101. ncbi Ultrasound-guided transrectal implantation of gold markers for prostate localization during external beam radiotherapy: complication rate and risk factors
    Johan F Langenhuijsen
    Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Radiat Oncol Biol Phys 69:671-6. 2007
    ..To report the complication rate and risk factors of transrectally implanted gold markers, used for prostate position verification and correction procedures...