E R Vossenaar

Summary

Affiliation: University Medical Center
Country: The Netherlands

Publications

  1. ncbi Citrullination of synovial proteins in murine models of rheumatoid arthritis
    Erik R Vossenaar
    Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 48:2489-500. 2003
  2. ncbi PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease
    Erik R Vossenaar
    Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands
    Bioessays 25:1106-18. 2003
  3. ncbi Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages
    E R Vossenaar
    Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands
    Ann Rheum Dis 63:373-81. 2004
  4. ncbi Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin
    Erik R Vossenaar
    Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands
    Arthritis Res Ther 6:R142-50. 2004
  5. ncbi Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritis
    Erik R Vossenaar
    Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands
    Arthritis Res Ther 6:107-11. 2004
  6. ncbi Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value
    Martinus A M van Boekel
    Department of Biochemistry, University of Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Arthritis Res 4:87-93. 2002
  7. ncbi Autoantibodies to citrullinated proteins in rheumatoid arthritis: clinical performance and biochemical aspects of an RA-specific marker
    Suzanne Nijenhuis
    Department of Biochemistry 161, Radboud University Nijmegen, PO Box 9101, NL-6500 HB Nijmegen, The Netherlands
    Clin Chim Acta 350:17-34. 2004
  8. ncbi The presence of citrullinated proteins is not specific for rheumatoid synovial tissue
    Erik R Vossenaar
    Department of Biochemistry 161, Radboud University Nijmegen, NL 6500 HB Nijmegen, The Netherlands
    Arthritis Rheum 50:3485-94. 2004
  9. ncbi Autoantibodies to citrullinated (poly)peptides: a key diagnostic and prognostic marker for rheumatoid arthritis
    Albert J W Zendman
    Department of Biochemistry, Nijmegen Center for Molecular Life Science, University of Nijmegen, Nijmegen, The Netherlands
    Autoimmunity 37:295-9. 2004
  10. ncbi Anti-CCP antibodies: the new rheumatoid factor in the serology of rheumatoid arthritis
    Walther J van Venrooij
    Department of Biochemistry 161, University of Nijmegen, Nijmegen, The Netherlands
    Autoimmun Rev 3:S17-9. 2004

Detail Information

Publications14

  1. ncbi Citrullination of synovial proteins in murine models of rheumatoid arthritis
    Erik R Vossenaar
    Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 48:2489-500. 2003
    ....
  2. ncbi PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease
    Erik R Vossenaar
    Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands
    Bioessays 25:1106-18. 2003
    ..This article contains supplementary material which may be viewed at the BioEssays website at http://www.interscience.wiley.com/jpages/0265-9247/suppmat/2003/25/v25.1106.html...
  3. ncbi Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages
    E R Vossenaar
    Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands
    Ann Rheum Dis 63:373-81. 2004
    ..Peptidylcitrulline can be generated by post-translational conversion of arginine residues. This process, citrullination, is catalysed by a group of calcium dependent peptidylarginine deiminase (PAD) enzymes...
  4. ncbi Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin
    Erik R Vossenaar
    Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands
    Arthritis Res Ther 6:R142-50. 2004
    ....
  5. ncbi Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritis
    Erik R Vossenaar
    Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands
    Arthritis Res Ther 6:107-11. 2004
    ..It thus appears that it may take years for initial events that cause the generation of anti-CCP antibodies to develop into full-blown disease...
  6. ncbi Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value
    Martinus A M van Boekel
    Department of Biochemistry, University of Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Arthritis Res 4:87-93. 2002
    ..We conclude that, at present, the antibody response directed to citrullinated antigens has the most valuable diagnostic and prognostic potential for RA...
  7. ncbi Autoantibodies to citrullinated proteins in rheumatoid arthritis: clinical performance and biochemical aspects of an RA-specific marker
    Suzanne Nijenhuis
    Department of Biochemistry 161, Radboud University Nijmegen, PO Box 9101, NL-6500 HB Nijmegen, The Netherlands
    Clin Chim Acta 350:17-34. 2004
    ....
  8. ncbi The presence of citrullinated proteins is not specific for rheumatoid synovial tissue
    Erik R Vossenaar
    Department of Biochemistry 161, Radboud University Nijmegen, NL 6500 HB Nijmegen, The Netherlands
    Arthritis Rheum 50:3485-94. 2004
    ..Although the presence of citrullinated proteins in rheumatoid synovium has been described in the literature, it is uncertain whether their presence is specific for RA. The present study was undertaken to investigate this...
  9. ncbi Autoantibodies to citrullinated (poly)peptides: a key diagnostic and prognostic marker for rheumatoid arthritis
    Albert J W Zendman
    Department of Biochemistry, Nijmegen Center for Molecular Life Science, University of Nijmegen, Nijmegen, The Netherlands
    Autoimmunity 37:295-9. 2004
  10. ncbi Anti-CCP antibodies: the new rheumatoid factor in the serology of rheumatoid arthritis
    Walther J van Venrooij
    Department of Biochemistry 161, University of Nijmegen, Nijmegen, The Netherlands
    Autoimmun Rev 3:S17-9. 2004
  11. ncbi Absence of citrulline-specific autoantibodies in animal models of autoimmunity
    Erik R Vossenaar
    University of Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:2370-2. 2004
  12. ncbi ABAP: antibody-based assay for peptidylarginine deiminase activity
    Albert J W Zendman
    Department of Biomolecular Chemistry, Nijmegen Center for Molecular Life Sciences, Institute for Molecules and Materials, Radboud University Nijmegen, Nijmegen NL 6500 HB, The Netherlands
    Anal Biochem 369:232-40. 2007
    ..Our results demonstrate that this antibody-based assay for PAD activity, called ABAP, is very sensitive and can be applied to monitor PAD activity in biological samples...
  13. ncbi Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity
    Karin Lundberg
    Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    Arthritis Res Ther 7:R458-67. 2005
    ..We also show that citrullinated proteins and the enzyme PAD4 are not detectable in healthy joints, and that the appearance and amounts in arthritic joints of experimental animals are correlated with the severity of inflammation...
  14. ncbi Methylation of arginine residues interferes with citrullination by peptidylarginine deiminases in vitro
    Reinout Raijmakers
    Department of Biomolecular Chemistry, Nijmegen Center for Molecular Life Sciences, Institute for Molecules and Materials, Radboud University Nijmegen, Nijmegen, The Netherlands
    J Mol Biol 367:1118-29. 2007
    ....