Research Topics
Genomes and Genes | Holger RehmannSummaryAffiliation: University Medical Center Utrecht Country: The Netherlands Publications
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Publications
Structure of Epac2 in complex with a cyclic AMP analogue and RAP1BHolger Rehmann
Department of Physiological Chemistry, Centre for Biomedical Genetics and Cancer Genomics Centre, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Nature 455:124-7. 2008....- Epac2: a sulfonylurea receptor?Holger Rehmann
Department of Molecular Cancer Research, Centre for Biomedical Genetics and Cancer Genomics Centre, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Biochem Soc Trans 40:6-10. 2012..Sulfonylureas, such as tolbutamide, glibenclamide or acetohexamide, form a class of orally applicable drugs used in the treatment of non-insulin-dependent diabetes mellitus... - Capturing cyclic nucleotides in action: snapshots from crystallographic studiesHolger Rehmann
Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Nat Rev Mol Cell Biol 8:63-73. 2007..Recent structural insights have now made it possible to propose a general structural mechanism for how cyclic nucleotides regulate these proteins... - Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor EpacHolger Rehmann
Department of Physiological Chemistry and Centre of Biomedical Genetics, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
J Biol Chem 278:38548-56. 2003.... - Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited stateHolger Rehmann
Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Nature 439:625-8. 2006..Mutational analysis suggests a model for cAMP-induced Epac activation with rigid body movement of the regulatory region, the features of which are universally conserved in cAMP-regulated proteins... - Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteinsMartijn Gloerich
Department of Physiological Chemistry, Center for Biomedical Genetics, and Cancer Genomics Center, University Medical Center Utrecht, Utrecht, Netherlands
Mol Cell Biol 30:5421-31. 2010..We conclude that ERM proteins are involved in the spatial regulation of Epac1 and cooperate with cAMP- and Rap-mediated signaling to regulate adhesion to the extracellular matrix... - The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activityMartijn Gloerich
Molecular Cancer Research, Centre for Biomedical Genetics and Cancer Genomics Centre, University Medical Center Utrecht, 3584 CG Utrecht, Netherlands
J Cell Biol 193:1009-20. 2011..These results reveal a novel mechanism of Epac1 regulation and elucidate an unexpected link between the NPC and cAMP signaling... - Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction controlWillem Jan Pannekoek
Molecular Cancer Research, Centre of Biomedical Genetics and Cancer Genomics Centre, University Medical Center Utrecht, Utrecht, The Netherlands
Cell Signal 23:2056-64. 2011..We conclude that PDZ-GEF activates Rap1 under resting conditions to stabilize cell-cell junctions and maintain basal integrity. Activation of Rap1 by cAMP/Epac1 induces junctional actin to further tighten cell-cell contacts... - Biochemistry of the Rap-specific guanine nucleotide exchange factors PDZ-GEF1 and -2H Bea Kuiperij
Department of Physiological Chemistry, Centre for Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
Methods Enzymol 407:174-86. 2006..In this chapter, we give a detailed description of the methods that were used to unravel this mechanism in vitro and in vivo... - The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctionsNadia Dubé
Department of Physiological Chemistry, Centre for Biomedical Genetics and Cancer Genomics Centre, Utrecht, The Netherlands
Cell Signal 20:1608-15. 2008..Our results present the first direct evidence that PDZ-GEF2 plays a critical role in the maturation of adherens junctions... - Structural dynamics in the activation of EpacShannon M Harper
Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
J Biol Chem 283:6501-8. 2008..The results reveal the critical elements of the CNB domain of Epac required for activation and highlight the role of dynamics in this process... - GEFs and GAPs: critical elements in the control of small G proteinsJohannes L Bos
Department of Physiological Chemistry and Centre of Biomedical Genetics, UMC Utrecht Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Cell 129:865-77. 2007..Recent evidence suggests that these proteins may be potential therapeutic targets for developing drugs to treat various diseases, including cancer... - The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent mannerJudith H Raaijmakers
Department of Physiological Chemistry and Centre of Biomedical Genetics, UMC Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
Cell Signal 19:1249-57. 2007..Since it was shown previously that Arap3 has a higher affinity for PI(3,4,5,)P3 than for PI(3,4)P2, we propose that the SAM domain of Arap3 can function to recruit a negative regulator of PI3K signaling into the effector complex... - Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2H Bea Kuiperij
Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Centre Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands
Biochim Biophys Acta 1593:141-9. 2003..We conclude that both PDZ-GEF1 and 2 are specific for Rap1 and Rap2 and unresponsive to cAMP and various other nucleotides... - Characterization of the activation of the Rap-specific exchange factor Epac by cyclic nucleotidesHolger Rehmann
Department of Physiological Chemistry, Centre for Biomedical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
Methods Enzymol 407:159-73. 2006..This is of particular interest for the development of Epac-specific analogs, which do not act on other cellular cAMP targets such as protein kinase A (PKA) or for the design of therapeutic agents targeting Epac... - Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor EpacHolger Rehmann
Department of Physiological Chemistry and Centre of Biomedical Genetics, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
J Biol Chem 278:23508-14. 2003..From these results we conclude that the LID region plays a pivotal role in the communication between the regulatory and catalytic part of Epac... - Phylogeny of the CDC25 homology domain reveals rapid differentiation of Ras pathways between early animals and fungiTeunis J P van Dam
Theoretical Biology and Bioinformatics, Department of Biology, Science Faculty, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
Cell Signal 21:1579-85. 2009..Finally, a comparison of the domain composition of the Ras guanine nucleotide exchange factors shows that domain addition and diversification occurred both prior to and after the fungal-animal split... - Structure and regulation of the cAMP-binding domains of Epac2Holger Rehmann
Max Planck Institut fur molekulare Physiologie, Otto Hahn Strasse 11, D 44227, Dortmund, Germany
Nat Struct Biol 10:26-32. 2003..We identify a hinge region that couples cAMP binding to a conformational change of the C-terminal regions. Mutations in the hinge of Epac can uncouple cAMP binding from its exchange activity... - cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cellsGuoxin Kang
Department of Physiology and Neuroscience, New York University School of Medicine, New York, NY, USA
J Physiol 573:595-609. 2006.... - Differences between the interaction of beta-catenin with non-phosphorylated and single-mimicked phosphorylated 20-amino acid residue repeats of the APC proteinLara Tickenbrock
Max Planck Institut fur molekulare Physiologie, Otto Hahn Strasse 11, D 44227 Dortmund, Germany
J Mol Biol 327:359-67. 2003..These results indicate structural differences between the E-cadherin/beta-catenin and the APC/beta-catenin complexes and provide quantitative evidence for the importance of the APC phosphorylation for its interaction with beta-catenin... - Structural insight into the recognition of the H3K4me3 mark by the TFIID subunit TAF3Hugo van Ingen
Bijvoet Centre for Biomolecular Research, Utrecht University, 3584 CH Utrecht, The Netherlands
Structure 16:1245-56. 2008..Interference by asymmetric dimethylation of arginine 2 suggests that a H3R2/K4 "methyl-methyl" switch in the histone code dynamically regulates TFIID-promoter association... - Signal transduction: thumbs up for inactivationHolger Rehmann
Nature 429:138-9. 2004 - Cyclic nucleotide analogs as probes of signaling pathwaysHeiko Poppe
Nat Methods 5:277-8. 2008 - A novel cyclic AMP-dependent Epac-Rit signaling pathway contributes to PACAP38-mediated neuronal differentiationGeng-Xian Shi
Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, 741 South Limestone Street, Lexington, KY 40536-0509, USA
Mol Cell Biol 26:9136-47. 2006.... - Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFsHelmut Kae
Department of Microbiology and Immunology, University of British Columbia, 3540 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada
EMBO Rep 8:477-82. 2007..This RasGEF target specificity provides a mechanism for one upstream signal to regulate two downstream processes using independent pathways...