Research Topics
| Frank MiedemaSummaryAffiliation: University Medical Center Utrecht Country: The Netherlands Publications
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Detail Information
Publications
The HIV RNA setpoint theory revisitedRonald B Geskus
Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
Retrovirology 4:65. 2007..Both markers were evaluated on a scale that is directly related to AIDS risk...- A brief history of HIV vaccine research: stepping back to the drawing board?Frank Miedema
University Medical Center Utrecht, Utrecht, The Netherlands
AIDS 22:1699-703. 2008..Here, the history of HIV vaccine development from the discovery of HIV-1 in 1983 until 2008, the underlying ideas on protective immunity to HIV and potential avenues for vaccine research are discussed... - Abundance of early functional HIV-specific CD8+ T cells does not predict AIDS-free survival timeIngrid M M Schellens
Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
PLoS ONE 3:e2745. 2008.... - Restoration of the CD4 T cell compartment after long-term highly active antiretroviral therapy without phenotypical signs of accelerated immunological agingNienke Vrisekoop
Department of Immunology, University Medical Center, Utrecht, The Netherlands
J Immunol 181:1573-81. 2008..Irrespective of baseline CD4 T cell counts, reconstitution occurred without a significant effect on T cell aging as reflected by markers for replicative history... - Immunological analysis of treatment interruption after early highly active antiretroviral therapyIngrid M M Schellens
Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
Viral Immunol 23:609-18. 2010..Degranulation contributed more to the overall CD8(+) T-cell response than cytokine production. Whether increased T-cell functionality is a cause or consequence of low viral load remains to be elucidated... - Long-term restoration of the human T-cell compartment after thymectomy during infancy: a role for thymic regeneration?Rogier van Gent
Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
Blood 118:627-34. 2011..Whereas thymectomy has severe effects on the establishment of the naive T-cell compartment during early childhood, our data suggest that functional regrowth of thymic tissue can limit its effects in subsequent years... - Loss of HIV-1-derived cytotoxic T lymphocyte epitopes restricted by protective HLA-B alleles during the HIV-1 epidemicIngrid M M Schellens
aDepartment of Immunology, University Medical Center Utrecht, The Netherlands
AIDS 25:1691-700. 2011..Here we investigated whether adaptations to cellular immunity have also accumulated during the epidemic... - In vivo dynamics of stable chronic lymphocytic leukemia inversely correlate with somatic hypermutation levels and suggest no major leukemic turnover in bone marrowRogier van Gent
Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
Cancer Res 68:10137-44. 2008..Furthermore, in contrast to lymph nodes, the bone marrow does not seem to be a major CLL proliferation site... - Growth hormone resurrects adult human thymus during HIV-1 infectionKiki Tesselaar
Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
J Clin Invest 118:844-7. 2008..While the long-term immunological and clinical benefits of growth hormone treatment remain unclear, the data suggest a way in which to enhance thymopoiesis and peripheral T cell production in immunodeficient individuals... - Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral poolNienke Vrisekoop
Department of Immunology, University Medical Center Utrecht, 3508 AB, Utrecht, The Netherlands
Proc Natl Acad Sci U S A 105:6115-20. 2008..Thus, our data are incompatible with a substantial short-lived RTE population in human adults and suggest that the few naïve T cells that are newly produced are preferentially incorporated in the peripheral pool... - Limited role for the thymus in SIV pathogenesisJose A M Borghans
Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
Eur J Immunol 35:42-5. 2005..Their data therefore suggest that the main cause of CD4(+) T cell loss during SIV infection is the peripheral effect of SIV, and not its effect on thymic output... - Reconstitution of naive T cells during antiretroviral treatment of HIV-infected adults is dependent on ageJames Cohen Stuart
Department of Virology, Eijkman-Winkler Institute, University Utrecht, Utrecht, The Netherlands
AIDS 16:2263-6. 2002..CONCLUSION: These observations suggest that the thymus contributes considerably to the regeneration of naive T cells in adults on HAART, and that the impact of HIV infection on naive T cell production is small, or rapidly reversible... - Prognostic value of HIV-1 Gag-specific CD4+ T-cell responses for progression to AIDS analyzed in a prospective cohort studyChristine A Jansen
Department of Immunology, University Medical Center Utrecht, Lundlaan 6, 3508 AB, Utrecht, The Netherlands
Blood 107:1427-33. 2006..Our results are compatible with viral load determining the nature and magnitude of HIV-specific CD4+ T-cell responses, rather than HIV-specific CD4+ T-cell responses controlling HIV plasma viral load... - CTL escape and increased viremia irrespective of HIV-specific CD4+ T-helper responses in two HIV-infected individualsMark J Geels
Department of Human Retrovirology, Academic Medical Centre, University of Amsterdam, The Netherlands
Virology 345:209-19. 2006..This suggests that loss of T-cell reactivity may not be directly linked to HIV-specific CD4(+) T-cell responses but that increased viremia after CTL escape may influence CD4(+) T-helper responses... - Short communication: No detrimental immunological effects of mycophenolate mofetil and HAART in treatment-naive acute and chronic HIV-1-infected patientsNienke Vrisekoop
Department of Clinical Viro-Immunology, Sanquin Research and Landsteiner Laboratory of the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
AIDS Res Hum Retroviruses 21:991-6. 2005..Still, there was no evidence for detrimental effects of treatment with mycophenolate mofetil in addition to HAART on CD4+ T cell reconstitution or HIV-specific immunity... - HIV-specific CD4+ T cells and viremia: who's in control?Christine A Jansen
Department of Clinical Viro-Immunology, Sanquin Research and Landsteiner Laboratory of the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Trends Immunol 27:119-24. 2006..This influences ideas about the type of cellular immunity a protective HIV vaccine should induce... - Long-term highly active antiretroviral therapy in chronic HIV-1 infection: evidence for reconstitution of antiviral immunityChristine A Jansen
Department of Clinical Viro-Immunology, Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands
Antivir Ther 11:105-16. 2006.... - T cell subset and cytokine profiles in human visceral leishmaniasis during active and asymptomatic or sub-clinical infection with Leishmania donovaniAsrat Hailu
Faculty of Medicine, Department of Microbiology, Immunology and Parasitology, Addis Ababa University, PO Box 9086, Addis Ababa, Ethiopia
Clin Immunol 117:182-91. 2005..Plasma concentrations of IFN-gamma and IL-10 were elevated in VL... - Tuberculin skin test conversion and reactivity rates among adults with and without human immunodeficiency virus in urban settings in EthiopiaBelete Tegbaru
Ethio Netherlands AIDS Research Project, Ethiopian Health and Nutrition Research Institute EHNRI, P O Box 1242, Addis Ababa, Ethiopia
Clin Vaccine Immunol 13:784-9. 2006..This indicates the need for other sensitive and specific diagnostic and screening methods to detect TB infection, particularly among HIV-positive persons, so that they can be given prophylactic isoniazid therapy... - Stable pattern of HIV-1 subtype C Gag-specific T-cell responses coincides with slow rate of CD4 T-cell decline in HIV-infected EthiopiansAster Tsegaye
Ethio Netherlands AIDS Research Project, Ethiopian Health and Nutrition Research Institute, PO Box 1242, Addis Ababa, Ethiopia
AIDS 21:369-72. 2007..The persistence of strong and broad anti-Gag cytotoxic T-lymphocyte responses was associated with a slow rate of CD4 T-cell decline and with human leukocyte antigen alleles from the B27 supertype... - CD4 cell counts of 800 cells/mm3 or greater after 7 years of highly active antiretroviral therapy are feasible in most patients starting with 350 cells/mm3 or greaterLuuk Gras
HIV Monitoring Foundation, Amsterdam, The Netherlands
J Acquir Immune Defic Syndr 45:183-92. 2007..CD4 cell count changes in therapy-naive patients were investigated during 7 years of highly active antiretroviral therapy (HAART) in an observational cohort... - HIV-1 viral rebound dynamics after a single treatment interruption depends on time of initiation of highly active antiretroviral therapyRadjin Steingrover
Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, and Center for Infection and Immunity Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
AIDS 22:1583-8. 2008.... - Amsterdam Cohort Study on HIV and AIDS: impact of exposure to UVR as estimated by means of a 2-year retrospective questionnaire on immune parameters in HIV positive malesJaap Maas
Amsterdam Cohort Study, Municipal Health Service, University of Amsterdam, Amsterdam, The Netherlands
Int J Hyg Environ Health 205:373-7. 2002..These findings suggest that exposure to sunlight does not have a suppressive effect on the above mentioned immunological parameters in HIV-infected persons... - A nonprogressive clinical course in HIV-infected individuals expressing human leukocyte antigen B57/5801 is associated with preserved CD8+ T lymphocyte responsiveness to the HW9 epitope in NefMarjon Navis
Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam at the Academic Medical Center, Amsterdam, The Netherlands
J Infect Dis 197:871-9. 2008..The results of the present study suggest that preservation of HW9-specific T cell responses is associated with a more benign clinical course of infection... - Intravenous immunoglobulin (IVIG) treatment for modulation of immune activation in human immunodeficiency virus type 1 infected therapy-naive individualsJoost N Vermeulen
IATEC, c o Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
AIDS Res Hum Retroviruses 23:1348-53. 2007..Our results support the hypothesis that T cell activation, rather than direct HIV-1 infection, mediates the loss of CD4+ T cells and suggest that immunomodulating therapy in HIV-1 infection could indeed be effective... - An unanticipated lack of consensus cytotoxic T lymphocyte epitopes in HIV-1 databases: the contribution of prediction programsIngrid M M Schellens
Department of Immunology, University Medical Center, The Netherlands
AIDS 22:33-7. 2008..Most consensus HIV-1-specific cytotoxic T lymphocytes epitopes presented via intensively studied HLA molecules are thought to be known.. - Viral replication capacity as a correlate of HLA B57/B5801-associated nonprogressive HIV-1 infectionMarjon Navis
Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam CINIMA at the Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands
J Immunol 179:3133-43. 2007.... - Mitochondrial DNA decline in T cells of HIV-1 seroconverters may be dependent on immune activationMiriam Casula
IATEC, Pietersbergweg 9, 1105 BM Amsterdam, The Netherlands
J Infect Dis 196:371-6. 2007..However, the mtDNA dynamics within this heterogeneous cell population during HIV-1 infection are not fully understood... - Shift of CMV-specific CD4+ T-cells to the highly differentiated CD45RO-CD27- phenotype parallels loss of proliferative capacity and precedes progression to HIV-related CMV end-organ diseaseCorine Bronke
Department of Clinical Viro Immunology, Sanquin Research and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Clin Immunol 124:190-9. 2007.... - HIV-1 Subtype C gag-specific T-cell responses in relation to human leukocyte antigens in a diverse population of HIV-infected EthiopiansAster Tsegaye
Ethiopian Netherlands AIDS Research Project, Ethiopian Health and Nutrition Research Institute, Addis Ababa, Ethiopia
J Acquir Immune Defic Syndr 45:389-400. 2007..The most frequently targeted Gag peptides overlapped with those previously described for HIV-1 subtype C-infected southern Africans, and therefore can be used in a multiethnic vaccine... - Low CD4 T cell counts before HIV-1 seroconversion do not affect disease progression in Ethiopian factory workersYared Mekonnen
Ethio-Netherlands AIDS Research Project, Ethiopian Health and Nutrition Research Institute, Addis Ababa, Ethiopia
J Infect Dis 192:739-48. 2005..CONCLUSIONS: Low baseline CD4 T cell counts do not imply shorter survival times in Ethiopians than in other populations, presumably because of a slower decline in CD4 T cell counts... - Reconstitution of EBV latent but not lytic antigen-specific CD4+ and CD8+ T cells after HIV treatment with highly active antiretroviral therapyErwan Piriou
Department of Clinical Viro-Immunology, Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 175:2010-7. 2005..In conclusion, long-term HAART does not alter the EBV DNA load, but does lead to a restoration of EBNA1-specific T cell responses, which might allow better control of EBV-infected cells when applied early enough during HIV infection... - Analysis of the effect of highly active antiretroviral therapy during acute HIV-1 infection on HIV-specific CD4 T cell functionsChristine A Jansen
Department of Clinical Viro-Immunology, Sanquin Research and Landsteiner Laboratory, University of Amsterdam, The Netherlands
AIDS 19:1145-54. 2005.... - Early viral load and CD4+ T cell count, but not percentage of CCR5+ or CXCR4+ CD4+ T cells, are associated with R5-to-X4 HIV type 1 virus evolutionRonald P Van Rij
Sanquin and the Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, The Netherlands
AIDS Res Hum Retroviruses 19:389-98. 2003..Our results exclude target cell availability as a driving force for R5-to-X4 virus phenotype evolution... - Low versus high CD4 cell count as starting point for introduction of antiretroviral treatment in resource-poor settings: a scenario-based analysisJohannes A Bogaards
Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, The Netherlands
Antivir Ther 8:43-50. 2003..In a hospital-based setting in resource-poor environments this ensures an efficient treatment allocation... - Thymic output: a bad TREC recordMette D Hazenberg
Department of Clinical Viro-Immunology, Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands
Nat Immunol 4:97-9. 2003 - Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clueDebbie van Baarle
Dept of Clinical Viro Immunology, Sanquin Research at CLB and Landsteiner Laboratory of the Academic Medical Center, University of Amsterdam, The Netherlands
Trends Immunol 23:586-91. 2002..We postulate that CD27(-) effector CD8(+) T cells might be required for adequate control of chronic viral infection and prevention of disease development... - Lack of Epstein-Barr virus- and HIV-specific CD27- CD8+ T cells is associated with progression to viral disease in HIV-infectionDebbie van Baarle
Department of Clinical Viro Immunology, CLB Sanquin and Landsteiner Laboratory of the Academic Medical Center, University of Amsterdam, The Netherlands
AIDS 16:2001-11. 2002..To investigate the underlying mechanism of this loss of immune control phenotypic analysis of HIV- and Epstein-Barr virus (EBV)-specific CD8+ T cells was performed... - HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressorsStephen A Migueles
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
Nat Immunol 3:1061-8. 2002..In addition, the relative absence of these functions in progressors may represent a mechanism by which HIV avoids immunological control... - Primary HIV-1 subtype C infection in EthiopiaTobias F Rinke de Wit
Ethio-Netherlands AIDS Research Project (ENARP) at the Ethiopian Health and Nutrition Research Institute (EHNRI, Addis Ababa, Ethiopia
J Acquir Immune Defic Syndr 30:463-70. 2002..One subject demonstrated a window period of at least 204 days, combined with a high preseroconversion viral load and no decline of CD4 T cells over a follow-up period of at least 3 years... - Absolute level of Epstein-Barr virus DNA in human immunodeficiency virus type 1 infection is not predictive of AIDS-related non-Hodgkin lymphomaDebbie van Baarle
Department of Clinical Viro Immunology, Sanquin Research at CLB, and Department of Hematology, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, The Netherlands
J Infect Dis 186:405-9. 2002..EBV DNA was also detectable in serum at some time points but at a lower level... - Discordant responses during antiretroviral therapy: role of immune activation and T cell redistribution rather than true CD4 T cell lossMette D Hazenberg
Department of Clinical Viro-Immunology, Sanquin Research, CLB and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, The Netherlands
AIDS 16:1287-9. 2002..Low reactivity to rebounding virus may preserve normal T lymphocyte distribution over blood and tissues and be associated with stable peripheral blood T cell numbers in virological failures to HAART... - Long-term follow-up: no effect of therapeutic vaccination with HIV-1 p17/p24:Ty virus-like particles on HIV-1 disease progressionCatharina E A Lindenburg
The Municipal Health Service of Amsterdam, Cluster Infectious Diseases, Amsterdam, The Netherlands
Vaccine 20:2343-7. 2002..98). In conclusion, therapeutic vaccination with p24-VLP is not related to slower HIV-1 disease progression... - Functional restoration of human immunodeficiency virus and Epstein-Barr virus-specific CD8(+) T cells during highly active antiretroviral therapy is associated with an increase in CD4(+) T cellsStefan Kostense
Department of Clinical Viro Immunology, CLB and Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Eur J Immunol 32:1080-9. 2002..Overall, these data indicate that HAART improves the antigen responsiveness of both HIV- and EBV-specific T cells, which is associated with an increase in CD4(+) T cells... - Persistent numbers of tetramer+ CD8(+) T cells, but loss of interferon-gamma+ HIV-specific T cells during progression to AIDSStefan Kostense
Department of Clinical Viro-Immunology, CLB/Sanquin Blood Supply Foundation, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
Blood 99:2505-11. 2002..These data indicate that the loss of HIV-specific CD8(+) T-cell activity is not due to physical depletion, but is mainly due to progressively impaired function of HIV-specific CD8(+) T cells... - Depletion of naive CD4 T cells by CXCR4-using HIV-1 variants occurs mainly through increased T-cell death and activationMette D Hazenberg
Department of Clinical Viro-Immunology, Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands
AIDS 17:1419-24. 2003..Our data suggest that the accelerated naive CD4 T-cell decline induced by X4 variants is caused mainly by increased death and recruitment to the memory compartment of these cells... - Persistent immune activation in HIV-1 infection is associated with progression to AIDSMette D Hazenberg
Department of Clinical Viro-Immunology, Sanquin Research at CLB, Tropical Medicine and AIDS, Amsterdam, The Netherlands
AIDS 17:1881-8. 2003..These data support the hypothesis that persistent hyperactivation of the immune system may lead to erosion of the naive T cell pool and CD4 T cell depletion... - Lymphocyte numbers and function in relation to periodontitis and smokingBruno G Loos
Department of Periodontology, Academic Center for Dentistry Amsterdam, Amsterdam, The Netherlands
J Periodontol 75:557-64. 2004..Taking smoking into consideration, the aim of this study was to analyze numbers of circulating T (CD3+) cells and their CD4+ and CD8+ subpopulations, B (CD19+) cells, and T-cell proliferative capacity in periodontitis... - Natural controlled HIV infection: preserved HIV-specific immunity despite undetectable replication competent virusNico Kloosterboer
Sanquin Research at CLB, Landsteiner Laboratory at the Academic Medical Center, Department of Clinical Viro Immunology, Plesmanlaan 125, University of Amsterdam, 1066 CX Amsterdam, The Netherlands
Virology 339:70-80. 2005..These data implicate that very low-level antigen exposure is sufficient for sustained HIV-specific immunity and suggest the possibility of a multi-factorial control of HIV infection... - Expression of chemokine receptors CCR5 and CXCR4 on CD4+ T cells and plasma chemokine levels during treatment of active tuberculosis in HIV-1-coinfected patientsDawit Wolday
Ethio Netherlands AIDS Research Project ENARP and Ethiopian Health and Nutrition Research Institute EHNRI, Addis Ababa, Ethiopia
J Acquir Immune Defic Syndr 39:265-71. 2005..This, in turn, may contribute, at least in part, to the observed persistently elevated plasma HIV viremia in coinfected patients despite anti-TB treatment... - High plasma HIV load in the CRF01-AE outbreak among injecting drug users in FinlandPia S Kivelä
Division of Infectious Diseases, Helsinki University Central Hospital, Helsinki, Finland
Scand J Infect Dis 37:276-83. 2005..The difference could not be explained by the use of antiretrovirals. The higher viral load may have contributed to the rapid spread of the recombinant virus in the Finnish outbreak... - Novel method for detection of virus-specific CD41+ T cells indicates a decreased EBV-specific CD4+ T cell response in untreated HIV-infected subjectsErwan R Piriou
Department of Clinical Viro-Immunology, Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Eur J Immunol 35:796-805. 2005..Interestingly, numbers of EBV-specific CD4(+) and CD8(+) T cells were inversely correlated with EBV viral load, suggesting an important role also for EBV-specific CD4(+) T cells in the control of EBV infection... - Dynamics of cytomegalovirus (CMV)-specific T cells in HIV-1-infected individuals progressing to AIDS with CMV end-organ diseaseCorine Bronke
Department of Clinical Viro-Immunology, Sanquin Research and Landsteiner Laboratory, Amsterdam, The Netherlands
J Infect Dis 191:873-80. 2005..Increasing CMV-infected cell counts in the face of high CMV-specific perforin- and granzyme B-expressing CD8(+) T cell counts may explain the immune pathological characteristics of CMV disease... - Significance of senescence for virus-specific memory T cell responses: rapid ageing during chronic stimulation of the immune systemDebbie van Baarle
Department of Clinical Viro Immunology, Sanquin Research and Landsteiner Laboratory, University of Amsterdam, 1066 CX Amsterdam, The Netherlands
Immunol Lett 97:19-29. 2005..We discuss data suggesting that T cell defects may arise in individuals because of chronic antigen activation leading to rapid ageing of the memory CD8+ T cell pool... - High responsiveness of HLA-B57-restricted Gag-specific CD8+ T cells in vitro may contribute to the protective effect of HLA-B57 in HIV-infectionChristine A Jansen
Department of Clinical Viro-Immunology, Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, The Netherlands
Eur J Immunol 35:150-8. 2005..B57-restricted KAFSPEVIPMF-specific CD8(+) T cells have relatively high responsiveness, which could contribute to the protective effect of HLA-B57 in HIV infection... - Characterization of virus-specific CD8(+) effector T cells in the course of HIV-1 infection: longitudinal analyses in slow and rapid progressorsChristine A Jansen
Department of Clinical Viro-Immunology, Sanquin Research and Landsteiner Laboratory of the Academic Medical Center, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
Clin Immunol 113:299-309. 2004..Thus, in individuals with progressive HIV infection, HIV-specific T cells are less differentiated already early in infection. This apparent block in differentiation may be partly caused by chronic viremia or lack of CD4(+) T-cell help... - Highly active antiretroviral therapy with or without mycophenolate mofetil in treatment-naive HIV-1 patientsSanjay U C Sankatsing
Department of Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, University of Amsterdam, The Netherlands
AIDS 18:1925-31. 2004..CONCLUSION: The addition of MMF to a triple class antiretroviral regimen in treatment-naive patients does not significantly increase the plasma HIV-1 RNA decay rate or the decay rate of the latently infected cellular reservoir... - Pre-seroconversion immune status predicts the rate of CD4 T cell decline following HIV infectionLiselotte van Asten
Municipal Health Service, Sanquin Research at CLB and Academic Medical Centre and the Department of Human Retrovirology, Academic Medical Centre, Amsterdam, The Netherlands
AIDS 18:1885-93. 2004..CONCLUSION: Among IDU, immune status prior to HIV infection as measured by TREC content affects the disease course after HIV seroconversion... - Establishment of the CD4+ T-cell pool in healthy children and untreated children infected with HIV-1Mette D Hazenberg
Department of Clinical Viro-Immunology, Sanquin Research at CLB, Amsterdam, The Netherlands
Blood 104:3513-9. 2004..We postulate that in children infected with HIV, similar to adults infected with HIV, continuous activation of naive T cells leads to erosion of the naive T-cell pool and may be a major factor in lowering CD4(+) T-cell numbers... - Altered EBV viral load setpoint after HIV seroconversion is in accordance with lack of predictive value of EBV load for the occurrence of AIDS-related non-Hodgkin lymphomaErwan R Piriou
Department of Clinical Viro-Immunology, Sanquin Research at CLB and Landsteiner Laboratory. Department of Human Retrovirology and Department of Hematology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 172:6931-7. 2004..These data may thus help to explain the lack of predictive value of EBV load for the occurrence of AIDS-related lymphoma... - Selective decrease in circulating V alpha 24+V beta 11+ NKT cells during HIV type 1 infectionHans J J van der Vliet
Department of Medical Oncology, Pathology, and Internal Medicine, Free University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
J Immunol 168:1490-5. 2002..In this longitudinal study no evidence was found to support an important role of Valpha24+Vbeta11+ NKT cells in determining the rate of progression during HIV-1 infection...