Research Topics
Genomes and Genes | Wietse KuisSummaryAffiliation: University Medical Center Country: The Netherlands Publications
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Detail Information
Publications
Mirrored symptoms in mother and child with chronic fatigue syndromeElise M van de Putte
Department of Pediatrics, Wilhelmina Children s Hospital, University Medical Center, Utrecht, The Netherlands
Pediatrics 117:2074-9. 2006....- Is chronic fatigue syndrome a connective tissue disorder? A cross-sectional study in adolescentsE M van de Putte
Department of Pediatric, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, Netherlands
Pediatrics 115:e415-22. 2005.... - Chronic fatigue syndrome and health control in adolescents and parentsE M van de Putte
Department of Paediatrics, Wilhelmina Children s Hospital, University Medical Center, Utrecht, Netherlands
Arch Dis Child 90:1020-4. 2005..To explore the locus of health control in adolescents with chronic fatigue syndrome (CFS) and their parents in comparison with healthy adolescents and their parents... - Bystander suppression of experimental arthritis by nasal administration of a heat shock protein peptideEvelien Zonneveld-Huijssoon
Correspondence to Berent J Prakken, Department of Pediatric Immunology, KC 01 069 0, University Medical Centre Utrecht, Wilhelmina Children s Hospital, Lundlaan 6 PO Box 85090, 3584 EA 3508 AB Utrecht, The Netherlands
Ann Rheum Dis 70:2199-206. 2011..A study was undertaken to determine whether mucosal administration of these bystander epitopes can be similarly effective in suppressing arthritis... - Self-investigation in adolescent chronic fatigue syndrome: narrative changes and health improvementStefan M van Geelen
Division of Pediatric Psychology, University Medical Center Utrecht, Utrecht, The Netherlands
Patient Educ Couns 83:227-33. 2011..A small-scale intervention study into narrative self-investigation in adolescent chronic fatigue syndrome (CFS)... - Effects of an educational video film in fatigued children and adolescents: a randomised controlled trialRob J Bakker
Department of Pediatrics, Antonius Ziekenhuis, Sneek, The Netherlands
Arch Dis Child 96:457-60. 2011..In many cases standard management for chronic fatigue syndrome (CFS) in children and adolescents is ineffective... - Adolescent chronic fatigue syndrome: a follow-up studyStefan M van Geelen
Department of Pediatrics, University Medical Center Utrecht, Lundlaan 6, Utrecht, The Netherlands
Arch Pediatr Adolesc Med 164:810-4. 2010..To describe the symptomatic and educational long-term outcomes, health care use, and risk factors of nonrecovery in adolescent chronic fatigue syndrome (CFS)... - Vaccination leads to an aberrant FOXP3 T-cell response in non-remitting juvenile idiopathic arthritisArash Ronaghy
Department of Pediatrics, Center for Cellular and Molecular Intervention, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Ann Rheum Dis 70:2037-43. 2011.... - The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal childrenMarieke J H van Summeren
Department of Paediatrics, University Medical Centre Utrecht, PO Box 85090, 3508 AB Utrecht, The Netherlands
Br J Nutr 102:1171-8. 2009..These findings demonstrate that in healthy, prepubertal children, modest supplementation with MK-7 increases circulating concentrations of MK-7 and increases osteocalcin carboxylation... - Alexithymia in adolescents with chronic fatigue syndromeElise M van de Putte
Department of Pediatrics, Wilhelmina Children s Hospital, University Medical Center Utrecht The Netherlands
J Psychosom Res 63:377-80. 2007..Comorbidity such as anxiety and depression were analyzed as possible confounding factors. Secondly, alexithymia was investigated as a prognostic factor for the recovery of CFS... - CD30 discriminates heat shock protein 60-induced FOXP3+ CD4+ T cells with a regulatory phenotypeIsme de Kleer
Center for Molecular and Cellular Immunology, University Medical Center Utrecht, The Netherlands
J Immunol 185:2071-9. 2010..These findings have implications for the generation and isolation of pure populations of Ag-specific Tregs, with the potential to prevent and treat human inflammatory diseases... - Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritisWilco de Jager
Department of Pediatrics, Centre for Cellular and Molecular Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands
Arthritis Rheum 60:2782-93. 2009..Since IL-18 can drive NK cell function, we examined how the high plasma levels of this cytokine are related to the documented NK cell failure in these patients... - FOXP3+ CD4+ Tregs lose suppressive potential but remain anergic during transient inflammation in humanAlvin W L Schadenberg
Department of Pediatric Immunology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Eur J Immunol 41:1132-42. 2011..These data show that inflammation inhibits Treg function through soluble factors present in plasma. These results underscore the functional role of FOXP3(+) Tregs during inflammation in vivo... - Stem cell transplantation for autoimmune disorders. Refractory juvenile idiopathic arthritisNico M Wulffraat
Department of Paediatric Immunology and Rheumatology, Wilhelmina Children s Hospital, University Medical Center Utrecht, P O Box 85090, Utrecht 3508 AB, The Netherlands
Best Pract Res Clin Haematol 17:277-89. 2004..It is still unclear why especially patients with systemic juvenile idiopathic arthritis are at risk of episodes of reactive haemophagocytosis... - Case report: severe central nervous system involvement in juvenile dermatomyositisElisabeth F Elst
Department of Pediatric Immunology, University Medical Center of Utrecht, Wilhelmina Children s Hospital, mailbox KC 03 063 0, 3508 AB Utrecht, The Netherlands
J Rheumatol 30:2059-63. 2003..The clinical symptoms and further investigations in our patients show CNS involvement in JDM. Although rarely reported, CNS vasculopathy can be a serious and life-threatening complication of JDM... - Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndromeJoost Frenkel
Division of Pediatrics, Wilhelmina Children s Hospital, KE 04 133 1, University Medical Center Utrecht, PO Box 85090, 3580 AB Utrecht, The Netherlands
Arthritis Rheum 46:2794-803. 2002.... - Heat shock proteins in juvenile idiopathic arthritis: keys for understanding remitting arthritis and candidate antigens for immune therapyBerent Prakken
Department of Pediatric Immunology, University Medical Center Utrecht, University Hospital for Children and Youth, PO Box 85090, Utrecht 3508 AB, The Netherlands
Curr Rheumatol Rep 4:466-73. 2002..Taken together, these data imply that immune modulation with hsps can be an effective way to restore natural occurring T cell responses, and, thus, treat JIA and rheumatoid arthritis... - Risk factors for persistent fatigue with significant school absence in children and adolescentsRobert J Bakker
Department of Pediatrics, Antonius Ziekenhuis, Sneek, Netherlands
Pediatrics 124:e89-95. 2009..To assess children and adolescents with severe fatigue who are referred to pediatricians and to examine whether factors can be identified at their first visit that predict worse outcomes at 1 year... - Vitamin K status is associated with childhood bone mineral contentMarieke J H van Summeren
Department of Paediatric Immunology, University Medical Centre Utrecht, PO Box 85090, Utrecht, The Netherlands
Br J Nutr 100:852-8. 2008..In order to determine the significance of these findings for childhood bone health, additional paediatric studies are needed... - Mutations in the perforin gene can be linked to macrophage activation syndrome in patients with systemic onset juvenile idiopathic arthritisSebastiaan J Vastert
Department of Paediatric Immunology, Wilhelmina Children s Hospital, University Medical Centre Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands
Rheumatology (Oxford) 49:441-9. 2010..Interestingly, SoJIA patients display decreased levels of perforin in NK cells and diminished NK cell function as well. Here, we analysed PRF1 and its putative promoter in SoJIA patients with or without a history of MAS... - Overt and occult rheumatic diseases: the child with chronic feverJoost Frenkel
Department of General Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Suite KE.04.133.1, P.O. Box 85090, The Netherlands
Best Pract Res Clin Rheumatol 16:443-69. 2002..We discuss how this knowledge has influenced diagnosis and treatment of these rare genetic disorders and how it might change our approach to the more common rheumatic diseases... - Systemic JIA: new developments in the understanding of the pathophysiology and therapySebastiaan J Vastert
Department of Pediatric Immunology Wilhelmina Children s Hospital, University Medical Center Utrecht, Lundlaan 6, 3584 EA, Utrecht, The Netherlands
Best Pract Res Clin Rheumatol 23:655-64. 2009..These therapies might also change the long-term outcome of this disease. However, controlled trials set up in international collaboration are needed to determine the optimal treatment strategies for all sJIA patients... - High prevalence of methotrexate intolerance in juvenile idiopathic arthritis: development and validation of a methotrexate intolerance severity scoreMaja Bulatović
University Medical Centre Utrecht, Utrecht, The Netherlands
Arthritis Rheum 63:2007-13. 2011..To design and validate a new questionnaire for identifying patients with methotrexate (MTX) intolerance, and to determine the prevalence of MTX intolerance in patients with juvenile idiopathic arthritis (JIA) using this questionnaire... - Autologous stem cell transplantation for autoimmunity induces immunologic self-tolerance by reprogramming autoreactive T cells and restoring the CD4+CD25+ immune regulatory networkIsme de Kleer
University Medical Center Utrecht, Wilhelmina Children s Hospital, Home Mailbox KC 03 063 0, Department of Pediatric Immunology, PO Box 85090, 3508 AB Utrecht, The Netherlands
Blood 107:1696-702. 2006.... - Tolerogenic immune responses to novel T-cell epitopes from heat-shock protein 60 in juvenile idiopathic arthritisSylvia Kamphuis
Department of Paediatric Immunology, IACOPO Institute for Translational Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands
Lancet 366:50-6. 2005.... - Pan-DR-binding Hsp60 self epitopes induce an interleukin-10-mediated immune response in rheumatoid arthritisHuib de Jong
University Medical Centre Utrecht, Utrecht, The Netherlands
Arthritis Rheum 60:1966-76. 2009..This study was undertaken to characterize the disease specificity and function of pan-DR-binding Hsp60-derived epitopes as possible modulators of autoimmune inflammation in RA... - Self-investigation to explore the impact of juvenile arthritis on adolescent life: a case-studyCoralie E Fuchs
Department of Pediatric Psychology, Wilhelmina Children s Hospital, University Medical Center Utrecht, The Netherlands
Patient Educ Couns 72:163-7. 2008..To gain insight into the personal experience and feelings of an adolescent with a chronic disease... - Radiologic features in juvenile idiopathic arthritis: a first step in the development of a standardized assessment methodMarion A J van Rossum
Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 48:507-15. 2003.... - Blood and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-sectional studyWilco de Jager
Department of Pediatric Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
Ann Rheum Dis 66:589-98. 2007..Although onset and disease course differ, the subtypes of JIA share the occurrence of chronic inflammation of the joints, with infiltrations of immunocompetent cells that secrete inflammatory mediators... - Novel self-epitopes derived from aggrecan, fibrillin, and matrix metalloproteinase-3 drive distinct autoreactive T-cell responses in juvenile idiopathic arthritis and in healthSylvia Kamphuis
Department of Paediatric Immunology and IACOPO, Institute for Translational Medicine, University Medical Center Utrecht, PO Box 85090, 3508 AB Utrecht, The Netherlands
Arthritis Res Ther 8:R178. 2006..Additional experiments need to be performed to explore their qualities and role in disease pathogenesis in further detail... - Safety of measles, mumps and rubella vaccination in juvenile idiopathic arthritisMarloes W Heijstek
Department of Paediatric Immunology, Wilhelmina Children s Hospital, University Medical Centre Utrecht, Room KC 03 0630, PO Box 85090, 3508 AB Utrecht, The Netherlands
Ann Rheum Dis 66:1384-7. 2007..To assess the effect of measles, mumps and rubella (MMR) vaccination on disease activity in children with juvenile idiopathic arthritis (JIA)... - Novel pan-DR-binding T cell epitopes of adenovirus induce pro-inflammatory cytokines and chemokines in healthy donorsLianne M Haveman
Department of Pediatric Immunology and Hematology, Wilhelmina Children's Hospital, University Medical Center, KC.03.063.0, Lundlaan 6, Postbus 85090, 3508 AB, Utrecht, The Netherlands
Int Immunol 18:1521-9. 2006..Based on the broad recognition and the induced cytokine and chemokine profile, the detected epitopes can be regarded as potential candidates to select adenovirus-specific T cells for immune intervention in the immunocompromised host... - Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cellsWilco de Jager
Department of Pediatric Immunology, University Medical Center Utrecht, Wilhelmina Children's Hospital, 3584 EA Utrecht, The Netherlands
Clin Diagn Lab Immunol 10:133-9. 2003..It will provide a more complete picture in differences between activated lymphocyte cytokine profiles from healthy individuals and those from patients with chronic inflammatory diseases... - Hsp60 in inflamed muscle tissue is the target of regulatory autoreactive T cells in patients with juvenile dermatomyositisElisabeth F Elst
University Medical Center Utrecht, Utrecht, The Netherlands
Arthritis Rheum 58:547-55. 2008..The purpose of this study was to determine whether Hsp60 could serve as an autoantigen in juvenile DM... - Safety and efficacy of meningococcal c vaccination in juvenile idiopathic arthritisEvelien Zonneveld Huijssoon
Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
Arthritis Rheum 56:639-46. 2007.... - Personality and chronic fatigue syndrome: methodological and conceptual issuesStefan M van Geelen
Department of Psychology, Wilhelmina Children s Hospital, University Medical Center Utrecht, The Netherlands
Clin Psychol Rev 27:885-903. 2007..New insights into personality and CFS might be gained by systematically studying the self-narratives of patients with the syndrome... - Temperature dependence of mutant mevalonate kinase activity as a pathogenic factor in hyper-IgD and periodic fever syndromeSander M Houten
Departments of Paediatrics Emma Children s Hospital and Clinical Chemistry, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Hum Mol Genet 11:3115-24. 2002..Our results suggest that minor elevations in temperature can set off a chain of events with MK becoming progressively rate-limiting, leading to a temporary deficiency of isoprenoid end-products, which induces inflammation and fever... - Circulating calcification inhibitors and vascular properties in children after renal transplantationMarieke J H van Summeren
Department of Pediatric Immunology, University Medical Centre Utrecht, Lundlaan 6, Room KE 04 133 1, 3584 EA Utrecht, The Netherlands
Pediatr Nephrol 23:985-93. 2008..Future prospective studies in pediatric ESRD and transplant patients are needed to learn more about the role of calcification inhibitors in relation to the prevention of vascular damage... - Development of a standardized method of assessment of radiographs and radiographic change in juvenile idiopathic arthritis: introduction of the Dijkstra composite scoreMarion A J van Rossum
Emma Children s Hospital AMC, Pediatric Rheumatology, Amsterdam, The Netherlands
Arthritis Rheum 52:2865-72. 2005..To evaluate the sensitivity to change of a newly developed radiologic assessment tool, the Dijkstra score, and to develop a numeric composite score and progressor classification scheme to apply in juvenile idiopathic arthritis (JIA) trials... - Improved multiplex immunoassay performance in human plasma and synovial fluid following removal of interfering heterophilic antibodiesWilco de Jager
Department of Pediatric Immunology, University Medical Center Utrecht, Wilhelmina Children's Hospital, Utrecht, The Netherlands
J Immunol Methods 300:124-35. 2005..We show that pre-absorption with protein-L is a powerful tool for removal of interfering immunoglobulins from human bodily fluids to be used in immunoassays for studying changes in protein patterns... - Long-term outcome of juvenile idiopathic arthritis following a placebo-controlled trial: sustained benefits of early sulfasalazine treatmentMarion A J van Rossum
Emma Children s Hospital AMC, Paediatric Rheumatology, G8 205, PO Box 22660, 1100 DD Amsterdam, The Netherlands
Ann Rheum Dis 66:1518-24. 2007..The current study determines the long-term outcome of the trial participants and evaluates whether the benefits of SSZ allocation are sustained over time... - Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapySalima Hacein-Bey-Abina
Laboratoire INSERM, , Paris, France
N Engl J Med 346:1185-93. 2002..CONCLUSIONS: Ex vivo gene therapy with gamma(c) can safely correct the immune deficiency of patients with X-linked severe combined immunodeficiency... - Expression of myeloid-related proteins 8 and 14 in systemic-onset juvenile rheumatoid arthritisMichael Frosch
Institute of Experimental Dermatology and Department of Pediatrics, University of Munster, Munster, Germany
Arthritis Rheum 48:2622-6. 2003.... - Preliminary core sets of measures for disease activity and damage assessment in juvenile systemic lupus erythematosus and juvenile dermatomyositisNicolino Ruperto
IRCCS G Gasalini, Pediatria II, Genova, Italy
Rheumatology (Oxford) 42:1452-9. 2003..To identify preliminary core sets of outcome variables for disease activity and damage assessment in juvenile systemic lupus erythematosus (JSLE) and juvenile dermatomyositis (JDM)... - Pronounced elevation of undercarboxylated osteocalcin in healthy childrenMarieke van Summeren
Department of Pediatric Immunology, University Medical Centre Utrecht, 3584 EA Utrecht, The Netherlands
Pediatr Res 61:366-70. 2007..These findings suggest a pronounced low vitamin K status of bone during growth. The question remains, however, whether children would benefit from higher vitamin K intake, for instance, by improved bone health or stronger bones... - Monitoring neutrophil activation in juvenile rheumatoid arthritis by S100A12 serum concentrationsDirk Foell
Institute of Experimental Dermatology and Department of Pediatrics, University of Muenster, Muenster, Germany
Arthritis Rheum 50:1286-95. 2004..The aim of our study was to determine neutrophil activation in juvenile rheumatoid arthritis (JRA) by analyzing S100A12 (EN-RAGE; calgranulin C), a proinflammatory protein secreted by human neutrophils...