Research Topics
Species | I HammingSummaryAffiliation: University Medical Center Groningen Country: The Netherlands Publications
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Detail Information
Publications
ACE inhibition has adverse renal effects during dietary sodium restriction in proteinuric and healthy ratsI Hamming
Department of Pathology and Laboratory Medicine, University Medical Center Groningen and University of Groningen, The Netherlands
J Pathol 209:129-39. 2006..Further studies should elucidate the mechanisms underlying these observations and their impact on long-term renoprotection...- The emerging role of ACE2 in physiology and diseaseI Hamming
Department of Pathology and Laboratory Medicine, University Medical Center Groningen and University of Groningen, The Netherlands
J Pathol 212:1-11. 2007..This review covers available information on the genetic, structural and functional properties of ACE2. Its role in a variety of (patho)physiological conditions and therapeutic options of modulation are discussed... - Differential regulation of renal angiotensin-converting enzyme (ACE) and ACE2 during ACE inhibition and dietary sodium restriction in healthy ratsI Hamming
Department of Pathology and Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands
Exp Physiol 93:631-8. 2008..Therefore, we propose that the beneficial effects of ACE inhibitors are predominantly mediated by modulation of ACE and not ACE2. Whether this also applies to renal disease conditions should be investigated in future studies... - Effect of combining ACE inhibition with aldosterone blockade on proteinuria and renal damage in experimental nephrosisA B Kramer
Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Kidney Int 71:417-24. 2007..In conclusion, ACEi/aldoRB effectively reduced proteinuria and markers of tubular injury and prevented renal damage in this rat model of chronic proteinuria-induced renal damage... - Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesisI Hamming
Department of Pathology and Laboratory Medicine, University Hospital Groningen, The Netherlands
J Pathol 203:631-7. 2004..This epithelial expression, together with the presence of ACE2 in vascular endothelium, also provides a first step in understanding the pathogenesis of the main SARS disease manifestations... - Renal ACE2 expression in human kidney diseaseA T Lely
Department of Nephrology, Groningen University Medical Centre, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
J Pathol 204:587-93. 2004..Further studies should elucidate the possible protective mechanisms involved in the de novo expression of ACE2 in renal disease... - ACE inhibitor use and the increased long-term risk of renal failure in diabetesI Hamming
Kidney Int 70:1377-8; author reply 1378. 2006 - Angiotensin-converting enzyme 2 (ACE2) expression and activity in human carotid atherosclerotic lesionsJ C Sluimer
Department of Pathology, University of Maastricht, Cardiovascular Research Institute Maastricht, Maastricht, The Netherlands
J Pathol 215:273-9. 2008..These results suggest a differential regulation of ACE2 activity during the progression of atherosclerosis and suggest that this novel molecule of the renin-angiotensin system may play a role in the pathogenesis of atherosclerosis... - Antihypertensive therapy induces compartment-specific chemokine expression and a Th1 immune response in the clipped kidney of Goldblatt hypertensive ratsO M Steinmetz
Dept of Medicine, Division of Nephrology, University Hospital of Hamburg Eppendorf, 20246 Hamburg, Germany
Am J Physiol Renal Physiol 292:F876-87. 2007..These findings suggest that the Th1 chemokines IP10 and Mig as well as their receptor CXCR3 are potential targets for therapeutic interventions in ischemic nephropathy...