Marc Bijl

Summary

Affiliation: University Hospital Groningen
Country: The Netherlands

Publications

  1. ncbi Do elevated levels of serum-soluble fas contribute to the persistence of activated lymphocytes in systemic lupus erythematosus?
    M Bijl
    Department of Clinical Immunology, University Hospital, Groningen, The Netherlands
    J Autoimmun 11:457-63. 1998
  2. ncbi Mycophenolate mofetil prevents a clinical relapse in patients with systemic lupus erythematosus at risk
    M Bijl
    Department of Clinical Immunology, University Hospital, Groningen, The Netherlands
    Ann Rheum Dis 62:534-9. 2003
  3. ncbi Endothelial activation, endothelial dysfunction and premature atherosclerosis in systemic autoimmune diseases
    M Bijl
    Department of Internal Medicine, Division of Clinical Immunology, University Hospital Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Neth J Med 61:273-7. 2003
  4. ncbi Serum amyloid P component levels are not decreased in patients with systemic lupus erythematosus and do not rise during an acute phase reaction
    M Bijl
    Department of Internal Medicine, Division of Clinical Immunology, University Hospital, PO Box 30 001, 9700 RB Groningen, Netherlands
    Ann Rheum Dis 63:831-5. 2004
  5. ncbi Fas expression on peripheral blood lymphocytes in systemic lupus erythematosus (SLE): relation to lymphocyte activation and disease activity
    M Bijl
    Department of Internal Medicine, Division of Clinical Immunology, University Hospital, Groningen, The Netherlands
    Lupus 10:866-72. 2001
  6. ncbi New insights into the pathogenesis of systemic lupus erythematosus (SLE): the role of apoptosis
    M Bijl
    Department of Internal Medicine, Division of Clinical Immunology, University Hospital, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Neth J Med 59:66-75. 2001
  7. ncbi Effects of smoking on activation markers, Fas expression and apoptosis of peripheral blood lymphocytes
    M Bijl
    Department of Internal Medicine, University Hospital, Groningen, The Netherlands
    Eur J Clin Invest 31:550-3. 2001
  8. ncbi Expression of costimulatory molecules on peripheral blood lymphocytes of patients with systemic lupus erythematosus
    M Bijl
    Department of Clinical Immunology, University Hospital, Groningen, The Netherlands
    Ann Rheum Dis 60:523-6. 2001
  9. ncbi Reduced uptake of apoptotic cells by macrophages in systemic lupus erythematosus: correlates with decreased serum levels of complement
    M Bijl
    Department of Internal Medicine, Division of Clinical Immunology, University Hospital, The Netherlands
    Ann Rheum Dis 65:57-63. 2006
  10. ncbi Cardiac abnormalities in SLE: pancarditis
    M Bijl
    Department of Internal Medicine, University Hospital, Groningen, The Netherlands
    Lupus 9:236-40. 2000

Collaborators

Detail Information

Publications73

  1. ncbi Do elevated levels of serum-soluble fas contribute to the persistence of activated lymphocytes in systemic lupus erythematosus?
    M Bijl
    Department of Clinical Immunology, University Hospital, Groningen, The Netherlands
    J Autoimmun 11:457-63. 1998
    ..Serum levels of sFas correlate with percentages of activated B cells but not with that of activated T cells...
  2. ncbi Mycophenolate mofetil prevents a clinical relapse in patients with systemic lupus erythematosus at risk
    M Bijl
    Department of Clinical Immunology, University Hospital, Groningen, The Netherlands
    Ann Rheum Dis 62:534-9. 2003
    ....
  3. ncbi Endothelial activation, endothelial dysfunction and premature atherosclerosis in systemic autoimmune diseases
    M Bijl
    Department of Internal Medicine, Division of Clinical Immunology, University Hospital Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Neth J Med 61:273-7. 2003
    ..It is supposed that chronic EC dysfunction, as present in patients with systemic autoimmune disorders, contributes to the development of premature atherosclerosis and results in an increased prevalence of cardiovascular disease...
  4. ncbi Serum amyloid P component levels are not decreased in patients with systemic lupus erythematosus and do not rise during an acute phase reaction
    M Bijl
    Department of Internal Medicine, Division of Clinical Immunology, University Hospital, PO Box 30 001, 9700 RB Groningen, Netherlands
    Ann Rheum Dis 63:831-5. 2004
    ..Serum amyloid P component (SAP) and acute phase proteins like C-reactive protein contribute to the clearance of apoptotic cells. This response is diminished in systemic lupus erythematosus (SLE)...
  5. ncbi Fas expression on peripheral blood lymphocytes in systemic lupus erythematosus (SLE): relation to lymphocyte activation and disease activity
    M Bijl
    Department of Internal Medicine, Division of Clinical Immunology, University Hospital, Groningen, The Netherlands
    Lupus 10:866-72. 2001
    ..Increased Fas expression results in a higher susceptibility for Fas-mediated apoptosis, which might contribute to the increased levels of apoptotic lymphocytes in SLE patients...
  6. ncbi New insights into the pathogenesis of systemic lupus erythematosus (SLE): the role of apoptosis
    M Bijl
    Department of Internal Medicine, Division of Clinical Immunology, University Hospital, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Neth J Med 59:66-75. 2001
    ..In this review we will discuss the data which supply evidence for this theory. We will focus on SLE as the prototype of autoimmune disease and will review both animal studies and clinical studies in SLE patients...
  7. ncbi Effects of smoking on activation markers, Fas expression and apoptosis of peripheral blood lymphocytes
    M Bijl
    Department of Internal Medicine, University Hospital, Groningen, The Netherlands
    Eur J Clin Invest 31:550-3. 2001
    ....
  8. ncbi Expression of costimulatory molecules on peripheral blood lymphocytes of patients with systemic lupus erythematosus
    M Bijl
    Department of Clinical Immunology, University Hospital, Groningen, The Netherlands
    Ann Rheum Dis 60:523-6. 2001
    ..The expression of costimulatory molecules on peripheral blood lymphocytes in patients with SLE in conjunction with disease activity was measured to evaluate whether expression of costimulatory molecules in SLE is increased...
  9. ncbi Reduced uptake of apoptotic cells by macrophages in systemic lupus erythematosus: correlates with decreased serum levels of complement
    M Bijl
    Department of Internal Medicine, Division of Clinical Immunology, University Hospital, The Netherlands
    Ann Rheum Dis 65:57-63. 2006
    ..Decrease of phagocytosis of apoptotic cells occurs in systemic lupus erythematosus (SLE). Factors underlying this decrease are, presently, unknown...
  10. ncbi Cardiac abnormalities in SLE: pancarditis
    M Bijl
    Department of Internal Medicine, University Hospital, Groningen, The Netherlands
    Lupus 9:236-40. 2000
    ..Treatment with high dose corticosteroids resulted in a gradual, almost complete recovery. Literature concerning cardiac manifestations in lupus is reviewed...
  11. ncbi Transient osteoporosis of the hip: presentation of (a)typical cases and a review of the literature
    M Bijl
    Department of Rheumatology, University Hospital, Groningen, The Netherlands
    Clin Exp Rheumatol 17:601-4. 1999
    ..Two patients with TOH, a father and daughter, are described. Such a familial appearance has not been reported before. Based on HLA-typing, the existence of an HLA-associated genetic predisposition nevertheless seems unlikely...
  12. ncbi Serum amyloid P component binds to late apoptotic cells and mediates their uptake by monocyte-derived macrophages
    Marc Bijl
    Department of Internal Medicine, University Hospital, Groningen, The Netherlands
    Arthritis Rheum 48:248-54. 2003
    ....
  13. ncbi Cell-mediated immune responses to influenza vaccination in Wegener's granulomatosis
    Albert Holvast
    Department of Rheumatology and Clinical Immunology, University Medical Centre Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Ann Rheum Dis 69:924-7. 2010
    ..In Wegener's granulomatosis (WG), antibody responses to influenza vaccination appear to be similar to those in healthy controls, but cell-mediated responses have not been studied...
  14. ncbi Effect of a second, booster, influenza vaccination on antibody responses in quiescent systemic lupus erythematosus: an open, prospective, controlled study
    Albert Holvast
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Rheumatology (Oxford) 48:1294-9. 2009
    ..In SLE, a decreased antibody response on influenza vaccination has been reported. In this study, we assessed whether a booster vaccination could improve antibody responses, as determined by seroprotection rates, in SLE patients...
  15. ncbi Opsonization of late apoptotic cells by systemic lupus erythematosus autoantibodies inhibits their uptake via an Fcgamma receptor-dependent mechanism
    Esther Reefman
    University Medical Center Groningen, and University of Groningen, Groningen, The Netherlands
    Arthritis Rheum 56:3399-411. 2007
    ..The aim of this study was to investigate whether the binding of SLE autoantibodies to apoptotic cells influences the phagocytosis of these cells by macrophages...
  16. ncbi Cell-mediated immune responses to inactivated trivalent influenza-vaccination are decreased in patients with common variable immunodeficiency
    Sander Van Assen
    Department of Internal Medicine, Division of Infectious Diseases, University Medical Center Groningen, The Netherlands
    Clin Immunol 141:161-8. 2011
    ..Concluding, CMI responses following influenza vaccination are hampered in CVID-patients compared to HC. Additional protective strategies against influenza other than vaccination are warranted...
  17. ncbi Inflammatory clearance of apoptotic cells after UVB challenge
    Marc Bijl
    Division of Clinical Immunology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen Groningen The Netherlands
    Autoimmunity 40:244-8. 2007
    ..In this review, we will focus on apoptotic cells, their elimination, and the consequences of a disturbed elimination of apoptotic cells on the development of UVB induced inflammatory skin lesions...
  18. ncbi High mobility group box 1 (HMGB1) and anti-HMGB1 antibodies and their relation to disease characteristics in systemic lupus erythematosus
    Deena A Abdulahad
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Arthritis Res Ther 13:R71. 2011
    ..In this study we determined levels of HMGB1 and anti-HMGB1 in SLE patients in comparison to healthy controls (HC) and analysed their relation with disease activity...
  19. ncbi AGE and their receptor RAGE in systemic autoimmune diseases: an inflammation propagating factor contributing to accelerated atherosclerosis
    Hans L A Nienhuis
    Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Autoimmunity 42:302-4. 2009
    ..The AGE-RAGE interaction might act as a pro-inflammatory loop in these patients, contributing to chronic low grade inflammation rendering these individuals susceptible for development of accelerated atherosclerosis...
  20. ncbi Humoral responses after influenza vaccination are severely reduced in patients with rheumatoid arthritis treated with rituximab
    Sander Van Assen
    Department of Internal Medicine, Division of Infectious Diseases, University Medical Center Groningen, Groningen, The Netherlands
    Arthritis Rheum 62:75-81. 2010
    ..We also undertook to assess the safety of influenza vaccination and the effects of previous influenza vaccination...
  21. ncbi Patients with humoral primary immunodeficiency do not develop protective anti-influenza antibody titers after vaccination with trivalent subunit influenza vaccine
    Sander Van Assen
    Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Clin Immunol 136:228-35. 2010
    ..Previous vaccination in patients and treatment with IVIg did not result in a higher rate of postvaccination titer > or =40. In conclusion, patients with hPID show hardly any humoral response following influenza vaccination...
  22. ncbi Is disturbed clearance of apoptotic keratinocytes responsible for UVB-induced inflammatory skin lesions in systemic lupus erythematosus?
    Esther Reefman
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, PO Box 30, 001, 9700 RB Groningen, The Netherlands
    Arthritis Res Ther 8:R156. 2006
    ....
  23. ncbi Angiopoietin-2 is highly correlated with inflammation and disease activity in recent-onset rheumatoid arthritis and could be predictive for cardiovascular disease
    Johanna Westra
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Rheumatology (Oxford) 50:665-73. 2011
    ....
  24. ncbi Studies of cell-mediated immune responses to influenza vaccination in systemic lupus erythematosus
    Albert Holvast
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Arthritis Rheum 60:2438-47. 2009
    ..This study was therefore undertaken to assess cell-mediated responses to influenza vaccination in patients with SLE...
  25. ncbi Is small artery elasticity decreased prior to intima-media thickening in patients with longstanding rheumatoid arthritis?
    Helmy J Hinkema
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    J Rheumatol 38:2133-40. 2011
    ....
  26. ncbi Enhanced endothelium-dependent microvascular responses in patients with Wegener's granulomatosis
    Hans L A Nienhuis
    Department of Internal Medicine, Division of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Rheumatol 34:1875-81. 2007
    ..To assess endothelial cell (EC) function of the cutaneous microcirculation in patients with Wegener's granulomatosis (WG) and to relate EC function to EC activation and presence of atherosclerosis...
  27. ncbi Ultraviolet light and cutaneous lupus
    Marc Bijl
    Department of Internal Medicine, Division of Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Lupus 15:724-7. 2006
    ..We review the role of apoptotic cells and autoantibodies in the pathogenesis of UVB induced skin lesions...
  28. ncbi Longitudinal study on premature atherosclerosis in patients with systemic lupus erythematosus
    Karina de Leeuw
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Atherosclerosis 206:546-50. 2009
    ..To determine risk factors of accelerated atherosclerosis and progression of intima-media thickness (IMT) in patients with systemic lupus erythematosus (SLE)...
  29. ncbi Small artery elasticity is decreased in patients with systemic lupus erythematosus without increased intima media thickness
    Hans L A Nienhuis
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, 9713 GZ, The Netherlands
    Arthritis Res Ther 12:R181. 2010
    ....
  30. ncbi Fcgamma receptors in the initiation and progression of systemic lupus erythematosus
    Esther Reefman
    Department of Internal Medicine, Division of Clinical Immunology, University Hospital, Groningen, The Netherlands
    Immunol Cell Biol 81:382-9. 2003
    ..This review focuses on the role of Fcgamma receptors in the initiation of autoantibody production, inflammatory handling of immune complexes, and disease development in systemic lupus erythematosus...
  31. ncbi Advanced glycation endproducts are increased in rheumatoid arthritis patients with controlled disease
    Lodewijk de Groot
    Department of Rheumatology and Clinical Immunology, University Medical Centre, University of Groningen, Groningen, The Netherlands
    Arthritis Res Ther 13:R205. 2011
    ....
  32. ncbi Risk factors and early detection of atherosclerosis in rheumatoid arthritis
    Lodewijk de Groot
    Department of Rheumatology and Clinical Immunology, University Medical Center, Groningen, The Netherlands
    Eur J Clin Invest 40:835-42. 2010
    ..This cannot be explained alone by the increased prevalence of traditional cardiovascular risk factors like smoking and hypertension. Other factors therefore seem to be involved in the pathogenesis of atherosclerosis in RA...
  33. ncbi Accumulation of advanced glycation endproducts in patients with systemic lupus erythematosus
    K de Leeuw
    Department of Internal Medicine, Division of Clinical Immunology, University Medical Centre Groningen, Groningen, The Netherlands
    Rheumatology (Oxford) 46:1551-6. 2007
    ....
  34. ncbi Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus
    Sebastian Dolff
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Arthritis Res Ther 13:R157. 2011
    ..The novel cytokine interleukin-21 (IL-21) is suggested to be crucial for triggering T-cell responses towards IL-17 producing cells. Thus, we aimed to investigate the ability of T-cells to produce IL-21 and IL-17 in SLE patients...
  35. ncbi Apoptosis in human skin: role in pathogenesis of various diseases and relevance for therapy
    Esther Reefman
    Departments of Rheumatology and Clinical Immunology, University Hospital Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Ann N Y Acad Sci 1051:52-63. 2005
    ..This paper will review the different forms of cell death in the skin and discuss the role of apoptosis in diseases like skin cancer, psoriasis, and systemic lupus erythematosus...
  36. ncbi The contribution of inherited and acquired thrombophilic defects, alone or combined with antiphospholipid antibodies, to venous and arterial thromboembolism in patients with systemic lupus erythematosus
    Jan Leendert P Brouwer
    Division of Haemostasis, Thrombosis and Rheology, Department of Hematology, University Hospital Groningen The Netherlands
    Blood 104:143-8. 2004
    ..In conclusion, factor V Leiden and the prothrombin mutation contribute to the risk of VTE in patients with SLE, and potentiate this risk when one of these thrombophilic defects are combined with LA and/or ACAs...
  37. ncbi Accelerated atherosclerosis in patients with Wegener's granulomatosis
    K de Leeuw
    Department of Clinical Immunology, University Hospital, PO Box 30 001, 9700 RB Groningen, Netherlands
    Ann Rheum Dis 64:753-9. 2005
    ..In addition to traditional risk factors, non-traditional risk factors such as endothelial activation and excessive vascular remodelling might be determinants of the progression of atherosclerosis in patients with an autoimmune disease...
  38. ncbi Traditional and non-traditional risk factors contribute to the development of accelerated atherosclerosis in patients with systemic lupus erythematosus
    K de Leeuw
    Department of Internal Medicine, Division of Clinical Immunology, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands
    Lupus 15:675-82. 2006
    ..Non-traditional risk factors, such as endothelial activation, altered vascular remodelling and disease duration, might play an additional role...
  39. ncbi Quantitation of autoantibodies in systemic autoimmune diseases: clinically useful?
    C G M Kallenberg
    Department of Internal Medicine, University Medical Center Groningen, The Netherlands
    Lupus 15:397-402. 2006
    ..Consequently, treatment based on changes in levels of the respective autoantibodies only seems at present not justified, in view of the toxicity of currently available immunosuppressive regimens...
  40. ncbi [Acute acalculous cholecystitis: not only in the intensive care department]
    J H M van Steijn
    afd Interne Geneeskunde, Academisch Ziekenhuis, Postbus 30 001, 9700 RB Groningen
    Ned Tijdschr Geneeskd 146:1305-8. 2002
    ..To improve the outcome, a high and early index of suspicion is needed. Hepatobiliary scintigraphy should be included in the diagnostic pathway...
  41. ncbi Lack of association of C-C chemokine receptor 5 ?32 deletion status with rheumatoid arthritis, systemic lupus erythematosus, lupus nephritis, and disease severity
    Henk A Martens
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    J Rheumatol 37:2226-31. 2010
    ....
  42. ncbi Regulators of B-cell activity in SLE: a better target for treatment than B-cell depletion?
    S Dolff
    Department of Rheumatology, University Medical Center Groningen, Groningen, The Netherlands
    Lupus 18:575-80. 2009
    ..More insight into B-cell regulation in SLE, and particularly in regulatory B cells, could lead to novel therapeutic strategies...
  43. ncbi Soluble TRAIL concentrations are raised in patients with systemic lupus erythematosus
    M N Lub-de Hooge
    Department of Clinical Immunology University Hospital Groningen, PO Box 30.001, 9700 RB Groningen, Netherlands
    Ann Rheum Dis 64:854-8. 2005
    ..CONCLUSIONS: Serum sTRAIL concentrations are increased SLE patients. This seems to be disease specific and could indicate a role for TRAIL in SLE pathophysiology...
  44. ncbi Safety and efficacy of influenza vaccination in systemic lupus erythematosus patients with quiescent disease
    A Holvast
    Department of Clinical Immunology, University Medical Center Groningen, University of Groningen, PO Box 30 001, 9700 RB Groningen, Netherlands
    Ann Rheum Dis 65:913-8. 2006
    ..to assess the safety and efficacy of influenza vaccination in patients with systemic lupus erythematosus (SLE), and to evaluate the influence of immunosuppressive drugs on the immune response...
  45. ncbi Levels of complement in sera from inactive SLE patients, although decreased, do not influence in vitro uptake of apoptotic cells
    M E Grevink
    Department of Internal Medicine, Division of Clinical Immunology, University Hospital, PO Box 30.001, 9700 RB Groningen, The Netherlands
    J Autoimmun 24:329-36. 2005
    ..However, decreased levels of complement do not result in a significantly reduced in vitro uptake of apoptotic Jurkat cells by MDM...
  46. ncbi IgG subclass distribution of autoantibodies differs between renal and extra-renal relapses in patients with systemic lupus erythematosus
    M Bijl
    Department of Clinical Immunology, University Hospital, 9700 RB Groningen, The Netherlands
    Rheumatology (Oxford) 41:62-7. 2002
    ....
  47. ncbi Accelerated atherosclerosis in patients with systemic autoimmune diseases
    Karina de Leeuw
    Department of Internal Medicine, Division of Clinical Immunology, University Hospital, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Ann N Y Acad Sci 1051:362-71. 2005
    ..This review updates information on the factors that contribute to accelerated atherosclerosis in patients with systemic autoimmune diseases, such as disease-related factors, inflammatory mediators, and advanced glycation end products...
  48. ncbi Treatment of lupus nephritis
    Sebastian Dolff
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands
    Expert Rev Clin Immunol 6:901-11. 2010
    ..We review recently reported data on current treatment regimens in LN, in particular in the context of the International Society of Nephrology/Renal Pathology Society 2003 classification...
  49. ncbi Influenza vaccination in systemic lupus erythematosus: safe and protective?
    Bert Holvast
    Department of Clinical Immunology, University Medical Center Groningen, University of Groningen, The Netherlands
    Autoimmun Rev 6:300-5. 2007
    ..Because of the decreased immunogenicity of the current influenza vaccine in SLE, new influenza vaccination strategies should be explored to improve vaccination efficacy...
  50. ncbi Prognostic value of renal hemodynamic characteristics in patients with proliferative lupus nephritis
    Henk A Martens
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen UMCG, University of Groningen, Groningen, The Netherlands
    Kidney Blood Press Res 30:175-81. 2007
    ..In this study, we evaluate the prognostic value of renal hemodynamic function tests on the renal outcome in patients with proliferative LN...
  51. ncbi Familial occurrence of autoimmune diseases and autoantibodies in a Caucasian population of patients with systemic lupus erythematosus
    S Corporaal
    University Hospital, Groningen, The Netherlands
    Clin Rheumatol 21:108-13. 2002
    ..These findings support the genome-wide screening of SLE patients to unravel factors responsible for genetic susceptibility to SLE...
  52. ncbi An extensive screen of the HLA region reveals an independent association of HLA class I and class II with susceptibility for systemic lupus erythematosus
    H A Martens
    Department of Rheumatology and Clinical Immunology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Scand J Rheumatol 38:256-62. 2009
    ..In this study, we analysed the involvement of the HLA region in susceptibility for SLE in a stable founder, Caucasian population of SLE patients...
  53. ncbi Coexpression of CD177 and membrane proteinase 3 on neutrophils in antineutrophil cytoplasmic autoantibody-associated systemic vasculitis: anti-proteinase 3-mediated neutrophil activation is independent of the role of CD177-expressing neutrophils
    N Hu
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, The Netherlands
    Arthritis Rheum 60:1548-57. 2009
    ....
  54. ncbi Why rheumatologists should be involved in the treatment of lupus nephritis
    Cees Gm Kallenberg
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB Groningen, The Netherlands
    Nat Clin Pract Nephrol 4:60-1. 2008
  55. ncbi Patients' perceptions of the effects of systemic lupus erythematosus on health, function, income, and interpersonal relationships: a comparison with Wegener's granulomatosis
    Maarten M Boomsma
    Clinical Immunology, University Hospital Groningen, Groningen, The Netherlands
    Arthritis Rheum 47:196-201. 2002
    ..To describe the patients' perceptions of the effects of systemic lupus erythematosus (SLE) and Wegener's granulomatosis (WG) on health, function, income, and interpersonal relationships...
  56. ncbi Analysis of C1q polymorphisms suggests association with systemic lupus erythematosus, serum C1q and CH50 levels and disease severity
    H A Martens
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Ann Rheum Dis 68:715-20. 2009
    ..Polymorphisms of the C1qA gene are associated with low serum C1q levels in patients with cutaneous LE, but C1q polymorphisms have not been studied in patients with systemic lupus...
  57. ncbi Vascular responsiveness in the microcirculation of patients with systemic lupus erythematosus is not impaired
    K de Leeuw
    Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, University Medical Center, Groningen, The Netherlands
    Lupus 17:1010-7. 2008
    ..Therefore, LDF of the microcirculation seems not to be the appropriate method to distinguish those SLE patients with an increased risk to develop CVD...
  58. ncbi Type I interferons are involved in the development of ultraviolet B-induced inflammatory skin lesions in systemic lupus erythaematosus patients
    E Reefman
    Departments of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Ann Rheum Dis 67:11-18. 2008
    ..To investigate the involvement of type I interferons and endothelial cell adhesion molecules in the development of ultraviolet B (UVB)-induced systemic lupus erythaematosus (SLE) skin lesions...
  59. ncbi Additional value of positron emission tomography in diagnosis and follow-up of patients with large vessel vasculitides
    K de Leeuw
    Department of Clinical Immunology, University Hospital, Groningen, The Netherlands
    Clin Exp Rheumatol 22:S21-6. 2004
    ..CONCLUSION: PET is a promising new technique for the diagnosis of large vessel vasculitides. Furthermore, PET appears to be a valuable tool for the assessment of disease activity during follow-up and of the response to therapy...
  60. ncbi Clinical images: blue-purple ears
    H A Martens
    University Medical Center Groningen, Groningen, The Netherlands
    Arthritis Rheum 56:673. 2007
  61. ncbi Fcgamma receptor polymorphisms in systemic lupus erythematosus: association with disease and in vivo clearance of immune complexes
    H M Dijstelbloem
    University Hospital Groningen, The Netherlands
    Arthritis Rheum 43:2793-800. 2000
    ..We analyzed 3 functional FcgammaR polymorphisms in a strictly Caucasian population of SLE patients, and determined the influence of these polymorphisms on the clearance of immune complexes in vivo...
  62. ncbi Skin sensitivity to UVB irradiation in systemic lupus erythematosus is not related to the level of apoptosis induction in keratinocytes
    E Reefman
    Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, 9700 RB Groningen, The Netherlands
    Rheumatology (Oxford) 45:538-44. 2006
    ..As sunlight exposure is one of the factors that can trigger disease activity, we hypothesized that UV light may induce increased numbers of apoptotic cells in SLE...
  63. ncbi Molecular genetic analyses of human NKG2C (KLRC2) gene deletion
    Risa Miyashita
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Int Immunol 16:163-8. 2004
    ..These results indicated that NKG2C deletion is commonly present in Japanese and Dutch, suggesting that NKG2C is not essential for survival and reproduction, and is not associated with rheumatic diseases...
  64. ncbi Autoantibodies against protective molecules--C1q, C-reactive protein, serum amyloid P, mannose-binding lectin, and apolipoprotein A1: prevalence in systemic lupus erythematosus
    Yehuda Shoenfeld
    Center for Autoimmune Diseases and Department of Medicine B, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Ann N Y Acad Sci 1108:227-39. 2007
    ..These autoantibodies may play a pathogenic role in the development or perpetuation of autoimmunity in SLE...
  65. ncbi Do apoptotic cells accumulate in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation? Comment on the article by Kuhn et al
    Esther Reefman
    Arthritis Rheum 54:3373-4. 2006
  66. ncbi Treatment with cyclophosphamide delays the progression of chronic lesions more effectively than does treatment with azathioprine plus methylprednisolone in patients with proliferative lupus nephritis
    Cecile Grootscholten
    Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 56:924-37. 2007
    ....
  67. ncbi Standardised assessment of membrane proteinase 3 expression. Analysis in ANCA-associated vasculitis and controls
    Andre P van Rossum
    Department of Rheumatology and Clinical Immunology, Groningen University Medical Centre, University of Groningen, The Netherlands
    Ann Rheum Dis 66:1350-5. 2007
    ..Using neutrophils before and after priming with TNFalpha, we assessed percentages of mPR3(+) neutrophils in patients with AAV and in disease and healthy controls...
  68. ncbi Role of the Fcgamma receptor IIA polymorphism in the antiphospholipid syndrome: an international meta-analysis
    Fotini B Karassa
    University of Ioannina School of Medicine, Ioannina, Greece
    Arthritis Rheum 48:1930-8. 2003
    ..To assess the impact of the FcgammaRIIA-R/H131 polymorphism on the risk for antiphospholipid syndrome (APS), both primary and secondary to systemic lupus erythematosus (SLE)...
  69. ncbi Smoking and increased apoptosis in patients with systemic lupus erythematosus: comment on the article by Costenbader et al
    Marc Bijl
    Arthritis Rheum 50:3733; author reply 3733. 2004
  70. ncbi Interobserver agreement of scoring of histopathological characteristics and classification of lupus nephritis
    Cecile Grootscholten
    Division of Nephrology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Nephrol Dial Transplant 23:223-30. 2008
    ..Assessing renal biopsies from patients with lupus nephritis (LN) is a difficult task and it is subject to interobserver variability. In this study the interobserver agreement amongst five nephropathologists was analysed...
  71. ncbi Reduced number and impaired function of circulating progenitor cells in patients with systemic lupus erythematosus
    Jan Renier A J Moonen
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, The Netherlands
    Arthritis Res Ther 9:R84. 2007
    ..003). We conclude that CPC numbers are reduced in SLE patients and functionality is partly impaired. We suggest these findings reflect increased susceptibility to apoptosis of CPCs from SLE patients...
  72. ncbi Association of poly(ADP-ribose) polymerase 1 and a novel candidate locus, LOC127086, with systemic lupus erythematosus
    Henk A Martens
    Ann Rheum Dis 66:424-5. 2007
  73. ncbi Health-related quality of life and treatment burden in patients with proliferative lupus nephritis treated with cyclophosphamide or azathioprine/ methylprednisolone in a randomized controlled trial
    Cecile Grootscholten
    Division of Nephrology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Rheumatol 34:1699-707. 2007
    ..We expected better HRQOL during AZA treatment...