Martin J B Taphoorn

..In clinical practice, assessing HRQOL may be helpful in the communication between doctor and patient and may facilitate treatment decisions...

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..This paper reports the health-related quality of life (HRQOL) of the patients in this trial...

..Cognitive function is now also recognised as an independent prognostic factor in the survival of glioma patients. Additionally, cognitive deterioration can be the first indicator of progressive disease after treatment...

..This study examined the validity and reliability of the questionnaire in a multi-national, multi-lingual study...

..We concluded that baseline HRQOL is not related to duration of survival and that long-term survivors show improvement of HRQOL to a level comparable to that of the healthy...

..In this study the ELD-making process in HGG patients is described...

..The possibility of deleterious effects is important to consider when prescribing antiepileptic drug treatment...

..Our study demonstrates that HGG patients, unlike the general cancer population, have specific symptoms in the end-of-life phase. Further research is needed in order to develop specific palliative care guidelines for these patients...

..Each patient in whom a low-grade glioma is suspected should receive specific treatment advice from a neuro-oncological team...

..In conclusion, low-grade glioma patients suffer from a number of neuropsychological and psychological problems that are aggravated by the severity of epilepsy and by the intensity of the treatment...

..To investigate the toxicity of temozolomide (TMZ) in patients with brain tumors and appropriate nursing interventions...

..Finally, we describe studies in patients with cancers outside the CNS, to highlight further possibilities for the prevention and treatment of cognitive deficits...

..Before the diagnosis of SMART syndrome can be established other causes, such as local tumour recurrence, leptomeningeal disease or ischemic disease should be ruled out...

..The risk on vascular complications in patients with brain metastases is increased and needs special attention. Treatment of psychiatric complications e.g. delirium or depression may also improve quality of life...

..This is one of a few studies that have explored the value of baseline symptoms and health-related quality of life (HRQOL) in predicting survival in patients with brain cancer...

..Responses to first line temozolomide are strongly correlated to loss of 1p. Response to second line alkylating treatment is modest even in tumours with 1p/19q loss. For further improvement of outcome in OD novel treatments are needed...

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..In this trial we compared radiotherapy alone with radiotherapy plus temozolomide, given concomitantly with and after radiotherapy, in terms of efficacy and safety...

..This and other studies suggest that disease and treatment factors other than standard focal RT may be more important with respect to increasing the risk of neurocognitive sequelae in patients with low-grade gliomas...

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..We argue that an aberrantly regulated inside-out signaling pathway underlies constitutive integrin activation on the adherent leukemic cell population...

..These cases show the importance of diagnosing a meningeal or intracerebral plasma cell granuloma correctly, since it has both therapeutical and prognostic implications...

..We present a review on the effects of irradiation on the BBB and subsequently discuss the potential value for therapeutic applications...