Research Topics
| Ronald van ReeSummaryAffiliation: Sanquin Research Country: The Netherlands Publications
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Publications
Clinical importance of cross-reactivity in food allergyRonald van Ree
Department of Immunopathology, Sanquin Research, Amsterdam, The Netherlands
Curr Opin Allergy Clin Immunol 4:235-40. 2004..Review of recent developments in the field of cross-reactivity in food allergy and the clinical relevance of these developments...- IgE binding to pepsin-digested food extractsJaap H Akkerdaas
Sanquin Research, Department of Immunopathology and Laboratory for Experimental and Clinical Immunology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Int Arch Allergy Immunol 138:203-8. 2005..This can increase the clinical prognostic value of food allergy serology... - Cloning of oleosin, a putative new hazelnut allergen, using a hazelnut cDNA libraryJaap H Akkerdaas
Academical Medical Center, Department of Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands
Mol Nutr Food Res 50:18-23. 2006..Hazelnut contains multiple isoforms of oleosin. IgE binding of a hazelnut-allergic patient to a recombinant version suggest that hazelnut oleosin is an allergen, as has been described for peanut and sesame... - Characterization of natural Dac g 1 variants: an alternative to recombinant group 1 allergensErica van Oort
Department of Immunopathology, Sanquin Research, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
J Allergy Clin Immunol 114:1124-30. 2004..Thus, purified Dac g 1 is an alternative to recombinant group 1 allergens... - Allergen-specific IgE testing in the diagnosis of food allergy and the event of a positive match in the bioinformatics searchRonald van Ree
Academic Medical Center, Amsterdam, The Netherlands
Mol Nutr Food Res 50:645-54. 2006..Further studies are also required to prove the usefulness of targeted serum screening, i. e., the testing of gene products from organisms not known to be allergenic with sera from subjects allergic to related species... - Diminished response to grass pollen allergen challenge in subjects with concurrent house dust mite allergySusanne M Reinartz
Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
Rhinology 47:192-8. 2009..Different combinations of allergic sensitization may lead to different clinical manifestations of allergic disease... - A novel approach for the detection of potentially hazardous pepsin stable hazelnut proteins as contaminants in chocolate-based foodJaap H Akkerdaas
Sanquin Research, Department of Immunopathology and Laboratory for Experimental and Clinical Immunology, Academic Medical Centre, University of Amsterdam, 1066 CX Amsterdam, The Netherlands
J Agric Food Chem 52:7726-31. 2004..It can be concluded that the application of antibodies directed to pepsin-digested food extracts in ELISA can facilitate specific detection of stable proteins that have the highest potential of inducing severe food anaphylaxis... - The major grass pollen group 5 allergen from Dactylis glomerata and its C-terminal split product both behave as dimers: implications for allergen standardizationErica van Oort
Sanquin, Department of Immunopathology and Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Int Arch Allergy Immunol 136:113-22. 2005..The aim of this study was to investigate these group 5 molecular entities and to compare their allergenicity and behavior in quantitative immunoassays... - Substitution of Pichia pastoris-derived recombinant proteins with mannose containing O- and N-linked glycans decreases specificity of diagnostic testsErica van Oort
Sanquin, Department of Immunopathology and Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Int Arch Allergy Immunol 135:187-95. 2004..CONCLUSION: Production of recombinant molecules in yeast (or moulds) can introduce IgG-binding glycans that negatively affect the specificity of diagnostic tests... - Lipid transfer proteins from fruit: cloning, expression and quantificationLaurian Zuidmeer
Department of Immunopathology, Sanquin, Amsterdam, The Netherlands
Int Arch Allergy Immunol 137:273-81. 2005..Assays for the measurement of LTP will increase the traceability of this potentially dangerous allergen... - Indoor allergens: relevance of major allergen measurements and standardizationRonald van Ree
Department of Experimental Immunology, Academic Medical Center, Amsterdam, The Netherlands
J Allergy Clin Immunol 119:270-7; quiz 278-9. 2007..This will also ensure that primary and secondary prevention strategies aiming at regulating allergen exposure will stay on solid ground... - Quadrupole time-of-flight mass spectrometry: a method to study the actual expression of allergen isoforms identified by PCR cloningJohannes P F G Helsper
Plant Research International, Wageningen, Amsterdam, The Netherlands
J Allergy Clin Immunol 110:131-8. 2002..CONCLUSION: Q-TOF MSMS is a powerful tool to find out whether an allergen isoform, detected at the cDNA level, is really expressed in quantities relevant for the allergic patient... - How accurate and safe is the diagnosis of hazelnut allergy by means of commercial skin prick test reagents?Jaap H Akkerdaas
Department of Immunopathology, Sanquin Research at CLB, Amsterdam, The Netherlands
Int Arch Allergy Immunol 132:132-40. 2003..These shortcomings in standardisation and quality control can potentially cause a false-negative diagnosis in subjects at risk of severe reactions to hazelnuts... - IgE to Bet v 1 and profilin: cross-reactivity patterns and clinical relevanceMarjolein Wensing
Department of Dermatology/Allergology, University Medical Centre Utrecht, The Netherlands
J Allergy Clin Immunol 110:435-42. 2002..In analogy to anticarbohydrate IgE, cross-reactive IgE against food profilins have no or very limited clinical relevance... - Effect of in vitro gastric and duodenal digestion on the allergenicity of grape lipid transfer proteinEmilia Vassilopoulou
Allergy Research Laboratories, 2nd Paediatric Clinic, University of Athens Greece, 41 Fidippidou str, Athens 11527, Greece
J Allergy Clin Immunol 118:473-80. 2006..Severe grape allergy has been linked to lipid transfer protein (LTP) sensitization. LTPs are known to be resistant to pepsin digestion, although the effect of gastroduodenal digestion on its allergenicity has not been reported... - Lipid transfer protein allergy: primary food allergy or pollen/food syndrome in some casesLaurian Zuidmeer
Laboratory of Allergy, Department of Experimental Immunology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Curr Opin Allergy Clin Immunol 7:269-73. 2007..To summarize recent findings on non-specific lipid transfer proteins in food allergy, with a specific focus on the localization, stability and route of sensitization... - Lipid transfer protein from Hevea brasiliensis (Hev b 12), a cross-reactive latex proteinDonald H Beezhold
Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
Ann Allergy Asthma Immunol 90:439-45. 2003..We sought to determine whether Hevea brasiliensis produces LTP and whether it would bind immunoglobulin E from latex-allergic patients... - Apple allergy across Europe: how allergen sensitization profiles determine the clinical expression of allergies to plant foodsMontserrat Fernandez-Rivas
Allergy Unit, Fundacion Hospital Alcorcon, Madrid
J Allergy Clin Immunol 118:481-8. 2006..Allergy to a plant food can either result from direct sensitization to that food or from primary sensitization to pollen, latex, or another food... - Clinical reactivity to hazelnut in children: association with sensitization to birch pollen or nuts?Annebeth E Flinterman
J Allergy Clin Immunol 118:1186-9. 2006 - Hazelnut allergy: from pollen-associated mild allergy to severe anaphylactic reactionsAnnebeth E Flinterman
Department of Dermatology, University Medical Centre Utrecht, Utrecht, The Netherlands
Curr Opin Allergy Clin Immunol 8:261-5. 2008..There is a need to predict which subjects are at risk for severe reactions. In this study, possibilities for 'component-resolved diagnosis', based on sensitization to different allergens in hazelnut, are discussed... - Lipid transfer protein-linked hazelnut allergy in children from a non-Mediterranean birch-endemic areaAnnebeth E Flinterman
Department of Dermatology Allergology, University Medical Centre, Utrecht, The Netherlands
J Allergy Clin Immunol 121:423-428.e2. 2008..In areas without birches, severe reactions are more prevalent and linked to sensitization to the lipid transfer protein (LTP) Cor a 8... - IgE-mediated food allergy diagnosis: Current status and new perspectivesRiccardo Asero
Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy
Mol Nutr Food Res 51:135-47. 2007.... - Allergenicity assessment of genetically modified crops--what makes sense?Richard E Goodman
Department of Food Science and Technology, University of Nebraska, Lincoln, Nebraska, 68583 0955, USA
Nat Biotechnol 26:73-81. 2008..However, not all tests currently being applied to assessing allergenicity have a sound scientific basis. Recent events with transgenic crops reveal the fallacy of applying such tests to GM crops... - Severe immediate allergic reactions to grapes: part of a lipid transfer protein-associated clinical syndromeEmilia Vassilopoulou
Allergy Research Centre, Second Pediatric Clinic, University of Athens, Athens, Greece
Int Arch Allergy Immunol 143:92-102. 2007..A considerable number of patients have referred to our department for severe reactions to grapes, and several IgE binding proteins were detected... - Measurement of lipid transfer protein in 88 apple cultivarsAna I Sancho
Institute of Food Research, Norwich, UK
Int Arch Allergy Immunol 146:19-26. 2008..Fruits are a major cause of food allergy in adults. Lipid transfer proteins (LTP) are implicated in severe allergic reactions to fruits, but little is known about LTP content in different cultivars... - Optimized techniques for the extraction of grape allergens appropriate for in vivo and in vitro testing and diagnosisEmilia V Vassilopoulou
Allergy Research Centre of 2nd Paediatric Clinic, University of Athens, Athens, Greece
Mol Nutr Food Res 51:360-6. 2007.... - Effect of postharvest storage on the expression of the apple allergen Mal d 1Ana I Sancho
Institute of Food Research, Norwich Research Park, Colney, UK
J Agric Food Chem 54:5917-23. 2006..In conclusion, Mal d 1 gene expression was significantly increased during modified atmosphere storage. Individuals suffering from birch pollen-apple allergy syndrome might experience fewer problems consuming freshly picked apples... - Cooking birch pollen-related food: divergent consequences for IgE- and T cell-mediated reactivity in vitro and in vivoBarbara Bohle
Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
J Allergy Clin Immunol 118:242-9. 2006..To avoid this food, allergy allergologists and guidebooks advise patients to consume birch pollen-related foods after heating... - Immunoblot and radioallergosorbent test inhibition studies of allergenic cross-reactivity of the predatory mite Amblyseius cucumeris with the house dust mite Dermatophagoides pteronyssinusNicolette W de Jong
Department of Allergology, Erasmus MC, Rotterdam, The Netherlands
Ann Allergy Asthma Immunol 93:281-7. 2004..In 1999, an extensive study among bell pepper growers showed that a predatory mite, Amblyseius cucumeris, is a potentially relevant source of occupational allergens because 23% of the population had positive skin prick test reactions... - Ara h 8, a Bet v 1-homologous allergen from peanut, is a major allergen in patients with combined birch pollen and peanut allergyDiana Mittag
Department of Dermatology, University Hospital, Zurich
J Allergy Clin Immunol 114:1410-7. 2004..CONCLUSIONS: Peanut allergy might be mediated in a subgroup of our patients by means of cross-reaction of Bet v 1 with the homologous peanut allergen Ara h 8... - Two novel types of O-glycans on the mugwort pollen allergen Art v 1 and their role in antibody bindingRenaud Leonard
Division of Biochemistry, Department of Chemistry, Universitaet fuer Bodenkultur Wien, Muthgasse 18, A-1190 Vienna, Austria
J Biol Chem 280:7932-40. 2005..Mono-beta-arabinosylated hydroxyproline residues thus constitute a new, potentially cross-reactive, carbohydrate determinant in plant proteins... - Molecular and immunological characterization of profilin from mugwort pollenNicole Wopfner
Institute of Genetics, University of Salzburg, A-5020 Salzburg, Austria
Biol Chem 383:1779-89. 2002..Inhibition experiments showed extensive IgE cross-reactivity of recombinant mugwort profilin and profilin from various pollen and food extracts... - Art v 1, the major allergen of mugwort pollen, is a modular glycoprotein with a defensin-like and a hydroxyproline-rich domainMartin Himly
Institute of Genetics and General Biology, University of Salzburg, A-5020 Salzburg, Austria
FASEB J 17:106-8. 2003..However, posttranslational modifications did not influence T-cell recognition. Thus, recombinant nonglycosylated Art v 1 is a good starting template for engineering hypoallergenic vaccines for weed-pollen therapy... - Silencing the major apple allergen Mal d 1 by using the RNA interference approachLuud J W J Gilissen
Allergy Consortium Wageningen, Wageningen, The Nertherlands
J Allergy Clin Immunol 115:364-9. 2005..Apple allergy is dominated by IgE antibodies against Mal d 1 in areas where birch pollen is endemic. Apples with significantly decreased levels of Mal d 1 would allow most patients in these areas to eat apples without allergic reactions... - Assessing genetically modified crops to minimize the risk of increased food allergy: a reviewRichard E Goodman
Food Allergy Research and Resource Program, University of Nebraska, Lincoln, NE 68583 0955, USA
Int Arch Allergy Immunol 137:153-66. 2005..Based on the evidence to date, the current assessment process has worked well to prevent the unintended introduction of allergens in commercial GM crops... - In vivo assessment with prick-to-prick testing and double-blind, placebo-controlled food challenge of allergenicity of apple cultivarsSuzanne T H P Bolhaar
Department of Dermatology, University Hospital Utrecht, The Netherlands
J Allergy Clin Immunol 116:1080-6. 2005..Apple cultivars have been reported to differ in allergenicity on the basis of in vitro and skin prick tests with apple extracts... - An antibody produced in tobacco expressing a hybrid beta-1,4-galactosyltransferase is essentially devoid of plant carbohydrate epitopesHans Bakker
Business Unit Bioscience, Plant Research International, Wageningen University and Research Center, Droevendaalsesteeg 1, 6708 PB, Wageningen, The Netherlands
Proc Natl Acad Sci U S A 103:7577-82. 2006..Hence, a transgenic plant expressing the hybrid GalT might yield more effective and safer monoclonals for therapeutic purposes than WT plants and even transgenic plants expressing the unchanged GalT... - Recombinant lipid transfer protein Cor a 8 from hazelnut: a new tool for in vitro diagnosis of potentially severe hazelnut allergyFrauke Schocker
Forschungszentrum Borstel, Division of Biochemical and Molecular Allergology, Borstel, Germany
J Allergy Clin Immunol 113:141-7. 2004..CONCLUSIONS: Cor a 8 is a relevant allergen for a majority of Spanish patients with hazelnut allergy that can cause severe allergic reactions... - Allergy, parasites, and the hygiene hypothesisMaria Yazdanbakhsh
Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands
Science 296:490-4. 2002..The induction of a robust anti-inflammatory regulatory network by persistent immune challenge offers a unifying explanation for the observed inverse association of many infections with allergic disorders...