Research Topics
Genomes and Genes | L A JoostenSummaryAffiliation: Rheumatology Research Laboratory Country: The Netherlands Publications
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Publications
An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritisL A Joosten
Rheumatology Research Laboratory and Department of Internal Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
J Immunol 165:6553-8. 2000..The present study indicates that IL-18 is a proinflammatory cytokine during the onset of murine SCW arthritis, and this inflammatory role of IL-18 is IFN-gamma independent...- Murine antigen-induced arthritisWim B van den Berg
Radboud University Nijmegen Medical Centre, The Netherlands
Methods Mol Med 136:243-53. 2007..Concomitant boosting of the immune response with Bordetella pertussis adds to this. T-cell mediated flares can be induced by local or systemic rechallenge with low dose antigen, and display a strong erosive phenotype... - Local interleukin-12 gene transfer promotes conversion of an acute arthritis to a chronic destructive arthritisLeo A B Joosten
Rheumatology Research Laboratory, University Medical Center Nijmegen, Nijmegen, The Netherlands
Arthritis Rheum 46:1379-89. 2002.... - Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritisL A Joosten
Department of Rheumatology, University Hospital Nijmegen, Nijmegen, The Netherlands
Arthritis Res 1:81-91. 1999..Furthermore, it was demonstrated that exposure to IL-4 during the immunization stage reduced onset and severity of CIA. However, after cessation of IL-4 treatment disease expression increased to control values... - Synergistic protection against cartilage destruction by low dose prednisolone and interleukin-10 in established murine collagen arthritisL A Joosten
Department of Rheumatology, University Hospital Nijmegen, The Netherlands
Inflamm Res 48:48-55. 1999..To investigate potential synergy of low dosages glucocorticosteroids (GC's) and interleukin-10 (IL-10), using established murine collagen-induced arthritis (CIA) as a model... - IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammationL A Joosten
Department of Rheumatology, University Hospital Nijmegen, The Netherlands
J Immunol 163:5049-55. 1999..These results indicate that blocking of IL-1 is a cartilage- and bone-protective therapy in destructive arthritis, whereas the TNF-alpha antagonist has little effect on tissue destruction... - Intra-articular IL-10 gene transfer regulates the expression of collagen-induced arthritis (CIA) in the knee and ipsilateral pawE Lubberts
Rheumatology Research Laboratory, Department of Rheumatology, University Hospital Nijmegen, Nijmegen, The Netherlands
Clin Exp Immunol 120:375-83. 2000..These data indicate that local over-expression of IL-10 in the knee joint of mice regulates the expression of collagen arthritis, probably through down-regulation of TNF-alpha... - IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritisE Lubberts
Rheumatology Research Laboratory, Department of Rheumatology, University Medical Center St Radboud, Nijmegen, The Netherlands
J Immunol 167:1004-13. 2001..These findings suggest IL-17 to be a novel target for the treatment of destructive arthritis and may have implications for tissue destruction in other autoimmune diseases... - Regulatory role of interleukin 10 in joint inflammation and cartilage destruction in murine streptococcal cell wall (SCW) arthritis. More therapeutic benefit with IL-4/IL-10 combination therapy than with IL-10 treatment aloneE Lubberts
Department of Rheumatology, University Hospital Nijmegen, The Netherlands
Cytokine 10:361-9. 1998..In conclusion, the data is consistent with a dominant role of IL-10 in natural suppression of arthritis expression, whereas combined treatment with IL-4 and IL-10 appears to be of potential therapeutic value... - A tropism-modified adenoviral vector increased the effectiveness of gene therapy for arthritisA C Bakker
University Hospital Nijmegen, Nijmegen, The Netherlands
Gene Ther 8:1785-93. 2001..These results show that targeting integrins with the RGD-modified AdV improved the outcome of gene therapy for arthritis... - Prevention of murine collagen-induced arthritis in the knee and ipsilateral paw by local expression of human interleukin-1 receptor antagonist protein in the kneeA C Bakker
University Hospital Nijmegen, The Netherlands
Arthritis Rheum 40:893-900. 1997..To determine the efficacy of local human interleukin-1 receptor antagonist (HuIL-1Ra) gene therapy in murine collagen-induced arthritis (CIA)... - IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosionE Lubberts
Rheumatology Research Laboratory, Department of Rheumatology, University Hospital Nijmegen, Nijmegen, The Netherlands
J Clin Invest 105:1697-710. 2000..IL-4 also enhanced synthesis of type I procollagen, suggesting that it promoted tissue repair. These findings may have significant implications for the prevention of bone erosion in arthritis... - Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritisC Plater-Zyberk
Serono Pharmaceutical Research Institute, Geneva, Switzerland. Rheumatology Research Laboratory, University Medical Center Nijmegen, Nijmegen, The Netherlands
J Clin Invest 108:1825-32. 2001..IL-18 neutralizing antibody or rhIL-18BP could therefore represent new disease-modifying anti-rheumatic drugs that warrant testing in clinical trials in patients with rheumatoid arthritis... - Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice. A comparative study using anti-TNF alpha, anti-IL-1 alpha/beta, and IL-1RaL A Joosten
University Hospital Nijmegen, The Netherlands
Arthritis Rheum 39:797-809. 1996..To examine the role of tumor necrosis factor alpha (TNF alpha), interleukin-1 alpha (IL-1 alpha), and IL-1 beta in collagen-induced arthritis (CIA), immediately after onset and during the phase of established arthritis... - Lethal Escherichia coli and Salmonella typhimurium endotoxemia is mediated through different pathwaysM G Netea
Division of General Internal Medicine, Department of Medicine, Nijmegen University Medical Center, Nijmegen, The Netherlands
Eur J Immunol 31:2529-38. 2001..In conclusion, TNF and LT play a central role in the lethality due to E. coli LPS, whereas the lethal effects of S. typhimurium LPS are mediated through mechanisms also involving other cytokines such as IFN-gamma, IL-1 and IL-18... - Protective effect of rimexolone on cartilage damage in arthritic mice: a comparative study with triamcinolone hexacetonideL A Joosten
Department of Rheumatology, University Hospital Nijmegen, The Netherlands
Agents Actions 31:135-42. 1990..An advantage of rimexolone over THA is its prolonged retention, which may explain its sustained anti-inflammatory action, and the lack of systemic effects... - Effects of treatment with a fully human anti-tumour necrosis factor alpha monoclonal antibody on the local and systemic homeostasis of interleukin 1 and TNFalpha in patients with rheumatoid arthritisP Barrera
Department of Rheumatology, University Hospital, Nijmegen, The Netherlands
Ann Rheum Dis 60:660-9. 2001.... - TNF alpha and IL-1 beta are separate targets in chronic arthritisW B van den Berg
Department of Rheumatology, University Hospital Nijmegen, The Netherlands
Clin Exp Rheumatol 17:S105-14. 1999..These observations provide evidence for the potential uncoupling of joint inflammation and erosive changes and underline the need for TNF alpha/IL-1 directed combination-therapy approaches... - Amelioration of established murine collagen-induced arthritis with anti-IL-1 treatmentW B van den Berg
Department of Rheumatology, University Hospital Nijmegen, The Netherlands
Clin Exp Immunol 95:237-43. 1994..It is concluded that IL-1 is an important determinant in both inflammation and cartilage destruction in collagen arthritis, and this may have implications for therapy in human arthritis... - Localization and quantification of the insulin-like growth factor-1 receptor in mouse articular cartilage by confocal laser scanning microscopyP J Verschure
Department of Rheumatology, University Hospital Nijmegen, The Netherlands
J Histochem Cytochem 42:765-73. 1994..The variable distribution of IGF-1 receptor in chondrocytes of articular cartilage suggests that effects of IGF-1 on chondrocytes may be distinctly heterogeneous in the different mouse articular cartilage zones... - IL-17 produced by Paneth cells drives TNF-induced shockNozomi Takahashi
Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, Netherlands
J Exp Med 205:1755-61. 2008..These data indicate that innate immune cytokine responses in the local mucosa may participate in rapidly amplifying responses to systemic inflammatory challenges... - Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistanceMihai G Netea
Department of Internal Medicine and Nijmegen University Center for Infectious Diseases, Geert Grooteplein 8, 6500 HB, Nijmegen, The Netherlands
Nat Med 12:650-6. 2006..In addition, rIL-18 reversed hyperglycemia in Il18-/- mice through activation of STAT3 phosphorylation. These findings indicate a new role of IL-18 in the homeostasis of energy intake and insulin sensitivity... - Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritisMieke F Roelofs
Department of Rheumatology Research and Advanced Therapeutics, Nijmegen Center for Molecular Life Sciences, The Netherlands
J Immunol 176:7021-7. 2006..These findings suggest a role for HSPB8 during the inflammatory process in autoimmune diseases such as RA... - Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritisMarije I Koenders
University Medical Center St. Radboud, Nijmegen, The Netherlands
Arthritis Rheum 52:3239-47. 2005..Prevention of IL-17R signaling warrants consideration as a therapeutic target in chronic destructive arthritis... - Interleukin-18 promotes joint inflammation and induces interleukin-1-driven cartilage destructionLeo A B Joosten
Rheumatology Research Laboratory and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
Am J Pathol 165:959-67. 2004..These findings implicate that IL-18, in contrast to TNF, contributes through separate pathways to joint inflammation and cartilage destruction... - Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritisLeo A B Joosten
Rheumatology Research Laboratory, University Medical Center Nijmegen, Nijmegen, The Netherlands
Arthritis Rheum 48:339-47. 2003.... - Growth plate damage, a feature of juvenile idiopathic arthritis, can be induced by adenoviral gene transfer of oncostatin M: a comparative study in gene-deficient miceAlfons S K de Hooge
Rheumatology Research Laboratory, University Medical Center Nijmegen, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
Arthritis Rheum 48:1750-61. 2003..The effect of OSM on murine connective tissue and the presence of OSM in human synovial fluid make involvement of OSM in human arthropathies very likely... - T cell dependence of chronic destructive murine arthritis induced by repeated local activation of Toll-like receptor-driven pathways: crucial role of both interleukin-1beta and interleukin-17Leo A B Joosten
Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Arthritis Rheum 58:98-108. 2008..The present study was undertaken to develop a mouse model of chronic destructive arthritis induced by repeated intraarticular (IA) exposure to bacterial cell wall fragments and to investigate the cytokine dependence of this model... - Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88Leo A B Joosten
Rheumatology Research Laboratory and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
J Immunol 171:6145-53. 2003..Since agonists of the Toll-like pathway are abundantly involved in both septic and rheumatoid arthritis, targeting of MyD88 may be a novel therapy in inflammatory joint diseases... - Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritisShahla Abdollahi-Roodsaz
Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Clin Invest 118:205-16. 2008.... - Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis modelsFons A J van de Loo
Department of Rheumatology, University Medical Center Nijmegen, Nijmegen, The Netherlands
Am J Pathol 163:1525-37. 2003..This showed that the involvement of NADPH oxidase in arthritis is probably far more complex and that oxygen radicals might also be important in controlling disease severity, and reducing joint inflammation and connective tissue damage... - Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: a comparative study using anti-TNFalpha, anti-IL-1alpha/beta and IL-1RaLeo A B Joosten
University Hospital Nijimegen, Nijimegen, The Netherlands
Arthritis Rheum 58:S110-22. 2008..To examine the role of tumor necrosis factor alpha (TNF alpha), interleukin-1 alpha (IL-1 alpha), and IL-1 beta in collagen-induced arthritis (CIA), immediately after onset and during the phase of established arthritis... - Interleukin-32 induces the differentiation of monocytes into macrophage-like cellsMihai G Netea
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Proc Natl Acad Sci U S A 105:3515-20. 2008..Thus, IL-32 not only contributes to host responses through the induction of proinflammatory cytokines but also directly affects specific immunity by differentiating monocytes into macrophage-like cells... - The functional variant (Asp299gly) of toll-like receptor 4 (TLR4) influences TLR4-mediated cytokine production in rheumatoid arthritisMieke F Roelofs
Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Rheumatol 35:558-61. 2008..To investigate functional consequences of the Toll-like receptor 4 (TLR4) variant (Asp299Gly) in rheumatoid arthritis (RA)... - Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritisLeo A B Joosten
Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
Proc Natl Acad Sci U S A 105:9017-22. 2008..Whether a distorted balance between the function of Nod1 and/or Nod2 is involved in the pathogenesis of human autoinflammatory or autoimmune disease, such as rheumatoid arthritis, remains to be elucidated... - IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balanceErik Lubberts
Rheumatology and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
J Immunol 170:2655-62. 2003..These findings suggest T cell IL-17 to be an important inducer of RANKL expression leading to loss of the RANKL/OPG balance, stimulating osteoclastogenesis and bone erosion in arthritis... - Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritisShahla Abdollahi-Roodsaz
Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Arthritis Rheum 56:2957-67. 2007..The objective of this study was to investigate the involvement of TLR-4 activation in the development and progression of autoimmune destructive arthritis... - Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanismMihai G Netea
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
PLoS Med 3:e277. 2006..Interleukin (IL)-32 is a newly described proinflammatory cytokine that seems likely to play a role in inflammation and host defense. Little is known about the regulation of IL-32 production by primary cells of the immune system... - Interleukin-17 acts independently of TNF-alpha under arthritic conditionsMarije I Koenders
Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
J Immunol 176:6262-9. 2006..These data provide further understanding of the cytokine interplay during inflammation and demonstrate that, despite a strong TNF dependency under naive conditions, IL-17 acts independently of TNF under arthritic conditions... - IL-32, a proinflammatory cytokine in rheumatoid arthritisLeo A B Joosten
Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, The Netherlands
Proc Natl Acad Sci U S A 103:3298-303. 2006..IL-32, strongly associated with TNFalpha, IL-1beta, and IL-18, appears to play a role in human RA and may be a novel target in autoimmune diseases... - Influence of heme oxygenase 1 modulation on the progression of murine collagen-induced arthritisIsabel Devesa
University of Valencia, Burjassot, Valencia, Spain
Arthritis Rheum 52:3230-8. 2005.... - Induction of cartilage damage by overexpression of T cell interleukin-17A in experimental arthritis in mice deficient in interleukin-1Marije I Koenders
University Medical Center St Radboud, Nijmegen, The Netherlands
Arthritis Rheum 52:975-83. 2005..To examine the capacity of T cell interleukin-17A (IL-17A; referred to hereinafter as IL-17) to induce cartilage damage during experimental arthritis in the absence of IL-1... - Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gammaTimothy R D J Radstake
University Medical Center Nijmegen, Nijmegen, The Netherlands
Arthritis Rheum 50:3856-65. 2004..The synergistic effect of IL-12 and IL-18 on T cell IFNgamma production seems to regulate expression of TLR-2 and TLR-4 in the synovial tissue of RA patients... - Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosionErik Lubberts
University Medical Center Nijmegen, Nijmegen, The Netherlands
Arthritis Rheum 50:650-9. 2004..Our data strongly indicate that IL-17 neutralization could provide an additional therapeutic strategy for RA, particularly in situations in which elevated IL-17 may attenuate the response to anti-tumor necrosis factor/anti-IL-1 therapy...