Research Topics
Genomes and Genes | Fons Aj van de LooSummaryAffiliation: Radboud University Nijmegen Medical Centre Country: The Netherlands Publications
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Publications
A crucial role for tumor necrosis factor receptor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritisOnno J Arntz
Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands
Arthritis Res Ther 12:R61. 2010..The objective is to investigate the role of TNFR1 in the synovial lining cells (SLC) and the reticuloendothelial system (RES) during experimental arthritis...- Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodelingEsmeralda N Blaney Davidson
Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Geert Grooteplein 26 28, Nijmegen, 6500 HB, The Netherlands
Arthritis Res Ther 9:R102. 2007..Moreover, BMP contributes to the intrinsic repair capacity of damaged cartilage. Increased matrix turnover might be functional in replacing matrix molecules in the repair of a damaged cartilage matrix... - Inflammation-responsive promoters for fine-tuned gene therapy in rheumatoid arthritisFons A J van de Loo
University Medical Center Nijmegen, Nijmegen Center for Molecular Life Sciences, Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Geert Grooteplein 26 28, 6500 HB Nijmegen, The Netherlands
Curr Opin Mol Ther 6:537-45. 2004..The merging of these modalities may provide a flexible system to fine-tune transgene expression, which is a prerequisite for the implementation of gene therapy in RA... - Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis modelsFons A J van de Loo
Department of Rheumatology, University Medical Center Nijmegen, Nijmegen, The Netherlands
Am J Pathol 163:1525-37. 2003..This showed that the involvement of NADPH oxidase in arthritis is probably far more complex and that oxygen radicals might also be important in controlling disease severity, and reducing joint inflammation and connective tissue damage... - Gene therapy works in animal models of rheumatoid arthritis...so what!Fons A J van de Loo
Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands
Curr Rheumatol Rep 8:386-93. 2006.... - A pivotal role for antigen-presenting cells overexpressing SOCS3 in controlling invariant NKT cell responses during collagen-induced arthritisSharon Veenbergen
Correspondence to F A J van de Loo, Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Geert Grooteplein 26 28, 6500 HB Nijmegen, The Netherlands
Ann Rheum Dis 70:2167-75. 2011..A study was undertaken to investigate the contribution of SOCS3 in regulating invariant natural killer T (iNKT) cell responses during collagen-induced arthritis (CIA)... - Immunocytokines: the long awaited therapeutic magic bullet in rheumatoid arthritis?Fons A van de Loo
Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen 6525 GA, The Netherlands
Arthritis Res Ther 11:132. 2009..In principle, the scFv-targeting system is plastic enough to allow for personalized strategies... - Toll-like receptor 4 signalling is specifically TGF-beta-activated kinase 1 independent in synovial fibroblastsJeroen Geurts
Department of Rheumatology, Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Rheumatology (Oxford) 50:1216-25. 2011..In this study, we sought to determine the role of the MAP3K TGF-?-activated kinase 1 (TAK1) in cytokine and TLR-mediated signalling... - Soluble IL-18 receptor complex: a new star in the firmament of rheumatoid arthritis diagnosis?Fons Aj van de Loo
Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands
Arthritis Res Ther 13:111. 2011..The information obtained from these markers does not, however, provide a complete picture of the disease and treatment efficacy. New biomarkers based on cytokine receptor complexes are promising for RA theragnostics... - Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients?Fons A J van de Loo
Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, University Medical Center Nijmegen, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
Arthritis Res Ther 6:183-96. 2004..Evidence from animal models convincingly supports the application of gene therapy in RA, and the feasibility of gene therapy was recently demonstrated in phase I clinical trials... - Adenoviral transfer of murine oncostatin M elicits periosteal bone apposition in knee joints of mice, despite synovial inflammation and up-regulated expression of interleukin-6 and receptor activator of nuclear factor-kappa B ligandAlfons S K de Hooge
Rheumatology Research Laboratory, University Medical Center Nijmegen, Nijmegen, The Netherlands
Am J Pathol 160:1733-43. 2002..Our results show that OSM favors bone apposition at periosteal sites instead of resorption in vivo. This effect was not dependent on or inhibited by IL-6... - Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosionErik Lubberts
University Medical Center Nijmegen, Nijmegen, The Netherlands
Arthritis Rheum 50:650-9. 2004..Our data strongly indicate that IL-17 neutralization could provide an additional therapeutic strategy for RA, particularly in situations in which elevated IL-17 may attenuate the response to anti-tumor necrosis factor/anti-IL-1 therapy... - Increase in expression of receptor activator of nuclear factor kappaB at sites of bone erosion correlates with progression of inflammation in evolving collagen-induced arthritisErik Lubberts
University Medical Center Nijmegen, Nijmegen, The Netherlands
Arthritis Rheum 46:3055-64. 2002..This study was undertaken to identify in vivo the hitherto-unknown origin and localization of RANK-expressing osteoclast precursor cells at sites of bone erosion in arthritis... - Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritisLeo A B Joosten
Rheumatology Research Laboratory, University Medical Center Nijmegen, Nijmegen, The Netherlands
Arthritis Rheum 48:339-47. 2003.... - Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritisMarije I Koenders
University Medical Center St. Radboud, Nijmegen, The Netherlands
Arthritis Rheum 52:3239-47. 2005..Prevention of IL-17R signaling warrants consideration as a therapeutic target in chronic destructive arthritis... - Interleukin-23 is critical for full-blown expression of a non-autoimmune destructive arthritis and regulates interleukin-17A and RORgammat in gammadelta T cellsFerry Cornelissen
Department of Rheumatology, Erasmus Medical Center Rotterdam, Dr, Molewaterplein 50, Rotterdam, 3015 GE, The Netherlands
Arthritis Res Ther 11:R194. 2009..In addition, the regulatory potential of IL-23 in IL-17A and retinoic acid-related orphan receptor gamma t (RORgammat) expression in CD4+ and TCRgammadelta+ T cells was evaluated systemically as well as at the site of inflammation... - IL-17 produced by Paneth cells drives TNF-induced shockNozomi Takahashi
Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, Netherlands
J Exp Med 205:1755-61. 2008..These data indicate that innate immune cytokine responses in the local mucosa may participate in rapidly amplifying responses to systemic inflammatory challenges... - Tumor necrosis factor-interleukin-17 interplay induces S100A8, interleukin-1?, and matrix metalloproteinases, and drives irreversible cartilage destruction in murine arthritis: rationale for combination treatment during arthritisMarije I Koenders
Radboud University Nijmegen Medical Centre, Department of Rheumatology, Nijmegen, The Netherlands
Arthritis Rheum 63:2329-39. 2011.... - Local interleukin-12 gene transfer promotes conversion of an acute arthritis to a chronic destructive arthritisLeo A B Joosten
Rheumatology Research Laboratory, University Medical Center Nijmegen, Nijmegen, The Netherlands
Arthritis Rheum 46:1379-89. 2002.... - TLR2 promotes Th2/Th17 responses via TLR4 and TLR7/8 by abrogating the type I IFN amplification loopMark H Wenink
Department of Rheumatology, Radboud University Nijmegen Medical Center, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
J Immunol 183:6960-70. 2009..This shift in T cell responses was inherent to the inability of TLR2-stimulated DCs to produce IL-12p70 and was dependent on the production of IL-1 and IL-6... - IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balanceErik Lubberts
Rheumatology and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
J Immunol 170:2655-62. 2003..These findings suggest T cell IL-17 to be an important inducer of RANKL expression leading to loss of the RANKL/OPG balance, stimulating osteoclastogenesis and bone erosion in arthritis... - Interleukin-18 promotes joint inflammation and induces interleukin-1-driven cartilage destructionLeo A B Joosten
Rheumatology Research Laboratory and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
Am J Pathol 165:959-67. 2004..These findings implicate that IL-18, in contrast to TNF, contributes through separate pathways to joint inflammation and cartilage destruction... - Interleukin-17 acts independently of TNF-alpha under arthritic conditionsMarije I Koenders
Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
J Immunol 176:6262-9. 2006..These data provide further understanding of the cytokine interplay during inflammation and demonstrate that, despite a strong TNF dependency under naive conditions, IL-17 acts independently of TNF under arthritic conditions... - The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal modelsErik Lubberts
Department of Rheumatology, Rheumatology Research and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
Arthritis Res Ther 7:29-37. 2005..Anti-IL-17 cytokine therapy is of interest as an additional new anti-rheumatic strategy for RA, in particular in situations in which elevated IL-17 might attenuate the response to anti-TNF/anti-IL-1 therapy... - Induction of cartilage damage by overexpression of T cell interleukin-17A in experimental arthritis in mice deficient in interleukin-1Marije I Koenders
University Medical Center St Radboud, Nijmegen, The Netherlands
Arthritis Rheum 52:975-83. 2005..To examine the capacity of T cell interleukin-17A (IL-17A; referred to hereinafter as IL-17) to induce cartilage damage during experimental arthritis in the absence of IL-1... - Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1Marije I Koenders
Department of Rheumatology, Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center, 189, Geert Grooteplein Zuid 26 28, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Am J Pathol 167:141-9. 2005..These data indicate that IL-17 is an important upstream mediator in joint pathology during flare-up of experimental arthritis... - Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88Leo A B Joosten
Rheumatology Research Laboratory and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
J Immunol 171:6145-53. 2003..Since agonists of the Toll-like pathway are abundantly involved in both septic and rheumatoid arthritis, targeting of MyD88 may be a novel therapy in inflammatory joint diseases... - The role of IL-17 and family members in the pathogenesis of arthritisErik Lubberts
University Medical Center Nijmegen, Geert Grooteplein Zuid 26 28, 6500 HB, Nijmegen, The Netherlands
Curr Opin Investig Drugs 4:572-7. 2003..Anti-IL-17 cytokine therapy may be an interesting new antirheumatic approach to the prevention of joint destruction, in addition to anti-TNF and anti-IL-1 therapy... - Fcgamma receptors directly mediate cartilage, but not bone, destruction in murine antigen-induced arthritis: uncoupling of cartilage damage from bone erosion and joint inflammationPeter L van Lent
Rheumatology Department, Radboud University Medical Centre, Nijmegen, The Netherlands
Arthritis Rheum 54:3868-77. 2006..To determine the relationship between synovial inflammation and the concomitant occurrence of cartilage and bone erosion during conditions of variable inflammation using various Fcgamma receptor knockout (FcgammaR(-/-)) mice... - The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypesTimothy R D J Radstake
Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
PLoS ONE 4:e5903. 2009..Systemic sclerosis (SSc) is an autoimmune disease where controversy on Th1/Th2 balance dominates. We investigated whether the recently discovered Th17 pattern was present in SSc... - Cytokines in the pathogenesis of rheumatoid arthritis and collagen-induced arthritisErik Lubberts
Rheumatology Research Laboratory, Department of Rheumatology, University Hospital Nijmegen, The Netherlands
Adv Exp Med Biol 520:194-202. 2003 - Trapped in a vicious loop: Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synoviumShahla Abdollahi-Roodsaz
Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Arthritis Res Ther 13:105. 2011.... - IL-17/Th17 targeting: on the road to prevent chronic destructive arthritis?Erik Lubberts
Department of Rheumatology, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Cytokine 41:84-91. 2008..This might help to reach the ultimate goal not only to treat RA patients but to prevent the development of this crippling disease... - A novel Saa3-promoter reporter distinguishes inflammatory subtypes in experimental arthritis and human synovial fibroblastsJeroen Geurts
Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
Ann Rheum Dis 70:1311-9. 2011....