Research Topics
Species | D W SwinkelsSummaryAffiliation: Radboud University Nijmegen Medical Centre Country: The Netherlands Publications
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Publications
Regulation of hepcidin: insights from biochemical analyses on human serum samplesErwin H J M Kemna
Department of Clinical Chemistry 441, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Blood Cells Mol Dis 40:339-46. 2008..Future studies are needed to validate the combined utility of this predictive algorithm together with actual measured hepcidin levels in clinical diagnosis...- Rapid genotyping of single nucleotide polymorphisms using novel minor groove binding DNA oligonucleotides (MGB probes)Jacques B de Kok
Department of Clinical Chemistry, University Medical Centre, Nijmegen, The Netherlands
Hum Mutat 19:554-9. 2002..Hum Mutat 19:554-559, 2002... - Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implicationsErwin H J M Kemna
Department of Clinical Chemistry, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Clin Chem 53:620-8. 2007..Recent reports on the measurement of urine and serum hepcidin by surface-enhanced laser-desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) necessitate analytical and clinical evaluation of MS-based methodologies... - Inflammation-induced hepcidin-25 is associated with the development of anemia in septic patients: an observational studyLucas T van Eijk
Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, Geert Grooteplein zuid 10, PO Box 9201, 6500 HB Nijmegen, The Netherlands
Crit Care 15:R9. 2011..However, the association between inflammation, hepcidin release and anemia has not been demonstrated in this group of patients. Therefore, we explored the association between hepcidin and sepsis-associated anemia... - Advances in quantitative hepcidin measurements by time-of-flight mass spectrometryDorine W Swinkels
Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
PLoS ONE 3:e2706. 2008.... - Synopsis of the Dutch multidisciplinary guideline for the diagnosis and treatment of hereditary haemochromatosisD W Swinkels
Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Neth J Med 65:452-5. 2007..We therefore recommend world-wide efforts to collaboratively address these remaining issues... - Hereditary hemochromatosis: genetic complexity and new diagnostic approachesDorine W Swinkels
Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen
Clin Chem 52:950-68. 2006..This review describes new insights in mechanisms of iron overload, which are needed to understand new developments in diagnostic medicine... - [From gene to disease; HFE-mutations in primary haemochromatosis]D W Swinkels
afd Klinische Chemie, Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HB Nijmegen
Ned Tijdschr Geneeskd 147:652-6. 2003..In other cases, liver biopsy remains the gold standard for the diagnosis of primary haemochromatosis. First-degree relatives of index patients should be screened for the disease... - A novel (Leu183Pro-)mutation in the HFE-gene co-inherited with the Cys282Tyr mutation in two unrelated Dutch hemochromatosis patientsDorine W Swinkels
Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Blood Cells Mol Dis 40:334-8. 2008..These findings may have implications for HFE-testing of iron overloaded heterozygous Cys282Tyr-patients of Northern European origin and their relatives... - Morbidity and mortality in first-degree relatives of C282Y homozygous probands with clinically detected haemochromatosis compared with the general population: the HEmochromatosis FAmily Study (HEFAS)E M G Jacobs
Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, The Netherlands
Neth J Med 65:425-33. 2007..Family screening has been suggested as a sophisticated model for the early detection of HFE-related hereditary haemochromatosis (HH). However, until now, controlled studies on the morbidity and mortality in families with HH are lacking... - Impact of waist circumference versus adiponectin level on subclinical atherosclerosis: a cross-sectional analysis in a sample from the general populationS Holewijn
Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Intern Med 267:588-98. 2010.... - [Hereditary haemochromatosis: novel genes, novel diseases and hepcidin]J P H Bergmans
Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HS Nijmegen
Ned Tijdschr Geneeskd 151:1121-7. 2007.... - Real-time quantification of human telomerase reverse transcriptase mRNA in tumors and healthy tissuesJ B de Kok
Departments of Clinical Chemistry, Surgery, Pathology, and Urology, University Hospital Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Clin Chem 46:313-8. 2000..This method may be of interest for molecular tumor diagnostics in tissues and corresponding body fluids, washings, or brushes... - Non-transferrin-bound iron is associated with plasma level of soluble intercellular adhesion molecule-1 but not with in vivo low-density lipoprotein oxidationL J H van Tits
Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Atherosclerosis 194:272-8. 2007..Excess body iron is associated with increased cardiovascular disease risk, possibly via non-transferrin-bound iron (NTBI)-mediated enhancement of inflammation and oxidation of low-density lipoprotein (LDL)... - Hereditary haemochromatosisM C H Janssen
Radboud University Medical Centre, Department of General Internal Medicine 463, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Best Pract Res Clin Gastroenterol 23:171-83. 2009..Overall, at least four main types of hereditary haemochromatosis (HH) have been identified. This review describes the systematic diagnostic and therapeutic strategy and pitfalls for patients suspected for HH and their relatives... - Changing aspects of HFE-related hereditary haemochromatosis and endeavours to early diagnosisE M G Jacobs
Department of Clinical Chemistry, University Medical Centre Groningen, Groningen, The Netherlands
Neth J Med 65:419-24. 2007.... - Impact of the introduction of a guideline on the targeted detection of hereditary haemochromatosisE M G Jacobs
Department of Clinical Chemistry 564, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Neth J Med 63:205-14. 2005.... - [Diagnosis of 5 patients with possible primary hemochromatosis]E M G Jacobs
Afd Algemene Inwendige Geneeskunde, Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HB Nijmegen
Ned Tijdschr Geneeskd 147:666-70. 2003..In case of doubt as to the diagnosis, histological examination of the liver with a qualitative or quantitative iron determination is the golden standard... - Apolipoprotein B, non-HDL cholesterol and LDL cholesterol for identifying individuals at increased cardiovascular riskS Holewijn
Division of Vascular Medicine, Department of General Internal Medicine, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
J Intern Med 268:567-77. 2010.... - Brachial artery diameter is related to cardiovascular risk factors and intima-media thicknessS Holewijn
Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Eur J Clin Invest 39:554-60. 2009..We determined the relation of FMD, BAD and NMD with known CV risk factors and intima-media thickness (IMT), a well-established surrogate marker of atherosclerosis, in a community-based population, the Nijmegen Biomedical Study (NBS)... - Survivin mRNA expression is elevated in malignant urothelial cell carcinomas and predicts time to recurrenceI J Schultz
Department of Clinical Chemistry 564, University Medical Center Nijmegen, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
Anticancer Res 23:3327-31. 2003..Expression of the inhibitor of apoptosis protein survivin is up-regulated in many tumors of epithelial origin and frequently shows a relationship with disease prognosis... - Need for early recognition and therapeutic guidelines of congenital sideroblastic anaemiaM L H Cuijpers
Department of Haematology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Int J Hematol 94:97-100. 2011..Increased awareness, as well as development of evidence-based clinical guidelines, is required for timely diagnosis and adequate treatment... - Primary haemochromatosis: a missed cause of chronic fatigue syndrome?D W Swinkels
Department of Clinical Chemistry 564, University Medical Centre St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Neth J Med 60:429-33. 2002..To determine whether patients previously diagnosed as chronic fatigue syndrome (CFS) actually have primary haemochomatosis (PH)... - Glomerular filtration rate by single-injection inulin clearance: definition of a workable protocol for childrenD W Swinkels
Department of Clinical Chemistry, University Hospital Nijmegen, The Netherlands
Ann Clin Biochem 37:60-6. 2000.... - Blood lipid levels and prostate cancer risk; a cohort studyD E G Kok
1 Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands 2 Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
Prostate Cancer Prostatic Dis 14:340-5. 2011..17-15.67). The results of this study suggest that blood lipid levels may influence risk of prostate cancer. However, the exact roles of different cholesterol fractions on prostate cancer aggressiveness should be further evaluated... - Quantitative measurement of telomerase reverse transcriptase (hTERT) mRNA in urothelial cell carcinomasJ B de Kok
Department of Clinical Chemistry, University Hospital Nijmegen, Nijmegen, The Netherlands
Int J Cancer 87:217-20. 2000..We conclude that standardized real-time measurement of hTERT expression can be used for early tumor detection and may be used for determination of prognosis in urothelial cell carcinomas of the bladder... - Age- and gender-specific reference values of estimated GFR in Caucasians: the Nijmegen Biomedical StudyJ F M Wetzels
Department of Nephrology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
Kidney Int 72:632-7. 2007..73 m(2) in similar aged women. In these healthy persons, GFR declined approximately 0.4 ml/min/year. Our study provides age- and gender-specific reference values of GFR in a population of Caucasian persons without identifiable risk... - New method for faecal fat determination by mid-infrared spectroscopy, using a transmission cell: an improvement in standardizationB S Jakobs
Department of Clinical Chemistry, University Hospital Nijmegen St Radboud, The Netherlands
Ann Clin Biochem 37:343-9. 2000..The new FT-IR method, using primary standards, is simple and rapid, and provides satisfactory intra- and inter-laboratory precision for the diagnosis and monitoring of steatorrhoea... - Time-course analysis of serum hepcidin, iron and cytokines in a C282Y homozygous patient with Schnitzler's syndrome treated with IL-1 receptor antagonistMarcel van Deuren
Department of Clinical Chemistry, 441 Radboud University, Nijmegen Medical Center, Nijmegen, The Netherlands
Haematologica 94:1297-300. 2009.... - Hepcidin: from discovery to differential diagnosisErwin H J M Kemna
Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, P O Box 9101 6500 HB Nijmegen, The Netherlands
Haematologica 93:90-7. 2008..Ongoing studies in humans should provide us with more information on the etiology of iron metabolism disorders in order to create new therapeutic strategies and improve differential diagnosis protocols for these diseases... - Effect of the new HJV-L165X mutation on penetrance of HFEBoukje A C van Dijk
Blood 109:5525-6. 2007 - Serum non-transferrin-bound iron and low-density lipoprotein oxidation in heterozygous hemochromatosisLambertus J H van Tits
Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Biochem Biophys Res Commun 345:371-6. 2006..Mean lag-phase of in vitro LDL oxidation was also not significantly different between both study groups. Conclusion: these findings do not support the hypothesis that NTBI promotes oxidative modification of plasma LDL... - Nitric oxide does not contribute to inflammation-induced hypoferremia in humansErwin H J M Kemna
Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Acta Haematol 118:149-52. 2007 - Is serum cystatin C the marker of choice to predict glomerular filtration rate in paediatric patients?Hans L Willems
Department of Clinical Chemistry, University Medical Centre, Nijmegen, The Netherlands
Ann Clin Biochem 40:60-4. 2003..It has been suggested that serum cystatin C (cyst-C) concentration provides a better indication of changes in glomerular filtration rate (GFR) than does serum creatinine concentration... - Shedding & shaving: disclosure of proteomic expressions on a bacterial faceHarold Tjalsma
Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Proteomics 8:1415-28. 2008..Together this shows that these combined gel-free approaches can reveal novel proteomic decorations on a bacterial face and may provide leads for future studies on protein sorting in B. subtilis and other Gram-positive bacteria... - Simultaneous proteomic and genomic analysis of primary Ta urothelial cell carcinomas for the prediction of tumor recurrenceIman J Schultz
Departments of Clinical Chemistry, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
Anticancer Res 27:1051-8. 2007..The prediction of tumor recurrence in patients with Ta urothelial cell carcinoma is inaccurate and new prognostic markers are desirable... - CDC91L1 (PIG-U) mRNA expression in urothelial cell carcinomasIman J Schultz
Department of Clinical Chemistry, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Int J Cancer 116:282-4. 2005..Our results suggest, in contrast to those of Guo et al. (Nat Med 2004;10:374-81), that the oncogene CDC91L1 is not overexpressed at the mRNA level in urothelial cell carcinomas and cannot be used to predict the course of the disease... - Thyroid function and prevalence of anti-thyroperoxidase antibodies in a population with borderline sufficient iodine intake: influences of age and sexElizabeth H Hoogendoorn
Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Clin Chem 52:104-11. 2006..We present a large European population-based study of thyroid function, performed in a population with longstanding borderline sufficient iodine intake... - Normalization of gene expression measurements in tumor tissues: comparison of 13 endogenous control genesJacques B de Kok
Department of Clinical Chemistry, University Medical Centre Nijmegen, Nijmegen, The Netherlands
Lab Invest 85:154-9. 2005..We recommend this gene for future studies to standardize gene expression measurements in cancer research and tumor diagnostics until a definite gold standard has been determined... - Bladder cancer diagnosis and recurrence prognosis: comparison of markers with emphasis on survivinIman J Schultz
Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
Clin Chim Acta 368:20-32. 2006..Also, important requirements for a successful implementation of such markers in a hospital setting are discussed. Finally, future directions for the discovery of new diagnostic or prognostic candidate markers will be mentioned... - Serum ferritin levels are increased in patients with glomerular diseases and proteinuriaAmanda J W Branten
Department of Medicine, Division of Nephrology, University Medical Center Nijmegen, Nijmegen, The Netherlands
Nephrol Dial Transplant 19:2754-60. 2004..Recently, ferritin has been identified as a predictive factor in the development and progression of atherosclerosis. This is the first report on serum ferritin levels in patients with proteinuria... - Survivin and MKI67 mRNA expression in bladder washings of patients with superficial urothelial cell carcinoma correlate with tumor stage and grade but do not predict tumor recurrenceIman J Schultz
Clin Chem 52:1440-2. 2006 - Profiling the humoral immune response in colon cancer patients: diagnostic antigens from Streptococcus bovisHarold Tjalsma
Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Int J Cancer 119:2127-35. 2006..This makes profiling of the humoral immune response against "silent" S. bovis infections a promising diagnostic tool for the early detection of human colon cancer, which is crucial for the effective treatment of this disease... - Gene expression analysis for the prediction of recurrence in patients with primary Ta urothelial cell carcinomaIman J Schultz
Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Eur Urol 51:416-22; discussion 422-3. 2007..This study aims at discriminating between patients with primary Ta UCC and long or short recurrence-free periods... - Survivin mRNA copy number in bladder washings predicts tumor recurrence in patients with superficial urothelial cell carcinomasIman J Schultz
Department of Clinical Chemistry, University Medical Center Nijmegen, Nijmegen, The Netherlands
Clin Chem 50:1425-8. 2004 - Proteomic inventory of "anchorless" proteins on the colon adenocarcinoma cell surfaceHarold Tjalsma
Department of Clinical Chemistry, 441, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Biochim Biophys Acta 1764:1607-17. 2006.... - Results of an international round robin for the quantification of serum non-transferrin-bound iron: Need for defining standardization and a clinically relevant isoformEsther M G Jacobs
Department of Clinical Chemistry, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands
Anal Biochem 341:241-50. 2005.... - Preeclampsia and the C282Y mutation in the hemochromatosis (HFE) geneIngrid P Senden
Clin Chem 50:973-4. 2004 - Difference between free circulating plasma and serum DNA in patients with colorectal liver metastasesMyriam A M A Thijssen
Department of Clinical Chemistry, University Medical Centre Nijmegen, The Netherlands
Anticancer Res 22:421-5. 2002..However, it is unclear whether DNA from plasma or from serum better reflects the clinical status... - DD3(PCA3), a very sensitive and specific marker to detect prostate tumorsJacques B de Kok
Department of Clinical Chemistry, University Medical Centre Nijmegen, 6500 HB Nijmegen, The Netherlands
Cancer Res 62:2695-8. 2002..Consequently, DD3 measurements may be used for clinical application in prostate needle biopsies or bodily fluids such as blood, ejaculate, urine, or prostate massage fluid... - Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancerSimon N Stacey
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 40:703-6. 2008..The nearest gene, MRPS30, was previously implicated in apoptosis, ER-positive tumors and favorable prognosis. A recently reported signal in FGFR2 was also found to associate specifically with ER-positive breast cancer... - Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancerJulius Gudmundsson
deCODE Genetics, 101 Reykjavik, Iceland
Nat Genet 40:281-3. 2008..23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease... - Prediction of recurrence in Ta urothelial cell carcinoma by real-time quantitative PCR analysis: a microarray validation studyIman J Schultz
Department of Clinical Chemistry, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
Int J Cancer 119:1915-9. 2006..In conclusion, we were not able to confirm the microarray gene expression pattern of the 26 genes shown by Dyrskjøt et al. The discovery of accurate recurrence predictive markers, therefore, remains a challenge... - Polymorphisms in the E-cadherin (CDH1) gene promoter and the risk of bladder cancerLambertus A Kiemeney
Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Department of Epidemiology and Biostatistics, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
Eur J Cancer 42:3219-27. 2006..We studied the association between both polymorphisms and the risk of bladder cancer... - Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetesJulius Gudmundsson
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 39:977-83. 2007..Results from eight case-control groups, including one West African and one Chinese, demonstrate that this variant confers protection against type 2 diabetes... - Blood donation, body iron status and carotid intima-media thicknessMarielle F Engberink
Wageningen University, Division of Human Nutrition, Wageningen, The Netherlands
Atherosclerosis 196:856-62. 2008..CIMT was not significantly related to NTBI. Frequent blood donation, resulting in lowered body iron, might give some protection against accelerated atherosclerosis... - Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24Julius Gudmundsson
deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
Nat Genet 39:631-7. 2007..The newly identified variant shows a stronger association with affected individuals who have an earlier age at diagnosis... - The prognostic role of the STK15 T91A polymorphism and of STK15 mRNA expression in patients with urothelial cell carcinomaIman J Schultz
Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Anticancer Res 27:1025-30. 2007..The prognostic role of the STK15 T91A polymorphism and of STK15 mRNA expression was investigated in patients with urothelial cell carcinoma (UCC)...