Leo M Heunks

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi Plasma from septic shock patients induces loss of muscle protein
    Hieronymus W H van Hees
    Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, Geert Grooteplein zuid 10, 6525 GA, Nijmegen, The Netherlands
    Crit Care 15:R233. 2011
  2. ncbi Diaphragm adaptations in patients with COPD
    Coen A C Ottenheijm
    Dept of Molecular and Cellular Biology, University of Arizona, Tucson, USA
    Respir Res 9:12. 2008
  3. ncbi Bench-to-bedside review: hypercapnic acidosis in lung injury--from 'permissive' to 'therapeutic'
    Marloes M Ijland
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Geert Grooteplein 10, 6500 HB Nijmegen, The Netherlands
    Crit Care 14:237. 2010
  4. ncbi Clinical review: the ABC of weaning failure--a structured approach
    Leo M Heunks
    Department of Intensive Care Medicine 632, Radboud University Nijmegen Medical Centre, Postbox 9101, 6500 HB Nijmegen, The Netherlands
    Crit Care 14:245. 2010
  5. ncbi Non-invasive mechanical ventilation for diagnostic bronchoscopy using a new face mask: an observational feasibility study
    Leo M A Heunks
    Department of Intensive Care Medicine 551, Radboud University Medical Centre, Postbox 9101, 6500 HB Nijmegen, The Netherlands
    Intensive Care Med 36:143-7. 2010
  6. ncbi The calcium sensitizer levosimendan improves human diaphragm function
    Jonne Doorduin
    Radboud University Nijmegen Medical Centre, Department of Critical Care Medicine, Geert Grooteplein zuid 10, 6525 GA Nijmegen, The Netherlands
    Am J Respir Crit Care Med 185:90-5. 2012
  7. ncbi Diaphragm dysfunction in chronic obstructive pulmonary disease
    Coen A C Ottenheijm
    Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
    Am J Respir Crit Care Med 172:200-5. 2005
  8. ncbi Activation of the ubiquitin-proteasome pathway in the diaphragm in chronic obstructive pulmonary disease
    Coen A C Ottenheijm
    Department of Pulmonary Diseases, 454, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands
    Am J Respir Crit Care Med 174:997-1002. 2006
  9. ncbi Mechanical ventilation induces a Toll/interleukin-1 receptor domain-containing adapter-inducing interferon beta-dependent inflammatory response in healthy mice
    Michiel Vaneker
    Department of Anesthesiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Anesthesiology 111:836-43. 2009
  10. ncbi Levosimendan enhances force generation of diaphragm muscle from patients with chronic obstructive pulmonary disease
    Hieronymus W H van Hees
    Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Respir Crit Care Med 179:41-7. 2009

Collaborators

Detail Information

Publications20

  1. ncbi Plasma from septic shock patients induces loss of muscle protein
    Hieronymus W H van Hees
    Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, Geert Grooteplein zuid 10, 6525 GA, Nijmegen, The Netherlands
    Crit Care 15:R233. 2011
    ..The aim of the present study was to investigate if plasma from septic shock patients induces skeletal muscle atrophy and to examine the time course of plasma-induced muscle atrophy during ICU stay...
  2. ncbi Diaphragm adaptations in patients with COPD
    Coen A C Ottenheijm
    Dept of Molecular and Cellular Biology, University of Arizona, Tucson, USA
    Respir Res 9:12. 2008
    ..Treatment of diaphragm dysfunction in COPD is complex since its etiology is unclear, but recent findings indicate the ubiquitin-proteasome pathway as a prime target to attenuate diaphragm wasting in COPD...
  3. ncbi Bench-to-bedside review: hypercapnic acidosis in lung injury--from 'permissive' to 'therapeutic'
    Marloes M Ijland
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Geert Grooteplein 10, 6500 HB Nijmegen, The Netherlands
    Crit Care 14:237. 2010
    ..In addition, the potential concerns in the clinical setting will be outlined...
  4. ncbi Clinical review: the ABC of weaning failure--a structured approach
    Leo M Heunks
    Department of Intensive Care Medicine 632, Radboud University Nijmegen Medical Centre, Postbox 9101, 6500 HB Nijmegen, The Netherlands
    Crit Care 14:245. 2010
    ..This review presents a structural framework ('ABCDE') for the assessment and treatment of difficult-to-wean patients. Earlier recognition of the underlying causes may expedite weaning from mechanical ventilation...
  5. ncbi Non-invasive mechanical ventilation for diagnostic bronchoscopy using a new face mask: an observational feasibility study
    Leo M A Heunks
    Department of Intensive Care Medicine 551, Radboud University Medical Centre, Postbox 9101, 6500 HB Nijmegen, The Netherlands
    Intensive Care Med 36:143-7. 2010
    ..The purpose of this study is to present a modified total face mask to aid bronchoscopy during non-invasive positive pressure ventilation...
  6. ncbi The calcium sensitizer levosimendan improves human diaphragm function
    Jonne Doorduin
    Radboud University Nijmegen Medical Centre, Department of Critical Care Medicine, Geert Grooteplein zuid 10, 6525 GA Nijmegen, The Netherlands
    Am J Respir Crit Care Med 185:90-5. 2012
    ..No drugs are available to improve respiratory muscle function in these patients. Recently, we have shown that the calcium sensitizer levosimendan enhances the force-generating capacity of isolated diaphragm fibers...
  7. ncbi Diaphragm dysfunction in chronic obstructive pulmonary disease
    Coen A C Ottenheijm
    Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
    Am J Respir Crit Care Med 172:200-5. 2005
    ..Our data suggest that enhanced diaphragm protein degradation through the ubiquitin-proteasome pathway plays a role in loss of contractile protein and, consequently, failure of the diaphragm to generate force...
  8. ncbi Activation of the ubiquitin-proteasome pathway in the diaphragm in chronic obstructive pulmonary disease
    Coen A C Ottenheijm
    Department of Pulmonary Diseases, 454, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands
    Am J Respir Crit Care Med 174:997-1002. 2006
    ..In the present study we hypothesized that the loss of contractile protein content is associated with activation of the ubiquitin-proteasome pathway in the diaphragm of patients with mild to moderate COPD...
  9. ncbi Mechanical ventilation induces a Toll/interleukin-1 receptor domain-containing adapter-inducing interferon beta-dependent inflammatory response in healthy mice
    Michiel Vaneker
    Department of Anesthesiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Anesthesiology 111:836-43. 2009
    ....
  10. ncbi Levosimendan enhances force generation of diaphragm muscle from patients with chronic obstructive pulmonary disease
    Hieronymus W H van Hees
    Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Respir Crit Care Med 179:41-7. 2009
    ..The effects of levosimendan on skeletal muscle contractility are unknown. Patients with chronic obstructive pulmonary disease (COPD) suffer from diaphragm weakness, which is associated with decreased calcium sensitivity...
  11. ncbi Low-tidal-volume mechanical ventilation induces a toll-like receptor 4-dependent inflammatory response in healthy mice
    Michiel Vaneker
    Department of Anesthesiology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Anesthesiology 109:465-72. 2008
    ..A role for proinflammatory pathways has been proposed. The current studies analyzed the roles of Toll-like receptor (TLR) 4 and TLR2 involvement in the inflammatory response after MV in the healthy lung...
  12. ncbi Proteasome inhibition improves diaphragm function in congestive heart failure rats
    Hieronymus W H van Hees
    Deptartment of Pulmonary Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 294:L1260-8. 2008
    ..The present study demonstrates that treatment with a clinically used proteasome inhibitor improves diaphragm function by restoring myosin content in CHF...
  13. ncbi Diaphragm single-fiber weakness and loss of myosin in congestive heart failure rats
    Hieronymus W H van Hees
    Department of Pulmonary Diseases 454, University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Am J Physiol Heart Circ Physiol 293:H819-28. 2007
    ..Furthermore, CHF decreases myofibrillar Ca(2+) sensitivity and slows cross-bridge cycling kinetics in diaphragm fibers...
  14. ncbi Diaphragm muscle fiber dysfunction in chronic obstructive pulmonary disease: toward a pathophysiological concept
    Coen A C Ottenheijm
    Department of Pulmonary Diseases, 454 Radboud University, Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Am J Respir Crit Care Med 175:1233-40. 2007
    ..Treatment of diaphragm dysfunction in COPD is complex because its etiology is unclear, but recent findings show promise for the use of proteasome inhibitors in syndromes associated with muscle wasting, such as the diaphragm in COPD...
  15. ncbi Supplemental oxygen prevents exercise-induced oxidative stress in muscle-wasted patients with chronic obstructive pulmonary disease
    Hanneke A C van Helvoort
    Radboud University Nijmegen Medical Centre, Department of Pulmonary Diseases (454, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
    Am J Respir Crit Care Med 173:1122-9. 2006
    ..Inhibition of neutrophil activation and ATP degradation appears to be involved in this effect...
  16. ncbi Titin and diaphragm dysfunction in chronic obstructive pulmonary disease
    Coen A C Ottenheijm
    Department of Pulmonary Diseases, 454 Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
    Am J Respir Crit Care Med 173:527-34. 2006
    ..Interestingly, these changes occur already in patients with mild to moderate COPD...
  17. ncbi Nitric oxide modulates neuromuscular transmission during hypoxia in rat diaphragm
    Xiaoping Zhu
    Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
    Muscle Nerve 33:104-12. 2006
    ..These data provide insight in the underlying mechanisms of hypoxia-induced neurotransmission failure. This is important as respiratory muscle failure may result from hypoxia in vivo...
  18. ncbi Hypoxia-induced skeletal muscle fiber dysfunction: role for reactive nitrogen species
    Coen A C Ottenheijm
    Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 290:L127-35. 2006
    ..Reoxygenation of the muscle bundle partially restores bundle contractility but completely reverses contractile protein dysfunction...
  19. ncbi Hypoxia-induced dysfunction of rat diaphragm: role of peroxynitrite
    Xiaoping Zhu
    Dept. of Pulmonary Diseases, University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 288:L16-26. 2005
    ....
  20. ncbi Oxidative and nitrosative stress in the diaphragm of patients with COPD
    Hanneke J H Wijnhoven
    Department of Pulmonary Diseases, Radboud University Nijmegen Medical Centre, The Netherlands
    Int J Chron Obstruct Pulmon Dis 1:173-9. 2006
    ..These results indicate that in COPD the diaphragm adapts to a higher work load by increasing catalase activity, resulting in a reduction in oxidative damage to lipids and tyrosine nitration of proteins...