Esmeralda N Blaney Davidson

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling
    Esmeralda N Blaney Davidson
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Geert Grooteplein 26 28, Nijmegen, 6500 HB, The Netherlands
    Arthritis Res Ther 9:R102. 2007
  2. ncbi Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity
    E N Blaney Davidson
    Experimental Rheumatology and Advanced Therapeutics, St Radboud University Medical Centre Nijmegen, Geert Grooteplein 26, 6525 GA Nijmegen, The Netherlands
    Arthritis Res Ther 7:R1338-47. 2005
  3. ncbi Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice
    Esmeralda N Blaney Davidson
    Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Immunol 182:7937-45. 2009
  4. ncbi Resemblance of osteophytes in experimental osteoarthritis to transforming growth factor beta-induced osteophytes: limited role of bone morphogenetic protein in early osteoarthritic osteophyte formation
    E N Blaney Davidson
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 56:4065-73. 2007
  5. ncbi TGF beta-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7
    Esmeralda N Blaney Davidson
    Experimental Rheumatology and Advanced Therapeutics, St, Radboud University Medical Centre Nijmegen, Geert Grooteplein 26 28, 6525 GA Nijmegen, The Netherlands
    Arthritis Res Ther 8:R65. 2006
  6. ncbi A role for age-related changes in TGFbeta signaling in aberrant chondrocyte differentiation and osteoarthritis
    Peter M van der Kraan
    Experimental Rheumatology and Advanced Therapeutics, NCMLS, Radboud University, Medical Centre Nijmegen, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands
    Arthritis Res Ther 12:201. 2010
  7. ncbi Expression of transforming growth factor-beta (TGFbeta) and the TGFbeta signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation
    E N Blaney Davidson
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Medical Centre, Geert Grooteplein 26-28, 6525 GA Nijmegen, The Netherlands
    Ann Rheum Dis 65:1414-21. 2006
  8. ncbi TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis: modulation and integration of signaling pathways through receptor-Smads
    P M van der Kraan
    Experimental Rheumatology and Advanced Therapeutics, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Osteoarthritis Cartilage 17:1539-45. 2009
  9. ncbi Catabolic factors and osteoarthritis-conditioned medium inhibit chondrogenesis of human mesenchymal stem cells
    Genoveva T H Heldens
    Experimental Rheumatology and Advanced Therapeutics, St Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Tissue Eng Part A 18:45-54. 2012
  10. ncbi TGF-beta and osteoarthritis
    E N Blaney Davidson
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, The Netherlands
    Osteoarthritis Cartilage 15:597-604. 2007

Collaborators

Detail Information

Publications11

  1. ncbi Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling
    Esmeralda N Blaney Davidson
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Geert Grooteplein 26 28, Nijmegen, 6500 HB, The Netherlands
    Arthritis Res Ther 9:R102. 2007
    ..Moreover, BMP contributes to the intrinsic repair capacity of damaged cartilage. Increased matrix turnover might be functional in replacing matrix molecules in the repair of a damaged cartilage matrix...
  2. ncbi Reduced transforming growth factor-beta signaling in cartilage of old mice: role in impaired repair capacity
    E N Blaney Davidson
    Experimental Rheumatology and Advanced Therapeutics, St Radboud University Medical Centre Nijmegen, Geert Grooteplein 26, 6525 GA Nijmegen, The Netherlands
    Arthritis Res Ther 7:R1338-47. 2005
    ..In conclusion, TGF-beta appears to play an important role in repair of cartilage and a lack of TGF-beta responsiveness in old mice might be at the root of OA development...
  3. ncbi Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice
    Esmeralda N Blaney Davidson
    Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Immunol 182:7937-45. 2009
    ..Our data suggest that dominant ALK1 signaling results in deviant chondrocyte behavior, thereby contributing to age-related cartilage destruction and OA...
  4. ncbi Resemblance of osteophytes in experimental osteoarthritis to transforming growth factor beta-induced osteophytes: limited role of bone morphogenetic protein in early osteoarthritic osteophyte formation
    E N Blaney Davidson
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 56:4065-73. 2007
    ..The purpose of this study was to investigate the respective contributions of TGFbeta and BMP-2 to OA...
  5. ncbi TGF beta-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7
    Esmeralda N Blaney Davidson
    Experimental Rheumatology and Advanced Therapeutics, St, Radboud University Medical Centre Nijmegen, Geert Grooteplein 26 28, 6525 GA Nijmegen, The Netherlands
    Arthritis Res Ther 8:R65. 2006
    ..TGFbeta-induced synovial fibrosis was blocked by locally inhibiting TGFbeta signaling in the synovial lining by simultaneously transfecting it with an adenovirus overexpressing Smad7...
  6. ncbi A role for age-related changes in TGFbeta signaling in aberrant chondrocyte differentiation and osteoarthritis
    Peter M van der Kraan
    Experimental Rheumatology and Advanced Therapeutics, NCMLS, Radboud University, Medical Centre Nijmegen, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands
    Arthritis Res Ther 12:201. 2010
    ..In this paper we summarize concepts in OA, its link with ageing and disturbed growth factor responses, and a potential role of TGFbeta signaling in OA development...
  7. ncbi Expression of transforming growth factor-beta (TGFbeta) and the TGFbeta signalling molecule SMAD-2P in spontaneous and instability-induced osteoarthritis: role in cartilage degradation, chondrogenesis and osteophyte formation
    E N Blaney Davidson
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Medical Centre, Geert Grooteplein 26-28, 6525 GA Nijmegen, The Netherlands
    Ann Rheum Dis 65:1414-21. 2006
    ..Additionally, our results indicate that TGFbeta3 is involved in early osteophyte development, whereas BMP might be involved in late osteophyte development...
  8. ncbi TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis: modulation and integration of signaling pathways through receptor-Smads
    P M van der Kraan
    Experimental Rheumatology and Advanced Therapeutics, Radboud University, Nijmegen Medical Centre, Nijmegen, The Netherlands
    Osteoarthritis Cartilage 17:1539-45. 2009
    ..This review is focused on the modulation of receptor-Smad signaling and how this modulation can affect chondrocyte differentiation and potentially osteoarthritis development...
  9. ncbi Catabolic factors and osteoarthritis-conditioned medium inhibit chondrogenesis of human mesenchymal stem cells
    Genoveva T H Heldens
    Experimental Rheumatology and Advanced Therapeutics, St Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Tissue Eng Part A 18:45-54. 2012
    ....
  10. ncbi TGF-beta and osteoarthritis
    E N Blaney Davidson
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, The Netherlands
    Osteoarthritis Cartilage 15:597-604. 2007
    ..In this review, we will focus on the potential therapeutic intervention in OA with TGF-beta, application of the growth factor TGF-beta in cartilage repair and on the side effects of TGF-beta treatment that could occur...
  11. ncbi Connective tissue growth factor/CCN2 overexpression in mouse synovial lining results in transient fibrosis and cartilage damage
    E N Blaney Davidson
    St. Radboud University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 54:1653-61. 2006
    ..Overexpression of CTGF in knee joints results in reversible cartilage damage, induced either by the high CTGF levels or via factors produced by the CTGF-induced fibrotic tissue...