Research Topics
Genomes and Genes | Tilman M HackengSummaryAffiliation: Maastricht University Country: The Netherlands Publications
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Publications
Conformational changes in activated protein C caused by binding of the first epidermal growth factor-like module of protein ST M Hackeng
Departments of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
Biochem J 349:757-64. 2000..Thus we provide direct evidence for binding of protein S-EGF1 to APC and show that it induces a conformational change in APC...- Chemical synthesis and spontaneous folding of a multidomain protein: anticoagulant microprotein ST M Hackeng
Department of Molecular and Experimental Medicine, Skaggs Institute for Chemical Biology, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 97:14074-8. 2000..These results demonstrate that total chemical synthesis of proteins offers an effective way to generate multidomain biologically active proteins... - Total chemical synthesis of human matrix Gla proteinT M Hackeng
Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, The Netherlands
Protein Sci 10:864-70. 2001..In conclusion, facile and efficient chemical synthesis in combination with native chemical ligation yielded MGP preparations that can aid in unraveling the mechanism by which MGP prevents vascular calcification... - Protein S stimulates inhibition of the tissue factor pathway by tissue factor pathway inhibitorTilman M Hackeng
Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands
Proc Natl Acad Sci U S A 103:3106-11. 2006..Our data suggest that protein S deficiency not only increases the risk of thrombosis by impairing the protein C system but also by reducing the ability of TFPI to down-regulate the extrinsic coagulation pathway... - Regulation of TFPI function by protein ST M Hackeng
Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
J Thromb Haemost 7:165-8. 2009.... - Effect of oral contraceptives on the anticoagulant activity of protein S in plasmaRory R Koenen
Department of Biochemistry, Cardiovascular Research Institute Maastricht, The Netherlands
Thromb Haemost 93:853-9. 2005..Functional impairment of protein S as a result of hormonal influence may, at least in part, contribute to the thrombotic risk of OC users... - Inhibition of thrombin generation by protein S at low procoagulant stimuli: implications for maintenance of the hemostatic balanceKristin M Seré
Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, 6200 MD Maastricht, The Netherlands
Blood 104:3624-30. 2004.... - The Ser460Pro mutation in recombinant protein S Heerlen does not affect its APC-cofactor and APC-independent anticoagulant activitiesRory R Koenen
Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, The Netherlands
Thromb Haemost 91:1105-14. 2004.... - The thrombin-sensitive region of protein S mediates phospholipid-dependent interaction with factor XaSubramanian Yegneswaran
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
J Biol Chem 283:33046-52. 2008..In controls, the TSR domain did not alter the anisotropy of DEGR-fIXa(i) and DEGR-fVIIa(i), respectively. These data demonstrate that membrane-bound fXa binding to protein S involves the TSR of protein S... - Protein S as cofactor for TFPITilman M Hackeng
Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, Maastricht, The Netherlands
Arterioscler Thromb Vasc Biol 29:2015-20. 2009..The current review describes the background of the TFPI-cofactor activity of protein S as well as the rationale for the observation that the TFPI/protein S system particularly inhibits the TF pathway at low procoagulant stimuli... - Molecular MRI of early thrombus formation using a bimodal alpha2-antiplasmin-based contrast agentRobbert Jan J H M Miserus
Department of Radiology, Maastricht University Medical Centre, Maastricht, The Netherlands
JACC Cardiovasc Imaging 2:987-96. 2009..We aimed to investigate whether early thrombus formation can be visualized with in vivo magnetic resonance imaging (MRI) by the use of a novel bimodal alpha(2)-antiplasmin-based contrast agent (CA)... - Gadolinium-labeled quantum dots for molecular magnetic resonance imaging: R1 versus R2 mappingMarlies Oostendorp
Department of Radiology, Maastricht University Medical Centre MUMC, Maastricht, The Netherlands
Magn Reson Med 64:291-8. 2010..At a field strength of 7 T, longitudinal relaxation rate-based measures were superior to transverse relaxation rate-based measures in detecting both the level and spatial extent of contrast agent-induced relaxation rate changes... - Early atherosclerosis exhibits an enhanced procoagulant stateJulian Ilcheff Borissoff
Laboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Universiteitsingel 50, PO Box 616, Box 8, 6200 MD Maastricht, The Netherlands
Circulation 122:821-30. 2010..In the present study, we examined for the first time the activity and presence of relevant coagulation proteins in relation to the progression of atherosclerosis... - Re-evaluation of the role of the protein S-C4b binding protein complex in activated protein C-catalyzed factor Va-inactivationLisbeth F A Maurissen
Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, Maastricht, The Netherlands
Blood 111:3034-41. 2008..These results are of interest for carriers of the factor V(Leiden) mutation (R(506)Q), as protein S-C4BP effectively enhances APC-catalyzed factor Va (R(306)) inactivation in plasma containing factor V(Leiden)... - Pharmacokinetics of contrast agents targeted to the tumor vasculature in molecular magnetic resonance imagingMarlies Oostendorp
Department of Radiology, Maastricht University Medical Centre MUMC, Maastricht, The Netherlands
Contrast Media Mol Imaging 5:9-17. 2010..Summarizing, molecular DCE-MRI with pharmacokinetic modeling provides unique information on contrast agent delivery and angiogenic activity in tumors... - The APC-independent anticoagulant activity of protein S in plasma is decreased by elevated prothrombin levels due to the prothrombin G20210A mutationRory R Koenen
Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, 6200 MD Maastricht, The Netherlands
Blood 102:1686-92. 2003..47 +/- 0.21; n = 46). We propose that the decreased APC-independent anticoagulant activity of protein S in plasma with elevated prothrombin levels may contribute to the thrombotic risk associated with the prothrombin G20210A mutation... - Nanoparticles for optical molecular imaging of atherosclerosisKim Douma
Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands
Small 5:544-57. 2009..In this review, we provide an overview of both current optical nanoparticles and targeting ligands for optical molecular imaging of atherosclerotic lesions and speculate on their applicability in the clinical setting... - Regulation of coagulation by protein SElisabetta Castoldi
Department of Biochemistry, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
Curr Opin Hematol 15:529-36. 2008..In this review, the regulation of thrombin generation by protein S and the pathophysiological implications of protein S deficiency are discussed in the light of recent findings on the anticoagulant function(s) of protein S... - Blocking of frizzled signaling with a homologous peptide fragment of wnt3a/wnt5a reduces infarct expansion and prevents the development of heart failure after myocardial infarctionHilde Laeremans
Department of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht, Maastricht University, 50 Universiteitssingel, 6229ER Maastricht PO Box 616, 6200MD Maastricht, Netherlands
Circulation 124:1626-35. 2011..In this study, we evaluated Frizzled as a novel therapeutic target for MI. These Frizzled proteins act as receptors for Wnt proteins and were previously shown to be expressed in the healing infarct... - Nepsilon-(thiaprolyl)-lysine as a handle for site-specific protein conjugationPieter Van de Vijver
Department of Biochemistry, Cardiovascular Research Institute Maastricht, University Maastricht, The Netherlands
Biopolymers 94:465-74. 2010..This side chain protection strategy enables the use of readily available thiol-reactive probes for the modification of internally disulfide bonded proteins... - Similar hypercoagulable state and thrombosis risk in type I and type III protein S-deficient individuals from families with mixed type I/III protein S deficiencyElisabetta Castoldi
Department of Biochemistry, Maastricht University P O Box 616, 6200 Maastricht, The Netherlands
Haematologica 95:1563-71. 2010.... - Noninvasive diagnosis of ruptured peripheral atherosclerotic lesions and myocardial infarction by antibody profilingKitty B J M Cleutjens
Department of Pathology, Cardiovascular Research Institute Maastricht CARIM, University of Maastricht, Maastricht, The Netherlands
J Clin Invest 118:2979-85. 2008.... - The circulating inactive form of matrix Gla Protein (ucMGP) as a biomarker for cardiovascular calcificationEllen C M Cranenburg
VitaK, Maastricht University, Maastricht, The Netherlands
J Vasc Res 45:427-36. 2008..Here we report on the development of an ucMGP assay and the potential diagnostic utility of monitoring serum ucMGP levels... - Optical and magnetic resonance imaging of cell death and platelet activation using annexin a5-functionalized quantum dotsLenneke Prinzen
Department of Biophysics, University of Maastricht, and Department of Radiology, University Hospital Maastricht, The Netherlands
Nano Lett 7:93-100. 2007..The nanoparticle is suitable for both anatomic and subcellular imaging of structures in the vessel wall and is a promising bimodal contrast agent for future in vivo imaging studies... - Stimuli of sensory-motor nerves terminate arterial contractile effects of endothelin-1 by CGRP and dissociation of ET-1/ET(A)-receptor complexesMerlijn J P M T Meens
Department of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht CARIM, Maastricht University, Maastricht, The Netherlands
PLoS ONE 5:e10917. 2010..We tested whether the quasi-irreversible receptor-binding of ET-1 (i) limits reversing effects of the antagonists and (ii) can be selectively dissociated by an endogenous counterbalancing mechanism... - Nucleophilic catalysis of hydrazone formation and transimination: implications for dynamic covalent chemistryAnouk Dirksen
Department of Cell Biology, Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Am Chem Soc 128:15602-3. 2006..The strong enhancement in the rate of hydrazone equilibration broadens the scope of this stable imine in the field of dynamic covalent chemistry... - cNGR: a novel homing sequence for CD13/APN targeted molecular imaging of murine cardiac angiogenesis in vivoAlexandra Buehler
CARIM, University of Maastricht, Maastricht, The Netherlands
Arterioscler Thromb Vasc Biol 26:2681-7. 2006..Here, we investigated the feasibility of selective imaging of cardiac angiogenesis using the cNGR-CD13/APN system... - Design and synthesis of a bimodal target-specific contrast agent for angiogenesisAnouk Dirksen
Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands
Org Lett 6:4857-60. 2004.... - A structural model of the SHBG domain of human variant protein S HeerlenGerry A F Nicolaes
Thromb Haemost 96:538-40. 2006 - In vivo clearance of human protein S in a mouse model: influence of C4b-binding protein and the Heerlen polymorphismCecile V Denis
INSERM U 143, Kremlin Bicetre, France
Arterioscler Thromb Vasc Biol 25:2209-15. 2005..To explore the effect of the Heerlen polymorphism and C4b-binding protein (C4BP) on protein S catabolism in vitro and in vivo...