Arjan Blokland

Summary

Affiliation: Maastricht University
Country: The Netherlands

Publications

  1. ncbi Pharmacokinetics of acute tryptophan depletion using a gelatin-based protein in male and female Wistar rats
    L A W Jans
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Amino Acids 37:349-57. 2009
  2. ncbi Effects of haloperidol and d-amphetamine on working and reference memory performance in a spatial cone field task
    A Blokland
    Faculty of Psychology, Maastricht Brain and Behaviour Institute, Maastricht University, The Netherlands
    Behav Pharmacol 9:429-36. 1998
  3. ncbi Delayed non-matching to position performance in aged hybrid Fischer 344 x brown Norway rats: a longitudinal study
    Arjan Blokland
    Section of Neurocognition, Faculty of Psychology, Brain and Behavior Institute, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Brain Res Bull 64:39-46. 2004
  4. ncbi Evaluation of DOI, 8-OH-DPAT, eticlopride and amphetamine on impulsive responding in a reaction time task in rats
    A Blokland
    Faculty of Psychology, Brain am Behaviour Institute and European Graduate School of Neurosciences, Maastricht University, The Netherlands
    Behav Pharmacol 16:93-100. 2005
  5. ncbi Analysis of spatial orientation strategies of male and female Wistar rats in a Morris water escape task
    Arjan Blokland
    Faculty of Psychology, Maastricht University, The Netherlands
    Behav Brain Res 171:216-24. 2006
  6. ncbi Improving memory: a role for phosphodiesterases
    A Blokland
    Department of Psychology, Brain and Behavior Institute, EURON, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Curr Pharm Des 12:2511-23. 2006
  7. ncbi Anxiogenic and depressive-like effects, but no cognitive deficits, after repeated moderate tryptophan depletion in the rat
    Arjan Blokland
    Faculty of Psychology, Maastricht Brain and Behaviour Institute, Maastricht University, The Netherlands
    J Psychopharmacol 16:39-49. 2002
  8. ncbi Dissociable effects of histamine H1 antagonists on reaction-time performance in rats
    A Blokland
    Maastricht Brain and Behaviour Institute, Faculty of Psychology, Section Neurocognition, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Pharmacol Biochem Behav 70:427-36. 2001
  9. ncbi A detailed analysis of rats' spatial memory in a probe trial of a Morris task
    Arjan Blokland
    Faculty of Psychology, Brain and Behavior Institute, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Behav Brain Res 154:71-5. 2004
  10. ncbi Local inhibition of hippocampal nitric oxide synthase does not impair place learning in the Morris water escape task in rats
    A Blokland
    Faculty of Psychology, European Graduate School of Neuroscience EURON Department of Psychiatry and Neuropsychology, Maastricht University, The Netherlands
    Eur J Neurosci 11:223-32. 1999

Collaborators

Detail Information

Publications90

  1. ncbi Pharmacokinetics of acute tryptophan depletion using a gelatin-based protein in male and female Wistar rats
    L A W Jans
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Amino Acids 37:349-57. 2009
    ..The method of acute tryptophan depletion described here can be used to study the relationship between serotonin and behaviour in both male and female rats...
  2. ncbi Effects of haloperidol and d-amphetamine on working and reference memory performance in a spatial cone field task
    A Blokland
    Faculty of Psychology, Maastricht Brain and Behaviour Institute, Maastricht University, The Netherlands
    Behav Pharmacol 9:429-36. 1998
    ..Further, the deficits induced by haloperidol and d-amphetamine may not be specifically related with impaired mnemonic functions...
  3. ncbi Delayed non-matching to position performance in aged hybrid Fischer 344 x brown Norway rats: a longitudinal study
    Arjan Blokland
    Section of Neurocognition, Faculty of Psychology, Brain and Behavior Institute, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Brain Res Bull 64:39-46. 2004
    ..Pathology of the frontal cortex seems to predict a faster rate of forgetting in aging rats...
  4. ncbi Evaluation of DOI, 8-OH-DPAT, eticlopride and amphetamine on impulsive responding in a reaction time task in rats
    A Blokland
    Faculty of Psychology, Brain am Behaviour Institute and European Graduate School of Neurosciences, Maastricht University, The Netherlands
    Behav Pharmacol 16:93-100. 2005
    ..Eticlopride did not affect impulsive responding. The present data suggest that 5-HT2A receptors and dopamine (but not D2 receptors) are associated with motor impulsivity...
  5. ncbi Analysis of spatial orientation strategies of male and female Wistar rats in a Morris water escape task
    Arjan Blokland
    Faculty of Psychology, Maastricht University, The Netherlands
    Behav Brain Res 171:216-24. 2006
    ..CUE learning is not sex-dependent. The ability to use EGO strategies appears not to be different between male and female Wistar rats, but appears dependent on pre-exposure to the task...
  6. ncbi Improving memory: a role for phosphodiesterases
    A Blokland
    Department of Psychology, Brain and Behavior Institute, EURON, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Curr Pharm Des 12:2511-23. 2006
    ..This may lead to the discovery and development of new memory enhancing drugs that selectively inhibit such isoforms. Such drugs may exert their effects only in specific brain areas and hence possess an improved side effect profile...
  7. ncbi Anxiogenic and depressive-like effects, but no cognitive deficits, after repeated moderate tryptophan depletion in the rat
    Arjan Blokland
    Faculty of Psychology, Maastricht Brain and Behaviour Institute, Maastricht University, The Netherlands
    J Psychopharmacol 16:39-49. 2002
    ..The present findings indicate that repeated moderate TRP depletion leads to anxiogenic and depressive-like behaviour in the rat and corroborates the notion of the involvement of serotonin in these behaviours...
  8. ncbi Dissociable effects of histamine H1 antagonists on reaction-time performance in rats
    A Blokland
    Maastricht Brain and Behaviour Institute, Faculty of Psychology, Section Neurocognition, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Pharmacol Biochem Behav 70:427-36. 2001
    ..These findings suggest that the reaction-time task may be a sensitive tool for assessing effects of drugs on psychomotor function...
  9. ncbi A detailed analysis of rats' spatial memory in a probe trial of a Morris task
    Arjan Blokland
    Faculty of Psychology, Brain and Behavior Institute, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Behav Brain Res 154:71-5. 2004
    ..Our findings suggest that the evaluation of the spatial memory of rats in a probe trial in the Morris water escape task requires a more detailed analysis...
  10. ncbi Local inhibition of hippocampal nitric oxide synthase does not impair place learning in the Morris water escape task in rats
    A Blokland
    Faculty of Psychology, European Graduate School of Neuroscience EURON Department of Psychiatry and Neuropsychology, Maastricht University, The Netherlands
    Eur J Neurosci 11:223-32. 1999
    ..On the basis of the present data it was concluded that hippocampal NO is not critically involved in place learning in rats...
  11. ncbi Intra-striatal haloperidol and scopolamine injections: effects on choice reaction time performance in rats
    A Blokland
    Faculty of Psychology, Section of Biological Psychology, Maastricht, The Netherlands
    Eur Neuropsychopharmacol 9:523-31. 1999
    ....
  12. ncbi Cognition-enhancing properties of subchronic phosphatidylserine (PS) treatment in middle-aged rats: comparison of bovine cortex PS with egg PS and soybean PS
    A Blokland
    Faculty of Psychology, Brain and Behavior Institute, Maastricht, The Netherlands
    Nutrition 15:778-83. 1999
    ..The performance of rats treated with E-PS did not deviate from that of vehicle-treated rats. On the basis of the present study, it was concluded that S-PS, but not E-PS, may have comparable effects on cognition when compared with BC-PS...
  13. ncbi Phosphodiesterase 2 and 5 inhibition attenuates the object memory deficit induced by acute tryptophan depletion
    Eva L Van Donkelaar
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Eur J Pharmacol 600:98-104. 2008
    ....
  14. ncbi Attenuation of fear-like response by escitalopram treatment after electrical stimulation of the midbrain dorsolateral periaqueductal gray
    Lee Wei Lim
    Department of Neuroscience, Maastricht University, Faculty of Health, Medicine and Life Sciences, Maastricht, The Netherlands
    Exp Neurol 226:293-300. 2010
    ..These results suggest that the fear-like response, which was observed 12 h after dlPAG stimulation, could be considered as a relevant animal model for panic disorder with anticipatory anxiety/agoraphobic symptoms...
  15. ncbi Increased plasma corticosterone levels after periaqueductal gray stimulation-induced escape reaction or panic attacks in rats
    Lee Wei Lim
    Department of Neuroscience, Maastricht University, The Netherlands
    Behav Brain Res 218:301-7. 2011
    ..In conclusion, the present study clearly demonstrated that PA or escape response activates the HPA axis and it remains difficult to anticipate the mechanism underlying HPA axis during PAs and its relationship with 5-HT drugs...
  16. ncbi Motor and cognitive improvement by deep brain stimulation in a transgenic rat model of Huntington's disease
    Yasin Temel
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neurosci Lett 406:138-41. 2006
    ..This data indicate that GPe DBS can be used to treat cognitive and motor dysfunction in HD...
  17. ncbi Acute tryptophan depletion in C57BL/6 mice does not induce central serotonin reduction or affective behavioural changes
    Eva L Van Donkelaar
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neurochem Int 56:21-34. 2010
    ..Although in healthy mice no clear central serotonin or functional effects were observed, further research is indicated using mice with pre-existing serotonin dysfunction, as they might be more vulnerable to acute tryptophan depletion...
  18. ncbi The effects of acute tryptophan depletion on affective behaviour and cognition in Brown Norway and Sprague Dawley rats
    L A W Jans
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    J Psychopharmacol 24:605-14. 2010
    ..The present study suggests that acute tryptophan depletion effects are strain dependent on the behavioural and the neurochemical level...
  19. ncbi Effect of buspirone on the behavioral regulation of rats in low versus high anxiety conditions
    Lee Wei Lim
    Department of Neuroscience, Faculty of Medicine, Health and Life Sciences, Maastricht University, Maastricht, The Netherlands
    Arzneimittelforschung 58:269-76. 2008
    ....
  20. ncbi Acute tryptophan depletion potentiates 3,4-methylenedioxymethamphetamine-induced cerebrovascular hyperperfusion in adult male Wistar rats
    Eva L Van Donkelaar
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
    J Neurosci Res 88:1557-68. 2010
    ....
  21. ncbi Influence of chronic mild stress on the behavioural effects of acute tryptophan depletion induced by a gelatin-based mixture
    Linda A W Jans
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    Behav Pharmacol 19:706-15. 2008
    ..In conclusion, CMS did not result in long-lasting vulnerability of the serotonergic system, measured by the behavioural response to ATD several weeks after the CMS had ended...
  22. ncbi Acute tryptophan depletion induced by a gelatin-based mixture impairs object memory but not affective behavior and spatial learning in the rat
    Cindy K J Lieben
    Department of Psychiatry and Neuropsychology, Division of Neuroscience, University Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Behav Brain Res 151:53-64. 2004
    ..Taken together, these data suggest that acute lowered central 5-HT levels are not associated with changes in affective behavior (i.e. anxiety and depression), but do impair object memory in adult rats...
  23. ncbi Fos immunoreactivity in the rat forebrain induced by electrical stimulation of the dorsolateral periaqueductal gray matter
    Lee Wei Lim
    Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
    J Chem Neuroanat 38:83-96. 2009
    ..In conclusion, we have shown that deep brain stimulation of the dlPAG produced a distinctive pattern of neuronal activation across forebrain regions as compared to the sham and control animals...
  24. ncbi Protection of nigral cell death by bilateral subthalamic nucleus stimulation
    Yasin Temel
    Department of Psychiatry and Neuropsychology, Division of Cellular Neurosciences, Maastricht University, and Department of Neurosurgery, University Hospital Maastricht, Maastricht, The Netherlands
    Brain Res 1120:100-5. 2006
    ..These data provide the first evidence in vivo that bilateral STN DBS is useful for protecting midbrain dopaminergic neurons from cell death in PD...
  25. ncbi Effects of right-hemisphere cortical infarction and muscarinic acetylcholine receptor blockade on spatial visual attention performance in rats
    Erik I Hoff
    Department of Psychiatry and Neuropsychology, Division Neuroscience, Maastricht University, Maastricht, The Netherlands
    Behav Brain Res 178:62-9. 2007
    ..Our study confirms the role of frontal and parietal cortices in attention performance in rats, and corroborates the theory that attention performance is impaired in hemispatial neglect in human stroke patients...
  26. ncbi Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice
    Tim Vanmierlo
    Department of Neuroscience, Maastricht University, Universiteitssingel 50, 6229, ER, Maastricht, The Netherlands
    Plant Foods Hum Nutr 66:149-56. 2011
    ..Thus, our data provide no contra-indication for nutritional intake of plant sterol enriched nutrition...
  27. ncbi Time-dependent involvement of cAMP and cGMP in consolidation of object memory: studies using selective phosphodiesterase type 2, 4 and 5 inhibitors
    Kris Rutten
    Department of Psychiatry and Neuropsychology, Brain and Behavior Institute, EURON, Maastricht University, 6200 MD Maastricht, The Netherlands
    Eur J Pharmacol 558:107-12. 2007
    ..Moreover, the present study provides further support that selective PDE-Is can influence memory consolidation in a time-dependent manner, assumingly by elevating central cAMP and cGMP levels...
  28. ncbi Phosphodiesterase type 5 inhibition improves early memory consolidation of object information
    Jos Prickaerts
    Department of Psychiatry and Neuropsychology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Neurochem Int 45:915-28. 2004
    ..It is discussed that further studies are needed, immunocytochemical and behavioral, to better understand the cGMP-mediated molecular mechanisms underlying memory formation...
  29. ncbi The selective 5-HT6 receptor antagonist Ro4368554 restores memory performance in cholinergic and serotonergic models of memory deficiency in the rat
    Cindy K J Lieben
    Department of Psychiatry and Neuropsychology, Division of Neuroscience, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Neuropsychopharmacology 30:2169-79. 2005
    ....
  30. ncbi LDL receptor deficiency results in decreased cell proliferation and presynaptic bouton density in the murine hippocampus
    Monique Mulder
    Department of Molecular Cell Biology, University of Maastricht, Maastricht, The Netherlands
    Neurosci Res 59:251-6. 2007
    ..These findings support the notion that, similar to its role in the periphery, the LDLR is important for the cellular uptake of cholesterol in the brain and that disturbance of this process affects neuronal plasticity...
  31. ncbi Hypomobility after DOI administration can be reversed by subthalamic nucleus deep brain stimulation
    Rob Hameleers
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Behav Brain Res 185:65-7. 2007
    ..p.) reduced the behavioural activity of the animals and that STN HFS reversed these effects. This study provides the first evidence that the therapeutic effect of STN HFS may also be mediated by a 5-HT-dependent mechanism...
  32. ncbi Deep brain stimulation of the nucleus accumbens core and shell: opposite effects on impulsive action
    Thibaut Sesia
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
    Exp Neurol 214:135-9. 2008
    ..However, different behavioral effects resulting from stimulation of the subterritories should be taken into account...
  33. ncbi Functional investigations into the role of dopamine and serotonin in partial bilateral striatal 6-hydroxydopamine lesioned rats
    Bart Scholtissen
    Department of Psychiatry and Neuropsychology, Maastricht University, EURON, P O Box 616, 6200 MD Maastricht, The Netherlands
    Pharmacol Biochem Behav 83:175-85. 2006
    ..Taken together, since serotonergic ligands have the same effect as dopaminergic ligands on reaction time responding indicated that 5-HT and DA release are agonistically linked in control and 6-OHDA lesioned rats...
  34. ncbi Progressive deterioration of reaction time performance and choreiform symptoms in a new Huntington's disease transgenic ratmodel
    Chunyan Cao
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands
    Behav Brain Res 170:257-61. 2006
    ..These data provide further experimental evidence that the tgHD rat can be considered as a relevant animal model of HD...
  35. ncbi Stress-mediated decreases in brain-derived neurotrophic factor as potential confounding factor for acute tryptophan depletion-induced neurochemical effects
    Eva L Van Donkelaar
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Maastricht University, 6200 MD Maastricht, The Netherlands
    Eur Neuropsychopharmacol 19:812-21. 2009
    ..Thus, BDNF-mediated mechanisms due to ATD and/or its application stress might underlie ATD-induced neurochemical and behavioural alterations...
  36. ncbi Cholinergic drugs affect novel object recognition in rats: relation with hippocampal EEG?
    Anke Sambeth
    Faculty of Psychology and Brain and Behavior Institute, Maastricht University, The Netherlands
    Eur J Pharmacol 572:151-9. 2007
    ..However, there was a clear dissociation between memory performance and EEG after combined treatment with drugs, which makes additional research where EEG and performance measures are co-registered imperative...
  37. ncbi 5,7-DHT lesion of the dorsal raphe nuclei impairs object recognition but not affective behavior and corticosterone response to stressor in the rat
    Cindy K J Lieben
    Department of Psychiatry and Neuropsychology Basal Neuroscience, University of Maastricht, Maastricht, The Netherlands
    Behav Brain Res 168:197-207. 2006
    ..The 5,7-DHT treatment did not affect the corticosterone response to a stressful situation. Overall, these results corroborate studies with acute tryptophan depletion suggesting a role of 5-HT in object memory, but not affective behavior...
  38. ncbi High-frequency stimulation of the dorsolateral periaqueductal gray and ventromedial hypothalamus fails to inhibit panic-like behaviour
    Lee Wei Lim
    Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
    Behav Brain Res 193:197-203. 2008
    ..The neuronal activation pattern resulting from dlPAG and VMH DBS was similar. These findings suggest that DBS of the dlPAG and VMH induces panic-related behaviours even at higher frequencies...
  39. ncbi The selective PDE5 inhibitor, sildenafil, improves object memory in Swiss mice and increases cGMP levels in hippocampal slices
    K Rutten
    Department of Psychiatry and Neuropsychology, Brain and Behavior Institute, Maastricht University, The Netherlands
    Behav Brain Res 164:11-6. 2005
    ..Taken together, inhibition of PDE5 improves object recognition memory in mice. Furthermore, a postsynaptic role of cGMP could be involved in this respect...
  40. ncbi Phosphodiesterase inhibitors enhance object memory independent of cerebral blood flow and glucose utilization in rats
    Kris Rutten
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, School of Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 34:1914-25. 2009
    ....
  41. ncbi Dissociable effects of acetylcholinesterase inhibitors and phosphodiesterase type 5 inhibitors on object recognition memory: acquisition versus consolidation
    Jos Prickaerts
    Department of Psychiatry and Neuropsychology, Brain and Behavior Institute, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands
    Psychopharmacology (Berl) 177:381-90. 2005
    ..Phosphodiesterase enzyme type 5 (PDE5) inhibitors and acetylcholinesterase (AChE) inhibitors have cognition-enhancing properties. However, it is not known whether these drug classes affect the same memory processes...
  42. ncbi Assessment of spatial learning abilities of mice in a new circular maze
    Guido Koopmans
    Department of Psychiatry and Neuropsychology, Brain and Behaviour Institute, Maastricht University, Maastricht, The Netherlands
    Physiol Behav 79:683-93. 2003
    ..Further, our data with different strains indicate that different measures of behavior should be evaluated to assess the spatial learning performance of mice...
  43. ncbi Acetylcholine and attention
    Inge Klinkenberg
    Faculty of Psychology and Neuroscience, Department of Neuropsychology and Psychopharmacology, European Graduate School of Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Behav Brain Res 221:430-42. 2011
    ..Thus, it appears that the role of ACh in cognition is different per brain region and between nicotinic versus muscarinic receptor subtypes...
  44. ncbi Sex differences in the effect of acute tryptophan depletion on declarative episodic memory: a pooled analysis of nine studies
    Anke Sambeth
    Department of Neurocognition, Faculty of Psychology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Neurosci Biobehav Rev 31:516-29. 2007
    ..The findings provide further support for a critical role of serotonin in declarative episodic memory...
  45. ncbi Long-term behavioral outcome after early-life hyperthermia-induced seizures
    Evi M P Lemmens
    Department of Neurosurgery, Maastricht University, Maastricht, The Netherlands
    Epilepsy Behav 14:309-15. 2009
    ....
  46. ncbi Selective phosphodiesterase inhibitors: a promising target for cognition enhancement
    Olga A H Reneerkens
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Psychopharmacology (Berl) 202:419-43. 2009
    ..However, recently phosphodiesterases (PDEs) have gained increased attention as a potential new target for cognition enhancement. Inhibition of PDEs increases the intracellular availability of the second messengers cGMP and/or cAMP...
  47. ncbi Memory impairments in humans after acute tryptophan depletion using a novel gelatin-based protein drink
    A Sambeth
    Faculty of Psychology and Neuroscience, Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The Netherlands
    J Psychopharmacol 23:56-64. 2009
    ..Our study provides further evidence that impairment in long-term episodic and elementary spatial memory after ATD is related to lowered tryptophan levels in plasma...
  48. ncbi Differential effects of subthalamic nucleus stimulation in advanced Parkinson disease on reaction time performance
    Yasin Temel
    Departments of Neurosurgery and Cellular Neuroscience, European Graduate School of Neuroscience EURON, University Hospital Maastricht, PO Box 5800, 6202, AZ, Maastricht, The Netherlands
    Exp Brain Res 169:389-99. 2006
    ..The STN seems to be an important modulator of cognitive processing and STN DBS can differentially affect motor and associative circuits...
  49. ncbi Performance of different mouse strains in an object recognition task
    Ayhan Sik
    Department of Psychiatry and Neuropsychology, Brain and Behaviour Institute, Maastricht University, 6200 MD Maastricht, The Netherlands
    Behav Brain Res 147:49-54. 2003
    ..The present data show that object memory can be assessed in mice and, in contrast to other memory tasks, appears to be less strain-dependent. The reliability of the discrimination measures is discussed...
  50. ncbi The subthalamic nucleus: From response selection to execution
    Sonny K H Tan
    Department of Psychiatry and Neuropsychology, Division Cellular Neurosciences, Maastricht University, Maastricht, The Netherlands
    J Chem Neuroanat 31:155-61. 2006
    ..In the present review, we discuss the findings of these preclinical studies on cognitive parameters and outline the anatomical and functional place of the STN in the basal ganglia cognitive circuit...
  51. ncbi Human apolipoprotein C-I expression in mice impairs learning and memory functions
    Karlygash Abildayeva
    Department of Molecular Cell Biology and Department of Basic Neurosciences, European Graduate School of Neuroscience, Institute Brain and Behavior, University of Maastricht, Maastricht, The Netherlands
    J Lipid Res 49:856-69. 2008
    ..In conclusion, human apoC-I expression impairs cognitive functions in mice independent of apoE expression, which supports the potential of a modulatory role for apoC-I during the development of AD...
  52. ncbi Dissociable effects in reaction time performance after unilateral cerebral infarction: a comparison between the left and right frontal cortices in rats
    Erik I Hoff
    Department of Psychiatry and Neuropsychology, Division Cellular Neuroscience, Maastricht Brain and Behaviour Institute, Maastricht, The Netherlands
    Brain Res 1069:182-9. 2006
    ..We conclude that measuring reaction time performance after frontal cortical infarction in rats could offer a useful tool to model particular human cognitive impairments following cerebral infarction...
  53. ncbi A comparison of scopolamine and biperiden as a rodent model for cholinergic cognitive impairment
    Inge Klinkenberg
    Faculty of Psychology and Neuroscience, Department of Neuropsychology and Psychopharmacology, European Graduate School of Neuroscience EURON, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 215:549-66. 2011
    ..However, its use remains controversial due to the wide spectrum of behavioral effects of this drug...
  54. ncbi Long-term consequences of repeated pentobarbital anaesthesia on choice reaction time performance in ageing rats
    A Blokland
    Faculty of Psychology, Maastricht Brain and Behaviour Institute, Maastricht University, The Netherlands
    Br J Anaesth 87:781-3. 2001
    ..These findings support the theory that repeated anaesthesia is a biological factor that affects cognitive ageing...
  55. ncbi cGMP, but not cAMP, in rat hippocampus is involved in early stages of object memory consolidation
    Jos Prickaerts
    Department of Psychiatry and Neuropsychology, European Graduate School of Neuroscience EURON, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Eur J Pharmacol 436:83-7. 2002
    ..In contrast, 8-Br-cAMP did not improve the memory performance at the doses tested. These results indicate that hippocampal cGMP but not cAMP is involved in early stages of consolidation of object memory...
  56. ncbi The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies
    Inge Klinkenberg
    Faculty of Psychology and Neuroscience, EURON, Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The Netherlands
    Neurosci Biobehav Rev 34:1307-50. 2010
    ..The use of muscarinic M1 antagonists is suggested as a more selective and effective way of inducing cholinergic-induced cognitive deficits...
  57. ncbi Premature responding following bilateral stimulation of the rat subthalamic nucleus is amplitude and frequency dependent
    Lieve Desbonnet
    Department of Neuroscience, European Graduate School of Neuroscience (EURON, Maastricht, The Netherlands
    Brain Res 1008:198-204. 2004
    ..Furthermore, the overall effects of DBS on neuronal cells cannot be classified simply as being "inhibitory" and evidently mediates its effects by more complex mechanisms than lesions of the same brain area...
  58. ncbi Acute and separate modulation of motor and cognitive performance in parkinsonian rats by bilateral stimulation of the subthalamic nucleus
    Yasin Temel
    Department of Psychiatry and Neuropsychology, Division Cellular Neurosciences, European Graduate School of Neuroscience EURON, The Netherlands
    Exp Neurol 193:43-52. 2005
    ....
  59. ncbi The functional role of the subthalamic nucleus in cognitive and limbic circuits
    Yasin Temel
    Department of Neurosurgery, University Hospital Maastricht, University of Maastricht, The Netherlands
    Prog Neurobiol 76:393-413. 2005
    ..In conclusion, it can be stated that the STN has anatomically a central position within the basal ganglia thalamocortical associative and limbic circuits and is functionally a potent regulator of these pathways...
  60. ncbi Acute effects of acetyl-L-carnitine on sodium cyanide-induced behavioral and biochemical deficits
    J Prickaerts
    Department of Psychiatry and Neuropsychology, European Graduate School of Neuroscience EURON, Maastricht University, The Netherlands
    Neurochem Int 33:435-43. 1998
    ..Further research is needed to characterize the mechanism of action of acetyl-L-carnitine in relation to sodium cyanide...
  61. ncbi Cognitive performance and biochemical markers in septum, hippocampus and striatum of rats after an i.c.v. injection of streptozotocin: a correlation analysis
    J Prickaerts
    Department of Psychiatry and Neuropsychology, European Graduate School of Neuroscience EURON, Maastricht University, The Netherlands
    Behav Brain Res 102:73-88. 1999
    ..Furthermore, intracerebroventricular injected streptozotocin may provide a relevant model for studying neurodegenerative changes due to a metabolic insufficiency and testing neuroprotective effects of substances...
  62. ncbi Perinatal asphyxia results in changes in presynaptic bouton number in striatum and cerebral cortex-a stereological and behavioral analysis
    W D Van de Berg
    Department of Pediatrics, Maastricht University, P Debyelaan 25, PO Box 5800, 6212 AZ, Maastricht, The Netherlands
    J Chem Neuroanat 20:71-82. 2000
    ..These results suggest that perinatal asphyxia induced neuronal loss, which is compensated for by an increase in presynaptic bouton numbers...
  63. ncbi Metrifonate improves working but not reference memory performance in a spatial cone field task
    J Prickaerts
    Department of Psychiatry and Neuropsychology, Maastricht Brain and Behavior Institute, Maastricht University, The Netherlands
    Eur J Pharmacol 380:61-5. 1999
    ..The present results suggest that metrifonate has cognition-enhancing properties which are likely to be related to aspects of (spatial) working memory...
  64. ncbi Apolipoprotein E protects against neuropathology induced by a high-fat diet and maintains the integrity of the blood-brain barrier during aging
    M Mulder
    Department of Psychiatry and Neuropsychology, Faculty of Medicine, Maastricht University, Maastricht, The Netherlands
    Lab Invest 81:953-60. 2001
    ..We therefore hypothesize that the role of apoE in the maintenance of the integrity of the BBB may be the mechanism by which apoE affects the progression of neurodegeneration, as seen in Alzheimer's disease...
  65. ncbi Nitric oxide synthase does not mediate neurotoxicity after an i.c.v. injection of streptozotocin in the rat
    J Prickaerts
    Department of Psychiatry and Neuropsychology, European Graduate School of Neuroscience, Maastricht University, The Netherlands
    J Neural Transm 107:745-66. 2000
    ..However, the present study cannot exclude the involvement of NO liberated from STREP in neuronal damage...
  66. ncbi Acute tryptophan depletion in rats alters the relationship between cerebral blood flow and glucose metabolism independent of central serotonin
    E L van Donkelaar
    Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands
    Neuroscience 163:683-94. 2009
    ....
  67. ncbi Effects of two selective phosphodiesterase type 5 inhibitors, sildenafil and vardenafil, on object recognition memory and hippocampal cyclic GMP levels in the rat
    J Prickaerts
    Department of Psychiatry and Neuropsychology, European Graduate School of Neuroscience EURON, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Neuroscience 113:351-61. 2002
    ..Taken together, these results suggest that inhibition of phosphodiesterase enzyme type 5 improves object recognition memory. This effect might be explained by increased levels of central cyclic GMP...
  68. ncbi Impact of perinatal asphyxia on the GABAergic and locomotor system
    W D J Van de Berg
    Department of Pediatrics, Research Institute Growth and Development GROW, University of Maastricht, The Netherlands
    Neuroscience 117:83-96. 2003
    ..Despite a considerable loss of striatal neurons, only minor deficits in motor performance were found after perinatal asphyxia...
  69. ncbi The PDE4 inhibitor rolipram reverses object memory impairment induced by acute tryptophan depletion in the rat
    K Rutten
    Department of Psychiatry and Neuropsychology, Brain and Behavior Institute, Maastricht University, Universiteitssingel 50, 6200 MD, Maastricht, The Netherlands
    Psychopharmacology (Berl) 192:275-82. 2007
    ..The selective type IV phosphodiesterase inhibitor, rolipram, has been shown to improve long-term memory and can reverse the cholinergic deficit caused by scopolamine. However, the underlying mechanisms of action of rolipram remain obscure...
  70. ncbi Influence of sex and estrous cycle on the effects of acute tryptophan depletion induced by a gelatin-based mixture in adult Wistar rats
    L A W Jans
    Department of Neurocognition, Faculty of Psychology, Maastricht University, 6200 MD Maastricht, The Netherlands
    Neuroscience 147:304-17. 2007
    ..It is concluded that sex and estrous cycle phase can influence the behavioral response to TRP depletion, and that females in pro-estrus/estrus show the strongest behavioral response to acute TRP depletion...
  71. ncbi Serotonergic vulnerability and depression: assumptions, experimental evidence and implications
    L A W Jans
    Faculty of Psychology, Department of Neurocognition, Maastricht University, Maastricht, The Netherlands
    Mol Psychiatry 12:522-43. 2007
    ....
  72. ncbi Rolipram reverses scopolamine-induced and time-dependent memory deficits in object recognition by different mechanisms of action
    K Rutten
    Department of Psychiatry and Neuropsychology, Brain and Behaviour Institute, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
    Neurobiol Learn Mem 85:132-8. 2006
    ..1 mg/kg. Although the improved memory performance in both conditions is likely to be explained by elevated cAMP levels, two separate working mechanisms might explain these effects...
  73. ncbi Acute tryptophan and serotonin depletion using an optimized tryptophan-free protein-carbohydrate mixture in the adult rat
    C K J Lieben
    Department of Neuropsychology and Psychiatry, Brain and Behavior Institute, University of Maastricht, P O Box 616, Maastricht MD 6200, The Netherlands
    Neurochem Int 44:9-16. 2004
    ..In conclusion, the TRP-free protein-carbohydrate nutritional mixture appears to be an efficient tool to substantially reduce plasma and central TRP levels in adult rat...
  74. ncbi Buspirone induced acute and chronic changes of neural activation in the periaqueductal gray of rats
    L W Lim
    Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neuroscience 155:164-73. 2008
    ..This indicates that the longitudinal anatomical structure of the PAG possesses a different level of receptor sensitivity of 5-HT(1A) in the pathophysiology of anxiety and panic disorder...
  75. ncbi Selective PDE inhibitors rolipram and sildenafil improve object retrieval performance in adult cynomolgus macaques
    K Rutten
    Department of Neuroscience, School for Mental Health and Neuroscience, Maastricht University, Universiteitssingel 50, PO Box 616, 6200 MD Maastricht, The Netherlands
    Psychopharmacology (Berl) 196:643-8. 2008
    ..However, studies evaluating the effects of PDE inhibition on prefrontal cortex-dependent cognition and in monkeys are rare...
  76. ncbi Automated scoring of novel object recognition in rats
    K Rutten
    Department of Neuroscience, School of Mental Health and Neuroscience, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands
    J Neurosci Methods 171:72-7. 2008
    ..82-0.87). We conclude that the use of small objects in combination with our program enables reliable automated scoring in the ORT, thus increasing the objectivity and validity of this task...
  77. ncbi Sub-chronic rolipram treatment leads to a persistent improvement in long-term object memory in rats
    K Rutten
    Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Universiteitssingel 50, P O Box 616, 6200 MD Maastricht, The Netherlands
    Neurobiol Learn Mem 90:569-75. 2008
    ..The long-term memory enhancing effects of rolipram might be explained by long-lasting neuronal changes by the chronic treatment due to recurring activation of the cAMP/PKA/CREB pathway leading to CREB phosphorylation...
  78. ncbi Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus
    Monique Mulder
    Department of Molecular Cell Biology, Maastricht University and University Hospital Maastricht, Maastricht, The Netherlands
    Neurobiol Dis 16:212-9. 2004
    ..A decrease in the number of presynaptic boutons may underlay these behavioral alterations. Therefore, the LDLR may be an important receptor for apoE in the central nervous system...
  79. ncbi Modeling Parkinson's disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway
    Ronald Deumens
    Department of Psychiatry and Neuropsychology, Brain and Behavior Institute, 6200 MD Maastricht, The Netherlands
    Exp Neurol 175:303-17. 2002
    ..The choice of the behavioral parameters determines the use of unilateral or bilateral lesions, although it is obvious that the bilateral model mimics the human situation more closely...
  80. ncbi Liver X receptor activation restores memory in aged AD mice without reducing amyloid
    Tim Vanmierlo
    Department of Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neurobiol Aging 32:1262-72. 2011
    ..However the beneficial effects of T0901317 on memory in the APPSLxPS1mut mice were independent of the A? plaque load in the hippocampus, but were associated with enhanced brain cholesterol turnover...
  81. ncbi The use of a test battery assessing affective behavior in rats: order effects
    Arjan Blokland
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Behav Brain Res 228:16-21. 2012
    ..The present study indicates that the performance of rats in a test can be dependent on the order in a test battery. Consequently, these data caution the interpretation of treatment effects in studies in which test batteries are used...
  82. ncbi Enhanced long-term potentiation and impaired learning in phosphodiesterase 4D-knockout (PDE4D) mice
    Kris Rutten
    Neuroscience Department, Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, CA 94304, USA
    Eur J Neurosci 28:625-32. 2008
    ....
  83. ncbi Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance
    Frank G Boess
    Bayer HealthCare AG, Pharma Research CNS, 42096 Wuppertal-Elberfeld, Germany
    Neuropharmacology 47:1081-92. 2004
    ..Our data provide strong evidence that inhibition of PDE2 can improve memory functions by enhancing neuronal plasticity...
  84. ncbi Learning and adult neurogenesis: survival with or without proliferation?
    Jos Prickaerts
    CNS Affective Spectrum Disorders, Johnson and Johnson Pharmaceutical Research and Development, Turnhoutseweg 30, B 2340, Beerse, Belgium
    Neurobiol Learn Mem 81:1-11. 2004
    ..Moreover, this learning-induced survival of granule cells, which were born before the actual learning experience, might provide a molecular mechanism for the 'use it or lose it' principle...
  85. ncbi Effects of the novel 5-HT(6) receptor antagonist RO4368554 in rat models for cognition and sensorimotor gating
    Rudy Schreiber
    Pharmacology, Discovery Group, Sepracor, Inc, 84 Waterford Drive, Marlborough, Massachusetts 01752 7010, USA
    Eur Neuropsychopharmacol 17:277-88. 2007
    ....
  86. ncbi Lack of evidence for reduced prefrontal cortical serotonin and dopamine efflux after acute tryptophan depletion
    Geoffrey Van der Plasse
    Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA, Amsterdam ZO, The Netherlands
    Psychopharmacology (Berl) 195:377-85. 2007
    ..Thus far, decreases in 5-HT efflux (thought to reflect synaptic release) were only reported after chronic tryptophan depletion or when ATD was combined with blockade of 5-HT reuptake...
  87. ncbi Increased anxiety and "depressive" symptoms months after MDMA ("ecstasy") in rats: drug-induced hyperthermia does not predict long-term outcomes
    Iain S McGregor
    School of Psychology, University of Sydney, Sydney, 2006 NSW, Australia
    Psychopharmacology (Berl) 168:465-74. 2003
    ..There is some uncertainty whether the acute hyperthermia caused by MDMA (ecstasy) plays a significant role in determining the long-term neurotoxic effects on brain 5-HT systems and associated changes in mood and behaviour...
  88. ncbi Inhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleus
    Yasin Temel
    Department of Neurosurgery, University Hospital Maastricht, 6202 AZ Maastricht, The Netherlands
    Proc Natl Acad Sci U S A 104:17087-92. 2007
    ..More generally, the powerful interaction between the STN and 5-HT system uncovered here offers insights into the high level of comorbidity of basal ganglia disease and mood disorder...
  89. ncbi Trajectories of delinquency and parenting styles
    Machteld Hoeve
    Netherlands Institute for the Study of Crime and Law Enforcement NWO NSCR, Leiden, The Netherlands
    J Abnorm Child Psychol 36:223-35. 2008
    ....