Andrea M Woltman

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi Corticosteroids prevent generation of CD34+-derived dermal dendritic cells but do not inhibit Langerhans cell development
    Andrea M Woltman
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 168:6181-8. 2002
  2. ncbi Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression
    Andrea M Woltman
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Blood 101:1439-45. 2003
  3. ncbi The novel cyclophilin-binding drug sanglifehrin A specifically affects antigen uptake receptor expression and endocytic capacity of human dendritic cells
    Andrea M Woltman
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 172:6482-9. 2004
  4. ncbi MIP-3alpha/CCL20 in renal transplantation and its possible involvement as dendritic cell chemoattractant in allograft rejection
    Andrea M Woltman
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Transplant 5:2114-25. 2005
  5. ncbi Renal tubular epithelial cells modulate T-cell responses via ICOS-L and B7-H1
    Simone de Haij
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Kidney Int 68:2091-102. 2005
  6. ncbi Induction of donor-specific T-cell hyporesponsiveness using dexamethasone-treated dendritic cells in two fully mismatched rat kidney transplantation models
    Annelein M Stax
    Department Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Transplantation 86:1275-82. 2008
  7. ncbi IL-10-producing macrophages preferentially clear early apoptotic cells
    Wei Xu
    Department of Nephrology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
    Blood 107:4930-7. 2006
  8. ncbi CD40L stimulation of rat dendritic cells specifically favors the IL-12/IL-10 ratio resulting in a strong T cell stimulatory capacity
    Annelein M Stax
    Leiden University Medical Center, Department of Nephrology, Leiden, The Netherlands
    Mol Immunol 45:2641-50. 2008
  9. ncbi Immune modulation of human dendritic cells by complement
    Giuseppe Castellano
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 37:2803-11. 2007
  10. ncbi Opsonization with C1q and mannose-binding lectin targets apoptotic cells to dendritic cells
    Alma J Nauta
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 173:3044-50. 2004

Collaborators

Detail Information

Publications16

  1. ncbi Corticosteroids prevent generation of CD34+-derived dermal dendritic cells but do not inhibit Langerhans cell development
    Andrea M Woltman
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 168:6181-8. 2002
    ..In view of the different functional capacities of dermal/interstitial DC and Langerhans cells, this might affect the overall cellular immune response...
  2. ncbi Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression
    Andrea M Woltman
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Blood 101:1439-45. 2003
    ..This mTOR/p27(KIP1)/mcl-1 survival seems unique for DCs and may provide novel opportunities to influence immune responses by specific interference with the life span of these cells...
  3. ncbi The novel cyclophilin-binding drug sanglifehrin A specifically affects antigen uptake receptor expression and endocytic capacity of human dendritic cells
    Andrea M Woltman
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 172:6482-9. 2004
    ..In contrast, FcalphaRI (CD89) and FcgammaRII (CD32) were increased by SFA. The explicit effect of SFA on the expression of Ag uptake receptors and Ag capture by DCs makes SFA unique among immunophilin-binding immunosuppressive drugs...
  4. ncbi MIP-3alpha/CCL20 in renal transplantation and its possible involvement as dendritic cell chemoattractant in allograft rejection
    Andrea M Woltman
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Am J Transplant 5:2114-25. 2005
    ..These data suggest a role for MIP-3alpha/CCL20 in amplification of the immune response during renal allograft rejection by attraction of CCR6+ inflammatory cells, which may include DC, to the site of inflammation...
  5. ncbi Renal tubular epithelial cells modulate T-cell responses via ICOS-L and B7-H1
    Simone de Haij
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    Kidney Int 68:2091-102. 2005
    ..Recently, new costimulatory molecules [inducible T cell costimulator-L (ICOS-L) and B7-H1] have been described, which appear to be involved in peripheral T-cell activation...
  6. ncbi Induction of donor-specific T-cell hyporesponsiveness using dexamethasone-treated dendritic cells in two fully mismatched rat kidney transplantation models
    Annelein M Stax
    Department Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Transplantation 86:1275-82. 2008
    ..Here, we investigated the immunoregulatory role of DexDC in two different rat acute rejection models of kidney transplantation...
  7. ncbi IL-10-producing macrophages preferentially clear early apoptotic cells
    Wei Xu
    Department of Nephrology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands
    Blood 107:4930-7. 2006
    ..Our studies suggest that, under steady-state conditions, IL-10-producing Mø2s are prominently involved in the clearance of early apoptotic cells...
  8. ncbi CD40L stimulation of rat dendritic cells specifically favors the IL-12/IL-10 ratio resulting in a strong T cell stimulatory capacity
    Annelein M Stax
    Leiden University Medical Center, Department of Nephrology, Leiden, The Netherlands
    Mol Immunol 45:2641-50. 2008
    ..This implies that the difference found in T cell stimulatory capacity by the stimulated DC is due to the cytokine profile of the DC at the time of T cell activation...
  9. ncbi Immune modulation of human dendritic cells by complement
    Giuseppe Castellano
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 37:2803-11. 2007
    ..Therefore, we hypothesize that, next to a pivotal role in the safe clearance of apoptotic cells, C1q regulates the threshold of DC activation and thereby prevents hyperactivation of the overall immune response...
  10. ncbi Opsonization with C1q and mannose-binding lectin targets apoptotic cells to dendritic cells
    Alma J Nauta
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 173:3044-50. 2004
    ..Therefore, we propose that early complement components support safe clearance of cellular debris by facilitating phagocytosis and possibly by immunomodulatory mechanisms, thus preventing autoimmunity...
  11. ncbi Dendritic cells and complement: at the cross road of innate and adaptive immunity
    Giuseppe Castellano
    Department of Nephrology, Leiden University Medical Center, C3-P, Albinusdreef 2, P.O. Box 9600, 2333 ZA Leiden, The Netherlands
    Mol Immunol 41:133-40. 2004
    ..This review focuses on novel findings, which have started to shed light on these intriguing components of the innate immune system...
  12. ncbi Maturation of dendritic cells abrogates C1q production in vivo and in vitro
    Giuseppe Castellano
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Blood 103:3813-20. 2004
    ..Therefore, immDCs may be considered an additional source of C1q in humans...
  13. ncbi Dendritic cells of IgA nephropathy patients have an impaired capacity to induce IgA production in naïve B cells
    Jan-Willem Eijgenraam
    Department of Nephrology, Leiden University Medical Centre, Leiden, The Netherlands
    Kidney Int 68:1604-12. 2005
    ....
  14. ncbi Functional modulation of dendritic cells to suppress adaptive immune responses
    Andrea M Woltman
    Department of Nephrology, Leiden University Medical Center, The Netherlands
    J Leukoc Biol 73:428-41. 2003
    ..A better understanding of DC immunobiology may lead to the development of specific therapies to prevent or dampen immune responses...
  15. ncbi Production of inflammatory mediators by renal epithelial cells is insensitive to glucocorticoids
    Simone de Haij
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Br J Pharmacol 137:197-204. 2002
    ..The lack of dexamethasone-mediated inhibition was specific for renal epithelial cells and could not be explained by an increased expression of the glucocorticoid receptor beta isoform...
  16. ncbi Human immature dendritic cells efficiently bind and take up secretory IgA without the induction of maturation
    Heleen C Heystek
    Department of Cell Biology and Histology, University of Amsterdam, Amsterdam Medical Center, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    J Immunol 168:102-7. 2002
    ....