Nienke van der Stoep

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi Diagnostic guidelines for high-resolution melting curve (HRM) analysis: an interlaboratory validation of BRCA1 mutation scanning using the 96-well LightScanner
    Nienke van der Stoep
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Hum Mutat 30:899-909. 2009
  2. ncbi E47, IRF-4, and PU.1 synergize to induce B-cell-specific activation of the class II transactivator promoter III (CIITA-PIII)
    Nienke van der Stoep
    Division of Molecular Biology, Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, E3 Q, PO Box 9600, 2300 RC Leiden, The Netherlands
    Blood 104:2849-57. 2004
  3. ncbi Constitutive and IFNgamma-induced activation of MHC2TA promoter type III in human melanoma cell lines is governed by separate regulatory elements within the PIII upstream regulatory region
    Nienke van der Stoep
    Division of Molecular Biology, Department of Immunohematology and Blood Transfusion, Building 1, E3 Q, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Mol Immunol 44:2036-46. 2007
  4. ncbi Transcriptional regulation of the MHC class II trans-activator (CIITA) promoter III: identification of a novel regulatory region in the 5'-untranslated region and an important role for cAMP-responsive element binding protein 1 and activating transcription
    Nienke van der Stoep
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands
    J Immunol 169:5061-71. 2002
  5. ncbi Epigenetic control of CIITA expression in leukemic T cells
    Tjadine M Holling
    Division of Molecular Biology, Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Building 1, E3-Q, Albinusdreef 2, 2333 ZA, The Netherlands
    Biochem Pharmacol 68:1209-13. 2004
  6. ncbi Transcriptional regulation of antigen presentation
    Peter J van den Elsen
    Department of Immunohematology and Blood Transfusion, Building 1, E3 Q, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Curr Opin Immunol 16:67-75. 2004
  7. ncbi Activated human T cells accomplish MHC class II expression through T cell-specific occupation of class II transactivator promoter III
    Tjadine M Holling
    Division of Molecular Biology, Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 168:763-70. 2002
  8. ncbi DNA methylation and expression of major histocompatibility complex class I and class II transactivator genes in human developmental tumor cells and in T cell malignancies
    Peter J van den Elsen
    Division of Molecular Biology, Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Clin Immunol 109:46-52. 2003
  9. ncbi Lack of IFN-gamma-mediated induction of the class II transactivator (CIITA) through promoter methylation is predominantly found in developmental tumor cell lines
    Nienke van der Stoep
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center (LUMC, Leiden, The Netherlands
    Int J Cancer 97:501-7. 2002
  10. ncbi Rapid and cost effective detection of small mutations in the DMD gene by high resolution melting curve analysis
    Rowida Almomani
    Center for Human and Clinical Genetics, LUMC, Einthovenweg 20, Leiden, The Netherlands
    Neuromuscul Disord 19:383-90. 2009

Collaborators

Detail Information

Publications11

  1. ncbi Diagnostic guidelines for high-resolution melting curve (HRM) analysis: an interlaboratory validation of BRCA1 mutation scanning using the 96-well LightScanner
    Nienke van der Stoep
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Hum Mutat 30:899-909. 2009
    ..A blind study using a total of 28 patient-derived DNA samples resulted also in 100% detection and showed an average specificity of 98%, indicating a low incidence of false positives (FPs)...
  2. ncbi E47, IRF-4, and PU.1 synergize to induce B-cell-specific activation of the class II transactivator promoter III (CIITA-PIII)
    Nienke van der Stoep
    Division of Molecular Biology, Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, E3 Q, PO Box 9600, 2300 RC Leiden, The Netherlands
    Blood 104:2849-57. 2004
    ..The finding that PU.1, IRF-4, and E47 play an important role in the B-cell-mediated activation of CIITA-PIII provides a link between antigen presentation functions and activation and differentiation events in B lymphocytes...
  3. ncbi Constitutive and IFNgamma-induced activation of MHC2TA promoter type III in human melanoma cell lines is governed by separate regulatory elements within the PIII upstream regulatory region
    Nienke van der Stoep
    Division of Molecular Biology, Department of Immunohematology and Blood Transfusion, Building 1, E3 Q, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Mol Immunol 44:2036-46. 2007
    ..Together, our data reveal the contribution of distinct elements and factors in the constitutive and IFNgamma-inducible expression of CIITA in melanoma cell lines of the skin...
  4. ncbi Transcriptional regulation of the MHC class II trans-activator (CIITA) promoter III: identification of a novel regulatory region in the 5'-untranslated region and an important role for cAMP-responsive element binding protein 1 and activating transcription
    Nienke van der Stoep
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, The Netherlands
    J Immunol 169:5061-71. 2002
    ..Together our results argue for an important role of ATF/CREB factors and the 5'-UTR of CIITA-PIII in the trans-activation of CIITA-PIII in B cells...
  5. ncbi Epigenetic control of CIITA expression in leukemic T cells
    Tjadine M Holling
    Division of Molecular Biology, Department of Immunohematology and Bloodtransfusion, Leiden University Medical Center, Building 1, E3-Q, Albinusdreef 2, 2333 ZA, The Netherlands
    Biochem Pharmacol 68:1209-13. 2004
  6. ncbi Transcriptional regulation of antigen presentation
    Peter J van den Elsen
    Department of Immunohematology and Blood Transfusion, Building 1, E3 Q, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Curr Opin Immunol 16:67-75. 2004
    ..Accordingly, recent studies include investigations into chromatin remodeling and epigenetic control mechanisms that modulate cell-type-specific transcriptional regulation of genes involved in antigen presentation...
  7. ncbi Activated human T cells accomplish MHC class II expression through T cell-specific occupation of class II transactivator promoter III
    Tjadine M Holling
    Division of Molecular Biology, Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Immunol 168:763-70. 2002
    ....
  8. ncbi DNA methylation and expression of major histocompatibility complex class I and class II transactivator genes in human developmental tumor cells and in T cell malignancies
    Peter J van den Elsen
    Division of Molecular Biology, Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    Clin Immunol 109:46-52. 2003
    ..In this review, we discuss the role of DNA methylation in relation to altered expression of MHC class I and CIITA genes as observed in malignancies and in development...
  9. ncbi Lack of IFN-gamma-mediated induction of the class II transactivator (CIITA) through promoter methylation is predominantly found in developmental tumor cell lines
    Nienke van der Stoep
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center (LUMC, Leiden, The Netherlands
    Int J Cancer 97:501-7. 2002
    ....
  10. ncbi Rapid and cost effective detection of small mutations in the DMD gene by high resolution melting curve analysis
    Rowida Almomani
    Center for Human and Clinical Genetics, LUMC, Einthovenweg 20, Leiden, The Netherlands
    Neuromuscul Disord 19:383-90. 2009
    ..Our results provide validation of HR-MCA as a powerful and inexpensive pre-sequencing scanning method. This technology is now ready for routine diagnostic use on DMD/BMD patients and female carriers...
  11. ncbi Class II transactivator (CIITA) deficiency in tumor cells: complicated mechanisms or not?
    Peter J van den Elsen
    Am J Pathol 163:373-5; author reply 375-6. 2003