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Genomes and GenesSpecies | Annette H M van der Helm-van MilSummaryAffiliation: Leiden University Medical Center Country: The Netherlands Publications
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Publications
Immunoglobulin A multiple myeloma presenting with Henoch-Schönlein purpura associated with reduced sialylation of IgA1Annette H M van der Helm-van Mil
Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
Br J Haematol 122:915-7. 2003..IgA multiple myeloma, secreting IgA1 molecules with decreased sialylation, presenting with a Henoch-Schönlein purpura-like syndrome was diagnosed...- A prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: how to guide individual treatment decisionsAnnette H M van der Helm-van Mil
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 56:433-40. 2007..However, 40-50% of patients with UA experience spontaneous remission. Thus, adequate decision-making regarding treatment of patients with early UA requires identification of those patients in whom RA will develop... - Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsetsAnnette H M van der Helm-van Mil
Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300RC Leiden, The Netherlands
Arthritis Res Ther 10:205. 2008..Additionally, although being scarcely explored, genetic variants affecting the severity of disease course are discussed... - Validation of a prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis: moving toward individualized treatment decision-makingAnnette H M van der Helm-van Mil
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 58:2241-7. 2008..Recently, a prediction rule was developed to estimate the chance of progression to RA in individual patients presenting with UA. This study investigates the accuracy of this prediction rule in independent cohorts of patients with UA... - The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritisAnnette H M van der Helm-van Mil
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 54:1117-21. 2006..We therefore determined the influence of the SE alleles and anti-CCP antibodies on the progression from recent-onset undifferentiated arthritis (UA) to RA... - Acute rheumatic fever and poststreptococcal reactive arthritis reconsideredAnnette H M van der Helm-van Mil
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Curr Opin Rheumatol 22:437-42. 2010..Therefore, this review explores similarities and dissimilarities in initial symptoms and signs, disease course and underlying pathophysiologic mechanisms... - Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritisAnnette H M van der Helm-van Mil
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Arthritis Res Ther 7:R949-58. 2005..In conclusion, the phenotype of RA patients with or without anti-CCP antibodies is similar with respect to clinical presentation but differs with respect to disease course... - How to avoid phenotypic misclassification in using joint destruction as an outcome measure for rheumatoid arthritis?Annette H M van der Helm-van Mil
Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
Rheumatology (Oxford) 49:1429-35. 2010.... - An independent role of protective HLA class II alleles in rheumatoid arthritis severity and susceptibilityAnnette H M van der Helm-van Mil
Department of Rheumatology, Leiden University Medical Center, RC Leiden, The Netherlands
Arthritis Rheum 52:2637-44. 2005.... - Genetic variants in the prediction of rheumatoid arthritisAnnette H M van der Helm-van Mil
Leiden University Medical Center, Department of Rheumatology, Leiden, The Netherlands
Ann Rheum Dis 69:1694-6. 2010.... - Hypernatremia from a hunger strike as a cause of osmotic myelinolysisAnnette H M van der Helm-van Mil
Department of Intensive Care, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
Neurology 64:574-5. 2005 - No association between tumour necrosis factor receptor type 2 gene polymorphism and rheumatoid arthritis severity: a comparison of the extremes of phenotypesA H M van der Helm-van Mil
Department of Rheumatology, C4 R, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
Rheumatology (Oxford) 43:1232-4. 2004..To assess the association between the tumour necrosis factor receptor 2 (TNFR2) 196 M/R single-nucleotide polymorphism and rheumatoid arthritis (RA) severity by taking advantage of the extremes of phenotype that exist in arthritis... - Emerging patterns of risk factor make-up enable subclassification of rheumatoid arthritisAnnette H M van der Helm-van Mil
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 56:1728-35. 2007 - TRAF1/C5 polymorphism is not associated with increased mortality in rheumatoid arthritis: two large longitudinal studiesJessica A B van Nies
Department of Rheumatology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Arthritis Res Ther 12:R38. 2010..As TRAF1/C5 associated mortality may not be restricted to RA, we also studied a large cohort of non-RA patients... - Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritisDiane Van der Woude
Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 60:916-23. 2009.... - Association of a single-nucleotide polymorphism in CD40 with the rate of joint destruction in rheumatoid arthritisMichael P M van der Linden
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 60:2242-7. 2009..The purpose of this study was to investigate whether these newly described genetic regions are associated with the rate of joint destruction... - The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptideAnnette H M van der Helm-van Mil
Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 56:425-32. 2007.... - The ACPA recognition profile and subgrouping of ACPA-positive RA patientsAnnemiek Willemze
Department of Rheumatology, Leiden University Medical Center, The Netherlands
Ann Rheum Dis 71:268-74. 2012..Here, the authors investigated whether specific epitope recognition allows the identification of specific RA subgroups and whether it is associated with clinical features of RA... - Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteinsTom W J Huizinga
Department of Rheumatology C4R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
Arthritis Rheum 52:3433-8. 2005..We undertook this study to make the first comparison of SE allele frequencies in the healthy population with those in RA patients who do or do not harbor anti-CCP antibodies... - Value of anti-modified citrullinated vimentin and third-generation anti-cyclic citrullinated peptide compared with second-generation anti-cyclic citrullinated peptide and rheumatoid factor in predicting disease outcome in undifferentiated arthritis and rhMichael P M van der Linden
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 60:2232-41. 2009.... - Association of HLA-DR3 with anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritisKirsten N Verpoort
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 52:3058-62. 2005..We undertook this study to investigate whether anti-CCP-negative RA is associated with other HLA-DRB1 alleles... - Prevalence of and predictive factors for sustained disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: results from two large early arthritis cohortsDiane Van der Woude
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 60:2262-71. 2009.... - Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis developmentAnouk L Feitsma
Departments of Immunohematology and Blood Transfusion and Rheumatology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands
Proc Natl Acad Sci U S A 104:19966-70. 2007..25; P = 0.003). These data show a protective NIMA-effect in a human autoimmune disease and indicate that a DERAA-positive mother can transfer protection against RA to her DERAA-negative child... - Long-term impact of delay in assessment of patients with early arthritisMichael P M van der Linden
Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 62:3537-46. 2010..Patient characteristics associated with components of delay (by the patient, by the general practitioner [GP], and overall) were assessed... - Distinct ACPA fine specificities, formed under the influence of HLA shared epitope alleles, have no effect on radiographic joint damage in rheumatoid arthritisHans Ulrich Scherer
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Ann Rheum Dis 70:1461-4. 2011..The authors investigated whether ACPA fine specificities, which are formed under the influence of SE alleles, associate with the extent of radiographic joint damage... - Predicting arthritis outcomes--what can be learned from the Leiden Early Arthritis Clinic?Diederik P C de Rooy
Department of Rheumatology, Leiden University Medical Center, C1 46, PO Box 9600, 2300 RC, Leiden, The Netherlands
Rheumatology (Oxford) 50:93-100. 2011..In early undifferentiated arthritis (UA), prediction of the development of RA is crucial, and in case of RA predicting the severity of the disease course may guide individualized treatment decisions... - Repair of joint erosions in rheumatoid arthritis: prevalence and patient characteristics in a large inception cohortMichael P M van der Linden
Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
Ann Rheum Dis 69:727-9. 2010..Joint destruction in rheumatoid arthritis (RA) was until recently seen as an irreversible state. Lately, it was found that repair of bone erosions occurs; however, little is known about its prevalence... - Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damageJing Shi
Department of Rheumatology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands
Proc Natl Acad Sci U S A 108:17372-7. 2011..These antibodies are predictive for a more severe clinical course in ACPA-negative RA-patients, indicating that anti-CarP antibodies are a unique and relevant serological marker for ACPA-negative RA... - The ACPA isotype profile reflects long-term radiographic progression in rheumatoid arthritisDiane Van der Woude
Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
Ann Rheum Dis 69:1110-6. 2010..The ACPA response has been shown to consist of various isotypes, but the consequences of differences in isotype distribution have not been extensively investigated... - A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritisFina A S Kurreeman
Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
PLoS Med 4:e278. 2007..We therefore aimed to investigate whether this locus would play a role in RA... - Aspects of early arthritis. Definition of disease states in early arthritis: remission versus minimal disease activityAnnette H M van der Helm-van Mil
Department of Rheumatology, Leiden University Medical Center, The Netherlands
Arthritis Res Ther 8:216. 2006..These definitions of remission refer to different disease states; therefore, we propose that the term remission is reserved for patients that are not treated with antirheumatic drugs... - Invasiveness of fibroblast-like synoviocytes is an individual patient characteristic associated with the rate of joint destruction in patients with rheumatoid arthritisTanja C A Tolboom
Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 52:1999-2002. 2005..001). CONCLUSION: The ex vivo invasive behavior of FLS from RA patients is associated with the rate of joint destruction and is a patient characteristic, given the much smaller intraindividual than interindividual FLS variation... - Improved treatment strategies reduce the increased mortality risk in early RA patientsJessica A B van Nies
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Rheumatology (Oxford) 49:2210-6. 2010..We investigated whether this change in treatment corresponds to reversal of excess mortality by studying a large inception cohort of early RA patients exposed to different treatment strategies... - The prognostic value of baseline erosions in undifferentiated arthritisMohamed M Thabet
Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, Leiden, PO Box 9600, 2300RC, The Netherlands
Arthritis Res Ther 11:R155. 2009..This study evaluates the predictive value of erosive joints for the disease outcome in UA as measured by RA development and disease persistency... - Variation in radiologic joint destruction in rheumatoid arthritis differs between monozygotic and dizygotic twins and pairs of unrelated patientsAnnette H M van der Helm-van Mil
Leiden University Medical Center, Leiden, The Netherlands
Arthritis Rheum 54:2028-30. 2006 - Understanding the genetic contribution to rheumatoid arthritisAnnette H M van der Helm-van Mil
Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
Curr Opin Rheumatol 17:299-304. 2005..The description of the new genetic risk factors and the interaction with environmental triggers as well as phenotypic features are gradually expanding the ability to predict disease susceptibility and course... - Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based studyRachel Knevel
Correspondence to Rachel Knevel, Department of Rheumatology, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
Ann Rheum Dis 71:707-9. 2012..The evaluation of the heritability of the severity of RA is basic to further studies on genetic factors. A study was undertaken to determine whether joint destruction is heritable... - [Mucocutaneous abnormalities in Chlamydia trachomatis-induced reactive arthritis]Koen D Quint
Leids Universitair Medisch Centrum, afd Dermatologie, Leiden, The Netherlands
Ned Tijdschr Geneeskd 154:A1614. 2010..It is important that the patient's partner is tested at the same time and if necessary treated simultaneously to prevent reinfection...