Claudia Coomans

Summary

Affiliation: Leiden University Medical Center
Location: Leiden, The Netherlands

Publications

  1. ncbi Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors
    Kate F Whitecross
    Cancer Immunology Program, The Peter MacCallum Cancer Centre, Trescowthick Research Laboratories, East Melbourne, Australia
    Blood 113:1982-91. 2009
  2. ncbi Thyroid hormone effects on whole-body energy homeostasis and tissue-specific fatty acid uptake in vivo
    Lars P Klieverik
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Endocrinology 150:5639-48. 2009
  3. ncbi Apolipoprotein CI enhances the biological response to LPS via the CD14/TLR4 pathway by LPS-binding elements in both its N- and C-terminal helix
    Jimmy F P Berbee
    Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Lipid Res 51:1943-52. 2010
  4. ncbi Blocking dopamine D2 receptors by haloperidol curtails the beneficial impact of calorie restriction on the metabolic phenotype of high-fat diet induced obese mice
    J E de Leeuw van Weenen
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    J Neuroendocrinol 23:158-67. 2011
  5. ncbi Circulating insulin stimulates fatty acid retention in white adipose tissue via KATP channel activation in the central nervous system only in insulin-sensitive mice
    Claudia P Coomans
    Departments of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Lipid Res 52:1712-22. 2011
  6. ncbi Stimulatory effect of insulin on glucose uptake by muscle involves the central nervous system in insulin-sensitive mice
    Claudia P Coomans
    Corresponding author Claudia P Coomans
    Diabetes 60:3132-40. 2011

Collaborators

Detail Information

Publications6

  1. ncbi Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors
    Kate F Whitecross
    Cancer Immunology Program, The Peter MacCallum Cancer Centre, Trescowthick Research Laboratories, East Melbourne, Australia
    Blood 113:1982-91. 2009
    ..Our studies provide important preclinical data on the binding specificity of ABT-737 and its usefulness against primary hematologic malignancies when used as a single agent and in combination with HDACi...
  2. ncbi Thyroid hormone effects on whole-body energy homeostasis and tissue-specific fatty acid uptake in vivo
    Lars P Klieverik
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands
    Endocrinology 150:5639-48. 2009
    ..The changes in whole-body lipid metabolism are accompanied by tissue-specific changes in TG-derived FA uptake in accordance with hyper- and hypometabolic states induced by thyrotoxicosis and hypothyroidism, respectively...
  3. ncbi Apolipoprotein CI enhances the biological response to LPS via the CD14/TLR4 pathway by LPS-binding elements in both its N- and C-terminal helix
    Jimmy F P Berbee
    Department of General Internal Medicine, Endocrinology and Metabolic Diseases, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    J Lipid Res 51:1943-52. 2010
    ..We conclude that apoCI contains structural elements in both its N-terminal and C-terminal helix to bind LPS and to enhance the proinflammatory response toward LPS via a mechanism similar to LBP...
  4. ncbi Blocking dopamine D2 receptors by haloperidol curtails the beneficial impact of calorie restriction on the metabolic phenotype of high-fat diet induced obese mice
    J E de Leeuw van Weenen
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Centre, Leiden, The Netherlands
    J Neuroendocrinol 23:158-67. 2011
    ....
  5. ncbi Circulating insulin stimulates fatty acid retention in white adipose tissue via KATP channel activation in the central nervous system only in insulin-sensitive mice
    Claudia P Coomans
    Departments of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
    J Lipid Res 52:1712-22. 2011
    ..Apparently, circulating insulin stimulates fatty acid uptake in WAT but not in BAT, directly and indirectly through the CNS...
  6. ncbi Stimulatory effect of insulin on glucose uptake by muscle involves the central nervous system in insulin-sensitive mice
    Claudia P Coomans
    Corresponding author Claudia P Coomans
    Diabetes 60:3132-40. 2011
    ..High-fat diet-induced obesity abolished the central effects of insulin on liver and muscle. These observations stress the role of central insulin resistance in the pathophysiology of diet-induced insulin resistance...