David A Baker

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi Downregulation of vertebrate Tel (ETV6) and Drosophila Yan is facilitated by an evolutionarily conserved mechanism of F-box-mediated ubiquitination
    M Guy Roukens
    Leiden University Medical Center LUMC, Department of Molecular Cell Biology, 2300 RC Leiden, The Netherlands
    Mol Cell Biol 28:4394-406. 2008
  2. ncbi Identification of a new site of sumoylation on Tel (ETV6) uncovers a PIAS-dependent mode of regulating Tel function
    M Guy Roukens
    Signaling and Transcription Laboratory, Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20, P O Box 9600, 2300 RC Leiden, The Netherlands
    Mol Cell Biol 28:2342-57. 2008
  3. ncbi Control of endothelial sprouting by a Tel-CtBP complex
    M Guy Roukens
    Leiden University Medical Center LUMC, Section of Growth Control and Transcription, Department of Molecular Cell Biology, 2300 RC Leiden, The Netherlands
    Nat Cell Biol 12:933-42. 2010
  4. ncbi The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis
    Rebecca Wilson
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK
    Nat Cell Biol 4:445-50. 2002
  5. ncbi Purine nucleotide cyclases in the malaria parasite
    David A Baker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Trends Parasitol 20:227-32. 2004
  6. ncbi The role of two novel regulatory sites in the activation of the cGMP-dependent protein kinase from Plasmodium falciparum
    Wensheng Deng
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Biochem J 374:559-65. 2003
  7. ncbi Adenylyl and guanylyl cyclases from the malaria parasite Plasmodium falciparum
    David A Baker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    IUBMB Life 56:535-40. 2004
  8. ncbi Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum
    David K Muhia
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom
    J Biol Chem 278:22014-22. 2003
  9. ncbi A novel cyclic GMP-dependent protein kinase is expressed in the ring stage of the Plasmodium falciparum life cycle
    Wensheng Deng
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Mol Microbiol 44:1141-51. 2002
  10. ncbi Structure, function and evolution of microbial adenylyl and guanylyl cyclases
    David A Baker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Mol Microbiol 52:1229-42. 2004

Collaborators

  • A C O Vertegaal
  • M Guy Roukens
  • Mariam Alloul-Ramdhani
  • Wensheng Deng
  • David K Muhia
  • Rebecca Wilson
  • Stefan Schulte-Merker
  • Josi Peterson-Maduro
  • Hans van Dam
  • Kazuki Kobayashi
  • Bart Baan
  • Crina I A Balog
  • Andre M Deelder
  • Setareh Moghadasi
  • Zeinab Anvarian
  • Paul J Hensbergen
  • Marjolein Op den Brouw
  • John M Kelly
  • Pauline Schaap
  • Ursula Eckstein-Ludwig
  • Asha Parbhu-Patel
  • Sanjeev Krishna
  • Claire A Swales
  • Shweta Saran
  • Spencer D Polley
  • David J Meyer
  • Mark Ditzel
  • Pascal Meier
  • Hermann Steller
  • Anna Zachariou
  • Julie Agapite
  • Lakshmi Goyal

Detail Information

Publications10

  1. ncbi Downregulation of vertebrate Tel (ETV6) and Drosophila Yan is facilitated by an evolutionarily conserved mechanism of F-box-mediated ubiquitination
    M Guy Roukens
    Leiden University Medical Center LUMC, Department of Molecular Cell Biology, 2300 RC Leiden, The Netherlands
    Mol Cell Biol 28:4394-406. 2008
    ..Here, we found that Fbl6 regulates Tel/Yan protein stability and allows appropriate spatiotemporal control of gene expression by these repressors...
  2. ncbi Identification of a new site of sumoylation on Tel (ETV6) uncovers a PIAS-dependent mode of regulating Tel function
    M Guy Roukens
    Signaling and Transcription Laboratory, Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20, P O Box 9600, 2300 RC Leiden, The Netherlands
    Mol Cell Biol 28:2342-57. 2008
    ....
  3. ncbi Control of endothelial sprouting by a Tel-CtBP complex
    M Guy Roukens
    Leiden University Medical Center LUMC, Section of Growth Control and Transcription, Department of Molecular Cell Biology, 2300 RC Leiden, The Netherlands
    Nat Cell Biol 12:933-42. 2010
    ..This work highlights Tel and its associated networks as potential targets for the development of therapeutic strategies to inhibit pathological angiogenesis...
  4. ncbi The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis
    Rebecca Wilson
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK
    Nat Cell Biol 4:445-50. 2002
    ..Our data suggest that IAPs suppress apoptosis by binding to and targeting caspases for ubiquitination...
  5. ncbi Purine nucleotide cyclases in the malaria parasite
    David A Baker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Trends Parasitol 20:227-32. 2004
  6. ncbi The role of two novel regulatory sites in the activation of the cGMP-dependent protein kinase from Plasmodium falciparum
    Wensheng Deng
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Biochem J 374:559-65. 2003
    ..The distinct activation properties of PfPKG from mammalian isoforms may be exploitable in the design of a parasite-specific inhibitor and development of a novel anti-malarial drug...
  7. ncbi Adenylyl and guanylyl cyclases from the malaria parasite Plasmodium falciparum
    David A Baker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    IUBMB Life 56:535-40. 2004
    ..Study of these enzymes could therefore lead to novel strategies for anti-malarial intervention in addition to providing unique insights into the intriguing biology of the parasite...
  8. ncbi Multiple splice variants encode a novel adenylyl cyclase of possible plastid origin expressed in the sexual stage of the malaria parasite Plasmodium falciparum
    David K Muhia
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom
    J Biol Chem 278:22014-22. 2003
    ....
  9. ncbi A novel cyclic GMP-dependent protein kinase is expressed in the ring stage of the Plasmodium falciparum life cycle
    Wensheng Deng
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Mol Microbiol 44:1141-51. 2002
    ..Biochemical analysis therefore shows that PfPKG is distinct from mammalian PKGs with respect to both cyclic nucleotide analogue activation and inhibition profiles...
  10. ncbi Structure, function and evolution of microbial adenylyl and guanylyl cyclases
    David A Baker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Mol Microbiol 52:1229-42. 2004
    ..A review is timely because the explosion of data from the various genome projects is providing new and exciting insights into protein function and evolution...