Cornelia F Allaart

Summary

Affiliation: Leiden University Medical Center
Country: The Netherlands

Publications

  1. ncbi Aiming at low disease activity in rheumatoid arthritis with initial combination therapy or initial monotherapy strategies: the BeSt study
    C F Allaart
    Department of Rheumatology, Leiden University Medical Center, RC Leiden, The Netherlands
    Clin Exp Rheumatol 24:S-77-82. 2006
  2. ncbi Treatment of recent-onset rheumatoid arthritis: lessons from the BeSt study
    Cornelia F Allaart
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    J Rheumatol Suppl 80:25-33. 2007
  3. ncbi Treatment strategies in recent onset rheumatoid arthritis
    Cornelia F Allaart
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Rheumatol 23:241-4. 2011
  4. ncbi The impact of four dynamic, goal-steered treatment strategies on the 5-year outcomes of rheumatoid arthritis patients in the BeSt study
    Naomi B Klarenbeek
    Department of Rheumatology, C 01 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Ann Rheum Dis 70:1039-46. 2011
  5. ncbi Accelerated hand bone mineral density loss is associated with progressive joint damage in hands and feet in recent-onset rheumatoid arthritis
    Melek Güler-Yüksel
    Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Arthritis Res Ther 12:R96. 2010
  6. ncbi Blood pressure changes in patients with recent-onset rheumatoid arthritis treated with four different treatment strategies: a post hoc analysis from the BeSt trial
    Naomi B Klarenbeek
    Department of Rheumatology, C 01 R, Leiden University Medical Center, P O Box 9600, Leiden 2300 RC, The Netherlands
    Ann Rheum Dis 69:1342-5. 2010
  7. ncbi A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis
    Judith A M Wessels
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 56:1765-75. 2007
  8. ncbi Cost-utility analysis of treatment strategies in patients with recent-onset rheumatoid arthritis
    Wilbert B Van Den Hout
    Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 61:291-9. 2009
  9. ncbi Comparison of treatment strategies in early rheumatoid arthritis: a randomized trial
    Yvonne P M Goekoop-Ruiterman
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Intern Med 146:406-15. 2007
  10. ncbi Patient preferences for treatment: report from a randomised comparison of treatment strategies in early rheumatoid arthritis (BeSt trial)
    Yvonne P M Goekoop-Ruiterman
    Leiden University Medical Center, Department of Rheumatology C1 R, PO Box 9600, 2300 RC Leiden, The Netherlands
    Ann Rheum Dis 66:1227-32. 2007

Collaborators

Detail Information

Publications48

  1. ncbi Aiming at low disease activity in rheumatoid arthritis with initial combination therapy or initial monotherapy strategies: the BeSt study
    C F Allaart
    Department of Rheumatology, Leiden University Medical Center, RC Leiden, The Netherlands
    Clin Exp Rheumatol 24:S-77-82. 2006
    ..To evaluate the efficacy and safety of four different treatment strategies for patients with early rheumatoid arthritis (RA)...
  2. ncbi Treatment of recent-onset rheumatoid arthritis: lessons from the BeSt study
    Cornelia F Allaart
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    J Rheumatol Suppl 80:25-33. 2007
    ..To determine the efficacy, toxicity, utilities, and costs of 4 treatment strategies for patients with recent-onset rheumatoid arthritis (RA)...
  3. ncbi Treatment strategies in recent onset rheumatoid arthritis
    Cornelia F Allaart
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Rheumatol 23:241-4. 2011
    ..To help rheumatologists choose the right treatment at the right time, this review describes recent trial outcomes, and studies into possible predictors for treatment strategy outcomes...
  4. ncbi The impact of four dynamic, goal-steered treatment strategies on the 5-year outcomes of rheumatoid arthritis patients in the BeSt study
    Naomi B Klarenbeek
    Department of Rheumatology, C 01 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Ann Rheum Dis 70:1039-46. 2011
    ..To compare clinical and radiological outcomes of four dynamic treatment strategies in recent-onset rheumatoid arthritis (RA) after 5 years follow-up...
  5. ncbi Accelerated hand bone mineral density loss is associated with progressive joint damage in hands and feet in recent-onset rheumatoid arthritis
    Melek Güler-Yüksel
    Department of Rheumatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
    Arthritis Res Ther 12:R96. 2010
    ....
  6. ncbi Blood pressure changes in patients with recent-onset rheumatoid arthritis treated with four different treatment strategies: a post hoc analysis from the BeSt trial
    Naomi B Klarenbeek
    Department of Rheumatology, C 01 R, Leiden University Medical Center, P O Box 9600, Leiden 2300 RC, The Netherlands
    Ann Rheum Dis 69:1342-5. 2010
    ..To evaluate the effect of disease activity and antirheumatic treatment on blood pressure (BP) in patients with recent-onset rheumatoid arthritis (RA)...
  7. ncbi A clinical pharmacogenetic model to predict the efficacy of methotrexate monotherapy in recent-onset rheumatoid arthritis
    Judith A M Wessels
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 56:1765-75. 2007
    ..To develop a clinical pharmacogenetic model to predict the efficacy of methotrexate (MTX) in rheumatoid arthritis (RA)...
  8. ncbi Cost-utility analysis of treatment strategies in patients with recent-onset rheumatoid arthritis
    Wilbert B Van Den Hout
    Department of Medical Decision Making, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 61:291-9. 2009
    ..To evaluate societal costs and quality-adjusted life years (QALYs) of treatment strategies for patients with recent-onset active rheumatoid arthritis (RA)...
  9. ncbi Comparison of treatment strategies in early rheumatoid arthritis: a randomized trial
    Yvonne P M Goekoop-Ruiterman
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Intern Med 146:406-15. 2007
    ..In patients with early rheumatoid arthritis, initial combination therapies provide earlier clinical improvement and less progression of joint damage after 1 year compared with initial monotherapies (as demonstrated in the BeSt study)...
  10. ncbi Patient preferences for treatment: report from a randomised comparison of treatment strategies in early rheumatoid arthritis (BeSt trial)
    Yvonne P M Goekoop-Ruiterman
    Leiden University Medical Center, Department of Rheumatology C1 R, PO Box 9600, 2300 RC Leiden, The Netherlands
    Ann Rheum Dis 66:1227-32. 2007
    ..To determine treatment preferences among patients with recent onset rheumatoid arthritis participating in a randomised controlled trial comparing four therapeutic strategies...
  11. ncbi The BeSt story: on strategy trials in rheumatoid arthritis
    Naomi B Klarenbeek
    Department of Rheumatology, C 01 R, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands
    Curr Opin Rheumatol 21:291-8. 2009
    ..To give an overview of recent strategy trials for the treatment of rheumatoid arthritis...
  12. ncbi Exploratory analysis of four polymorphisms in human GGH and FPGS genes and their effect in methotrexate-treated rheumatoid arthritis patients
    R J H M van der Straaten
    Leiden University Medical Center, Department of Clinical Pharmacy and Toxicology, P O Box 9600, 2300 RA Leiden, The Netherlands
    Pharmacogenomics 8:141-50. 2007
    ....
  13. ncbi Functional polymorphisms and methotrexate treatment outcome in recent-onset rheumatoid arthritis
    Wouter M Kooloos
    Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, PO Box 9600, NL 2300 RC Leiden, The Netherlands
    Pharmacogenomics 11:163-75. 2010
    ..Furthermore, tests for replication of previous research on these genetic variants were performed according to reported end points...
  14. ncbi Innovative treatment strategies for patients with rheumatoid arthritis
    Sjoerd M van der Kooij
    Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Rheumatol 20:287-94. 2008
    ..The present review provides an update on novel treatment strategies striving for remission in patients with recent onset of rheumatoid arthritis...
  15. ncbi Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis
    Judith A M Wessels
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 54:2830-9. 2006
    ..This study was undertaken to explore polymorphisms in genes contributing to antiinflammatory adenosine release as novel predictors of MTX treatment outcome...
  16. ncbi Drug-free remission: is it already possible?
    Marianne van den Broek
    Leiden University Medical Center, Leiden, The Netherlands
    Curr Opin Rheumatol 23:266-72. 2011
    ..To give an overview of recently published articles covering drug-free remission in rheumatoid arthritis (RA)...
  17. ncbi Efficacy of methotrexate treatment in patients with probable rheumatoid arthritis: a double-blind, randomized, placebo-controlled trial
    Henrike van Dongen
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 56:1424-32. 2007
    ..To determine whether patients with undifferentiated arthritis (UA; inflammatory, nontraumatic arthritis that cannot be diagnosed using current classification criteria) benefit from treatment with methotrexate (MTX)...
  18. ncbi Comparison of long term outcome of patients with rheumatoid arthritis presenting with undifferentiated arthritis or with rheumatoid arthritis: an observational cohort study
    J Van Aken
    Department of Rheumatology, Leiden University Medical Centre, The Netherlands
    Ann Rheum Dis 65:20-5. 2006
    ..CONCLUSION: The disease outcome of patients who present with UA that evolves into RA within 1 year is the same as that of patients who present with RA as measured by radiographic progression, disease activity, and functional capacity...
  19. ncbi The 620W allele is the PTPN22 genetic variant conferring susceptibility to RA in a Dutch population
    J Wesoly
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Rheumatology (Oxford) 46:617-21. 2007
    ..We tested this hypothesis in an independent white Dutch study...
  20. ncbi Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes
    Judith A M Wessels
    Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 54:1087-95. 2006
    ..To determine associations of methotrexate (MTX) efficacy and toxicity with single-nucleotide polymorphisms (SNPs) in genes coding for folate pathway enzymes in patients with early rheumatoid arthritis (RA)...
  21. ncbi Sick leave and work disability in patients with early arthritis
    Elisabeth J M Zirkzee
    Department of Rheumatology C1 R, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Clin Rheumatol 27:11-9. 2008
    ..Considerable proportions of patients received workplace adaptations and professional guidance with working problems...
  22. ncbi Limited efficacy of conventional DMARDs after initial methotrexate failure in patients with recent onset rheumatoid arthritis treated according to the disease activity score
    Sjoerd M van der Kooij
    Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, Netherlands
    Ann Rheum Dis 66:1356-62. 2007
    ..To determine the efficacy of subsequent disease modifying antirheumatic drug (DMARD) therapies after initial methotrexate (MTX) failure in patients with recent onset rheumatoid arthritis (RA), treated according to the DAS for 2 years...
  23. ncbi A matrix risk model for the prediction of rapid radiographic progression in patients with rheumatoid arthritis receiving different dynamic treatment strategies: post hoc analyses from the BeSt study
    K Visser
    Department of Rheumatology C1 R, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Ann Rheum Dis 69:1333-7. 2010
    ..To develop a matrix model for the prediction of rapid radiographic progression (RRP) in subpopulations of patients with recent-onset rheumatoid arthritis (RA) receiving different dynamic treatment strategies...
  24. ncbi Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial
    Y P M Goekoop-Ruiterman
    Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arthritis Rheum 52:3381-90. 2005
    ..We undertook this study to compare clinical and radiographic outcomes of 4 different treatment strategies, with intense monitoring in all patients...
  25. ncbi Efficacy of intraarticular infliximab in patients with chronic or recurrent gonarthritis: a clinical randomized trial
    A E van der Bijl
    Leiden University Medical Centre, Leiden, The Netherlands
    Arthritis Rheum 61:974-8. 2009
    ..To evaluate the efficacy and safety of intraarticular infliximab compared with intraarticular methylprednisolone in patients with gonarthritis...
  26. ncbi Discontinuing treatment in patients with rheumatoid arthritis in sustained clinical remission: exploratory analyses from the BeSt study
    N B Klarenbeek
    Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:315-9. 2011
    ..To determine the relapse rate after discontinuing treatment in patients with rheumatoid arthritis (RA) in sustained clinical remission, to identify predictors of a relapse and to evaluate treatment response after restarting treatment...
  27. ncbi Use of methotrexate in undifferentiated arthritis
    K Visser
    Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Rheumatol 28:S117-21. 2010
    ..During the last few years, more data on interventions in UA have become available that provide guidance in the prescription of drugs to UA patients...
  28. ncbi Clinical synovitis in a particular joint is associated with progression of erosions and joint space narrowing in that same joint, but not in patients initially treated with infliximab
    N B Klarenbeek
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 69:2107-13. 2010
    ..To assess the relationship between joint tenderness, swelling and joint damage progression in individual joints and to evaluate the influence of treatment on these relationships...
  29. ncbi DAS-driven therapy versus routine care in patients with recent-onset active rheumatoid arthritis
    Y P M Goekoop-Ruiterman
    Leiden University Medical Centre, Department of Rheumatology C 1 R, PO Box 9600, 2300 RC Leiden, The Netherlands
    Ann Rheum Dis 69:65-9. 2010
    ..To compare the efficacy of Disease Activity Score (DAS)-driven therapy and routine care in patients with recent-onset rheumatoid arthritis...
  30. ncbi Treatment with TNF-? inhibitor infliximab might reduce hand osteoarthritis in patients with rheumatoid arthritis
    M Güler-Yüksel
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Osteoarthritis Cartilage 18:1256-62. 2010
    ....
  31. ncbi Patient-reported outcomes in a randomized trial comparing four different treatment strategies in recent-onset rheumatoid arthritis
    S M van der Kooij
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 61:4-12. 2009
    ..To investigate the effectiveness of 4 different treatment strategies for recent-onset rheumatoid arthritis (RA) on 2-year patient-reported outcomes, including functioning and quality of life...
  32. ncbi Clinical and radiological efficacy of initial vs delayed treatment with infliximab plus methotrexate in patients with early rheumatoid arthritis
    S M van der Kooij
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 68:1153-8. 2009
    ..To compare the clinical and radiological efficacy of initial vs delayed treatment with methotrexate (MTX) and infliximab (IFX) in patients with recent onset rheumatoid arthritis (RA)...
  33. ncbi Drug-free remission, functioning and radiographic damage after 4 years of response-driven treatment in patients with recent-onset rheumatoid arthritis
    S M van der Kooij
    Leiden University Medical Center, The Netherlands
    Ann Rheum Dis 68:914-21. 2009
    ..To compare the occurrence of drug-free remission, functional ability and radiological damage after 4 years of response-driven treatment according to four different treatment strategies for rheumatoid arthritis (RA)...
  34. ncbi Cavitating pneumonia after treatment with infliximab and prednisone
    S M Arend
    Department of Infectious Diseases C5P 39, Leiden University Medical Center, P O Box 9600, 2300 RC, Leiden, The Netherlands
    Eur J Clin Microbiol Infect Dis 23:638-41. 2004
    ..The patient responded well to fluconazole. The risk of infection after treatment with TNF-alpha antagonists and the possible causative microorganisms are discussed...
  35. ncbi Undifferentiated arthritis--disease course assessed in several inception cohorts
    K N Verpoort
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Clin Exp Rheumatol 22:S12-7. 2004
    ....
  36. ncbi Ex vivo interleukin 1 receptor antagonist production on lipopolysaccharide stimulation is associated with rheumatoid arthritis and with joint damage
    J K de Vries-Bouwstra
    Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands
    Ann Rheum Dis 66:1033-7. 2007
    ....
  37. ncbi Bone mineral density in patients with recently diagnosed, active rheumatoid arthritis
    M Güler-Yüksel
    Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Ann Rheum Dis 66:1508-12. 2007
    ....
  38. ncbi Infliximab and methotrexate as induction therapy in patients with early rheumatoid arthritis
    A E van der Bijl
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 56:2129-34. 2007
    ..To evaluate the efficacy of infliximab plus methotrexate (MTX) as induction therapy in patients with early rheumatoid arthritis (RA)...
  39. ncbi Changes in bone mineral density in patients with recent onset, active rheumatoid arthritis
    M Güler-Yüksel
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Ann Rheum Dis 67:823-8. 2008
    ....
  40. ncbi Probability of continued low disease activity in patients with recent onset rheumatoid arthritis treated according to the disease activity score
    S M van der Kooij
    Department of Rheumatology C 01 R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Ann Rheum Dis 67:266-9. 2008
    ..To assess the duration and the probability of maintaining low disease activity once a low disease activity score (DAS) is achieved in recent onset rheumatoid arthritis (RA) patients...
  41. ncbi A high body mass index has a protective effect on the amount of joint destruction in small joints in early rheumatoid arthritis
    A H M van der Helm-van Mil
    Department of Rheumatology, Leiden University Medical Centre, PO Box 9600, 2300RC Leiden, The Netherlands
    Ann Rheum Dis 67:769-74. 2008
    ..Rheumatoid arthritis (RA) is marked by the presence of proinflammatory cytokines and, in general, the presence of high levels of inflammatory markers is associated with a severe disease course and joint damage...
  42. ncbi Fine specificity of the anti-citrullinated protein antibody response is influenced by the shared epitope alleles
    K N Verpoort
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 56:3949-52. 2007
    ..ACPA levels are higher in SE-positive patients with RA than in SE-negative patients with RA. The aim of the present study was to determine whether SE influences not only the magnitude but also the specificity of the ACPA response...
  43. ncbi Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial
    Y P M Goekoop-Ruiterman
    Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 58:S126-35. 2008
    ..We undertook this study to compare clinical and radiographic outcomes of 4 different treatment strategies, with intense monitoring in all patients...
  44. ncbi Changes in hand and generalised bone mineral density in patients with recent-onset rheumatoid arthritis
    M Güler-Yüksel
    Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands
    Ann Rheum Dis 68:330-6. 2009
    ....
  45. ncbi The Leiden Early Arthritis Clinic
    J Van Aken
    Leiden University Medical Center, Leiden, The Netherlands
    Clin Exp Rheumatol 21:S100-5. 2003
    ..Present and planned future studies, as described in this article, reconfirm the importance of an EAC framework to ensure that research continues on this disease in the Leiden EAC area...
  46. ncbi A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis
    Fina A S Kurreeman
    Department of Rheumatology, Leiden University Medical Centre, Leiden, The Netherlands
    PLoS Med 4:e278. 2007
    ..We therefore aimed to investigate whether this locus would play a role in RA...
  47. ncbi Combination therapy in rheumatoid arthritis
    Y P Goekoop
    Department of Rheumatology, Vr and OV0451;e Universiteit Medical Center, Amsterdam, The Netherlands
    Curr Opin Rheumatol 13:177-83. 2001
    ....
  48. ncbi Rheumatoid vasculitis treated with infliximab
    A Egon van der Bijl
    Department of Rheumatology, Leiden University Medical Centre, The Netherlands
    J Rheumatol 32:1607-9. 2005
    ..TNF-a antagonists should be considered as treatment in systemic RV, especially in patients who do not respond to immunosuppressive drugs or who have contraindication for such treatment...