Research Topics
Genomes and GenesSpecies | Juliette LeglerSummaryAffiliation: Institute for Environmental Studies Country: The Netherlands Publications
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Detail Information
Publications
Biomonitoring of estrogenic exposure and identification of responsible compounds in bream from Dutch surface watersCorine J Houtman
Institute for Environmental Studies, Vrije Universiteit Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
Environ Toxicol Chem 26:898-907. 2007..However, these compounds did not have high estrogenic potencies and their concentrations were not high enough to contribute significantly to the observed estrogenic activity...- Recombinational micro-evolution of functionally different metallothionein promoter alleles from Orchesella cinctaThierry K S Janssens
Vrije Universiteit, Institute of Ecological Sciences, Department of Animal Ecology, De Boelelaan 1085, Amsterdam, The Netherlands
BMC Evol Biol 7:88. 2007.... - The OBELIX project: early life exposure to endocrine disruptors and obesityJuliette Legler
Institutes for Environmental Studies VU University Amsterdam, Amsterdam, Netherlands
Am J Clin Nutr 94:1933S-1938S. 2011.... - Detection of estrogenic activity in sediment-associated compounds using in vitro reporter gene assaysJuliette Legler
Division of Toxicology, Wageningen University, The Netherlands
Sci Total Environ 293:69-83. 2002..Results indicate that metabolites of E2, NP and bisphenol A were less active than the parent compounds, while metabolites of methoxychlor were more estrogenic following microsomal incubations... - New insights into the endocrine disrupting effects of brominated flame retardantsJuliette Legler
Institute for Environmental Studies, VU University Amsterdam, De Boelelaan 1087, Amsterdam, The Netherlands
Chemosphere 73:216-22. 2008.... - Are brominated flame retardants endocrine disruptors?Juliette Legler
Institute for Environmental Studies IVM, Vrije Universiteit, De Boelelaan 1087, 1081 HV, Amsterdam, The Netherlands
Environ Int 29:879-85. 2003..Research gaps are outlined, as well as ongoing and future studies in the European community aimed at contributing to comprehensive risk assessments based on the endocrine-disrupting effects of BFRs... - Sample preparation method for the ER-CALUX bioassay screening of (xeno-)estrogenic activity in sediment extractsCorine J Houtman
Institute for Environmental Studies, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
Sci Total Environ 386:134-44. 2007..Application of the method to field samples showed that estrogenic activity can be found at different types of locations, and demonstrated that levels between locations may vary considerably over relatively short distances... - Toxicological profiling of sediments using in vitro bioassays, with emphasis on endocrine disruptionCorine J Houtman
Institute for Environmental Studies, Vrije Universiteit Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
Environ Toxicol Chem 23:32-40. 2004..The present study showed the occurrence of endocrine-disrupting potencies in sediments from the Dutch delta and the suitability of the ER- and DR-CALUX bioassays to direct endocrine-disruption TIE studies... - Identification of estrogenic compounds in fish bile using bioassay-directed fractionationCorine J Houtman
Institute for Environmental Studies, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
Environ Sci Technol 38:6415-23. 2004..Although chloroxylenol was shown for the first time to be weakly estrogenic, these compounds did not contribute significantly to the estrogenic activity observed... - Detection of estrogenic potency in wastewater and surface water with three in vitro bioassaysAlbertinka J Murk
Division of Toxicology, Wageningen University, The Netherlands
Environ Toxicol Chem 21:16-23. 2002..These first results of analyzing estrogenic potency in WTP water and surface water in The Netherlands indicate that further studies are warranted to investigate the actual risks for aquatic systems... - Toxicity profiling: An integrated effect-based tool for site-specific sediment quality assessmentTimo Hamers
Institute for Environmental Studies, VU University Amsterdam, The Netherlands
Integr Environ Assess Manag 6:761-73. 2010..Future perspectives in toxicity profiling include expansion of the battery of bioassays with test methods that cover other toxic endpoints or multiple endpoints, are high throughput, and improve the ecological relevance... - Effect-directed analysis of municipal landfill soil reveals novel developmental toxicants in the zebrafish Danio rerioJuliette Legler
Institute for Environmental Studies, VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
Environ Sci Technol 45:8552-8. 2011..This work revealed the presence of novel contaminants in the environment that may affect vertebrate development, which are not subject to monitoring or regulation under current soil quality assessment guidelines... - Biological measurement of estrogenic activity in urine and bile conjugates with the in vitro ER-CALUX reporter gene assayJuliette Legler
Division of Toxicology, Wageningen University, The Netherlands
Environ Toxicol Chem 21:473-9. 2002..Therefore, the measurement of deconjugated bile could form a useful (indirect) biomarker for internal dose of xenoestrogens in male fish... - Estrogenic and dioxin-like compounds in sediment from Zierikzee harbour identified with CALUX assay-directed fractionation combined with one and two dimensional gas chromatography analysesCorine J Houtman
Institute for Environmental Studies, Vrije Universiteit, De Boelelaan 1087, 1181 HV Amsterdam, The Netherlands
Chemosphere 65:2244-52. 2006..Some estrogenic activity of a relatively non-polar nature remained unidentified... - Development of a polydimethylsiloxane film-based passive dosing method in the in vitro DR-CALUX® assayPetra Booij
Institute for Environmental Studies, VU University Amsterdam, Amsterdam, The Netherlands
Environ Toxicol Chem 30:898-904. 2011..Use of PDMS for passive dosing of complex samples may represent a more realistic method for exposure in in vitro bioassays... - Dithiocarbamates induce craniofacial abnormalities and downregulate sox9a during zebrafish developmentAntonius Leonardus van Boxtel
Institute for Environmental Studies IVM, VU University, Amsterdam, The Netherlands
Toxicol Sci 117:209-17. 2010..Together, we provide evidence for a novel teratogenic endpoint and a molecular basis for a better understanding of DTC-induced teratogenesis in vertebrates... - Biological validation of a sample preparation method for ER-CALUX bioanalysis of estrogenic activity in sediment using mixtures of xeno-estrogensCorine J Houtman
Institute for Environmental Studies, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
Environ Sci Technol 40:2455-61. 2006..6 +/- 1.8 pg of EEQ/ g), and coefficient of variance (3.5 +/- 3.3%),this demonstrated the suitability of the sample preparation method for the analysis of mixtures of (xeno-)estrogenic compounds in sediment with the ER-CALUX assay... - Optimization and prevalidation of the in vitro ERalpha CALUX method to test estrogenic and antiestrogenic activity of compoundsBart van der Burg
BioDetection Systems BV, Science Park 406, Amsterdam, The Netherlands
Reprod Toxicol 30:73-80. 2010..This cell line proved to be a very suitable and reliable predictor of estrogenicity of chemicals and was able to readily rank a range of chemicals on the basis of their EC50 values... - Lysyl oxidase-like 3b is critical for cartilage maturation during zebrafish craniofacial developmentAntonius L Van Boxtel
Institute for Environmental Studies, VU University, Amsterdam, The Netherlands
Matrix Biol 30:178-87. 2011..Taken together, these data demonstrate a novel role for loxl3b in the maturation of craniofacial cartilage and can provide new insight into the specific genetic factors important in the pathogenesis of craniofacial birth defects... - Microarray analysis reveals a mechanism of phenolic polybrominated diphenylether toxicity in zebrafishAntonius L Van Boxtel
Institute for Environmental Studies and Department of Molecular Cell Physiology, Faculty of Earth and Life Sciences, VU University, Amsterdam, The Netherlands
Environ Sci Technol 42:1773-9. 2008..The results of this study emphasize the need for further investigation on the presence and toxicity of this class of polybrominated compounds... - In vitro profiling of the endocrine-disrupting potency of brominated flame retardantsTimo Hamers
Institute for Environmental Studies, Vrije Universiteit Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
Toxicol Sci 92:157-73. 2006..Based on their similarity in ED profiles, BFRs were classified into five different clusters. These findings support further investigation of the potential ED effects of these environmentally relevant BFRs in man and wildlife... - Dithiocarbamates are teratogenic to developing zebrafish through inhibition of lysyl oxidase activityAntonius L Van Boxtel
Institute for Environmental Studies IVM, VU University Amsterdam, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands
Toxicol Appl Pharmacol 244:156-61. 2010..Taken together, these results provide the first evidence that DTC induced teratogenic effects are, at least in part, caused by direct inhibition of LOX activity... - In vitro and in vivo antiestrogenic effects of polycyclic musks in zebrafishRichard H M M Schreurs
Institute for Risk Assessment Sciences, Utrecht University, P O Box 80176, 3508 TD, Utrecht, The Netherlands
Environ Sci Technol 38:997-1002. 2004..This makes the transgenic zebrafish assay a promising tool for the rapid detection of both estrogenic and antiestrogenic effects of chemicals in fish... - Intra- and interlaboratory calibration of the DR CALUX bioassay for the analysis of dioxins and dioxin-like chemicals in sedimentsHarrie T Besselink
BioDetection Systems B V BDS, Badhuisweg 3, 1031 CM Amsterdam, The Netherlands
Environ Toxicol Chem 23:2781-9. 2004..The results of this study are intended as a starting point for implementing the integrated chemical-biological assessment strategy and for systematic monitoring of dredged materials and related materials in the coming years... - An integrated assessment of estrogenic contamination and biological effects in the aquatic environment of The NetherlandsA Dick Vethaak
Institute for Coastal and Marine Management, P O Box 20907, 2500 EX The Hague, The Netherlands
Chemosphere 59:511-24. 2005.... - An in vitro/in vivo screening assay as a sensitive tool to assess endocrine disruptive activity in surface waterRinus Bogers
NOTOX B V, Hambakenwetering 7, 5231 DD s Hertogenbosch, The Netherlands
Environ Int 33:292-301. 2007..The other endpoints examined varied too much and required a higher number of fish or replicates to achieve sufficient power for statistical testing making them less animal friendly... - Comparison of in vivo and in vitro reporter gene assays for short-term screening of estrogenic activityJuliette Legler
Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht
Environ Sci Technol 36:4410-5. 2002..Zebrafish ERbeta and ERgamma showed higher transactivation by (xeno)estrogens relative to E2 than human ERbeta... - Estrogenic endpoints in fish early life-stage tests: luciferase and vitellogenin induction in estrogen-responsive transgenic zebrafishRinus Bogers
NOTOX Safety and Environmental Research, Hambakenwetering 7, 5231 DD s Hertogenbosch, The Netherlands
Environ Toxicol Chem 25:241-7. 2006..Additional value of using transgenic zebrafish lies in combining VTG measurement with the more mechanistic approach of luciferase induction in one experiment... - Estrogenic and esterase-inhibiting potency in rainwater in relation to pesticide concentrations, sampling season and locationTimo Hamers
Wageningen University-Toxicology Group, PO Box 8000, 6700 EA, The, Wageningen, Netherlands
Environ Pollut 123:47-65. 2003.... - Development of chronic tests for endocrine active chemicals. Part 2: an extended fish early-life stage test with an androgenic chemical in the fathead minnow (Pimephales promelas)Rinus Bogers
NOTOX Safety and Environmental Research, Hambakenwetering 7, 5231 DD s Hertogenbosch, The Netherlands
Aquat Toxicol 80:119-30. 2006..g., growth and SSC) required exposure during at least up to 63 dph to yield a significant effect. Androgenic effects on VTG production required even longer exposure, i.e., until sufficient number of females had matured...