Research Topics
Genomes and Genes | C Peter VerrijzerSummaryAffiliation: Erasmus MC Country: The Netherlands Publications
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Detail Information
Publications
EZH2-dependent chromatin looping controls INK4a and INK4b, but not ARF, during human progenitor cell differentiation and cellular senescenceSima Kheradmand Kia
Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Epigenetics Chromatin 2:16. 2009..Our results revealed a chromatin looping mechanism of long-range control and argue against models involving homogeneous spreading of PcG silencers across the INK4b-ARF-INK4a locus...
Biosynthetic enzyme GMP synthetase cooperates with ubiquitin-specific protease 7 in transcriptional regulation of ecdysteroid target genesJan A van der Knaap
Department of Biochemistry, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
Mol Cell Biol 30:736-44. 2010..These results revealed the cooperation between a biosynthetic enzyme and a ubiquitin protease in developmental gene control by hormone receptors...
Remodelers organize cellular chromatin by counteracting intrinsic histone-DNA sequence preferences in a class-specific mannerYuri M Moshkin
Department of Biochemistry and Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
Mol Cell Biol 32:675-88. 2012..We conclude that the cellular nucleosome landscape is the result of the balance between DNA sequence-driven nucleosome placement and active nucleosome repositioning by remodelers and the transcription machinery...
Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRDB Ashok Reddy
Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam, Netherlands
Mol Cell Biol 30:5234-44. 2010..Thus, there appears to be a hierarchical relationship in which transcription factor binding precedes remodeler recruitment...
Histone chaperones ASF1 and NAP1 differentially modulate removal of active histone marks by LID-RPD3 complexes during NOTCH silencingYuri M Moshkin
Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
Mol Cell 35:782-93. 2009..We conclude that histone chaperones ASF1 and NAP1 differentially modulate local chromatin structure during gene-selective silencing...
The transcriptional coactivator SAYP is a trithorax group signature subunit of the PBAP chromatin remodeling complexGillian E Chalkley
Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
Mol Cell Biol 28:2920-9. 2008..We conclude that SAYP is a signature subunit that plays a major role in the functional specificity of the PBAP holoenzyme...
dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencingAnna Lagarou
Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
Genes Dev 22:2799-810. 2008..Thus, dRAF removes an active mark from histone H3 and adds a repressive one to H2A. These findings reveal coordinate trans-histone regulation by a PcG complex to mediate gene repression...
SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locusSima Kheradmand Kia
Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
Mol Cell Biol 28:3457-64. 2008..Thus, various chromatin states can be modulated by SWI/SNF action. Collectively, these findings emphasize the close interconnectivity and dynamics of diverse chromatin modifications in cancer and gene control...
Deubiquitylating enzyme UBP64 controls cell fate through stabilization of the transcriptional repressor tramtrackPrashanth Kumar Bajpe
Department of Biochemistry, Erasmus University Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
Mol Cell Biol 28:1606-15. 2008..We conclude that the balance of TTK ubiquitylation by SINA and deubiquitylation by UBP64 constitutes a specific posttranslational switch controlling cell fate...
Functional differentiation of SWI/SNF remodelers in transcription and cell cycle controlYuri M Moshkin
Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
Mol Cell Biol 27:651-61. 2007..Our results suggest that the core subunits play architectural and enzymatic roles but that the signature subunits determine most of the functional specificity of SWI/SNF holoenzymes in general gene control...
