Research Topics
| Gianluca TrifiroSummaryAffiliation: Erasmus MC Country: The Netherlands Publications
| Collaborators
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Detail Information
Publications
Risk of cardiac valve regurgitation with dopamine agonist use in Parkinson's disease and hyperprolactinaemia: a multi-country, nested case-control studyGianluca Trifiro
Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
Drug Saf 35:159-71. 2012..Cases were patients who developed newly diagnosed CVR. Controls were CVR-free patients from the same cohorts and were matched to cases by age, sex, database and calendar year...- Risk of ischemic stroke associated with antidepressant drug use in elderly personsGianluca Trifiro
Department of Medical Informatics, Erasmus Medical Center, Rotterdam, The Netherlands
J Clin Psychopharmacol 30:252-8. 2010..To summarize, compared with nonuse, only SSRI use seems to be associated with an increased risk of ischemic stroke in elderly patients, particularly as a short-term effect... - Antipsychotic drug use and community-acquired pneumoniaGianluca Trifiro
Department of Medical Informatics, Erasmus University Medical Center, Dr Molewaterplein 50, 3000 DR, Rotterdam, The Netherlands
Curr Infect Dis Rep 13:262-8. 2011..Some general recommendations to clinicians are proposed to prevent the risk of pneumonia in patients requiring antipsychotic treatment... - Association of community-acquired pneumonia with antipsychotic drug use in elderly patients: a nested case-control studyGianluca Trifiro
Erasmus University Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Ann Intern Med 152:418-25, W139-40. 2010..However, epidemiologic evidence of the association between antipsychotic drug use and pneumonia is limited... - Prescribing pattern of antipsychotic drugs in the Italian general population 2000-2005: a focus on elderly with dementiaGianluca Trifiro
Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy
Int Clin Psychopharmacol 25:22-8. 2010..Similar trends were not observed in general population and elderly as a whole... - Data mining on electronic health record databases for signal detection in pharmacovigilance: which events to monitor?Gianluca Trifiro
Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
Pharmacoepidemiol Drug Saf 18:1176-84. 2009..Since mining on all possible events was considered to unduly increase the number of spurious signals, we wanted to create a ranked list of high-priority events... - Age-related changes in pharmacodynamics: focus on drugs acting on central nervous and cardiovascular systemsGianluca Trifiro
Department of Medical Informatics, Erasmus University Medical Center Dr Molewaterplein 50, 3000 DR, Rotterdam, The Netherlands
Curr Drug Metab 12:611-20. 2011..Clinicians should be aware of the age-related physiologic changes affecting several organ systems and their implications on the effect of drugs that are commonly prescribed to elderly patients... - EU-ADR healthcare database network vs. spontaneous reporting system database: preliminary comparison of signal detectionGianluca Trifiro
Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
Stud Health Technol Inform 166:25-30. 2011..The methodology for signal detection in EU-ADR is still under development and testing phase... - Prescribing pattern of anti-Parkinson drugs in Southern Italy: cross-sectional analysis in the years 2003-2005Gianluca Trifiro
Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria Gazzi, 98125 Messina, Italy
Parkinsonism Relat Disord 14:420-5. 2008..A high proportion of APD users (15-20%) received only one prescription during the study period... - Combining electronic healthcare databases in Europe to allow for large-scale drug safety monitoring: the EU-ADR ProjectPreciosa M Coloma
Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
Pharmacoepidemiol Drug Saf 20:1-11. 2011..In this proof-of-concept paper we describe the framework, process, and preliminary results of combining data from European electronic healthcare record (EHR) databases for large-scale monitoring of drug safety... - Use and tolerability of newer antipsychotics and antidepressants: a chart review in a paediatric settingMarianna Alacqua
Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria Gazzi, 98125 Messina, Italy
Pharm World Sci 30:44-50. 2008..To analyse the prescribing pattern and the safety profile of different atypical antipsychotics and selective serotonin reuptake inhibitors (SSRIs) during the years 2002-2003 in paediatric setting... - Antidepressant drugs: prevalence, incidence and indication of use in general practice of Southern Italy during the years 2003-2004Gianluca Trifiro
Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Messina, Italy
Pharmacoepidemiol Drug Saf 16:552-9. 2007..To estimate 1-year prevalence, 1-year incidence and indication of use of antidepressant (AD) drug treatment in general practice of Southern Italy during the years 2003-2004... - Prescribing pattern of drugs in the treatment of osteoarthritis in Italian general practice: the effect of rofecoxib withdrawalMarianna Alacqua
University of Messina, Messina, Italy
Arthritis Rheum 59:568-74. 2008..The aim of the present study was to compare the trend of nonsteroidal antiinflammatory drug (NSAID) use and other analgesics in osteoarthritis (OA) treatment before and after rofecoxib withdrawal in Italian general practice... - The risk of new onset heart failure associated with dopamine agonist use in Parkinson's diseaseM Mostafa Mokhles
Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands
Pharmacol Res 65:358-64. 2012..Among non-ergot dopamine agonists, we observed a statistically significant association between pramipexole use and heart failure, especially during the first months of therapy and in very old patients... - All-cause mortality associated with atypical and typical antipsychotics in demented outpatientsGianluca Trifiro
Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Italy
Pharmacoepidemiol Drug Saf 16:538-44. 2007..To estimate the association between use of typical and atypical antipsychotics and all-cause mortality in a population of demented outpatients... - Prescribing pattern of anti-epileptic drugs in an Italian setting of elderly outpatients: a population-based study during 2004-07Alessandro Oteri
Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Via Consolare Valeria, 98125 Messina, Italy
Br J Clin Pharmacol 70:514-22. 2010.... - Antipsychotic prescribing pattern among Italian general practitioners: a population-based study during the years 1999-2002Gianluca Trifiro
Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Messina, Via Consolare Valeria Gazzi, 98100 Messina, Italy
Eur J Clin Pharmacol 61:47-53. 2005..To assess the antipsychotic use and the prevalence/incidence of antipsychotic drug users in Italy during the years 1999-2002. To estimate the persistence with antipsychotic medications, and to measure their off-label use... - Use of antipsychotics in elderly patients with dementia: do atypical and conventional agents have a similar safety profile?Gianluca Trifiro
Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Italy
Pharmacol Res 59:1-12. 2009..More effective interventions are necessary to improve postmarket drug safety in vulnerable populations... - Suboptimal gastroprotective coverage of NSAID use and the risk of upper gastrointestinal bleeding and ulcers: an observational study using three European databasesEva M van Soest
Department of Medical Informatics, Erasmus University Medical Center, Postbus 2040, Rotterdam 3000 CA, The Netherlands
Gut 60:1650-9. 2011..09 to 3.28) for UGI bleeding alone, compared to full adherers. Conclusions The risk of UGI events was significantly higher in nsNSAID users with GPA non-adherence. This underlines the importance of strategies to improve GPA adherence... - Adverse drug events in emergency department population: a prospective Italian studyGianluca Trifiro
Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Messina, Messina, Italy
Pharmacoepidemiol Drug Saf 14:333-40. 2005..We therefore carried out a study to determine ADE incidence and ADE-related hospital admissions among emergency department (ED) visits, and to identify the risk factors for serious ADE leading to ED visit... - The EU-ADR project: preliminary results and perspectiveGianluca Trifiro
Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
Stud Health Technol Inform 148:43-9. 2009..The EU-ADR project aims to exploit different European electronic healthcare records (EHR) databases for drug safety signal detection. In this paper we describe the project framework and the preliminary results... - Interaction risk with proton pump inhibitors in general practice: significant disagreement between different drug-related information sourcesGianluca Trifiro
Department of Clinical and Experimental Medicine and Pharmacology, Pharmacology Unit, University of Messina, Messina, Italy
Br J Clin Pharmacol 62:582-90. 2006.... - Risk minimization activities of centrally authorized products in the EU: a descriptive studyInge M Zomerdijk
Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands
Drug Saf 35:299-314. 2012..This study describes the additional RMAs of centrally authorized medicinal products authorized between 1 January 1995 and 1 January 2010... - How much are biosimilars used in southern Italy?: a retrospective analysis of epoetin utilization in the local health unit of Messina in the years 2010-2011Chiara Loiacono
Department of Clinical and Experimental Medicine and Pharmacology, Unit of Pharmacology, University of Messina, Messina, Italy
BioDrugs 26:113-20. 2012..Epoetins are one of the three biologics for which biosimilars are available in Italy. So far, there is a lack of Italian national/regional longitudinal data about epoetin use... - Adverse drug reaction-related hospitalizations in persons aged 55 years and over: a population-based study in The NetherlandsRikje Ruiter
Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
Drugs Aging 29:225-32. 2012..However, a recent study conducted in the Netherlands found that ADR-related hospitalizations had stabilized during the years 1997-2007. Nonetheless, this study did not take into account the number of medicines used... - Clinically significant drug interactions with newer antidepressantsEdoardo Spina
Section of Pharmacology, Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy
CNS Drugs 26:39-67. 2012..Knowledge of the interaction potential of individual antidepressants is essential for safe prescribing and may help clinicians to predict and eventually avoid certain drug combinations...