Riccardo Fodde

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors
    Razvan L Miclea
    Department of Tissue Regeneration, Institute for Biomedical Technology, University of Twente, Enschede, The Netherlands
    BMC Dev Biol 9:26. 2009
  2. ncbi Smad4 haploinsufficiency: a matter of dosage
    Paola Alberici
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    Pathogenetics 1:2. 2008
  3. ncbi The stem of cancer
    Riccardo Fodde
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, The Netherlands
    Cancer Cell 15:87-9. 2009
  4. ncbi Nuclear beta-catenin expression and Wnt signalling: in defence of the dogma
    Riccardo Fodde
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    J Pathol 221:239-41. 2010
  5. ncbi Wnt/beta-catenin signaling in cancer stemness and malignant behavior
    Riccardo Fodde
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Curr Opin Cell Biol 19:150-8. 2007
  6. ncbi Stem cells and metastatic cancer: fatal attraction?
    Riccardo Fodde
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Med 3:e482. 2006
  7. ncbi Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis
    Claudia Gaspar
    Dept of Pathology, Erasmus MC, PO Box 2040, 3000CA Rotterdam, The Netherlands
    Am J Pathol 172:1363-80. 2008
  8. ncbi Chromosomal instability in MYH- and APC-mutant adenomatous polyps
    Joana Cardoso
    Department of Pathology, Josephine Nefkens Institute, Rotterdam, The Netherlands
    Cancer Res 66:2514-9. 2006
  9. ncbi A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis
    Claudia Gaspar
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    PLoS Genet 5:e1000547. 2009
  10. ncbi Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human
    Paola Alberici
    Department of Pathology, Josephine Nefkens Institute, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Am J Pathol 170:377-87. 2007

Collaborators

  • Hans Morreau
  • Judith M Boer
  • Ernst J Kuipers
  • Herman van Dekken
  • Thomas Brabletz
  • Lauri A Aaltonen
  • Jos Jonkers
  • Hugo W Tilanus
  • Ngoc H Le
  • Bas P L Wijnhoven
  • Winand N M Dinjens
  • Yongyi Wang
  • I P Tomlinson
  • Peter Hohenstein
  • Makoto Mark Taketo
  • Amit Agrawal
  • BORIS C R PASCHE
  • Antonio Di Cristofano
  • Claudia Gaspar
  • Ron Smits
  • Joana Cardoso
  • Patrick Franken
  • Lia Molenaar
  • Sabrina Roth
  • Paola Alberici
  • Wendy Van Veelen
  • Cor Breukel
  • Patrick F Franken
  • Brechtje A Grotenhuis
  • Lau Blonden
  • Martin A van der Valk
  • Joana Monteiro
  • Razvan L Miclea
  • Ramakrishnaiah Siddappa
  • Renee X de Menezes
  • Julian Sampson
  • Ugur Ozbek
  • Carla Rosenberg
  • Iris Nagtegaal
  • Yvonne M C Hendriks
  • Vladimir Bezrookove
  • Menno F Kielman
  • Cristina Albuquerque
  • Frits Meijlink
  • Werner Helvensteijn
  • Léon van Gurp
  • Myrte Theeuwes
  • Elvira R M Bakker
  • Andrea Sacchetti
  • J Jan B van Lanschot
  • Petra Sonneveld
  • Marcel Karperien
  • Berna Beverloo
  • Jan Maarten Wit
  • Robbert Rottier
  • Pinar Akçakaya
  • Tatsuya Kobayashi
  • Clemens Wgm Löwik
  • Ellen van Drunen
  • Henry M Kronenberg
  • Martin van der Valk
  • Geertje van der Horst
  • Cathy Aj Bosch
  • Els C Robanus-Maandag
  • Georges Rawadi
  • Lalini Raghoebir
  • Joyce Doorn
  • Linda van Rijn
  • Anouk Leusink
  • Ruud Licht
  • Anton Martens
  • Frank Janssen
  • Ingrid de Vries
  • Gabriela Möslein
  • Jan de Boer
  • Cristina Olivo
  • Marcin M Gorski
  • Clemens van Blitterswijk
  • Ari Ristimaki
  • Rodney J Scott
  • Jacqueline Bonten
  • Mieke Bevelander
  • Emma de Pater
  • Gerard C Grosveld
  • Sjozef van Baal
  • Kelli Boyd
  • Ayten Kandilci
  • Monique van Leerdam
  • Martijn H Breuning
  • Maurizio Genuardi

Detail Information

Publications28

  1. ncbi Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors
    Razvan L Miclea
    Department of Tissue Regeneration, Institute for Biomedical Technology, University of Twente, Enschede, The Netherlands
    BMC Dev Biol 9:26. 2009
    ..Adenomatous polyposis coli (Apc) is a key controller of beta-catenin turnover by down-regulating intracellular levels of beta-catenin...
  2. ncbi Smad4 haploinsufficiency: a matter of dosage
    Paola Alberici
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    Pathogenetics 1:2. 2008
    ..To date, the molecular and cellular consequences of SMAD4 haploinsufficiency on TGF-beta and BMP signaling and on genome-wide gene expression have not been investigated...
  3. ncbi The stem of cancer
    Riccardo Fodde
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, The Netherlands
    Cancer Cell 15:87-9. 2009
    ..Two recent publications provide experimental evidence that normal intestinal stem cells are the cells of origin of intestinal cancer in the mouse...
  4. ncbi Nuclear beta-catenin expression and Wnt signalling: in defence of the dogma
    Riccardo Fodde
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    J Pathol 221:239-41. 2010
    ....
  5. ncbi Wnt/beta-catenin signaling in cancer stemness and malignant behavior
    Riccardo Fodde
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Curr Opin Cell Biol 19:150-8. 2007
    ..Several intrinsic (cell-autonomous and/or autocrine) and extrinsic (paracrine, derived from the tumor microenvironment) factors may explain this heterogeneity of Wnt/beta-catenin signaling activity within the tumor mass...
  6. ncbi Stem cells and metastatic cancer: fatal attraction?
    Riccardo Fodde
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Med 3:e482. 2006
  7. ncbi Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis
    Claudia Gaspar
    Dept of Pathology, Erasmus MC, PO Box 2040, 3000CA Rotterdam, The Netherlands
    Am J Pathol 172:1363-80. 2008
    ....
  8. ncbi Chromosomal instability in MYH- and APC-mutant adenomatous polyps
    Joana Cardoso
    Department of Pathology, Josephine Nefkens Institute, Rotterdam, The Netherlands
    Cancer Res 66:2514-9. 2006
    ..The aneuploid changes detected at early stages of MYH-driven tumorigenesis may underlie accelerated tumor progression, increased cancer risk, and poor prognosis in MAP...
  9. ncbi A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis
    Claudia Gaspar
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    PLoS Genet 5:e1000547. 2009
    ..The striking phenotype of Apc(+/1572T) mice suggests that specific dosages of Wnt/beta-catenin signaling activity differentially affect tissue homeostasis and initiate tumorigenesis in an organ-specific fashion...
  10. ncbi Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human
    Paola Alberici
    Department of Pathology, Josephine Nefkens Institute, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Am J Pathol 170:377-87. 2007
    ....
  11. ncbi Quiescent stem cells in intestinal homeostasis and cancer
    Sabrina Roth
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    Cell Commun Adhes 18:33-44. 2011
    ..Because of their infrequent cycling, quiescent CSCs are refractory to chemo- and radiotherapy and are likely to play a role in tumour dissemination, dormancy and recurrence...
  12. ncbi Loss of APC function in mesenchymal cells surrounding the Müllerian duct leads to myometrial defects in adult mice
    Yongyi Wang
    Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Mol Cell Endocrinol 341:48-54. 2011
    ....
  13. ncbi Barrett's oesophageal adenocarcinoma encompasses tumour-initiating cells that do not express common cancer stem cell markers
    Brechtje A Grotenhuis
    Department of Surgery, Josephine Nefkens Institute, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Pathol 221:379-89. 2010
    ..However, antibodies directed against novel surface antigens are needed to detect subpopulations enriched for CSCs in EA by transplantation assays...
  14. ncbi APC dosage effects in tumorigenesis and stem cell differentiation
    Claudia Gaspar
    Dept. of Pathology, Josephine Nefkens Institute, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    Int J Dev Biol 48:377-86. 2004
    ..Hence, beta-catenin dosage-dependent effects may not only explain how a single pathway is involved in the development and homeostasis of different tissues, but also its pleiotrophic role in tumorigenesis...
  15. ncbi ?-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis
    Wendy Van Veelen
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, room L 63, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
    Gut 60:1204-12. 2011
    ..In addition, in contrast to the current belief that ?-catenin Y654 phosphorylation increases tumour progression to a more invasive phenotype, these results show that it rather increases tumour initiation by enhancing Wnt signalling...
  16. ncbi Generation of a tightly regulated doxycycline-inducible model for studying mouse intestinal biology
    Sabrina Roth
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    Genesis 47:7-13. 2009
    ..Thus, we have generated a novel doxycycline-inducible mouse model, providing a valuable tool to study the effect of different gene dosages on intestinal physiology and pathology...
  17. ncbi Cancer stemness and metastasis: therapeutic consequences and perspectives
    Joana Monteiro
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    Eur J Cancer 46:1198-203. 2010
    ....
  18. ncbi Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH
    Joana Cardoso
    Department of Pathology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
    Nucleic Acids Res 32:e146. 2004
    ....
  19. ncbi Morphological changes in tumour type after radiotherapy are accompanied by changes in gene expression profile but not in clinical behaviour
    Iris Nagtegaal
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    J Pathol 204:183-92. 2004
    ..It is concluded that tumour morphology equates to expression profile, but that external factors might influence both, leading to sub-optimal prognostication...
  20. ncbi cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo
    Ramakrishnaiah Siddappa
    Department of Tissue Regeneration, Institute for Biomedical Technology, University of Twente, 7500 AE, Enschede, The Netherlands
    Proc Natl Acad Sci U S A 105:7281-6. 2008
    ..As a consequence, PKA activation results in robust in vivo bone formation by hMSCs derived from orthopedic patients...
  21. ncbi SET-CAN, the product of the t(9;9) in acute undifferentiated leukemia, causes expansion of early hematopoietic progenitors and hyperproliferation of stomach mucosa in transgenic mice
    Ugur Ozbek
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Am J Pathol 171:654-66. 2007
    ....
  22. ncbi Somatic acquisition and signaling of TGFBR1*6A in cancer
    Boris Pasche
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, The Feinberg School of Medicine, Northwestern, University, Chicago, Ill 60611, USA
    JAMA 294:1634-46. 2005
    ..Epidemiological studies suggest that TGFBR1*6A may act as a tumor susceptibility allele. How TGFBR1*6A contributes to cancer development is largely unknown...
  23. ncbi Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillance
    Yvonne M C Hendriks
    Center of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Gastroenterology 127:17-25. 2004
    ..Hereditary nonpolyposis colorectal carcinoma (HNPCC) is caused by a mutated mismatch repair (MMR) gene. The aim of our study was to determine the cumulative risk of developing cancer in a large series of MSH6 mutation carriers...
  24. ncbi Premature chromosome condensation revisited: a novel chemical approach permits efficient cytogenetic analysis of cancers
    Vladimir Bezrookove
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Genes Chromosomes Cancer 38:177-86. 2003
    ....
  25. ncbi Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene
    Peter Hohenstein
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Genes Chromosomes Cancer 36:273-82. 2003
    ..Identification of a Smad4 mutation in the Sad mouse model provides further support for the involvement of the Smad genes, and thus the TGFB pathway, in the serrated/hyperplastic route to colorectal cancer...
  26. ncbi Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling
    Menno F Kielman
    Center for Human and Clinical Genetics, Leiden University Medical Center, Sylvius Laboratory, Wassenaarseweg 72, 2333 RA Leiden, The Netherlands
    Nat Genet 32:594-605. 2002
    ..Our results imply that constitutive activation of the Apc/beta-catenin signaling pathway results in differentiation defects in tissue homeostasis, and possibly underlies tumorigenesis in the colon and other self-renewing tissues...
  27. ncbi Cancer biology. A matter of dosage
    Riccardo Fodde
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, Netherlands
    Science 298:761-3. 2002
  28. ncbi The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade
    Cristina Albuquerque
    Centro de Investigacao de Patobiologia Molecular CIPM, Instituto Portugues de Oncologia Francisco Gentil, 1093 Lisbon, Portugal
    Hum Mol Genet 11:1549-60. 2002
    ..We propose that this selection process is aimed at a specific degree of beta-catenin signaling optimal for tumor formation, rather than at its constitutive activation by deletion of all of the beta-catenin downregulating motifs in APC...