J Heeney

Summary

Affiliation: Biomedical Primate Research Centre
Country: The Netherlands

Publications

  1. ncbi The critical role of CD4(+) T-cell help in immunity to HIV
    Jonathan Luke Heeney
    Department of Virology, Biomedical Primate Research Centre, P O Box 3306, 2280 GH Rijswijk, The Netherlands
    Vaccine 20:1961-3. 2002
  2. ncbi Requirement of diverse T-helper responses elicited by HIV vaccines: induction of highly targeted humoral and CTL responses
    Jonathan Luke Heeney
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Expert Rev Vaccines 3:S53-64. 2004
  3. ncbi Immune strategies utilized by lentivirus infected chimpanzees to resist progression to AIDS
    J Heeney
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Immunol Lett 51:45-52. 1996
  4. ncbi Zoonotic viral diseases and the frontier of early diagnosis, control and prevention
    J L Heeney
    Department of Virology, BPRC, Rijswijk, and the Department of Medical Microbiology, University of Leiden, Leiden, The Netherlands
    J Intern Med 260:399-408. 2006
  5. ncbi Origins of HIV and the evolution of resistance to AIDS
    Jonathan L Heeney
    Department of Virology, Biomedical Primate Research Centre, Rijswijk 2280 GH, Netherlands
    Science 313:462-6. 2006
  6. ncbi Transmission of simian immunodeficiency virus SIVcpz and the evolution of infection in the presence and absence of concurrent human immunodeficiency virus type 1 infection in chimpanzees
    Jonathan L Heeney
    Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 139, P O Box 3306, 2280 GH Rijswijk, The Netherlands
    J Virol 80:7208-18. 2006
  7. ncbi Immunological correlates of protection from HIV infection and disease
    Jonathan L Heeney
    Department of Virology, Biomedical Primate Research Centre, University of Leiden, The Netherlands
    Nat Immunol 7:1281-4. 2006
  8. ncbi A vaccine strategy utilizing a combination of three different chimeric vectors which share specific vaccine antigens
    J L Heeney
    Biomedical Primate Research Centre, Department of Virology, Rijswijk, The Netherlands
    J Med Primatol 29:268-73. 2000
  9. ncbi HIV-1 vaccine-induced immune responses which correlate with protection from SHIV infection: compiled preclinical efficacy data from trials with ten different HIV-1 vaccine candidates
    J Heeney
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Immunol Lett 66:189-95. 1999
  10. ncbi The role of type-1 and type-2 T-helper immune responses in HIV-1 vaccine protection
    J L Heeney
    Department of Virology, Biomedical Primate Research Center, Rijswijk, The Netherlands
    J Med Primatol 27:50-8. 1998

Collaborators

Detail Information

Publications13

  1. ncbi The critical role of CD4(+) T-cell help in immunity to HIV
    Jonathan Luke Heeney
    Department of Virology, Biomedical Primate Research Centre, P O Box 3306, 2280 GH Rijswijk, The Netherlands
    Vaccine 20:1961-3. 2002
    ..Protective T-helper responses were not skewed towards an IFN-gamma (Th1) or IL-4 (Th2) type response, but were balanced and characterised by the presence of a strong Ag-specific IL-2 response...
  2. ncbi Requirement of diverse T-helper responses elicited by HIV vaccines: induction of highly targeted humoral and CTL responses
    Jonathan Luke Heeney
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Expert Rev Vaccines 3:S53-64. 2004
    ..Our aim is to combine these with immunization strategies capable of eliciting potent cellular as well as humoral immune responses with the ultimate goal of providing mucosal barriers to HIV entry...
  3. ncbi Immune strategies utilized by lentivirus infected chimpanzees to resist progression to AIDS
    J Heeney
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Immunol Lett 51:45-52. 1996
    ....
  4. ncbi Zoonotic viral diseases and the frontier of early diagnosis, control and prevention
    J L Heeney
    Department of Virology, BPRC, Rijswijk, and the Department of Medical Microbiology, University of Leiden, Leiden, The Netherlands
    J Intern Med 260:399-408. 2006
    ..The monitoring and early diagnosis of these potential risks are overlapping frontiers of human and veterinary medicine. Here, current viral zoonotics and evolving threats are reviewed...
  5. ncbi Origins of HIV and the evolution of resistance to AIDS
    Jonathan L Heeney
    Department of Virology, Biomedical Primate Research Centre, Rijswijk 2280 GH, Netherlands
    Science 313:462-6. 2006
    ..Further understanding of host resistance factors and the mechanisms of disease in natural primate hosts may provide insight into unexplored therapeutic avenues for the prevention of AIDS...
  6. ncbi Transmission of simian immunodeficiency virus SIVcpz and the evolution of infection in the presence and absence of concurrent human immunodeficiency virus type 1 infection in chimpanzees
    Jonathan L Heeney
    Department of Virology, Biomedical Primate Research Centre, Lange Kleiweg 139, P O Box 3306, 2280 GH Rijswijk, The Netherlands
    J Virol 80:7208-18. 2006
    ....
  7. ncbi Immunological correlates of protection from HIV infection and disease
    Jonathan L Heeney
    Department of Virology, Biomedical Primate Research Centre, University of Leiden, The Netherlands
    Nat Immunol 7:1281-4. 2006
    ..These new insights may facilitate vaccine design and clinical evaluation...
  8. ncbi A vaccine strategy utilizing a combination of three different chimeric vectors which share specific vaccine antigens
    J L Heeney
    Biomedical Primate Research Centre, Department of Virology, Rijswijk, The Netherlands
    J Med Primatol 29:268-73. 2000
    ....
  9. ncbi HIV-1 vaccine-induced immune responses which correlate with protection from SHIV infection: compiled preclinical efficacy data from trials with ten different HIV-1 vaccine candidates
    J Heeney
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    Immunol Lett 66:189-95. 1999
    ..Immunity correlated with the magnitude of Nab responses, beta-chemokines and as well as balanced, qualitative T-helper responses...
  10. ncbi The role of type-1 and type-2 T-helper immune responses in HIV-1 vaccine protection
    J L Heeney
    Department of Virology, Biomedical Primate Research Center, Rijswijk, The Netherlands
    J Med Primatol 27:50-8. 1998
    ..These findings demonstrate the importance of both or mixed type-1 and type-2 Th responses in HIV-1 vaccine induced immunity while suggesting a possible role of persistent type-1 responses in maintaining protective immunity over time...
  11. ncbi Differences in early virus loads with different phenotypic variants of HIV-1 and SIV(cpz) in chimpanzees
    P ten Haaft
    Department of Virology, Biomedical Primate Research Centre, Rijswijk, The Netherlands
    AIDS 15:2085-92. 2001
    ..CONCLUSION: Infection of chimpanzees with NSI R5-utilizing isolates correlated with persistent viraemia (approximately 10(4) RNA equivalents/ml) in contrast to transient viraemia observed after infection with SI X4-utilizing isolates...
  12. ncbi Comparison of early plasma RNA loads in different macaque species and the impact of different routes of exposure on SIV/SHIV infection
    P ten Haaft
    Department of Virology, Biomedical Primate Research Center, Rijswijk, The Netherlands
    J Med Primatol 30:207-14. 2001
    ..v. routes of infection. In SHIV(89.6p)-infected macaques, no difference between species or between route of infection was observed with this particular chimeric virus...
  13. ncbi Characteristics of a pathogenic molecular clone of an end-stage serum-derived variant of simian immunodeficiency virus (SIV(F359))
    L Holterman
    Department of Virology, Biomedical Primate Research Centre, 2280 GH Rijswijk, The Netherlands
    J Virol 75:9328-38. 2001
    ....