Research Topics
| W WesterhofSummaryAffiliation: Academic Medical Center Country: The Netherlands Publications
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Detail Information
Publications
Hypermelanocytic guttate and macular segmental hypomelanosisW Westerhof
Netherlands Institute for Pigmentary Disorders, Amsterdam, The Netherlands
Br J Dermatol 151:701-5. 2004..It is paradoxical that a hypomelanotic macule shows a histological picture of an increase in normal functioning melanocytes. In all probability a deficient melanosome transfer is responsible for this unexpected phenomenon...- Generalized mottled pigmentation with postnatal skin blistering in three generationsWiete Westerhof
Netherlands Institute for Pigment Disorders, IWO Building, Academic Medical Center, Meibergdreef 35, 1105 AZ Amsterdam Zuidoost, The Netherlands
J Am Acad Dermatol 50:S65-9. 2004..Molecular biological investigation would be required to characterize the phenotype of this entity, which apparently was a mutation occurring in one family for three generations... - Propionibacterium acnes and the pathogenesis of progressive macular hypomelanosisWiete Westerhof
Netherlands Institute for Pigment Disorders, and the Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Arch Dermatol 140:210-4. 2004..We propose that a factor is produced by these strains of P acnes, which interfere with melanogenesis. Based on these observations, we are undertaking a clinical trial to find a treatment for this troubling, intractable disease... - The discovery of the human melanocyteWiete Westerhof
Netherlands Institute for Pigment Disorders, and Department of Dermatology Academic Medical Center, University of Amsterdam
Pigment Cell Res 19:183-93. 2006..The foundation established over the past 4000 yr is the basis for all current research into this fascinating cell type... - Treatment of acquired junctional melanocytic naevi by Q-switched and normal mode ruby laserW Westerhof
Netherlands Institute for Pigment Disorders and Department of Dermatology, IWO Building Academic Medical Centre, University of Amsterdam, Meibergdreef 35, The Netherlands
Br J Dermatol 148:80-5. 2003..Pigment laser treatment of benign pigmented lesions has shown a low potential for scarring by selectively targeting melanosomes in melanocytes and keratinocytes... - Mucopolysaccharides from psyllium involved in wound healingW Westerhof
Department of Dermatology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1005AZ Amsterdam, The Netherlands
Drugs Exp Clin Res 27:165-75. 2001.... - Evolutionary, biologic, and social aspects of skin colorWiete Westerhof
Color Foundation, Landsmeer, The Netherlands
Dermatol Clin 25:293-302, vii. 2007..Owing to its undeniable visibility, skin color has always had a sociologic connotation, which has up to the present time caused division between people... - Vitiligo puzzle: the pieces fall in placeWiete Westerhof
Color Foundation, Landsmeer, The Netherlands
Pigment Cell Res 20:345-59. 2007..A similar complex mechanism may also lead to some other autoimmune diseases... - Ultrastructural findings in progressive macular hypomelanosis indicate decreased melanin productionG N Relyveld
Netherlands Institute for Pigment Disorders, and Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Eur Acad Dermatol Venereol 22:568-74. 2008..The purpose of the study is to gain an insight into the pathogenesis of PMH... - Association of the Köbner phenomenon with disease activity and therapeutic responsiveness in vitiligo vulgarisM D Njoo
Netherlands Institute for Pigmentary Disorders, Academic Medical Centre, Amsterdam
Arch Dermatol 135:407-13. 1999..To investigate the association between the experimentally induced Kobner phenomenon (KP-e) and the Kobner phenomenon by history (KP-h), disease activity, and therapeutic responsiveness in vitiligo vulgaris... - The development of guidelines for the treatment of vitiligo. Clinical Epidemiology Unit of the Istituto Dermopatico dell'Immacolata-Istituto di Recovero e Cura a Carattere Scientifico (IDI-IRCCS) and the Archives of DermatologyM D Njoo
Netherlands Institute for Pigmentary Disorders, Academic Medical Center, University of Amsterdam
Arch Dermatol 135:1514-21. 1999..To develop and introduce evidence-based guidelines for the treatment of vitiligo in children and in adults... - Vitiligo. Pathogenesis and treatmentM D Njoo
Department of Dermatology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Am J Clin Dermatol 2:167-81. 2001..In widespread vitiligo, residual pigment can be removed by depigmentation agents. Sunscreens, camouflage products, and good guidance may help the patient cope better with the disease... - A systematic review of autologous transplantation methods in vitiligoM D Njoo
Netherlands Institute for Pigmentary Disorders, University of Amsterdam, The Netherlands
Arch Dermatol 134:1543-9. 1998..A systematic review of the effectiveness, safety, and applicability of autologous transplantation methods in vitiligo... - Treatment of vitiligo with UV-B radiation vs topical psoralen plus UV-AW Westerhof
The Netherlands Institute for Pigmentary Disorders, Amsterdam, The Netherlands
Arch Dermatol 133:1525-8. 1997..To compare the efficacy and safety of 2 treatment modalities, topical psoralen plus UV-A (PUVA) with unsubstituted psoralen and 311-nm UV-B radiation, in patients with vitiligo... - Repigmentation of leucodermic defects in piebaldism by dermabrasion and thin split-thickness skin grafting in combination with minigraftingM D Njoo
Netherlands Institute for Pigmentary Disorders, Academic Medical Centre, Amsterdam
Br J Dermatol 139:829-33. 1998..Complications were minor and easy to correct. Dermabrasion and split-skin grafting followed by minigrafting should be considered as the first choice of therapy in piebaldism... - Nonsurgical repigmentation therapies in vitiligo. Meta-analysis of the literatureM D Njoo
Netherlands Institute for Pigmentary Disorders, University of Amsterdam, The Netherlands
Arch Dermatol 134:1532-40. 1998..To assess the effectiveness and safety of nonsurgical repigmentation therapies in localized and generalized vitiligo by means of a meta-analysis... - UVB 311 nm tolerance of vitiligo skin increases with skin photo typeAnne Lou D B Caron-Schreinemachers
Netherlands Institute for Pigment Disorders, Amsterdam, The Netherlands
Acta Derm Venereol 85:24-6. 2005..We suggest that there must be a protection mechanism, other than that offered by melanin pigmentation. The antioxidant status may play a role in this phenomenon... - Treatment of vitiligo vulgaris with narrow-band UVB and oral Polypodium leucotomos extract: a randomized double-blind placebo-controlled studyM A Middelkamp-Hup
Netherlands Institute for Pigment Disorders, Department of Dermatology, Academic Medical Center, 1100 DD Amsterdam, The Netherlands
J Eur Acad Dermatol Venereol 21:942-50. 2007..The first choice treatment for vitiligo vulgaris is narrow-band UVB (NB-UVB), but no satisfactory treatment exists... - A new psoralen-containing gel for topical PUVA therapy: development, and treatment results in patients with palmoplantar and plaque-type psoriasis, and hyperkeratotic eczemaM A De Rie
Academic Medical Center, University of Amsterdam, Department of Dermatology, The Netherlands
Br J Dermatol 132:964-9. 1995.... - Aberrant expression of complement regulatory proteins, membrane cofactor protein and decay accelerating factor, in the involved epidermis of patients with vitiligoR M J G J van den Wijngaard
Department of Pathology (Room L-2-258, Academic Medical Centre, Amsterdam University, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Br J Dermatol 146:80-7. 2002.... - Progressive macular hypomelanosis: an overviewGermaine N Relyveld
The Netherlands Institute for Pigment Disorders, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Am J Clin Dermatol 8:13-9. 2007..There is insufficient information available as yet to comment on the recurrence rate after therapy... - Quantitative and objective evaluation of wound debriding properties of collagenase and fibrinolysin/desoxyribonuclease in a necrotic ulcer animal modelJ R Mekkes
Department of Dermatology, Academic Medical Center, University of Amsterdam, The Netherlands
Arch Dermatol Res 290:152-7. 1998..We conclude that collagenase is a suitable enzyme for wound debridement, but we were not able to detect clinical efficacy of fibrinolysin/DNAse in this model... - Benzoyl peroxide/clindamycin/UVA is more effective than fluticasone/UVA in progressive macular hypomelanosis: a randomized studyGermaine N Relyveld
Netherlands Institute for Pigment Disorders, Amsterdam, The Netherlands
J Am Acad Dermatol 55:836-43. 2006..CONCLUSION: Antimicrobial therapy in conjunction with light was more effective in repigmentation in patients with progressive macular hypomelanosis than a combination of anti-inflammatory therapy and light... - Difference in pathogenesis between vitiligo vulgaris and halo nevi associated with vitiligo is supported by an HLA association studyHannah C de Vijlder
Netherlands Institute for Pigment Disorders, Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Pigment Cell Res 17:270-4. 2004..083, P(u) = 0.0067). In conclusion, the differences in HLA association within clinical subtypes of vitiligo support our suggestion that vitiligo vulgaris and halo nevi associated with vitiligo have distinct pathogenic mechanisms... - Gene expression patterns in melanocytic cells: candidate markers for early stage and malignant transformationClifton B Meije
Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands
J Pathol 196:51-8. 2002..The Ras-related protein Rab5b showed lower levels of expression in highly metastatic than in other melanoma cells. These three cDNAs may therefore be involved in the early stage and malignant transformation of melanocytes... - Noninvasive techniques for the evaluation of skin colorSusan Taylor
Department of Dermatology, Columbia University, St Luke s Roosevelt Hospital Center, New York, NY, USA
J Am Acad Dermatol 54:S282-90. 2006..Dermoscopy is also useful for the differential diagnosis of benign melanocytic lesions and melanoma, and its use has been shown to significantly improve diagnostic accuracy... - Safety and efficacy of combined use of 4-hydroxyanisole (mequinol) 2%/tretinoin 0.01% solution and sunscreen in solar lentiginesJean Paul Ortonne
Hopital de l Archet, Service de Dermatologie, Rte Saint Antoine de Ginestière 151, 06002 Nice Cedex 03, France
Cutis 74:261-4. 2004..Our study shows that the mequinol 2%/tretinoin 0.01% solution is effective, convenient, and safe in the treatment of solar lentigines... - Increased epidermal functioning wild-type p53 expression in vitiligoKarin U Schallreuter
Clinical and Experimental Dermatology, Department of Biomedical Sciences, University of Bradford, West Yorkshire, UK
Exp Dermatol 12:268-77. 2003..Based on our results we hypothesize that the low incidence for actinic damage, basal cell and squamous cell carcinoma as documented in vitiligo could well reside in a protective function of up-regulated wild-type p53...