G N J Tytgat

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi Review article: treatment of mild and severe cases of GERD
    G N J Tytgat
    Academic Medical Center, Department of Gastroenterology and Hepatology, Amsterdam Zuidoost, The Netherlands
    Aliment Pharmacol Ther 16:73-8. 2002
  2. ncbi Acute upper GI bleeding: did anything change? Time trend analysis of incidence and outcome of acute upper GI bleeding between 1993/1994 and 2000
    M E van Leerdam
    Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands
    Am J Gastroenterol 98:1494-9. 2003
  3. ncbi Differences and similarities of adenocarcinomas of the esophagus and esophagogastric junction
    W A Marsman
    Departments of Surgery and Gastroenterology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Surg Oncol 92:160-8. 2005
  4. ncbi Are there unmet needs in acid suppression?
    G N J Tytgat
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Best Pract Res Clin Gastroenterol 18:67-72. 2004
  5. ncbi Lack of accuracy of the noninvasive Helicobacter pylori stool antigen test in patients with gastroduodenal ulcer bleeding
    M E van Leerdam
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Am J Gastroenterol 98:798-801. 2003
  6. ncbi Cancer of the esophagus and gastric cardia: recent advances
    G N J Tytgat
    Academic Medical Centre, Amsterdam, NL
    Dis Esophagus 17:10-26. 2004
  7. ncbi [The effect of Helicobacter pylori eradication on chronic use of acid-suppressant medication by patients in general practice; a randomised, double-blind study]
    G J B Hurenkamp
    Academisch Medisch Centrum Universiteit van Amsterdam, Meibergdreef 9, 11 05 AZ, Amsterdam
    Ned Tijdschr Geneeskd 148:2390-6. 2004
  8. ncbi Report of an Amsterdam working group on Barrett esophagus
    G J A Offerhaus
    Department of Pathology, Academic Medical Center Amsterdam, The Netherlands
    Virchows Arch 443:602-8. 2003
  9. ncbi More pathophysiologically oriented treatment of GORD?
    G E Boeckxstaens
    Department of Gastroenterology and Hepatology, Academic Medical Centre, 1105 AZ Amsterdam, The Netherlands
    Lancet 359:1267-8. 2002
  10. ncbi Efficacy and safety of oral ridogrel in the treatment of ulcerative colitis: two multicentre, randomized, double-blind studies
    G N J Tytgat
    Academisch Medisch Centrum, Amsterdam Zuidoost, The Netherlands
    Aliment Pharmacol Ther 16:87-99. 2002

Detail Information

Publications33

  1. ncbi Review article: treatment of mild and severe cases of GERD
    G N J Tytgat
    Academic Medical Center, Department of Gastroenterology and Hepatology, Amsterdam Zuidoost, The Netherlands
    Aliment Pharmacol Ther 16:73-8. 2002
    ..After this time, an attempt should be made to reduce the dose. A plan should be formulated for long-term treatment...
  2. ncbi Acute upper GI bleeding: did anything change? Time trend analysis of incidence and outcome of acute upper GI bleeding between 1993/1994 and 2000
    M E van Leerdam
    Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands
    Am J Gastroenterol 98:1494-9. 2003
    ..The incidence rate of ulcer bleeding remained stable. Prevention of ulcer bleeding is important...
  3. ncbi Differences and similarities of adenocarcinomas of the esophagus and esophagogastric junction
    W A Marsman
    Departments of Surgery and Gastroenterology, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Surg Oncol 92:160-8. 2005
    ..Special attention will be given to differences and similarities of adenocarcinomas of the gastric cardia and distal esophagus...
  4. ncbi Are there unmet needs in acid suppression?
    G N J Tytgat
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Best Pract Res Clin Gastroenterol 18:67-72. 2004
    ..Moreover, rebound acid secretion after abrupt stopping of PPI therapy may favour early symptomatic relapse, necessating step-down therapy to prevent prolongation of the need of acid suppression...
  5. ncbi Lack of accuracy of the noninvasive Helicobacter pylori stool antigen test in patients with gastroduodenal ulcer bleeding
    M E van Leerdam
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Am J Gastroenterol 98:798-801. 2003
    ..The HpSA test is not accurate for testing H. pylori infection in patients with PUB...
  6. ncbi Cancer of the esophagus and gastric cardia: recent advances
    G N J Tytgat
    Academic Medical Centre, Amsterdam, NL
    Dis Esophagus 17:10-26. 2004
    ....
  7. ncbi [The effect of Helicobacter pylori eradication on chronic use of acid-suppressant medication by patients in general practice; a randomised, double-blind study]
    G J B Hurenkamp
    Academisch Medisch Centrum Universiteit van Amsterdam, Meibergdreef 9, 11 05 AZ, Amsterdam
    Ned Tijdschr Geneeskd 148:2390-6. 2004
    ..To study the feasibility of tapering long-term acid-suppressant drugs (ASD) use in chronic dyspeptic patients in relation to Helicobacter pylori eradication...
  8. ncbi Report of an Amsterdam working group on Barrett esophagus
    G J A Offerhaus
    Department of Pathology, Academic Medical Center Amsterdam, The Netherlands
    Virchows Arch 443:602-8. 2003
  9. ncbi More pathophysiologically oriented treatment of GORD?
    G E Boeckxstaens
    Department of Gastroenterology and Hepatology, Academic Medical Centre, 1105 AZ Amsterdam, The Netherlands
    Lancet 359:1267-8. 2002
  10. ncbi Efficacy and safety of oral ridogrel in the treatment of ulcerative colitis: two multicentre, randomized, double-blind studies
    G N J Tytgat
    Academisch Medisch Centrum, Amsterdam Zuidoost, The Netherlands
    Aliment Pharmacol Ther 16:87-99. 2002
    ..Ridogrel at low doses inhibits thromboxane synthase. Oral ridogrel, from 5 mg once daily to 150 mg twice daily, improves the endoscopic appearance of colonic mucosa and clinical manifestations in mild to moderate ulcerative colitis...
  11. ncbi Reflections on the future of gastroenterology--unmet needs
    G N J Tytgat
    Academic Medical Center, Amsterdam, The Netherlands
    Adv Med Sci 52:7-10. 2007
  12. ncbi New developments in the endoscopic surveillance of Barrett's oesophagus
    J J G H M Bergman
    Department of Gastroenterology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands
    Gut 54:i38-42. 2005
    ....
  13. ncbi Review article: Helicobacter pylori infection in peptic ulcer haemorrhage
    M E van Leerdam
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Aliment Pharmacol Ther 16:66-78. 2002
    ..The success of eradication should always be confirmed because of the risk of recurrence of peptic ulcer disease and bleeding in H. pylori-infected patients...
  14. ncbi Gastrin (G) cells and somatostatin (D) cells in patients with dyspeptic symptoms: Helicobacter pylori associated and non-associated gastritis
    Y Liu
    Department of Pathology, Academic Medical Centre, University of Amsterdam, 1100 DD Amsterdam, The Netherlands
    J Clin Pathol 58:927-31. 2005
    ..Gastrin G cells and somatostatin D cells are important regulators of gastric acid secretion and alterations in their relative numbers may play a key role in gastroduodenal disease...
  15. ncbi Review article: management of mild and severe gastro-oesophageal reflux disease
    G N J Tytgat
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Aliment Pharmacol Ther 17:52-6. 2003
    ....
  16. ncbi How do primary care physicians use long-term acid suppressant drugs? A population-based analysis of Dutch general practices
    G J B Hurenkamp
    Dept of General Practice, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Fam Pract 51:241-5. 2002
    ..We investigated the magnitude of long-term prescription of acid suppressant drugs in general practice and the frequency and means of confirming the primary working diagnosis...
  17. ncbi Natural history of primary sclerosing cholangitis and prognostic value of cholangiography in a Dutch population
    C Y Ponsioen
    Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands
    Gut 51:562-6. 2002
    ..Median survival of patients with primary sclerosing cholangitis (PSC) has been estimated to be 12 years. Cholangiography is the gold standard for diagnosis but is rarely used in estimating prognosis...
  18. ncbi Pancreatic cancer after remote peptic ulcer surgery
    M Tascilar
    Department of Pathology, Academic Medical Center, University of Amsterdam, 1105 AZ, Amsterdam, The Netherlands
    J Clin Pathol 55:340-5. 2002
    ..However, the neoplastic process in patients who have undergone gastrectomy appears to be accelerated by factors related to the surgery itself...
  19. ncbi Gastric hypersensitivity induced by oesophageal acid infusion in healthy volunteers
    B D J van den Elzen
    Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands
    Neurogastroenterol Motil 21:160-9. 2009
    ..It should be emphasized though that aspiration from distal oesophagus may have attenuated the effect by reducing the acid-exposed area or by reducing the contact time...
  20. ncbi Role of endoscopy and biopsy in the work up of dyspepsia
    G N J Tytgat
    Department of Gastroenterology and Hepatology, Academic Medical Center, 9 Moibergdreef, 1105 AZ Amsterdam, The Netherlands
    Gut 50:iv13-6. 2002
    ..Although the correlation between mucosal alterations and symptom pattern is difficult, endoscopy will remain the initial investigation of choice for clinically relevant abnormalities that need proper detection and biopsy...
  21. ncbi A prospective randomized study of hydrophilic polymer-coated polyurethane versus polyethylene stents in distal malignant biliary obstruction
    A M van Berkel
    Dept of Gastroenterology and Hepatology C2 220, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Endoscopy 35:478-82. 2003
    ..We compared the patency rates with this new stent with the standard Amsterdam-type polyethylene (PE) stent in a prospective randomized trial...
  22. ncbi Effect of prolonged gastric distention on lower esophageal sphincter function and gastroesophageal reflux
    D P Hirsch
    Division of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Am J Gastroenterol 98:1696-704. 2003
    ..In addition, prolonged balloon distention increased the rate of TLESRs and created a postprandial state even 10 wk after balloon placement. After 20 wk these effects largely resolved, illustrating adaptation to this artificial situation...
  23. ncbi Role of nitric oxide in gastric motor and sensory functions in healthy subjects
    S D Kuiken
    Department of Gastroenterology and Hepatology, Academic Medical Centre Amsterdam, The Netherlands
    Gut 51:212-8. 2002
    ..Perception scores to gastric distension were not altered by L-NMMA. CONCLUSIONS: NO is involved in maintaining basal fundic tone and in meal induced fundic relaxation in humans, but not in visceral perception...
  24. ncbi Treatment of GI dysmotility in scleroderma with the new enterokinetic agent prucalopride
    G E Boeckxstaens
    Division of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Am J Gastroenterol 97:194-7. 2002
    ..However, further placebo-controlled double blind studies are needed for full documentation of the usefulness of prucalopride in patients with scleroderma...
  25. ncbi Is glutamate involved in transient lower esophageal sphincter relaxations?
    D P Hirsch
    Division of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Dig Dis Sci 47:661-6. 2002
    ..These findings suggest that glutamate may be involved in the neurocircuitry underlying TLESRs. However, as the effect was only marginal, additional studies are required to confirm our observations...
  26. ncbi Long term results of pneumatic dilation in achalasia followed for more than 5 years
    R L West
    Department of Gastroenterology, Academic Medical Center, University of Amsterdam, The Netherlands
    Am J Gastroenterol 97:1346-51. 2002
    ..CONCLUSIONS: The long term success rate of pneumatic dilation is rather low, resulting in permanent successful treatment of achalasia in only 40-50% of patients. Achalasia is a risk factor for esophageal cancer...
  27. ncbi Radial distribution of dilated intercellular spaces of the esophageal squamous epithelium in patients with reflux disease exhibiting discrete endoscopic lesions
    M Vieth
    Institute of Pathology, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Dig Dis 22:208-12. 2004
    ..We have assessed dilatation of intercellular spaces with regard to: (1) interobserver variability, and (2) whether the incidence of this varies between 'red streaks' and the adjacent normal looking squamous epithelium...
  28. ncbi Treatment of gastro-oesophageal reflux disease with rabeprazole in primary and secondary care: does Helicobacter pylori infection affect proton pump inhibitor effectiveness?
    N J Wit
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Aliment Pharmacol Ther 20:451-8. 2004
    ..The presence of the gastric pathogen, Helicobacter pylori influences acid suppression by proton pump inhibitors and treatment outcome in patients with gastro-oesophageal reflux disease...
  29. ncbi Helicobacter pylori associated gastric diseases and lymphoid tissue hyperplasia in gastric antral mucosa
    X Y Chen
    Department of Pathology, Renji Hospital, Shanghai Second Medical University, Shanghai Institute of Digestive Disease, Shanghai 200001, China
    J Clin Pathol 55:133-7. 2002
    ..To investigate the relation between Helicobacter pylori associated gastroduodenal diseases and lymphoid tissue hyperplasia in the antral mucosa and to pursue its evolution after eradication of H pylori...
  30. ncbi Transient lower oesophageal sphincter relaxations--a pharmacological target for gastro-oesophageal reflux disease?
    D P Hirsch
    Academic Medical Centre, Division of Gastroenterology and Hepatology, Amsterdam, The Netherlands
    Aliment Pharmacol Ther 16:17-26. 2002
    ....
  31. ncbi The proximal stomach and postprandial symptoms in functional dyspeptics
    G E Boeckxstaens
    Am J Gastroenterol 97:40-8. 2002
    ..CONCLUSIONS: No clear relationship could be demonstrated between postprandial symptoms and proximal stomach function...
  32. ncbi Effect of the low-affinity, noncompetitive N-methyl-d-aspartate receptor antagonist dextromethorphan on visceral perception in healthy volunteers
    S D Kuiken
    Department of Gastroenterology and Heptalogy, Academic Medical Centre, Amsterdam, The Netherlands
    Aliment Pharmacol Ther 16:1955-62. 2002
    ..Therefore, application of dextromethorphan as a visceral analgesic is questionable. Future studies with more specific NMDA receptor antagonist are warranted...
  33. ncbi Racecadotril versus loperamide: antidiarrheal research revisited
    S Huighebaert
    Consultant Pharmaceutical Sciences, La Hulpe, Belgium
    Dig Dis Sci 48:239-50. 2003
    ..The conclusion is that more research is needed before reliable conclusions can be drawn on the place of racecadotril in diarrhea treatment...