Research Topics
Genomes and GenesSpecies | P C F StokkersSummaryAffiliation: Academic Medical Center Country: The Netherlands Publications
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Detail Information
Publications
Laparoscopic ileocolic resection versus infliximab treatment of distal ileitis in Crohn's disease: a randomized multicenter trial (LIR!C-trial)Emma J Eshuis
Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
BMC Surg 8:15. 2008..The objective of this study is to compare infliximab treatment with laparoscopic ileocolic resection in patients with recurrent Crohn's disease of the distal ileum with respect to quality of life and costs...
Vertebral deformities and inflammatory bowel diseasePieter C F Stokkers
Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
Eur J Gastroenterol Hepatol 20:819-21. 2008..We here discuss the latest insights into the pathogenesis of inflammatory bowel disease-related bone loss and the implications for treatment...
New cytokine therapeutics for inflammatory bowel diseaseP C F Stokkers
Department of Gastroenterology and Hepatology, C2 111, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
Cytokine 28:167-73. 2004..Antisense therapy targeting lymphocyte migration has also been tested in IBD. Finally, the conventional drug thalidomide and possibly MAP-kinase inhibitors may become novel treatment entities for IBD...
Intravenous pamidronate in combination with calcium and vitamin D: highly effective in the treatment of low bone mineral density in inflammatory bowel diseasePieter C F Stokkers
Department of Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands
Scand J Gastroenterol 41:200-4. 2006..We investigated whether intravenous pamidronate is a safe and effective treatment...
Colonoscopic surveillance improves survival after colorectal cancer diagnosis in inflammatory bowel diseaseM W M D Lutgens
Department of Gastroenterology and Hepatology, University Medical Center, 3584 CX Utrecht, The Netherlands
Br J Cancer 101:1671-5. 2009..Colonoscopic surveillance provides the best practical means for preventing colorectal cancer (CRC) in inflammatory bowel disease (IBD) patients. Strong evidence for improved survival from surveillance programmes is sparse...
Narrow-band imaging versus high-definition endoscopy for the diagnosis of neoplasia in ulcerative colitisF J C van den Broek
Department of Gastroenterology and Hepatology, Academic Medical Centre Amsterdam, The Netherlands
Endoscopy 43:108-15. 2011..We compared new-generation narrow-band imaging (NBI) to high-definition endoscopy (HDE) for the detection of neoplasia and evaluated NBI for the differentiation of neoplastic from non-neoplastic mucosa...
Pilot study of probe-based confocal laser endomicroscopy during colonoscopic surveillance of patients with longstanding ulcerative colitisF J C van den Broek
Department of Gastroenterology and Hepatology, Academic Medical Centre Amsterdam, The Netherlands
Endoscopy 43:116-22. 2011..The use of probe-based confocal laser endomicroscopy (pCLE) may increase efficiency. This prospective pilot study aimed to evaluate the feasibility and diagnostic accuracy of pCLE in ulcerative colitis surveillance...
More right-sided IBD-associated colorectal cancer in patients with primary sclerosing cholangitisM M H Claessen
Department of Gastroenterology and Hepatology, University Medical Center Utrecht, The Netherlands
Inflamm Bowel Dis 15:1331-6. 2009....
Molecular prediction of disease risk and severity in a large Dutch Crohn's disease cohortR K Weersma
Department of Gastroenterology and Hepatology, University Medical Center Groningen and University of Groningen, P O Box 30001, 9700 RB Groningen, The Netherlands
Gut 58:388-95. 2009..We assessed the risk for both the development and severity of the disease by combining information from genetic variants associated with inflammatory bowel disease (IBD)...
Long-term outcomes following laparoscopically assisted versus open ileocolic resection for Crohn's diseaseE J Eshuis
Departments of Surgery, Academic Medical Centre, Amsterdam, The Netherlands
Br J Surg 97:563-8. 2010..Long-term results of laparoscopically assisted versus open ileocolic resection for Crohn's disease were evaluated in a randomized trial...
An unusual bleeding duodenal ulcerB W M Spanier
Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
Gut 57:373, 382. 2008
Laparoscopic resection with transcolonic specimen extraction for ileocaecal Crohn's diseaseE J Eshuis
Department of Surgery, Academic Medical Centre, Amsterdam, The Netherlands
Br J Surg 97:569-74. 2010..However, an incision is needed for specimen extraction. This prospective observational study assessed the feasibility of endoscopic transcolonic specimen removal...
Immunogenicity negatively influences the outcome of adalimumab treatment in Crohn's diseaseR L West
Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Aliment Pharmacol Ther 28:1122-6. 2008..Adalimumab is an effective treatment in patients with Crohn's disease; as it is a humanized anti-tumour necrosis factor monoclonal antibody, immunogenicity is thought not to be of any significance...
Suicide attempt in ulcerative colitis patient after 4 months of infliximab therapy--a case reportE J Eshuis
Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
J Crohns Colitis 4:591-3. 2010..Although the time between start of IFX therapy and onset of symptoms could suggest a correlation, this, of course, does not prove that IFX was the causative factor for his depression and suicide attempt...
Endoscopic tri-modal imaging for surveillance in ulcerative colitis: randomised comparison of high-resolution endoscopy and autofluorescence imaging for neoplasia detection; and evaluation of narrow-band imaging for classification of lesionsF J C van den Broek
Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
Gut 57:1083-9. 2008..Endoscopic tri-modal imaging (ETMI) incorporates white light endoscopy (WLE), autofluorescence imaging (AFI) and narrow-band imaging (NBI)...
High frequency of early colorectal cancer in inflammatory bowel diseaseM W M D Lutgens
Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, The Netherlands
Gut 57:1246-51. 2008..Our aim was to assess the time interval between onset of inflammatory bowel disease (IBD) and colorectal carcinoma (CRC), and subsequently evaluate how many patients developed cancer before their surveillance was recommended to commence...
Pharmacogenetics of thiopurine therapy in paediatric IBD patientsL de Ridder
Department of Paediatric Gastroenterology, Emma Children s Hospital Academic Medical Center, Amsterdam, The Netherlands
Aliment Pharmacol Ther 23:1137-41. 2006..The occurrence and type of adverse events to azathioprine may be related to thiopurine S-methyltransferase (TPMT) enzyme activity and to inosine triphophate pyrophosphatase (ITPase) deficiency...
Do Inflammatory Bowel Disease patients with anxiety and depressive symptoms receive the care they need?F Bennebroek Evertsz'
Department of Medical Psychology, Academic Medical Center, Amsterdam, The Netherlands
J Crohns Colitis 6:68-76. 2012..The study was designed to examine the extent to which: (1) IBD patients with anxiety and/or depressive symptoms receive mental treatment and (2) clinical and socio-demographic variables are associated with these symptoms...
Detection of inflammatory bowel disease: diagnostic performance of cross-sectional imaging modalitiesKarin Horsthuis
Department of Radiology, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
Abdom Imaging 33:407-16. 2008....
Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppressionZuzana Zelinkova
Laboratory of Experimental Internal Medicine, Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
Clin Gastroenterol Hepatol 4:44-9. 2006..The aim of our study was to determine the relative contribution of ITPA and TPMT mutations to the development of toxicity induced by AZA treatment in IBD patients...
Genetic analysis of innate immunity in Crohn's disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAPAlexandra Zhernakova
Complex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
Am J Hum Genet 82:1202-10. 2008..21). Both genes are located in extended haplotype blocks on 2q11-2q12 and 9q34.3, respectively. Our results indicate two IBD loci and further support the importance of the innate immune system in the predisposition to both CD and UC...
Genetic susceptibility has a more important role in pediatric-onset Crohn's disease than in adult-onset Crohn's diseaseLissy de Ridder
Department of Pediatric Gastroenterology, VU University Medical Center, and Department of Pediatric Gastroenterology, Emma Children s Hospital Academic Medical Center, Amsterdam, The Netherlands
Inflamm Bowel Dis 13:1083-92. 2007..We aimed to determine genotypes and phenotypes of patients with pediatric-onset IBD, to compare them with those of patients with adult-onset IBD and with controls, and to identify genotype-phenotype associations...
