Research Topics
| R O SchlingemannSummaryAffiliation: Academic Medical Center Country: The Netherlands Publications
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Detail Information
Publications
Treatment of retinal diseases with VEGF antagonistsR O Schlingemann
Department of Ophthalmology, University of Amsterdam, Academic Medical Centre, Amsterdam, The Netherlands
Prog Brain Res 175:253-67. 2009..This review provides an overview of the history of anti-VEGF treatment in the eye, its rationale, its efficacy, and its potential drawbacks...- A shift in the balance of vascular endothelial growth factor and connective tissue growth factor by bevacizumab causes the angiofibrotic switch in proliferative diabetic retinopathyRob J Van Geest
Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Br J Ophthalmol 96:587-90. 2012..This study investigated whether anti-VEGF agents induce accelerated fibrosis in patients with PDR, as predicted by this model... - Advanced glycation end products cause increased CCN family and extracellular matrix gene expression in the diabetic rodent retinaJ M Hughes
Ocular Angiogenesis Group, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Diabetologia 50:1089-98. 2007..We hypothesised that pathological effects of AGEs in the diabetic retina are a consequence of AGE-induced alterations in CCN family expression... - [The practice guideline 'The red eye' (first revision) of the Dutch College of General Practitioners; a response from the perspective ofthe ophthalmologist]R O Schlingemann
Academisch Medisch Centrum Universiteit van Amsterdam, afd Oogheelkunde, Postbus 22 660, 1100 DD Amsterdam
Ned Tijdschr Geneeskd 151:1219-21. 2007..This is important in the light of the limited implementation of the previous guideline 'The red eye' published in 1996... - Role of growth factors and the wound healing response in age-related macular degenerationReinier O Schlingemann
Ocular Angiogenesis Group, Department of Ophthalmology, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
Graefes Arch Clin Exp Ophthalmol 242:91-101. 2004..RPE senescence and hypoxia may also decrease expression of angiogenesis inhibitors such as PEDF, further shifting the balance to a pro-angiogenic state in the aging eye... - [The practice guideline 'Refraction errors' from the Dutch College of General Practitioners: response from the perspective of ophthalmology]R O Schlingemann
Academisch Medisch Centrum Universiteit van Amsterdam, afd Oogheelkunde, Meibergdreef 9, 1105 AZ Amsterdam
Ned Tijdschr Geneeskd 146:1771-4. 2002..Due to these short-comings, the guideline may fail to provide optimal preventive and therapeutic eye care for the target group of patients concerned... - [Eye problems due to contact lenses; an advisory report from the Health Council of the Netherlands]R O Schlingemann
Academisch Medisch Centrum Universiteit van Amsterdam, afd Oogheelkunde, Meibergdreef 9, 1105 AZ Amsterdam
Ned Tijdschr Geneeskd 146:1616-9. 2002..Moreover, lens fitting and follow-up of contact lens wearers should be a prerequisite for optometrists and ophthalmologists. However, the Dutch government has not taken action with respect to this last recommendation... - VEGF-A induced hyperpermeability of blood-retinal barrier endothelium in vivo is predominantly associated with pinocytotic vesicular transport and not with formation of fenestrations. Vascular endothelial growth factor-AP Hofman
Department of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands
Curr Eye Res 21:637-45. 2000..This was further investigated in material of an in vivo experimental model of VEGF-induced retinopathy... - Role of VEGF-A in endothelial phenotypic shift in human diabetic retinopathy and VEGF-A-induced retinopathy in monkeysP Hofman
Ocular Angiogenesis Group, Department of Ophthalmology, Academic Medical Center, University of Amsterdam, The Netherlands
Ophthalmic Res 33:156-62. 2001..PAL-E expression may reflect important endothelial changes involved in the disturbance of the blood-retina barrier in DR... - Lack of blood-brain barrier properties in microvessels of the prelaminar optic nerve headP Hofman
Department of Ophthalmology, Academic Medical Center, University of Amsterdam, The Netherlands
Invest Ophthalmol Vis Sci 42:895-901. 2001..CONCLUSIONS: Microvessels in the prelaminar region of the ONH lack classical BBB characteristics and display nonspecific permeability, possibly mediated by vesicular transport... - Endothelial cell hypertrophy induced by vascular endothelial growth factor in the retina: new insights into the pathogenesis of capillary nonperfusionP Hofman
Department of Ophthalmology, Academic Medical Center, Amsterdam, The Netherlands
Arch Ophthalmol 119:861-6. 2001..In addition, VEGF-induced endothelial cell hypertrophy may be causative for capillary closure in these diseases... - Differential expression of connective tissue growth factor in microglia and pericytes in the human diabetic retinaE J Kuiper
Department of Ophthalmology, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
Br J Ophthalmol 88:1082-7. 2004..The results suggest a distinct, but as yet unidentified, role of CTGF in the pathogenesis of diabetic retinopathy... - Vascular localization of heparan sulfate proteoglycans in retinas of patients with diabetes mellitus and in VEGF-induced retinopathy using domain-specific antibodiesA N Witmer
Ocular Angiogenesis Group, Department of Ophthalmology, University of Amsterdam, Academic Medical Center, Amsterdam, The Netherlands
Curr Eye Res 22:190-7. 2001..These results suggest that the mechanism underlying retinal leakage is different from diabetic glomerular capillary leakage... - Added value of OCT in evaluating the presence of leakage in patients with age-related macular degeneration treated with PDTM E J van Velthoven
Department of Ophthalmology, Academic Medical Centre, Amsterdam, The Netherlands
Graefes Arch Clin Exp Ophthalmol 244:1119-23. 2006..Assuming that 57% of the patients without leakage either on FA or OCT would remain stable without retreatment, the rate of probable ineffective retreatment could be reduced from 35% to 20%... - Amadori albumin in type 1 diabetic patients: correlation with markers of endothelial function, association with diabetic nephropathy, and localization in retinal capillariesC G Schalkwijk
Department of Clinical Chemistry, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
Diabetes 48:2446-53. 1999..06 [1.01-1.11]) per U/ml increase. Our results are consistent with a proposed pathophysiological role of Amadori albumin in microvascular complications of type 1 diabetic patients... - Vascular endothelial growth factors and angiogenesis in eye diseaseA N Witmer
Ocular Angiogenesis Group, Department of Ophthalmology, University of Amsterdam, Amsterdam, The Netherlands
Prog Retin Eye Res 22:1-29. 2003..On the other hand, this paracrine relation and other physiological functions of VEGFs may be endangered by therapeutic VEGF inhibition, as is currently used in several clinical trials in DR and AMD... - [Screening for diabetic retinopathy]W W Hartstra
afd Inwendige Geneeskunde, Academisch Medisch Centrum Universiteit van Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam
Ned Tijdschr Geneeskd 151:228-33. 2007..The impact of screening programmes can be further improved by applying the optimal method and by initiating an active implementation strategy... - VEGFR-3 in adult angiogenesisA N Witmer
Ocular Angiogenesis Group, Department of Ophthalmology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
J Pathol 195:490-7. 2001..The expression of VEGFR-3 in VEGF-A-induced iris neovascularization and in pre-existing blood vessels exposed to VEGF-A suggests that this receptor and possibly its ligands are recruited in VEGF-A-driven angiogenesis... - Vascular leucocyte adhesion molecules unaltered in the human retina in diabetesJ M Hughes
Ocular Angiogenesis Group, Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Br J Ophthalmol 88:566-72. 2004..Taken together, these results do not support the prevalent paradigm of increased adhesion molecule expression as a primary mechanism responsible for capillary occlusion reported in diabetic individuals... - Longstanding symptomatic choroidal hemangioma managed with limited PDT as initial or salvage therapyF D Verbraak
Department of Opthalmology, Room D2 435, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
Graefes Arch Clin Exp Ophthalmol 241:891-8. 2003..To describe the use of limited, low-irradiance, single-spot photodynamic therapy (PDT) with verteporfin for the treatment of symptomatic choroidal hemangiomas... - [Routine funduscopic examination in hypertensive patients not useful]B J van den Born
afd Inwendige Geneeskunde, Academisch Medisch Centrum Universiteit van Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam
Ned Tijdschr Geneeskd 148:464-8. 2004..Therefore it should not be used as a routine diagnostic tool unless a hypertensive crisis is indicated... - Single spot PDT in patients with circumscribed choroidal haemangioma and near normal visual acuityF D Verbraak
Laser Centre, Academic Medical Centre, Amsterdam, The Netherlands
Graefes Arch Clin Exp Ophthalmol 244:1178-82. 2006..Therefore, we studied the use of limited, single spot photodynamic therapy (PDT) with Visudyne for the timely treatment of CCH... - Effect of sulodexide on endothelial glycocalyx and vascular permeability in patients with type 2 diabetes mellitusL N Broekhuizen
Department of Vascular Medicine, Academic Medical Centre, Room F4 211, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Diabetologia 53:2646-55. 2010..In the present study we set out to evaluate whether: (1) glycocalyx is perturbed in individuals with type 2 diabetes mellitus, and (2) oral glycocalyx precursor treatment improves glycocalyx properties... - Twenty years' delay of fellow eye involvement in herpes simplex virus type 2-associated bilateral acute retinal necrosis syndromeR O Schlingemann
Department of Ophthalmology, University of Amsterdam, The Netherlands
Am J Ophthalmol 122:891-2. 1996..To describe a case of acute retinal necrosis with concurrent encephalitis and determine the causative virus. The patient had a history of presumed acute retinal necrosis in the left eye at the age of 8 years and recurrent genital herpes... - Evaluation of central serous retinopathy with en face optical coherence tomographyM E J van Velthoven
Department of Ophthalmology, Academic Medical Centre, PO Box 22660, 1100 DD Amsterdam, Netherlands
Br J Ophthalmol 89:1483-8. 2005..The authors describe the characteristic features observed in patients with a clinical diagnosis of CSR using the OCT ophthalmoscope... - Immunohistochemical localization of vascular endothelial growth factor receptors-1, -2 and -3 in human spinal cord: altered expression in amyotrophic lateral sclerosisW G M Spliet
Department of (Neuro)Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Neuropathol Appl Neurobiol 30:351-9. 2004..Moreover, the altered expression observed in ALS supports a role for these receptors in the complex reactive processes that are associated with the progression of spinal cord damage... - Orbital irradiation for Graves' ophthalmopathy: Is it safe? A long-term follow-up studyIris M M J Wakelkamp
Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
Ophthalmology 111:1557-62. 2004..We evaluated the frequency of long-term complications of orbital irradiation (radiation-induced tumors, cataract, and retinopathy) in comparison with glucocorticoids... - Combined en-face optical coherence tomography and confocal ophthalmoscopy findings in active multifocal and serpiginous chorioretinitisMirjam E J van Velthoven
Department of Ophthalmology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Am J Ophthalmol 141:972-5. 2006..To describe retinal changes in active multifocal and serpiginous chorioretinitis seen with en-face optical coherence tomography (OCT)... - Value of routine funduscopy in patients with hypertension: systematic reviewBert Jan H van den Born
Department of Internal Medicine, Academic Medical Centre, PO 22660, 1100 DD Amsterdam, Netherlands
BMJ 331:73. 2005..To evaluate the additional value of funduscopy in the routine management of patients with hypertension... - START Trial: a pilot study on STimulation of ARTeriogenesis using subcutaneous application of granulocyte-macrophage colony-stimulating factor as a new treatment for peripheral vascular diseaseNiels van Royen
Department of Cardiology, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
Circulation 112:1040-6. 2005..Experimental models showed beneficial effects of GM-CSF on collateral artery growth in the peripheral circulation. Thus, in the present study, we evaluated the effects of GM-CSF in patients with peripheral artery disease... - Association of connective tissue growth factor with fibrosis in vitreoretinal disorders in the human eyeEsther J Kuiper
Ocular Angiogenesis Group, Department of Ophthalmology, University of Amsterdam, The Netherlands
Arch Ophthalmol 124:1457-62. 2006..CLINICAL RELEVANCE: Connective tissue growth factor may be a therapeutic target for prevention of sight-threatening vitreoretinal scarring in the eye... - Altered expression patterns of VEGF receptors in human diabetic retina and in experimental VEGF-induced retinopathy in monkeyAntonella N Witmer
Ocular Angiogenesis Group, Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
Invest Ophthalmol Vis Sci 43:849-57. 2002.... - Expression of vascular endothelial growth factor receptors 1, 2, and 3 in quiescent endotheliaAntonella N Witmer
Ocular Angiogenesis Group, Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Histochem Cytochem 50:767-77. 2002..One of these functions may be involvement of VEGF in paracrine relations between epithelia and adjacent capillaries... - Connective tissue growth factor is necessary for retinal capillary basal lamina thickening in diabetic miceEsther J Kuiper
Department of Cell Biology and Histology, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
J Histochem Cytochem 56:785-92. 2008..We conclude that CTGF expression is necessary for diabetes-induced BL thickening and suggest that reduction of CTGF levels may be protective against the development of diabetic retinopathy... - Diabetes changes ionotropic glutamate receptor subunit expression level in the human retinaAna R Santiago
Center for Neuroscience and Cell Biology, Department of Zoology, University of Coimbra, Coimbra, Portugal
Brain Res 1198:153-9. 2008..These results suggest that early visual dysfunction in diabetic patients may be due, at least partially, to changes in glutamate receptor subunit expression or distribution... - Effect of VEGF-A on expression of profibrotic growth factor and extracellular matrix genes in the retinaEsther J Kuiper
Ocular Angiogenesis Group, Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Invest Ophthalmol Vis Sci 48:4267-76. 2007..The authors hypothesize that VEGF directly contributes to BM thickening in the diabetic retina by inducing expression of profibrotic growth factors and extracellular matrix (ECM) components... - Angiogenesis is not impaired in connective tissue growth factor (CTGF) knock-out miceEsther J Kuiper
Ocular Angiogenesis Group, Department of Ophthalmology, Academic Medical Center, University of Amsterdam, The Netherlands
J Histochem Cytochem 55:1139-47. 2007..Our data show that downregulation of CTGF levels does not affect neovascularization, indicating distinct roles of VEGF and CTGF in angiogenesis and fibrosis in eye conditions... - Decreased optical coherence tomography-measured pericentral retinal thickness in patients with diabetes mellitus type 1 with minimal diabetic retinopathyCarine Biallosterski
Department of Ophthalmology, Academic Medical Centre, Amsterdam, The Netherlands
Br J Ophthalmol 91:1135-8. 2007..A comparison of retinal thickness (RT) measurements with optical coherence tomography (OCT) in patients with type 1 diabetes mellitus (DM) and no or minimal diabetic retinopathy (DR) versus healthy controls... - Aminopeptidase A is a functional target in angiogenic blood vesselsSerena Marchio
The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Cancer Cell 5:151-62. 2004..Finally, we successfully treated tumor-bearing mice with APA binding peptides or anti-APA blocking monoclonal antibodies. These data show that APA is a regulator of blood vessel formation, and can serve as a functional vascular target...