Pavlina Konstantinova

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi Trans-inhibition of HIV-1 by a long hairpin RNA expressed within the viral genome
    Pavlina Konstantinova
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 4:15. 2007
  2. ncbi Silencing of HIV-1 with RNA interference: a multiple shRNA approach
    Olivier Ter Brake
    Department of Human Retrovirology, University of Amsterdam, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    Mol Ther 14:883-92. 2006
  3. ncbi RNAi-mediated inhibition of HIV-1 by targeting partially complementary viral sequences
    Ying Poi Liu
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, The Netherlands
    Nucleic Acids Res 37:6194-204. 2009
  4. ncbi Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron
    Ying Poi Liu
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Nucleic Acids Res 36:2811-24. 2008
  5. ncbi Titers of lentiviral vectors encoding shRNAs and miRNAs are reduced by different mechanisms that require distinct repair strategies
    Ying Poi Liu
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    RNA 16:1328-39. 2010
  6. ncbi Optimization of shRNA inhibitors by variation of the terminal loop sequence
    Nick C T Schopman
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, The Netherlands
    Antiviral Res 86:204-11. 2010
  7. ncbi In vivo knock-down of multidrug resistance transporters ABCC1 and ABCC2 by AAV-delivered shRNAs and by artificial miRNAs
    Florie Borel
    Department of Research and Development, Amsterdam Molecular Therapeutics, Amsterdam, The Netherlands
    J RNAi Gene Silencing 7:434-42. 2011
  8. ncbi Hairpin-induced tRNA-mediated (HITME) recombination in HIV-1
    Pavlina Konstantinova
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Nucleic Acids Res 34:2206-18. 2006
  9. ncbi Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs
    Florie Borel
    Department of Research and Development, Amsterdam Molecular Therapeutics, Amsterdam, The Netherlands
    Hepatology 55:821-32. 2012
  10. ncbi Apolipoprotein B knockdown by AAV-delivered shRNA lowers plasma cholesterol in mice
    Annemart Koornneef
    Department of Research and Development, Amsterdam Molecular Therapeutics, Amsterdam, The Netherlands
    Mol Ther 19:731-40. 2011

Collaborators

Detail Information

Publications10

  1. ncbi Trans-inhibition of HIV-1 by a long hairpin RNA expressed within the viral genome
    Pavlina Konstantinova
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Retrovirology 4:15. 2007
    ..In order to solve this problem, we constructed an HIV-1 variant with a 300 bp long hairpin structure in the 3' part of the genome corresponding to the Nef gene (HIV-lhNef)...
  2. ncbi Silencing of HIV-1 with RNA interference: a multiple shRNA approach
    Olivier Ter Brake
    Department of Human Retrovirology, University of Amsterdam, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands
    Mol Ther 14:883-92. 2006
    ..These results confirm that RNAi has great potential as an antiviral gene therapy approach and support our efforts to develop this strategy for treatment of HIV-1-infected individuals...
  3. ncbi RNAi-mediated inhibition of HIV-1 by targeting partially complementary viral sequences
    Ying Poi Liu
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, The Netherlands
    Nucleic Acids Res 37:6194-204. 2009
    ..These data suggest that targeting imperfect target sites by antiviral miRNAs or shRNAs provides an alternative RNAi approach for inhibition of pathogenic viruses...
  4. ncbi Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron
    Ying Poi Liu
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Nucleic Acids Res 36:2811-24. 2008
    ..These combined results indicate that a multiplex miRNA strategy may be a promising therapeutic approach to attack escape-prone viral pathogens...
  5. ncbi Titers of lentiviral vectors encoding shRNAs and miRNAs are reduced by different mechanisms that require distinct repair strategies
    Ying Poi Liu
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    RNA 16:1328-39. 2010
    ..These results show that not all sequences are compatible with the lentiviral vector system and that care should be taken in the design of lentiviral vectors encoding RNAi inducers...
  6. ncbi Optimization of shRNA inhibitors by variation of the terminal loop sequence
    Nick C T Schopman
    Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, The Netherlands
    Antiviral Res 86:204-11. 2010
    ..The optimized shRNA loop sequence is generally applicable for RNAi knockdown studies, and will allow us to develop a more potent gene therapy against HIV-1...
  7. ncbi In vivo knock-down of multidrug resistance transporters ABCC1 and ABCC2 by AAV-delivered shRNAs and by artificial miRNAs
    Florie Borel
    Department of Research and Development, Amsterdam Molecular Therapeutics, Amsterdam, The Netherlands
    J RNAi Gene Silencing 7:434-42. 2011
    ..These results demonstrate the feasibility of knocking down Abbc2 via AAV-delivered shRNAs to the liver, and encourage the use of miRNA in further therapeutics development...
  8. ncbi Hairpin-induced tRNA-mediated (HITME) recombination in HIV-1
    Pavlina Konstantinova
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    Nucleic Acids Res 34:2206-18. 2006
    ..The transient role of the cellular tRNA molecule as enhancer of retroviral recombination is illustrated by the eventual removal of inserted tRNA sequences by a subsequent recombination/deletion event...
  9. ncbi Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs
    Florie Borel
    Department of Research and Development, Amsterdam Molecular Therapeutics, Amsterdam, The Netherlands
    Hepatology 55:821-32. 2012
    ..Up-regulation of five ABC genes appears to be mediated by 13 cellular miRNAs in HCC patient samples. miRNA-based gene therapy may be a novel and promising way to affect the ABC profile and overcome clinical multidrug resistance...
  10. ncbi Apolipoprotein B knockdown by AAV-delivered shRNA lowers plasma cholesterol in mice
    Annemart Koornneef
    Department of Research and Development, Amsterdam Molecular Therapeutics, Amsterdam, The Netherlands
    Mol Ther 19:731-40. 2011
    ..These results demonstrate a robust dose-dependent knockdown of ApoB by AAV-delivered shRNA in murine liver, thus providing an excellent candidate for development of RNAi-based gene therapy for the treatment of hypercholesterolemia...