Ingeborg Klaassen

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi Altered expression of genes related to blood-retina barrier disruption in streptozotocin-induced diabetes
    Ingeborg Klaassen
    Ocular Angiogenesis Group, Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Exp Eye Res 89:4-15. 2009
  2. ncbi Differential TGF-{beta} signaling in retinal vascular cells: a role in diabetic retinopathy?
    Rob J Van Geest
    Ocular Angiogenesis Group, Departments of Ophthalmology and Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Invest Ophthalmol Vis Sci 51:1857-65. 2010
  3. ncbi Effect of VEGF-A on expression of profibrotic growth factor and extracellular matrix genes in the retina
    Esther J Kuiper
    Ocular Angiogenesis Group, Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Invest Ophthalmol Vis Sci 48:4267-76. 2007
  4. ncbi Connective tissue growth factor is necessary for retinal capillary basal lamina thickening in diabetic mice
    Esther J Kuiper
    Department of Cell Biology and Histology, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Histochem Cytochem 56:785-92. 2008
  5. ncbi The angio-fibrotic switch of VEGF and CTGF in proliferative diabetic retinopathy
    Esther J Kuiper
    Ocular Angiogenesis Group, Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 3:e2675. 2008
  6. ncbi Active HIF-1 in the normal human retina
    John M Hughes
    Department of Ophthalmology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Histochem Cytochem 58:247-54. 2010
  7. ncbi A shift in the balance of vascular endothelial growth factor and connective tissue growth factor by bevacizumab causes the angiofibrotic switch in proliferative diabetic retinopathy
    Rob J Van Geest
    Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Br J Ophthalmol 96:587-90. 2012
  8. ncbi A novel co-culture model of the blood-retinal barrier based on primary retinal endothelial cells, pericytes and astrocytes
    Joanna Wisniewska-Kruk
    Ocular Angiogenesis Group, Departments of Ophthalmology and Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Exp Eye Res 96:181-90. 2012
  9. ncbi CD34 marks angiogenic tip cells in human vascular endothelial cell cultures
    Martin J Siemerink
    Ocular Angiogenesis Group, Department of Ophthalmology and Department of Cell Biology and Histology, University of Amsterdam, Academic Medical Center, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Angiogenesis 15:151-63. 2012
  10. ncbi Angiogenesis is not impaired in connective tissue growth factor (CTGF) knock-out mice
    Esther J Kuiper
    Ocular Angiogenesis Group, Department of Ophthalmology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Histochem Cytochem 55:1139-47. 2007

Collaborators

Detail Information

Publications10

  1. ncbi Altered expression of genes related to blood-retina barrier disruption in streptozotocin-induced diabetes
    Ingeborg Klaassen
    Ocular Angiogenesis Group, Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Exp Eye Res 89:4-15. 2009
    ....
  2. ncbi Differential TGF-{beta} signaling in retinal vascular cells: a role in diabetic retinopathy?
    Rob J Van Geest
    Ocular Angiogenesis Group, Departments of Ophthalmology and Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Invest Ophthalmol Vis Sci 51:1857-65. 2010
    ....
  3. ncbi Effect of VEGF-A on expression of profibrotic growth factor and extracellular matrix genes in the retina
    Esther J Kuiper
    Ocular Angiogenesis Group, Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Invest Ophthalmol Vis Sci 48:4267-76. 2007
    ..The authors hypothesize that VEGF directly contributes to BM thickening in the diabetic retina by inducing expression of profibrotic growth factors and extracellular matrix (ECM) components...
  4. ncbi Connective tissue growth factor is necessary for retinal capillary basal lamina thickening in diabetic mice
    Esther J Kuiper
    Department of Cell Biology and Histology, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
    J Histochem Cytochem 56:785-92. 2008
    ..We conclude that CTGF expression is necessary for diabetes-induced BL thickening and suggest that reduction of CTGF levels may be protective against the development of diabetic retinopathy...
  5. ncbi The angio-fibrotic switch of VEGF and CTGF in proliferative diabetic retinopathy
    Esther J Kuiper
    Ocular Angiogenesis Group, Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 3:e2675. 2008
    ..We hypothesize that the balance between levels of pro-angiogenic VEGF and pro-fibrotic CTGF regulates angiogenesis, the angio-fibrotic switch, and the resulting fibrosis and scarring...
  6. ncbi Active HIF-1 in the normal human retina
    John M Hughes
    Department of Ophthalmology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Histochem Cytochem 58:247-54. 2010
    ..In human retina, staining of VEGF, GLUT-1, and CAIX was found. Our observations indicate that active HIF-1 signaling occurs constitutively in the normal human and rat retina, suggesting that HIF-1 has a physiological role in the retina...
  7. ncbi A shift in the balance of vascular endothelial growth factor and connective tissue growth factor by bevacizumab causes the angiofibrotic switch in proliferative diabetic retinopathy
    Rob J Van Geest
    Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Br J Ophthalmol 96:587-90. 2012
    ..This study investigated whether anti-VEGF agents induce accelerated fibrosis in patients with PDR, as predicted by this model...
  8. ncbi A novel co-culture model of the blood-retinal barrier based on primary retinal endothelial cells, pericytes and astrocytes
    Joanna Wisniewska-Kruk
    Ocular Angiogenesis Group, Departments of Ophthalmology and Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Exp Eye Res 96:181-90. 2012
    ..This in vitro model is the first co-culture model of the BRB that mimicks in vivo VEGF-dependent changes occurring in DME...
  9. ncbi CD34 marks angiogenic tip cells in human vascular endothelial cell cultures
    Martin J Siemerink
    Ocular Angiogenesis Group, Department of Ophthalmology and Department of Cell Biology and Histology, University of Amsterdam, Academic Medical Center, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Angiogenesis 15:151-63. 2012
    ..This novel strategy may open alternative avenues for future studies of molecular processes and functions in tip cells in angiogenesis...
  10. ncbi Angiogenesis is not impaired in connective tissue growth factor (CTGF) knock-out mice
    Esther J Kuiper
    Ocular Angiogenesis Group, Department of Ophthalmology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Histochem Cytochem 55:1139-47. 2007
    ..Our data show that downregulation of CTGF levels does not affect neovascularization, indicating distinct roles of VEGF and CTGF in angiogenesis and fibrosis in eye conditions...