A Boelen

Summary

Affiliation: Academic Medical Center
Country: The Netherlands

Publications

  1. ncbi Effect of lack of Interleukin-4, Interleukin-12, Interleukin-18, or the Interferon-gamma receptor on virus replication, cytokine response, and lung pathology during respiratory syncytial virus infection in mice
    Anita Boelen
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Med Virol 66:552-60. 2002
  2. ncbi Complete Inhibition of rhTSH-, Graves' Disease IgG-, and M22-Induced cAMP Production in Differentiated Orbital Fibroblasts by a Low-Molecular-Weight TSHR Antagonist
    Clementine J J van Zeijl
    Academic Medical Center, Department of Endocrinology, F5 171 Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
    J Clin Endocrinol Metab 97:E781-5. 2012
  3. ncbi Leptin administration restores the fasting-induced increase of hepatic type 3 deiodinase expression in mice
    Anita Boelen
    1 Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thyroid 22:192-9. 2012
  4. ncbi Beyond low plasma T3: local thyroid hormone metabolism during inflammation and infection
    Anita Boelen
    Department of Endocrinology and Metabolism, F5 165, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands
    Endocr Rev 32:670-93. 2011
  5. ncbi Type 3 deiodinase expression in inflammatory spinal cord lesions in rat experimental autoimmune encephalomyelitis
    Anita Boelen
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thyroid 19:1401-6. 2009
  6. ncbi Thyroid hormone receptor ? mediates acute illness-induced alterations in central thyroid hormone metabolism
    A Boelen
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    J Neuroendocrinol 21:465-72. 2009
  7. ncbi Impaired bacterial clearance in type 3 deiodinase-deficient mice infected with Streptococcus pneumoniae
    Anita Boelen
    Department of Endocrinology and Metabolism, F5 165, Academic Medical Center, Amsterdam, The Netherlands
    Endocrinology 150:1984-90. 2009
  8. ncbi Type 3 deiodinase is highly expressed in infiltrating neutrophilic granulocytes in response to acute bacterial infection
    Anita Boelen
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thyroid 18:1095-103. 2008
  9. ncbi Chronic local inflammation in mice results in decreased TRH and type 3 deiodinase mRNA expression in the hypothalamic paraventricular nucleus independently of diminished food intake
    A Boelen
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Endocrinol 191:707-14. 2006
  10. ncbi Differential effects of leptin and refeeding on the fasting-induced decrease of pituitary type 2 deiodinase and thyroid hormone receptor beta2 mRNA expression in mice
    A Boelen
    Department of Endocrinology, Metabolism, F5 165, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Endocrinol 190:537-44. 2006

Collaborators

Detail Information

Publications32

  1. ncbi Effect of lack of Interleukin-4, Interleukin-12, Interleukin-18, or the Interferon-gamma receptor on virus replication, cytokine response, and lung pathology during respiratory syncytial virus infection in mice
    Anita Boelen
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Med Virol 66:552-60. 2002
    ..A shift in the balance between Th1 and Th2 towards a Th2 response induced by missing IFNgamma signalling leads to aggravated pulmonary pathology. This is not caused by enhanced viral load...
  2. ncbi Complete Inhibition of rhTSH-, Graves' Disease IgG-, and M22-Induced cAMP Production in Differentiated Orbital Fibroblasts by a Low-Molecular-Weight TSHR Antagonist
    Clementine J J van Zeijl
    Academic Medical Center, Department of Endocrinology, F5 171 Meibergdreef 9, Amsterdam 1105 AZ, The Netherlands
    J Clin Endocrinol Metab 97:E781-5. 2012
    ..Our results suggest that GD-IgG- and M22-induced cAMP production in differentiated OF is exclusively mediated via the TSHR because it can be completely blocked by the LMW TSHR antagonist, Org 274179-0...
  3. ncbi Leptin administration restores the fasting-induced increase of hepatic type 3 deiodinase expression in mice
    Anita Boelen
    1 Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thyroid 22:192-9. 2012
    ..The present study shows that fasting-induced changes in mRNA expression of genes involved in hepatic hormone metabolism are influenced not only by decreased serum thyroid hormone levels but also by serum leptin...
  4. ncbi Beyond low plasma T3: local thyroid hormone metabolism during inflammation and infection
    Anita Boelen
    Department of Endocrinology and Metabolism, F5 165, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands
    Endocr Rev 32:670-93. 2011
    ..This review focuses on NTIS as a timing-related and organ-specific response to illness, occurring independently from the decrease in serum thyroid hormone levels and potentially relevant for disease progression...
  5. ncbi Type 3 deiodinase expression in inflammatory spinal cord lesions in rat experimental autoimmune encephalomyelitis
    Anita Boelen
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thyroid 19:1401-6. 2009
    ..As induction of D3 may play an important role in decreasing local bioavailability of thyroid hormone at inflammation sites, we hypothesized that D3 is induced in spinal cord inflammatory lesions in EAE...
  6. ncbi Thyroid hormone receptor ? mediates acute illness-induced alterations in central thyroid hormone metabolism
    A Boelen
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    J Neuroendocrinol 21:465-72. 2009
    ..Our results suggest that TR? is involved in suppression of the central component of the hypothalamic-pituitary-thyroid axis in acute illness...
  7. ncbi Impaired bacterial clearance in type 3 deiodinase-deficient mice infected with Streptococcus pneumoniae
    Anita Boelen
    Department of Endocrinology and Metabolism, F5 165, Academic Medical Center, Amsterdam, The Netherlands
    Endocrinology 150:1984-90. 2009
    ..Our results suggest a protective role for D3 in the defense against acute bacterial infection, probably by reinforcing the microbial killing capacity of neutrophils...
  8. ncbi Type 3 deiodinase is highly expressed in infiltrating neutrophilic granulocytes in response to acute bacterial infection
    Anita Boelen
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thyroid 18:1095-103. 2008
    ..Our earlier studies showed that granulocytes express type 3 deiodinase (D3) when activated during a turpentine-induced abscess. We hypothesized that D3 expression by granulocytes may also occur during bacterial infection...
  9. ncbi Chronic local inflammation in mice results in decreased TRH and type 3 deiodinase mRNA expression in the hypothalamic paraventricular nucleus independently of diminished food intake
    A Boelen
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Endocrinol 191:707-14. 2006
    ..In conclusion, central thyroid hormone metabolism is altered during chronic inflammation and this cannot solely be attributed to diminished food intake...
  10. ncbi Differential effects of leptin and refeeding on the fasting-induced decrease of pituitary type 2 deiodinase and thyroid hormone receptor beta2 mRNA expression in mice
    A Boelen
    Department of Endocrinology, Metabolism, F5 165, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Endocrinol 190:537-44. 2006
    ..This indicates that other postingestion signals may be necessary to modulate rapidly the fasting-induced decrease in pituitary D2 and TRbeta2 mRNA expression...
  11. ncbi Contribution of interleukin-12 to the pathogenesis of non-thyroidal illness
    A Boelen
    Department of Endocrinology and Metabolism, F5 171 Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Horm Metab Res 36:101-6. 2004
    ..In conclusion, IL-12 is involved in the central regulation of the HPT axis during illness but not in the peripheral regulation...
  12. ncbi Simultaneous changes in central and peripheral components of the hypothalamus-pituitary-thyroid axis in lipopolysaccharide-induced acute illness in mice
    A Boelen
    Department of Endocrinology and Metabolism, F5 171, Academic Medical Center, Meibergdreef 9, Amsterdam, The Netherlands
    J Endocrinol 182:315-23. 2004
    ..Serum T(3) and T(4) fell only after 24 h. Our results suggested almost simultaneous involvement of the whole HPT axis in the downregulation of thyroid hormone metabolism during acute illness...
  13. ncbi Interleukin-18, a proinflammatory cytokine, contributes to the pathogenesis of non-thyroidal illness mainly via the central part of the hypothalamus-pituitary-thyroid axis
    Anita Boelen
    Department of Endocrinology, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Endocrinol 151:497-502. 2004
    ..IL-18 is a proinflammatory cytokine which shares important biological properties with IL-12, such as interferon (IFN)-gamma-inducing activity...
  14. ncbi Induction of type 3 deiodinase activity in inflammatory cells of mice with chronic local inflammation
    A Boelen
    Department of Endocrinology and Metabolism, Academic Medical Center, Amsterdam, The Netherlands
    Endocrinology 146:5128-34. 2005
    ..In conclusion, local inflammation strongly induces D3 activity in inflammatory cells, especially in invading polymorphonuclear granulocytes, suggesting enhanced local degradation of T(3)...
  15. ncbi Acute inflammation increases pituitary and hypothalamic glycoprotein hormone subunit B5 mRNA expression in association with decreased thyrotrophin receptor mRNA expression in mice
    C J J van Zeijl
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Neuroendocrinol 23:310-9. 2011
    ..The observed differences between GPB5(-/-) and WT mice point to a distinct role for GPB5 in pituitary and hypothalamic TSHR suppression during acute illness...
  16. ncbi Interleukin-1beta modulates endogenous thyroid hormone receptor alpha gene transcription in liver cells
    J Kwakkel
    Department of Endocrinology and Metabolism, Academic Medical Center F5 165, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Endocrinol 194:257-65. 2007
    ..Cycloheximide experiments showed that the decreased promoter activity is independent of de novo protein synthesis and therefore most likely due to posttranslational modifications such as phosphorylation or subcellular relocalization...
  17. ncbi Skeletal muscle deiodinase type 2 regulation during illness in mice
    J Kwakkel
    Department of Endocrinology and Metabolism Laboratory of Endocrinology, Department of Clinical Chemistry, Academic Medical Center, University of Amsterdam, F5 165, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Endocrinol 203:263-70. 2009
    ..In contrast, muscle D2 mRNA decreases 48 h after a severe bacterial infection, which is associated with local Il1b mRNA expression and might also be due to diminished food-intake...
  18. ncbi Lacking thyroid hormone receptor beta gene does not influence alterations in peripheral thyroid hormone metabolism during acute illness
    J Kwakkel
    Department of Endocrinology and Metabolism, Academic Medical Center University of Amsterdam, F5 165, Meibergdreef 9, 1105 AZ Amsterdam The Netherlands
    J Endocrinol 197:151-8. 2008
    ..Other (TRbeta independent) mechanisms like decreased thyroidal secretion and decreased binding to thyroid hormone-binding proteins probably play a role in the early decrease in serum T3 observed in this study...
  19. ncbi Illness-induced changes in thyroid hormone metabolism: focus on the tissue level
    J Kwakkel
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    Neth J Med 69:224-8. 2011
    ..In this review we discuss systemic and local changes in thyroid hormone metabolism during illness, highlighting their physiological implications in terms of disease course...
  20. ncbi Differential involvement of nuclear factor-kappaB and activator protein-1 pathways in the interleukin-1beta-mediated decrease of deiodinase type 1 and thyroid hormone receptor beta1 mRNA
    J Kwakkel
    Department of Endocrinology and Metabolism, Academic Medical Center F5 165, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Endocrinol 189:37-44. 2006
    ..The decrease of TRbeta1 mRNA is exclusively mediated by the NFkappaB pathway, while the decrease of D1 mRNA requires inhibition of both the AP-1 and the NFkappaB pathways...
  21. ncbi Determination of thyroid hormones and their metabolites in tissue using SPE UPLC-tandem MS
    M T Ackermans
    Department of Clinical Chemistry, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Biomed Chromatogr 26:485-90. 2012
    ..This method enables us to link thyroid hormone tissue concentrations to local iodothyronine deiodinase expressions, which will enhance our understanding of the regulation of thyroid hormone metabolism on the tissue level...
  22. ncbi Induced illness in interleukin-6 (IL-6) knock-out mice: a causal role of IL-6 in the development of the low 3,5,3'-triiodothyronine syndrome
    A Boelen
    Department of Endocrinology, Academic Medical Center, University of Amsterdam, The Netherlands
    Endocrinology 137:5250-4. 1996
    ..In conclusion, acutely induced illness generates the low T3 syndrome, which is less marked in IL-6 knock-out mice than in wild-type mice. The data suggest a causal role of IL-6 in the development of the low T3 syndrome...
  23. ncbi Thyroid hormone receptor {alpha} modulates lipopolysaccharide-induced changes in peripheral thyroid hormone metabolism
    Joan Kwakkel
    Ph D Student, Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, F5 165, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    Endocrinology 151:1959-69. 2010
    ..We conclude that alterations in peripheral thyroid hormone metabolism induced by LPS administration are partly regulated via TRalpha...
  24. ncbi Transient hypothyroxinemia in juvenile glycoprotein hormone subunit B5 knock-out mice
    Clementine J J van Zeijl
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Mol Cell Endocrinol 321:231-8. 2010
    ..Thus, lacking GPB5 results in moderate deviations of the HPT-axis. The more pronounced differences observed in juvenile mice compared to adult mice are in agreement with the notion that GPB5 has a role during development...
  25. ncbi Effects of thyrotropin and thyrotropin-receptor-stimulating Graves' disease immunoglobulin G on cyclic adenosine monophosphate and hyaluronan production in nondifferentiated orbital fibroblasts of Graves' ophthalmopathy patients
    Clementine J J van Zeijl
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thyroid 20:535-44. 2010
    ..We hypothesize that TSHR activation, via cAMP signaling, results in induction of HAS1-3 mRNA expression and HA production by nondifferentiated GO orbital fibroblasts...
  26. ncbi Thyrotropin receptor-stimulating Graves' disease immunoglobulins induce hyaluronan synthesis by differentiated orbital fibroblasts from patients with Graves' ophthalmopathy not only via cyclic adenosine monophosphate signaling pathways
    Clementine J J van Zeijl
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thyroid 21:169-76. 2011
    ....
  27. ncbi Fasting-induced changes in the hypothalamus-pituitary-thyroid axis
    Anita Boelen
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Thyroid 18:123-9. 2008
    ..The overall result of these complex HPT axis changes in various tissues during fasting is downregulation of the HPT axis, which is assumed to represent an energy-saving mechanism, instrumental in times of food shortage...
  28. ncbi Effects of thyrotoxicosis and selective hepatic autonomic denervation on hepatic glucose metabolism in rats
    Lars P Klieverik
    Academic Medical Center, Univ of Amsterdam, Dept of Endocrinology and Metabolism, F5 162, 1105 AZ Amsterdam, The Netherlands
    Am J Physiol Endocrinol Metab 294:E513-20. 2008
    ..Sympathetic hepatic innervation contributes only to a limited extent to increased EGP during thyrotoxicosis, whereas parasympathetic hepatic innervation may function to restrain EGP in this condition...
  29. ncbi Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver
    Lars P Klieverik
    Department of Endocrinology and Metabolism, Department of Clinical Chemistry, Laboratory of Endocrinology, Academic Medical Center, University of Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 106:5966-71. 2009
    ..This represents a unique central pathway for modulation of hepatic glucose metabolism by thyroid hormone...
  30. ncbi Optimal management of Graves orbitopathy: a multidisciplinary approach
    M R Soeters
    Departments of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    Neth J Med 69:302-8. 2011
    ....
  31. ncbi Hypothalamic thyroid hormone catabolism acts as a gatekeeper for the seasonal control of body weight and reproduction
    Perry Barrett
    Rowett Research Institute, Greenburn Road, Buckburn, Aberdeen AB21 9SB, United Kingdom
    Endocrinology 148:3608-17. 2007
    ..Collectively, these data point to a pivotal role for hypothalamic DIO3 and T(3) catabolism in seasonal cycles of body weight and reproduction in mammals...
  32. ncbi Respiratory syncytial virus enhances respiratory allergy in mice despite the inhibitory effect of virus-induced interferon-gamma
    Marion Barends
    Research Laboratory for Infectious Diseases, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    J Med Virol 69:156-62. 2003
    ..In contrast, IL-12 is not involved in inhibiting nor increasing the RSV-enhanced allergy in 129/Sv/Ev mice...