Research Topics
| Kasia StepniewskaSummaryAffiliation: Mahidol University Country: Thailand Publications
| Collaborators
|
Detail Information
Publications
Poor quality vital anti-malarials in Africa - an urgent neglected public health priorityPaul N Newton
Wellcome Trust Mahosot Hospital Oxford University Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
Malar J 10:352. 2011..A vital component of malaria control rests on the availability of good quality artemisinin-derivative based combination therapy (ACT) at the correct dose. However, there are increasing reports of poor quality anti-malarials in Africa...- World Antimalarial Resistance Network I: clinical efficacy of antimalarial drugsRic N Price
International Health Program, Menzies School of Health Research and Charles Darwin University, Darwin, Northern Territory, Australia
Malar J 6:119. 2007..This resource will help guide rational drug policies that optimize antimalarial drug use, in the hope that the emergence and spread of resistance to new drugs can be, if not prevented, at least delayed... - Overestimating resistance in field testing of malaria parasites: simple methods for estimating high EC50 values using a Bayesian approachKasia Stepniewska
Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
Malar J 6:4. 2007..If isolates cannot be stored for re-testing, more accurate estimations of the degree of resistance can be obtained using a Bayesian approach to data analysis which is described here... - Some considerations in the design and interpretation of antimalarial drug trials in uncomplicated falciparum malariaKasia Stepniewska
Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
Malar J 5:127. 2006.... - Plasmodium falciparum gametocyte dynamics in areas of different malaria endemicityKasia Stepniewska
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
Malar J 7:249. 2008..The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity... - In vivo parasitological measures of artemisinin susceptibilityKasia Stepniewska
Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
J Infect Dis 201:570-9. 2010.... - Population pharmacokinetics of artesunate and amodiaquine in African childrenKasia Stepniewska
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
Malar J 8:200. 2009..The aim of this study was to evaluate the PK properties of a newly developed and registered fixed dose combination (FDC) of artesunate and amodiaquine... - The relationship between the haemoglobin concentration and the haematocrit in Plasmodium falciparum malariaSue J Lee
Mahidol Oxford Tropical Medicine Research Unit MORU, Mahidol University, Faculty of Tropical Medicine, 3rd Floor, 60th Anniversary Chalermprakiat Building, 420 6 Ratchawithi Rd, Ratchathewi District, Bangkok 10400, Thailand
Malar J 7:149. 2008..Anaemia is assessed either by measurement of the haematocrit or the haemoglobin concentration. For comparisons across studies, it is often necessary to derive one measure from the other... - In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-upKasia Stepniewska
Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Rd, Bangkok 10400, Thailand
Antimicrob Agents Chemother 48:4271-80. 2004..94) or if the entomological inoculation rate was known. In the assessment of drug efficacy against falciparum malaria, 28 days should be the minimum period of follow-up... - Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistanceNicholas J White
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
Malar J 8:253. 2009..The importance of anti-malarial treatment dosing has been underappreciated. Treatment recommendations are often for the lowest doses that produce "satisfactory" results... - Chloroquine pharmacokinetics in pregnant and nonpregnant women with vivax malariaSue Jean Lee
Mahidol Oxford Tropical Medicine Research Unit, MORU, Mahidol University, Bangkok, Thailand
Eur J Clin Pharmacol 64:987-92. 2008..We compared the pharmacokinetics of chloroquine in pregnant and nonpregnant women treated for Plasmodium vivax malaria... - Simplified antimalarial therapeutic monitoring: using the day-7 drug level?Nicholas J White
Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
Trends Parasitol 24:159-63. 2008..Measurement of the day-7 drug level should be considered as a routine part of antimalarial drug trials... - Population pharmacokinetics of lumefantrine in pregnant women treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malariaJoel Tarning
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Antimicrob Agents Chemother 53:3837-46. 2009..In conclusion, altered pharmacokinetic properties of lumefantrine contribute to the high rates of failure of artemether-lumefantrine treatment in later pregnancy. Dose optimization is urgently needed... - Effects of different antimalarial drugs on gametocyte carriage in P. vivax malariaSasithon Pukrittayakamee
Department of Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Am J Trop Med Hyg 79:378-84. 2008..4% versus 14.1%, P = 0.002). Sexual stage activities corresponded with asexual stage activity for all tested regimens. Treatment with potent antimalarial drugs reduces the transmission potential of P. vivax... - An ultrastructural study of the brain in fatal Plasmodium falciparum malariaEmsri Pongponratn
Department of Tropical Pathology, and Wellcome Trust Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Am J Trop Med Hyg 69:345-59. 2003..7) than in NCM patients (median = 6.9) (P = 0.042). The degree of sequestration of P. falciparum-infected erythrocytes in cerebral microvessels is quantitatively associated with pre-mortem coma... - Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trialArjen M Dondorp
Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Lancet 376:1647-57. 2010..We compared parenteral treatment with either artesunate or quinine in African children with severe malaria... - Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trialArjen Dondorp
Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
Lancet 366:717-25. 2005..2, 1.3-7.8; p=0.009). INTERPRETATION: Artesunate should become the treatment of choice for severe falciparum malaria in adults... - Risk factors for recurrent melioidosis in northeast ThailandDirek Limmathurotsakul
Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand
Clin Infect Dis 43:979-86. 2006..A recent study revealed that 25% of patients with recurrence had reinfection rather than a relapse resulting from a failure to cure. The aim of this study was to reevaluate these 2 patient groups to define their individual risk factors... - Haematinic treatment of anaemia increases the risk of Plasmodium vivax malaria in pregnancyMathieu Nacher
Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok 10400, Thailand
Trans R Soc Trop Med Hyg 97:273-6. 2003..vivax malaria. In P. vivax-endemic areas, systematic iron and folate supplementation confers both benefit and risk in pregnancy... - Pharmacokinetic study of artemether-lumefantrine given once daily for the treatment of uncomplicated multidrug-resistant falciparum malariaElizabeth A Ashley
Shoklo Malaria Research Unit, Mae Sot, Thailand
Trop Med Int Health 12:201-8. 2007..If the fixed antimalarial drug combination artemether-lumefantrine (AL) could be given once daily, this should improve adherence and thus effectiveness and lower the risk of selecting for resistance... - Population pharmacokinetic assessment of a new regimen of mefloquine used in combination treatment of uncomplicated falciparum malariaElizabeth A Ashley
Shoklo Malaria Research Unit, P O Box 46, Mae Sot, Tak 63110, Thailand
Antimicrob Agents Chemother 50:2281-5. 2006..This new regimen is well tolerated and results in an equivalent therapeutic response... - A phase III, randomized, non-inferiority trial to assess the efficacy and safety of dihydroartemisinin-piperaquine in comparison with artesunate-mefloquine in patients with uncomplicated Plasmodium falciparum malaria in southern LaosMayfong Mayxay
Wellcome Trust, Mahosot Hospital, Oxford University Tropical Medicine Research Collaboration, Mahosot Hospital, Vientiane, Laos
Am J Trop Med Hyg 83:1221-9. 2010..falciparum malaria in Laos and is associated with fewer adverse effects. The results of this study were similar to those of the larger multicentre study... - How much fat is necessary to optimize lumefantrine oral bioavailability?Elizabeth A Ashley
Shoklo Malaria Research Unit, Mae Sot, Thailand
Trop Med Int Health 12:195-200. 2007..The aim of this study was to describe the dose-response relationship between coadministration of fat and relative lumefantrine bioavailability, in order to determine the minimum amount of fat necessary to optimize absorption... - Two randomized controlled trials of ceftazidime alone versus ceftazidime in combination with trimethoprim-sulfamethoxazole for the treatment of severe melioidosisWirongrong Chierakul
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Clin Infect Dis 41:1105-13. 2005..CONCLUSION: We conclude that the addition of TMP-SMX to ceftazidime therapy during initial treatment of severe melioidosis does not reduce the acute mortality rate... - An open-label crossover study to evaluate potential pharmacokinetic interactions between oral oseltamivir and intravenous zanamivir in healthy Thai adultsSasithon Pukrittayakamee
Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Rd, Bangkok 10400, Thailand
Antimicrob Agents Chemother 55:4050-7. 2011..720, P = 0.002, n = 16) but not with the oseltamivir AUC (r(p) = 0.121, n = 16). There is no clinically significant pharmacokinetic interaction between oseltamivir and zanamivir... - Dihydroartemisinin-piperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomised clinical trialTinh Hien Tran
Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
Lancet 363:18-22. 2004..INTERPRETATION: Dihydroartemisinin-piperaquine is an inexpensive, safe, highly efficacious fixed-dose antimalarial combination treatment that could make an important contribution to the control of multidrug-resistant falciparum malaria... - The effects of Plasmodium falciparum and P. vivax infections on placental histopathology in an area of low malaria transmissionRose McGready
Shoklo Malaria Research Unit, Mae Sot, Thailand
Am J Trop Med Hyg 70:398-407. 2004..These findings emphasize the importance of treating malaria in pregnancy promptly with effective antimalarial drugs... - Open-label randomized trial of oral trimethoprim-sulfamethoxazole, doxycycline, and chloramphenicol compared with trimethoprim-sulfamethoxazole and doxycycline for maintenance therapy of melioidosisWipada Chaowagul
Medical Department, Sappasithiprasong Hospital, Ubon Ratchathani, Thailand
Antimicrob Agents Chemother 49:4020-5. 2005..7-fold increase of relapse or death. A combination of TMP-SMX and doxycycline is as effective as and better tolerated than the conventional four-drug regimen for the oral treatment phase of melioidosis... - The influence of HIV infection on clinical presentation, response to treatment, and outcome in adults with Tuberculous meningitisGuy E Thwaites
Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
J Infect Dis 192:2134-41. 2005..Tuberculous meningitis occurs more commonly in human immunodeficiency virus (HIV)-infected individuals than in HIV-uninfected individuals, but whether HIV infection alters the presentation and outcome of tuberculous meningitis is unknown... - The pharmacokinetics of artemether and lumefantrine in pregnant women with uncomplicated falciparum malariaRose McGready
Shoklo Malaria Research Unit, P.O. Box 46, Mae Sot, Tak, Thailand
Eur J Clin Pharmacol 62:1021-31. 2006..Further studies are needed to determine the optimum dose regimen of artemether-lumefantrine in pregnancy... - An open label randomized comparison of mefloquine-artesunate as separate tablets vs. a new co-formulated combination for the treatment of uncomplicated multidrug-resistant falciparum malaria in ThailandElizabeth A Ashley
Shoklo Malaria Research Unit, Tak, Thailand
Trop Med Int Health 11:1653-60. 2006..3). There was a lower incidence of early vomiting in the group receiving the fixed combination. CONCLUSION: This new fixed combination of mefloquine and artesunate was efficacious, well tolerated and convenient to administer... - Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparisonFrank Smithuis
, Yangon, Myanmar
Lancet 367:2075-85. 2006..Dihydroartemisinin-piperaquine is a good alternative to artesunate-mefloquine... - Dexamethasone for the treatment of tuberculous meningitis in adolescents and adultsGuy E Thwaites
Oxford University Clinical Research Unit at the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
N Engl J Med 351:1741-51. 2004.... - Effect of antituberculosis drug resistance on response to treatment and outcome in adults with tuberculous meningitisGuy E Thwaites
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
J Infect Dis 192:79-88. 2005..Tuberculous meningitis (TBM) caused by Mycobacterium tuberculosis resistant to 1 or more antituberculosis drugs is an increasingly common clinical problem, although the impact on outcome is uncertain... - Validation of a diagnostic algorithm for adult tuberculous meningitisM Estee Torok
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
Am J Trop Med Hyg 77:555-9. 2007..Validation in an HIV-endemic setting is required... - Evaluation of the Wayson stain for the rapid diagnosis of melioidosisElizabeth A Sheridan
J Clin Microbiol 45:1669-70. 2007 - A multi-center randomised controlled trial of gatifloxacin versus azithromycin for the treatment of uncomplicated typhoid fever in children and adults in VietnamChristiane Dolecek
Oxford University Clinical Research Unit, The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
PLoS ONE 3:e2188. 2008..Drug resistant typhoid fever is a major clinical problem globally. Many of the first line antibiotics, including the older generation fluoroquinolones, ciprofloxacin and ofloxacin, are failing... - Dexamethasone in Vietnamese adolescents and adults with bacterial meningitisThi Hoang Mai Nguyen
Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
N Engl J Med 357:2431-40. 2007..It is uncertain whether all adults with bacterial meningitis benefit from treatment with adjunctive dexamethasone...