Adjuvant mitotane treatment for adrenocortical carcinomaMassimo Terzolo
Universita di Torino, Turin, Italy
N Engl J Med 356:2372-80. 2007
..Whether the use of mitotane is beneficial as an adjuvant treatment has been controversial. Our aim was to evaluate the efficacy of adjuvant mitotane in prolonging recurrence-free survival...
- Adrenal incidentaloma: a new cause of the metabolic syndrome?
Massimo Terzolo
Dipartimento di Scienze Cliniche e Biologiche, Medicina Interna I, Clinica Medica, A S O San Luigi, 10043 Orbassano, Italy
J Clin Endocrinol Metab 87:998-1003. 2002
..Midnight serum cortisol appears as a sensitive marker of the metabolic effects of subclinical Cushing's syndrome...
- Acute administration of melatonin at two opposite circadian stages does not change responses to gonadotropin releasing hormone, thyrotropin releasing hormone and ACTH in healthy adult males
P Paccotti
Dipartimento di Biomedicina, Ospedale S Vito, Torino, Italy
J Endocrinol Invest 10:471-7. 1987
..The circadian chronosusceptibility of pituitary and adrenocortical cells to specific stimuli deserves interest to future investigation...
- Clinicopathological study of a series of 92 adrenocortical carcinomas: from a proposal of simplified diagnostic algorithm to prognostic stratification
Marco Volante
Division of Pathology, Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Turin, Italy
Histopathology 55:535-43. 2009
..The aim was to investigate the impact of individual pathological parameters in the diagnosis and prognosis of adrenocortical carcinoma...
- Emerging drugs for adrenocortical carcinoma
Alfredo Berruti
Department of Clinical and Biological Science, Oncologia Medica, University of Turin, Azienda Ospedaliera San Luigi, Regione Gonzole 10, 10043 Orbassano, Italy
Expert Opin Emerg Drugs 13:497-509. 2008
..Adrenocortical carcinoma (ACC) is an extremely rare aggressive disease. Few data are available on the efficacy of systemic antineoplastic treatments (mitotane and cytotoxic therapy) in the treatment of advanced disease...
- Hyperhomocysteinemia in patients with Cushing's syndrome
Massimo Terzolo
Dipartimento di Scienze Cliniche e Biologiche, Medicina Interna I, Universita di Torino, 10100 Torino, Italy
J Clin Endocrinol Metab 89:3745-51. 2004
..Hyperhomocysteinemia may be key to the prothrombotic state and increased cardiovascular risk of Cushing's syndrome...
- The neoplastic complications of acromegaly
M Terzolo
Department of Clinical and Biological Sciences, Internal Medicine I, A.S.O. San Luigi, University of Turin, Orbassano, Turin, Italy
J Endocrinol Invest 26:32-4. 2003
- Colonoscopic screening and follow-up in patients with acromegaly: a multicenter study in Italy
Massimo Terzolo
Dipartimento de Scienze Cliniche e Biologische, Clinica Medica, Universita di Torino, Italy
J Clin Endocrinol Metab 90:84-90. 2005
..Patients who are found to harbor a colonic neoplasia are at risk for recurrence...
- Subclinical Cushing's syndrome in adrenal incidentalomas
Massimo Terzolo
Division of Internal Medicine, University of Turin, Azienda Sanitaria Ospedaliera San Luigi, Regione Gonzole 10, 10043 Orbassano, Italy
Endocrinol Metab Clin North Am 34:423-39, x. 2005
..The authors' aim is to present up-to-date information on the most relevant issues of subclinical Cushing's syndrome by addressing the many uncertainties and controversies surrounding this ill-defined endocrine condition...
- Midnight serum cortisol as a marker of increased cardiovascular risk in patients with a clinically inapparent adrenal adenoma
Massimo Terzolo
Dipartimento di Scienze Cliniche e Biologiche, Medicina Interna I, Universita di Torino, Turin, Orbassano, Italy
Eur J Endocrinol 153:307-15. 2005
..In the present study, we have determined the prevalence of alterations of the hypothalamic-pituitary-adrenal axis in such patients and examined whether any correlation between endocrine data and the clinical phenotype exists...
- Subclinical Cushing's syndrome
Massimo Terzolo
Medicina Interna I, Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, ASO San Luigi, Orbassano, Italy
Pituitary 7:217-23. 2004
....
- Management of adrenal incidentalomas
M Terzolo
Medicina Interna I, Dipartimento di Scienze Cliniche e Biologiche, , Orbassano, Italy
Exp Clin Endocrinol Diabetes 115:166-70. 2007
- Ectopic ACTH syndrome: molecular bases and clinical heterogeneity
M Terzolo
Dipartimento di Scienze Cliniche e Biologiche, Medicina Interna I, Universita di Torino, Italy
Ann Oncol 12:S83-7. 2001
..Conversely, SCLC processes POMC in an aberrant way releasing high concentrations of ACTH precursors and less intact ACTH in the circulation...
- The limited value of the desmopressin test in the diagnostic approach to Cushing's syndrome
M Terzolo
Dipartimento di Scienze Cliniche e Biologiche, Medicina Interna I, A S O San Luigi, Universita di Torino, Italy
Clin Endocrinol (Oxf) 54:609-16. 2001
..The aim of the present study was to make a comparative evaluation of desmopressin and CRH tests in a consecutive cohort of patients with ACTH-dependent Cushing's syndrome and in a group of healthy subjects...
- Definition of an optimal strategy to evaluate and follow-up adrenal incidentalomas: time for further research
Massimo Terzolo
Medicina Interna I, Dipartimento di Scienze Cliniche e Biologiche, Facoltà di Medicina e Chirurgia San Luigi Gonzaga, Universita di Torino, ASO San Luigi Gonzaga, Regione Gonzole, 10, 10043 Orbassano, Torino, Italy
Eur J Endocrinol 161:529-32. 2009
..To add further to the argument of discussion, we also outline a clinically-oriented strategy for follow-up. In conclusion, the need for further research appears evident to define more efficient guidelines...
- Adjunctive treatment of adrenocortical carcinoma
Massimo Terzolo
Department of Clinical and Biological Sciences, Internal Medicine, University of Turin, Turin, Italy
Curr Opin Endocrinol Diabetes Obes 15:221-6. 2008
..Description of the adjunctive treatment strategies in patients with adrenocortical carcinoma after complete surgical resection...
- Subclinical Cushing's syndrome
Massimo Terzolo
Dipartimento di Scienze Cliniche e Biologiche, Medicina Interna I, A S O San Luigi, Universita di Torino, Italy
Arq Bras Endocrinol Metabol 51:1272-9. 2007
..Either adrenalectomy or careful observation associated with treatment of the metabolic syndrome have been suggested as treatment options...
- Low-dose monitored mitotane treatment achieves the therapeutic range with manageable side effects in patients with adrenocortical cancer
M Terzolo
Dipartimento di Scienze Cliniche e Biologiche, Medicina Interna I, Universita di Torino, Italy
J Clin Endocrinol Metab 85:2234-8. 2000
..The present data provide a rationale to change the approach to mitotane treatment in patients with adrenocortical carcinoma from high dose to low dose regimens...
- Management of adrenal incidentaloma
Massimo Terzolo
Medicina Interna I, Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, ASO San Luigi, Orbassano, Italy
Best Pract Res Clin Endocrinol Metab 23:233-43. 2009
..Also the management of this condition is largely empirical, and data are insufficient to indicate the superiority of a surgical or non-surgical approach to managing patients with subclinical Cushing's syndrome...
- The patients with incidentally discovered adrenal adenoma (incidentaloma) are not at increased risk of osteoporosis
G Osella
Dipartimento di Scienze Cliniche e Biologiche, Medicina Interna I, A O San Luigi, 10043 Orbassano, Torino, Italy
J Clin Endocrinol Metab 86:604-7. 2001
..The evaluation of BMD does not seem to be crucial in the management of incidentally discovered adrenal masses...
- Immunohistochemical assessment of Ki-67 in the differential diagnosis of adrenocortical tumors
M Terzolo
Dipartimento di Scienze Cliniche e Biologiche, Medicina Interna I, , Torino, Italy
Urology 57:176-82. 2001
..High levels of Ki-67 seem to indicate patients with adrenocortical cancer with a worse prognosis...
- The value of dehydroepiandrosterone sulfate measurement in the differentiation between benign and malignant adrenal masses
M Terzolo
Dipartimento di Scienze Cliniche e Biologiche, Medicina Interna, Azienda Ospedaliera San Luigi, Universita di Torino, Italy
Eur J Endocrinol 142:611-7. 2000
..Owing to their increasing rate of discovery as incidental findings, the characterization of adrenal masses is an important diagnostic problem which frequently challenges the clinician's skill...
- Favorable response of metastatic adrenocortical carcinoma to etoposide, adriamycin and cisplatin (EAP) chemotherapy. Report of two cases
A Berruti
Dipartimento di Scienze Cliniche e Biologische, , Italy
Tumori 78:345-8. 1992
..Chemotherapy with the EAP regimen (6 courses) without interrupting mitotane attained a partial remission lasting 21+ months. We suggest that the EAP scheme is active in advanced ACC and that its association with mitotane is feasible...
- Long-term disease free survival in a patient with metastatic adreno-cortical carcinoma after complete pathological response to chemotherapy plus mitotane
P Sperone
Department of Clinical Oncology, University of Torino, San Luigi Hospital, Orbassano, Italy
J Endocrinol Invest 29:560-2. 2006
..This report shows that chemotherapy plus mitotane could result in complete pathological remission, which may be a surrogate for long-term progression- free survival in metastatic ACC patients...
- Effects of high-intensity isokinetic exercise on salivary cortisol in athletes with different training schedules: relationships to serum cortisol and lactate
P Paccotti
Clinica Medica Generale, Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Italy
Int J Sports Med 26:747-55. 2005
..The interindividual differences in cortisol changes are likely to be related to the training status and mode as well as to the correspondence between the evaluation protocol and the discipline individually performed...
- Biochemical markers of bone and collagen turnover in acromegaly or Cushing's syndrome
A Piovesan
Dipartimento di Scienze Cliniche e Biologiche, , Turin, Italy
Horm Metab Res 26:234-7. 1994
..Patients with CS were evaluated measuring serum and urinary cortisol (UFC), ACTH, BGP, PICP, PIIINP.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Prevalence of adrenal incidentaloma in a contemporary computerized tomography series
S Bovio
Internal Medicine I, Department of Biological and Clinical Sciences, ASO San Luigi, University of Turin, Italy
J Endocrinol Invest 29:298-302. 2006
..Notwithstanding that our subjects were at increased risk of lung cancer, the rate of adrenal metastases was low. We think that the present results can be generalized even if we may disclose the lack of histological diagnosis...
- Misdiagnosis of Cushing's syndrome in a patient receiving rifampicin therapy for tuberculosis
M Terzolo
Department of Clinical and Biological Sciences, S. Luigi Hospital, University of Torino, Italy
Horm Metab Res 27:148-50. 1995
..The present case provides a practical example of the possibility to incorrectly suspecting Cushing's syndrome in patients treated with rifampicin, as previously envisaged by pharmacological studies...
- Pros and cons of dexamethasone suppression test for screening of subclinical Cushing's syndrome in patients with adrenal incidentalomas
G Reimondo
Internal Medicine I Endocrinology, Department of Clinical and Biological Sciences, A O U San Luigi Gonzaga, University of Turin, A S O San Luigi, Regione Gonzole 10, 10043 Orbassano, Italy
J Endocrinol Invest 34:e1-5. 2011
..The 8-mg DST seems to replicate by large the results of the 1-mg DST...
- Bone loss is more severe in primary adrenal than in pituitary-dependent Cushing's syndrome
M Minetto
Dipartimento di Scienze Cliniche e Biologiche, Clinica Medica Generale, AO San Luigi, Regione Gonzole 10, 10043 Orbassano TO, Italia
Osteoporos Int 15:855-61. 2004
..However, this hypothesis needs to be confirmed in large, prospective series of patients with Cushing's syndrome of different etiology...
- Adrenal pseudocyst mimicking cancer: a case report
S Bovio
Division of Internal Medicine I, Department of Biological and Clinical Science, A S O San Luigi, Orbassano, Italy
J Endocrinol Invest 30:256-8. 2007
..We report herein the case of an adrenal hemorrhagic pseudocyst that simulated adrenocortical cancer and argue on the clinical clues for a differential diagnosis with other adrenal tumors...
- AME position statement on adrenal incidentaloma
M Terzolo
Medicine I, AOU San Luigi Gonzaga, University of Turin, Regione Gonzole 10, Orbassano 10043, Italy
Eur J Endocrinol 164:851-70. 2011
..To assess currently available evidence on adrenal incidentaloma and provide recommendations for clinical practice...
- Interleukin-6 producing pheochromocytoma presenting with acute inflammatory syndrome
M Minetto
Department of Clinical and Biological Sciences, General Medical Clinic, San Luigi Hospital, Orbassano TO, Italy
J Endocrinol Invest 26:453-7. 2003
..To our knowledge, our paper represents the 6th case report of IL-6 secreting pheochromocytoma associated with clinical markers of inflammatory response...
- Acromegaly due to ectopic secretion of GHRH by bronchial carcinoid in a patient with empty sella
G Osella
Department of Biological and Clinical Sciences, University of Turin, Turin, Italy
J Endocrinol Invest 26:163-9. 2003
..Pituitary radiology showed an empty sella demonstrating for the first time its association with ectopic GHRH syndrome...
- Differential responses of serum and salivary interleukin-6 to acute strenuous exercise
M Minetto
Clinica Medica Generale, Dipartimento di Scienze Cliniche e Biologiche, , A.S.O. San Luigi, Regione Gonzole 10, 10043 Orbassano, Italy
Eur J Appl Physiol 93:679-86. 2005
..Concomitant monitoring of serum markers of inflammation, muscle metabolism and damage can provide information about muscle function properties and adaptations to physical effort in different types of athletes...
- Adrenal incidentalomas and subclinical Cushing's syndrome: is there evidence for glucocorticoid-induced osteoporosis?
A Angeli
Dipartimento di Scienze Cliniche e Biologiche, , Cattedra di Medicina Interna I, Azienda Ospedaliera S. Luigi, Orbassano/TO, Italy
Front Horm Res 30:73-85. 2002
- A rare case of adulthood-onset growth hormone deficiency presenting as sporadic, symptomatic hypoglycemia
A Pia
Division of Endocrinology and Metabolism, University of Turin, S. Luigi, Orbassano, Turin, Italy
J Endocrinol Invest 27:1060-4. 2004
..The possible pathogenesis of isolated adult onset GHD and the association of GHD with conditions predisposing to hypoglycemia are considered and discussed...
- Prospective evaluation of mitotane toxicity in adrenocortical cancer patients treated adjuvantly
Fulvia Daffara
Medicina Interna I, A S O San Luigi, Regione Gonzole, 10, 10043 Orbassano, Italy
Endocr Relat Cancer 15:1043-53. 2008
..A low-dose monitored regimen of mitotane is tolerable and able to maintain elevated drug concentrations in the long term. Mitotane exerts a complex effect on the endocrine system that may require multiple hormone replacement therapy...
- CYP11B2 -344T/C gene polymorphism and blood pressure in patients with acromegaly
Paolo Mulatero
Division of Internal Medicine, Hypertension Unit, Ospedale San Vito, Strada San Vito 34, 10133 Torino, Italy
J Clin Endocrinol Metab 91:5008-12. 2006
..The pathogenesis of increased blood pressure (BP) in acromegaly is unclear, and the role of IGF-I levels and the renin-angiotensin-aldosterone system (RAAS) in this disease remains controversial...
- Etoposide, doxorubicin and cisplatin plus mitotane in the treatment of advanced adrenocortical carcinoma: a large prospective phase II trial
Alfredo Berruti
Oncologia Medica, , Azienda Ospedaliera San Luigi, Regione Gonzole 10 10043 Orbassano, Torino, Italy
Endocr Relat Cancer 12:657-66. 2005
..Surgical resection of residual disease subsequent to chemotherapy leads to a more favourable outcome. The natural history of the disease is significantly influenced by the secretory status of the tumor...
- Prognostic significance of disordered calcium metabolism in hormone-refractory prostate cancer patients with metastatic bone disease
M Tucci
Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Oncologia Medica, Azienda Ospedaliera San Luigi di Orbassano, Torino, Italy
Prostate Cancer Prostatic Dis 12:94-9. 2009
..Patients with asymptomatic hypercalcemia could benefit of a strict follow-up and an immediate bisphosphonate treatment. Further prospective clinical trials are needed to confirm this finding...
- Increased osteoprotegerin levels in Cushing's syndrome are associated with an adverse cardiovascular risk profile
Andrea Dovio
Medicina Interna I, Dipartimento di Scienze Cliniche e Biologiche, Universita degli Studi di Torino, Reg Gonzole 10, 10043 Orbassano Torino, Italy
J Clin Endocrinol Metab 92:1803-8. 2007
..Serum osteoprotegerin (OPG) levels are increased in patients with cardiovascular disease and/or excess bone resorption...
- Screening of Cushing's syndrome in adult patients with newly diagnosed diabetes mellitus
Giuseppe Reimondo
Dipartimento di Scienze Cliniche e Biologiche, Medicina Interna I, A S O San Luigi, Universita di Torino, Regione Gonzole 10, 10043 Orbassano, Italy
Clin Endocrinol (Oxf) 67:225-9. 2007
..The threshold of adequate suppression after DST was set at 110 nmol/l...
- Gemcitabine plus metronomic 5-fluorouracil or capecitabine as a second-/third-line chemotherapy in advanced adrenocortical carcinoma: a multicenter phase II study
Paola Sperone
Dipartimento di Scienze Cliniche e Biologiche Università di Torino, Orbassano, Italy
Endocr Relat Cancer 17:445-53. 2010
..3 (range: 1-43) and 9.8 months (range: 3-73) respectively. Gemcitabine plus metronomic fluoropyrimidines is a well-tolerated and moderately active regimen in heavily pretreated ACC patients...
- Subclinical Cushing's syndrome: definition and management
M Terzolo
Internal Medicine I, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Italy
Clin Endocrinol (Oxf) 76:12-8. 2012
..Most of the recommendations made in this chapter reflects the view and the clinical experience of the Authors and are not based on solid evidence...
- Matrix metalloproteinase type 2 expression in malignant adrenocortical tumors: Diagnostic and prognostic significance in a series of 50 adrenocortical carcinomas
Marco Volante
Division of Pathology, Department of Clinical and Biological Sciences, University of Turin and San Luigi Hospital, Orbassano, Torino, Italy
Mod Pathol 19:1563-9. 2006
..In addition, a strong metalloproteinase type 2 expression in adrenocortical carcinoma was for the first time recognized as an unfavorable prognostic factor...
- Adrenocortical tumors with myxoid features: a distinct morphologic and phenotypical variant exhibiting malignant behavior
Mauro Papotti
Department of Clinical and Biological Sciences, University of Turin at St Luigi Hospital, Orbassano, Torino, Italy
Am J Surg Pathol 34:973-83. 2010
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- Evaluation of the effectiveness of midnight serum cortisol in the diagnostic procedures for Cushing's syndrome
Giuseppe Reimondo
Dipartimento di Scienze Cliniche e Biologiche, Medicina Interna I, A S O San Luigi, Universita di Torino, Orbassano 10043, Italy
Eur J Endocrinol 153:803-9. 2005
..The aim of the present study was to assess retrospectively the effectiveness of F24 for confirming the diagnosis in a consecutive series of 106 patients, in 78 of whom a definitive diagnosis of CS was made...
- Secondary hypoadrenalism
Giuseppe Reimondo
Dipartimento di Scienze Cliniche e Biologiche, Medicina Interna I, Universita di Torino, ASO San Luigi, Orbassano 10043, Italy
Pituitary 11:147-54. 2008
..Further studies with a systematic comparison of the different tests in large series of patients submitted to a prolonged follow-up are needed to solve the controversy of the optimal diagnostic strategy of SAI...
- The corticotrophin-releasing hormone test is the most reliable noninvasive method to differentiate pituitary from ectopic ACTH secretion in Cushing's syndrome
Giuseppe Reimondo
Dipartimento di Scienze Cliniche e Biologiche, Medicina Interna I, A S O San Luigi, Universita di Torino, Italy
Clin Endocrinol (Oxf) 58:718-24. 2003
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- A new simple HPLC method for measuring mitotane and its two principal metabolites Tests in animals and mitotane-treated patients
Sivia De Francia
Department of Clinical and Biological Sciences, Laboratory of Pharmacology, University of Turin, Ospedale San Luigi, Regione Gonzole 10, 10043 Orbassano TO, Italy
J Chromatogr B Analyt Technol Biomed Life Sci 837:69-75. 2006
..Blood samples from mitotane-treated patients revealed two correlations: plasma mitotane/dichlrodiphenylethene and plasma mitotane/red cell mitotane...
- Laboratory differentiation of Cushing's syndrome
Giuseppe Reimondo
Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Medicina Interna I, ASO San Lugi, Orbassano TO, Italy
Clin Chim Acta 388:5-14. 2008
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- The combined low-dose dexamethasone suppression corticotropin-releasing hormone test as a tool to rule out Cushing's syndrome
Giuseppe Reimondo
Dipartimento di Scienze Cliniche e Biologiche, Medicina Interna I, Universita di Torino, ASO San Luigi, Regione Gonzole, 10, 10043 Orbassano, Italy
Eur J Endocrinol 159:569-76. 2008
..The aim of the present study was to evaluate whether the LDDST-CRH test may have a place in the diagnostic strategy of CS...
- Progression of renal failure without proteinuria in a patient with type 1 diabetes
Giorgina Barbara Piccoli
Department of Internal Medicine, University of Turin, Italy
Nephrol Dial Transplant 19:3197-9. 2004
- Adrenal incidentaloma--a modern disease with old complications
Alberto Angeli
J Clin Endocrinol Metab 87:4869-71. 2002
- [Subclinical Cushing's syndrome in adrenal incidentalomas]
Silvia Bovio
Clinica Medica Generale, Azienda Ospedaliera San Luigi Gonzaga, Arbassano
Recenti Prog Med 97:6-15. 2006
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- Bone mineral density in acromegaly: the effect of gender, disease activity and gonadal status
Alfredo Scillitani
Division and Research Unit of Endocrinology, Ospedale Casa Sollievo della Sofferenza IRCCS, San Giovanni Rotondo FG, Italy
Clin Endocrinol (Oxf) 58:725-31. 2003
..We have evaluated BMD in 152 acromegalic patients of both sexes with varying disease activity and gonadal status...
- Non-functioning pituitary adenoma database: a useful resource to improve the clinical management of pituitary tumors
Emanuele Ferrante
Endocrinology Unit, Department of Medical Sciences, University of Milan, Fondazione IRCCS Ospedale Maggiore, Policlinico, Mangiagalli e Regina Elena, Via F Sforza, 35, 20122 Milan, Italy
Eur J Endocrinol 155:823-9. 2006
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- Desmopressin test in mild Cushing syndrome
Massimo Terzolo
Arch Intern Med 163:850-1. 2003
- Myxoid adrenocortical adenoma with a pseudoglandular pattern
Enrico R Bollito
Division of Pathology, San Luigi Gonzaga Hospital, Reg. Gonzole, 10-10043 Orbassano, Italy
Virchows Arch 445:414-8. 2004
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