Effect of Aronia melanocarpa fruit juice on indomethacin-induced gastric mucosal damage and oxidative stress in ratsS Valcheva-Kuzmanova
Department of Preclinical and Clinical Pharmacology and Biochemistry, Medical University, 55 Marin Drinov Str, 9002 Varna, Bulgaria
Exp Toxicol Pathol 56:385-92. 2005
..It could be suggested that this effect of AMFJ was probably due to the increased mucus production and interference with oxidative stress development as evidenced by the decreased plasma and gastric mucosal MDA...
Anxiolytic-like effect of Aronia melanocarpa fruit juice in ratsS Valcheva-Kuzmanova
Department of Preclinical and Clinical Pharmacology and Toxicology, Medical University, Varna, Bulgaria
Methods Find Exp Clin Pharmacol 31:651-4. 2009
..The effects of both AMFJ doses were comparable to the effect of diazepam (1 mg/kg). AMFJ neither changed significantly horizontal and vertical locomotor activity, nor did it adversely affect working memory...
Hepatoprotective effect of the natural fruit juice from Aronia melanocarpa on carbon tetrachloride-induced acute liver damage in ratsS Valcheva-Kuzmanova
Department of Preclinical and Clinical Pharmacology and Biochemistry, Medical University, 9002 Varna, Bulgaria
Exp Toxicol Pathol 56:195-201. 2004
..2ml kg(-1), 3rd and 4th days). NFJAM also prevented the CCl4-induced elevation of MDA formation and depletion of GSH content in rat liver...
Antihyperlipidemic effect of Aronia melanocarpa fruit juice in rats fed a high-cholesterol dietS Valcheva-Kuzmanova
Department of Preclinical and Clinical Pharmacology and Biochemistry, Medical University, 55 Marin Drinov Str, 9002 Varna, Bulgaria
Plant Foods Hum Nutr 62:19-24. 2007
..In conclusion, AMFJ showed an antihyperlipidemic effect in rats with hyperlipidemia and could be valuable in reducing this factor of cardiovascular risk...
Hypoglycemic and hypolipidemic effects of Aronia melanocarpa fruit juice in streptozotocin-induced diabetic ratsS Valcheva-Kuzmanova
Department of Preclinical and Clinical Pharmacology and Biochemistry, Medical University, Varna, Bulgaria
Methods Find Exp Clin Pharmacol 29:101-5. 2007
..In conclusion, AMFJ significantly decreased the streptozotocin-induced abnormalities in blood glucose and TG in diabetic rats and might be useful in prevention and control of diabetes mellitus and diabetes-associated complications...
The effects of melatonin on burn-induced inflammatory responses and coagulation disorders in ratsG Bekyarova
Department of Pathophysiology, Medical University of Varna, Varna, Bulgaria
Methods Find Exp Clin Pharmacol 32:299-303. 2010
..To conclude, melatonin as an antioxidant and anti-inflammatory agent exerted a suppressive effect on burn-induced disorders in blood coagulation and might be useful in the prevention of disseminated intravascular microthrombosis...
Protective effect of melatonin against oxidative hepatic injury after experimental thermal traumaG Bekyarova
Department of Pathophysiology, Medical University of Varna, Varna, Bulgaria
Methods Find Exp Clin Pharmacol 31:11-4. 2009
..In conclusion, the protective effect of melatonin is likely to be due to attenuated lipid peroxidation and interference with reduced oxidative stress and inflammatory response, as evidenced by decreased hepatic MDA and plasma CRP levels...