Research Topics
Genomes and GenesSpecies | Ru Band LuSummaryAffiliation: Tri-Service General Hospital Country: Taiwan Publications
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Publications
Dopamine D2 receptor gene (DRD2) is associated with alcoholism with conduct disorderR B Lu
Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
Alcohol Clin Exp Res 25:177-84. 2001..However, this needs to be further investigated by examining the differences among conduct disorder with alcoholism, conduct disorder only, and controls for the TaqI A and B system at DRD2...- No association of the MAOA gene with alcoholism among Han Chinese males in TaiwanRu Band Lu
Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
Prog Neuropsychopharmacol Biol Psychiatry 26:457-61. 2002..This finding suggests that no association exists between genetic variation at the MAOA locus and alcoholism in Chinese Han males... - Neither antisocial personality disorder nor antisocial alcoholism is associated with the MAO-A gene in Han Chinese malesRu Band Lu
Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
Alcohol Clin Exp Res 27:889-93. 2003..Therefore, association studies of alcoholism or antisocial personality disorder in Chinese may be more reliable if pure antisocial alcoholics, pure antisocial personality disorders, and normal controls as MAO-A gene are examined... - Possible interaction of alcohol dehydrogenase and aldehyde dehydrogenase genes with the dopamine D2 receptor gene in anxiety-depressive alcohol dependenceSan Yuan Huang
Department of Psychiatry, Tri Service General Hospital, Graduate Institute of Medical Sciences, Taipei, Taiwan, Republic of China
Alcohol Clin Exp Res 28:374-84. 2004..This study examined whether the DRD2 gene is associated with specific subtypes of alcohol dependence and evaluated the relationship between the DRD2 gene and alcohol-metabolizing genes in a specific subtype of alcohol dependence... - Association of monoamine oxidase A (MAOA) polymorphisms and clinical subgroups of major depressive disorders in the Han Chinese populationSan Yuan Huang
Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, 114, Taiwan, ROC
World J Biol Psychiatry 10:544-51. 2009..However, a potential role for a minor association with some specific subgroups and with different ethnic samples needs to be explored further... - MAOA interacts with the ALDH2 gene in anxiety-depression alcohol dependenceSheng Yu Lee
Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan
Alcohol Clin Exp Res 34:1212-8. 2010..The aim of this study was to determine whether the interaction between the MAOA and the ALDH2 genes is associated with ANX/DEP ALC... - Possible interaction between MAOA and DRD2 genes associated with antisocial alcoholism among Han Chinese men in TaiwanTso Jen Wang
Graduate Institute of Medical Sciences, National Defense Medical Center, Taiwan, ROC Tsaotun Psychiatric Center, Department of Health, Nantou, Taiwan, ROC
Prog Neuropsychopharmacol Biol Psychiatry 31:108-14. 2007..We concluded that the possible interactions between MAOA-uVNTR polymorphism and DRD2 TaqI A polymorphism might be related to Antisocial ALC among Han Chinese men in Taiwan... - Monoamine oxidase-A polymorphisms might modify the association between the dopamine D2 receptor gene and alcohol dependenceSan Yuan Huang
Department of Psychiatry, Tri Service General Hospital, Taiwan, ROC
J Psychiatry Neurosci 32:185-92. 2007..Therefore, the present study investigates whether the association between the dopamine D2 receptor (DRD2) gene and alcoholism is affected by different polymorphisms of the MAO type A (MAOA) gene... - Lack of association between the norepinephrine transporter gene and major depression in a Han Chinese populationChuan Chia Chang
Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
J Psychiatry Neurosci 32:121-8. 2007..This study aims to determine whether major depression is associated with the NET gene in a Han Chinese population... - Specific personality traits and dopamine, serotonin genes in anxiety-depressive alcoholism among Han Chinese in TaiwanShu Cheng Lin
Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC
Prog Neuropsychopharmacol Biol Psychiatry 31:1526-34. 2007..We attempted to investigate whether the dopamine D2 receptor (DRD2) and the serotonin transporter promoter region (5-HTTLPR) genes were involved in Novelty Seeking (NS) and Harm Avoidance (HA) of ANX/DEP ALC... - Neither single-marker nor haplotype analyses support an association between monoamine oxidase A gene and bipolar disorderSan Yuan Huang
Department of Psychiatry, National Defense Medical Center, Tri Service General Hospital, No 325, Cheng Kung Road, Sec 2, Nei Hu District, Taipei, 114, Taiwan
Eur Arch Psychiatry Clin Neurosci 258:350-6. 2008..Our results suggest that MAOA polymorphisms do not play a major role in pathogenesis of BD or its clinical subtypes in Han Chinese... - Norepinephrine transporter polymorphisms T-182C and G1287A are not associated with alcohol dependence and its clinical subgroupsSan Yuan Huang
Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
Drug Alcohol Depend 92:20-6. 2008..This study suggests that the polymorphisms of T-182C and G1287A in hSLC6A2 gene are not major risk factors in increasing susceptibility to either alcohol dependence or its clinical subtypes... - The COMT and DRD3 genes interacted in bipolar I but not bipolar II disorderSheng Yu Lee
Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
World J Biol Psychiatry 12:385-91. 2011..CONCLUSIONS. We provide initial evidence that the COMT Val158Met and DRD3 Ser9Gly genotypes interact in bipolar I and bipolar II disorders and that bipolar I and bipolar II are genetically distinct... - Distribution volume ratio of serotonin and dopamine transporters in euthymic patients with a history of major depression - a dual-isotope SPECT studyPei Chun Hsieh
Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan
Psychiatry Res 184:157-61. 2010.... - Age, gender, depression, and sexual dysfunction in TaiwanKao Ching Chen
Department of Psychiatry, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan 70428, Taiwan
J Sex Med 6:3056-62. 2009..The effects of age and gender on sexual function have attracted much attention in recent years, though few studies have focused on this issue in Asian populations... - Loudness dependence of auditory evoked potentials (LDAEP) correlates with the availability of dopamine transporters and serotonin transporters in healthy volunteers-a two isotopes SPECT studyI Hui Lee
Department of Psychiatry, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan, 70428, Taiwan, Republic of China
Psychopharmacology (Berl) 214:617-24. 2011..Here, we explore the relationship between LDAEP and dopamine and serotonin in the level of monoamine transporter availability... - Association study of the norepinephrine transporter gene polymorphisms and bipolar disorder in Han Chinese populationChuan Chia Chang
Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, ROC, Taiwan
World J Biol Psychiatry 8:188-95. 2007..However, replication studies with larger different ethnic samples are needed... - Association of promoter variants of human dopamine transporter gene with schizophrenia in Han ChineseSan Yuan Huang
Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC
Schizophr Res 116:68-74. 2010..The purpose of this study was to examine whether six polymorphisms within the DAT1 gene are associated with schizophrenia... - TPH1 is associated with major depressive disorder but not with SSRI/SNRI response in Taiwanese patientsHsuan Chi Wang
Department of Psychiatry, Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan
Psychopharmacology (Berl) 213:773-9. 2011.... - Availability of the serotonin transporter in patients with alcohol dependencePei Shen Ho
Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan
World J Biol Psychiatry 12:134-42. 2011..This study evaluated the differences in SERT availability between healthy controls and alcoholic patients and the impact of 5-HTTLPR polymorphisms on SERT availability... - Brain derived neurotrophic factor gene polymorphism (Val66Met) and short-term antidepressant response in major depressive disorderMei Hung Chi
Department of Psychiatry, Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan
J Affect Disord 126:430-5. 2010..To determine the association between the brain derived neurotrophic factor (BDNF) Val66Met polymorphism and short-term antidepressant response in Taiwanese patients with major depressive disorder (MDD)... - The ALDH2 and DRD2/ANKK1 genes interacted in bipolar II but not bipolar I disorderSheng Yu Lee
Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Pharmacogenet Genomics 20:500-6. 2010..We examined the association of the ALDH2 and DRD2/ANKK1 Taq IA polymorphisms with bipolar I and II disorders and possible interactions between these genes... - Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [Tc] TRODAT-1Ting Ting Chang
Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan
Bipolar Disord 12:102-6. 2010..Dopamine has been implicated in the etiology of bipolar disorder. The aim of this study was to explore striatal dopamine transporter (DAT) availability in euthymic bipolar patients... - The effectiveness of nicotine-patch therapy for smoking cessation in patients with schizophreniaKuei Ru Chou
National Defense Medical Center, School of Nursing, Nei Hu, Taipei 114, Taiwan, ROC
Int J Nurs Stud 41:321-30. 2004..The point-prevalence rates of abstinence from smoking were an abstinence of 26.9% at 8 weeks and 26.9% at a 3-month follow-up. At the 3-month follow-up, the rate of continuous smoking abstinence in the nicotine-patch group was 23.1%... - Sexual dysfunction and physicians' perception in medicated patients with major depression in TaiwanKao Ching Chen
Department of Psychiatry, College of Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
Depress Anxiety 25:E56-62. 2008..Because antidepressant-associated SD is highly prevalent and seriously underestimated by physicians, greater physicians' recognition and better patients' education are imperative when prescribing antidepressants... - The risk of eating disorders among female undergraduates in TaiwanHui Wen Yeh
Department of Nursing, Tri Service General Hospital, National Defense Medical Center and Taipei Medical University, Taipei, Taiwan
Arch Psychiatr Nurs 23:430-40. 2009..2% used rubber clothing and a diet patch to lose weight, 17.9% of the students used weight-loss drugs, and a few students sought medical assistance from weight-loss clinics or actually underwent liposuction (1.5%)... - The aldehyde dehydrogenase 2 gene is associated with heroin dependenceTzu Yun Wang
Department of Psychiatry, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Drug Alcohol Depend 120:220-4. 2012..Therefore, we investigated the association between the ALDH2 and DRD2/ANKK1 Taq IA polymorphisms and heroin dependence... - Validation of the Chinese version of the hypomania checklist (HCL-32) as an instrument for detecting hypo(mania) in patients with mood disordersYi Syuan Wu
Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, Taiwan, ROC
J Affect Disord 106:133-43. 2008..We aimed to determine the accuracy and validity of the Chinese version of the HCL-32 in an adult psychiatric setting. We also compared the results with prior studies carried out in a comparable sample... - Correlation between errors on the Wisconsin Card Sorting Test and the availability of striatal dopamine transporters in healthy volunteersPei Chun Hsieh
Department of Psychiatry, National Cheng Kung University Hospital and Dou liou Branch, Tainan, Taiwan
J Psychiatry Neurosci 35:90-4. 2010.... - Association study of the dopamine transporter gene with personality traits and major depressive disorder in the Han Chinese populationChang Chih Huang
Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
Pharmacogenet Genomics 21:94-7. 2011..In addition, DAT1 does not seem to affect personality traits observed in patients with major depression... - A possible association of the norepinephrine transporter gene in the development of heroin dependence in Han ChineseYi Wei Yeh
Department of Psychiatry, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
Pharmacogenet Genomics 21:197-205. 2011..The purpose of this study was to examine whether the NET gene is associated with the development of HD, and whether the NET gene influences specific personality traits... - Psychometric properties of the Chinese version of the Bipolar Spectrum Diagnostic ScaleHsin Chu
Department of Neurology, Graduate Institute of Aerospace Medicine, School of Medicine, National Defense Medical Center, Tri Service General Hospital, Taiwan
J Clin Nurs 19:2787-94. 2010..The aim of this study was to test the psychometric properties of the Chinese version of the Bipolar Spectrum Diagnostic Scale (C-BSDS) in a Chinese population to serve as an aid to clinical diagnosis of bipolar disorders... - Factors relevant to patient assaultive behavior and assault in acute inpatient psychiatric units in TaiwanKuei Ru Chou
National Defense Medical Center the daggerPsychiatric Department, Tri Service General Hospital and the double daggerPsychiatric Department, Cheng Hsin Hospital, Taipei, Taiwan, ROC
Arch Psychiatr Nurs 16:187-95. 2002..This reinforces the complexity of models in predicting assaults among psychiatric in-patients... - Executive functions in elderly menMu En Liu
Department of Psychiatry, Long Cyuan Veterans Hospital, Pingtung, Taiwan
Age (Dordr) 34:59-66. 2012..Executive function impairment is greater in elderly men diagnosed with major depression comorbid with cardiovascular disease than in those without cardiovascular disease... - Lower side effects of milnacipran than paroxetine in the treatment of major depression disorder among Han Chinese in TaiwanTing Ting Chang
Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University, Tainan 704, Taiwan, Republic of China
Chin J Physiol 51:387-93. 2008..Further investigation is needed to examine the clinical suitability of this drug for patients with liver impairments and for elderly patients suffering from major depression... - Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorderEugene Lin
Vita Genomics, Inc, Wugu Shiang, Taipei, Taiwan
Prog Neuropsychopharmacol Biol Psychiatry 33:1167-72. 2009..The aim of this study was to explore whether interaction among these genes could contribute to the pharmacogenomics of short-term antidepressant response in a Taiwanese population with major depressive disorder (MDD)... - Brain-derived neurotrophic factor Val66Met polymorphism: association with psychopathological symptoms of schizophrenia?Hsin An Chang
Department of Psychiatry, Tri Service General Hospital, Taipei, Taiwan, ROC
J Neuropsychiatry Clin Neurosci 21:30-7. 2009..However, this polymorphism may reduce psychopathology, in particular negative symptoms, in schizophrenia... - Neuropsychological functions in patients with bipolar I and bipolar II disorderYih Lynn Hsiao
Institute of Behavioral Medicine, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan 70428, Taiwan, ROC
Bipolar Disord 11:547-54. 2009..Cognitive impairment existed in both subtypes of bipolar disorder, and was greater in BP-I patients. Rehabilitation interventions should take into account potential cognitive differences between these bipolar subtypes... - The relationships between daily life events and the availabilities of serotonin transporters and dopamine transporters in healthy volunteers--a dual-isotope SPECT studyTzung Lieh Yeh
Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan
Neuroimage 45:275-9. 2009..All participants completed the Recent Life Change Questionnaire. The results showed that SERT and DAT may be sensitive to the presence of stressful events... - Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2*2 gene alleleYi Chyan Chen
Department of Psychiatry, National Defense Medical Center, Taipei, Taiwan
Pharmacogenet Genomics 19:588-99. 2009..The physiological basis for overcoming the protection in ALDH2*1/*2 alcoholics, however, remains unclear... - Evaluation of the effect of a life review group program on self-esteem and life satisfaction in the elderlyKai Jo Chiang
Department of Nursing, Tri Service General Hospital, Taipei, Taiwan, R O C
Int J Geriatr Psychiatry 23:7-10. 2008..This study was aimed at evaluating whether a Life Review Group Program (LRGP) improved the self-esteem and life satisfaction in the elderly... - Dopamine transporters and cognitive function in methamphetamine abuser after a short abstinence: A SPECT studyYuan Hwa Chou
Department of Psychiatry, Taipei Veterans General Hospital and National Yang Ming University, Taipei, Taiwan
Eur Neuropsychopharmacol 17:46-52. 2007..These findings indicate that DAT binding in METH abusers can be reversed in a short period of abstinence. The recovery of DAT binding was asymmetric and possibly parallel with the improvement of cognitive function... - Low doses of dextromethorphan attenuate morphine-induced rewarding via the sigma-1 receptor at ventral tegmental area in ratsShiou Lan Chen
Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan
Drug Alcohol Depend 117:164-9. 2011.... - Non-psychiatric physicians' knowledge, attitudes and behavior toward depressionShen Ing Liu
Department of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan
J Formos Med Assoc 107:921-31. 2008..Depression is a major health concern, often treated by non-psychiatrists. This study assessed self-reported knowledge, attitudes and treatment practices of non-psychiatric physicians in the recognition and management of depression... - Antinociceptive effects of morphine and naloxone in mu-opioid receptor knockout mice transfected with the MORS196A geneShiou Lan Chen
Department of Psychiatry, College of Medicine and Hospital, National Cheng Kung University, Tainan, Taiwan
J Biomed Sci 17:28. 2010..In this study we delivery this mutated MOR gene into pain related pathway to confirm the possibility of in vivo transfecting MORS196A gene and using naloxone as a new analgesic agent... - Memantine abolishes the formation of cocaine-induced conditioned place preference possibly via its IL-6-modulating effect in medial prefrontal cortexKuei Ying Lin
Institute of Behavioral Medicine, National Cheng Kung University College of Medicine, Tainan 701, Taiwan, ROC
Behav Brain Res 220:126-31. 2011..Moreover, an extremely low dose of memantine may decrease the acquisition of cocaine-induced CPP by reversing cocaine conditioning-increased IL-6 levels in mPFC... - The evolution and population genetics of the ALDH2 locus: random genetic drift, selection, and low levels of recombinationHiroki Oota
Department of Genetics, Yale University School of Medicine, 333 Cedar Street, PO Box 208005, New Haven, CT 06520 8005, USA
Ann Hum Genet 68:93-109. 2004..D. above the mean for a reference distribution of 117 autosomal biallelic markers. These high Fst values may indicate selection has operated at these or very tightly linked sites... - The association between DRD2/ANKK1, 5-HTTLPR gene, and specific personality trait on antisocial alcoholism among Han Chinese in TaiwanChin Yeh Wu
Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China
Am J Med Genet B Neuropsychiatr Genet 147:447-53. 2008..75, P = 0.01) However, no significant difference was found in the harm avoidance personality trait between these two groups of Han Chinese in Taiwan... - A global perspective on genetic variation at the ADH genes reveals unusual patterns of linkage disequilibrium and diversityMichael V Osier
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
Am J Hum Genet 71:84-99. 2002..It seems unlikely that this haplotype, which is rare or unobserved in other populations, reached such high frequency because of random genetic drift alone... - Acetaldehyde involvement in positive and negative alcohol expectancies in han Chinese persons with alcoholismCheng-Yi Hahn
Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Arch Gen Psychiatry 63:817-23. 2006.... - No alcoholism-protection effects of ADH1B*2 allele in antisocial alcoholics among Han Chinese in TaiwanRu Band Lu
Department of Psychiatry and Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, R O C
Alcohol Clin Exp Res 29:2101-7. 2005..This study was designed to stratify subjects by various ADH1B and ALDH2 genotypes for a more effective association study. The strata were: antisocial alcoholics, antisocial non-alcoholics, community alcoholics, and normal controls... - Characteristics of acute stress symptoms and nitric oxide concentration in young rescue workers in TaiwanChin-Bin Yeh
Department of Psychiatry, Tri-Service General Hospital, Taipei, Taiwan
Psychiatry Res 112:59-68. 2002..Longitudinal studies with plasma measures of NO are needed to clarify its potential role in the development and course of ASD and related syndromes... - Study of hepatotoxicity of naltrexone in the treatment of alcoholismMao-Hsiung Yen
Department of Pharmacology, National Defense Medical Center, Taipei, Taiwan
Alcohol 38:117-20. 2006..These findings provide further support that NTX is not hepatotoxic at the recommended daily dose and may be beneficial for patients with elevated liver enzymes... - Population variation in linkage disequilibrium across the COMT gene considering promoter region and coding region variationMellissa M C DeMille
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520-8005, USA
Hum Genet 111:521-37. 2002..Because other functional variation might exist, especially regulatory variation, these findings indicate that haplotypes would be more effective indicators of possible involvement of COMT in disease etiology... - Validation of the Chinese version of the Schizophrenia Quality of Life Scale Revision 4 (SQLS-R4) in Taiwanese patients with schizophreniaPo Ju Kuo
Department of Occupational Therapy, Jianan Mental Hospital, Tainan County, Taiwan
Qual Life Res 16:1533-8. 2007..This study provides a common ground for international researchers to understand quality of life in Taiwanese patients with schizophrenia... - World Health Organization/International Society for Biomedical Research on Alcoholism study on state and trait markers of alcohol use and dependence: back to the futureFriedrich M Wurst
Psychiatric University Hospital Basel, Switzerland
Alcohol Clin Exp Res 29:1268-75. 2005 - Developing a SNP panel for forensic identification of individualsKenneth K Kidd
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
Forensic Sci Int 164:20-32. 2006..Expansion of this panel to approximately 50 comparable SNPs should give match probabilities of about 10(-15) with a small global range...