Research Topics
Genomes and Genes | Yen Chou ChenSummaryAffiliation: Taipei Medical University Country: Taiwan Publications
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Publications
In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) productionShing-Chuan Shen
Department of Dermatology, School of Medicine, Taipei Medical University, Taipei, Taiwan
Eur J Pharmacol 446:187-94. 2002..In conclusion, data obtained both in vitro and in vivo suggest that wogonin and quercetin exert inhibitory activity on lipopolysaccharide-induced NO production through suppression of iNOS expression...- Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase-2 gene expressions by rutin, quercetin, and quercetin pentaacetate in RAW 264.7 macrophagesY C Chen
Graduate Institute of Pharmacognosy Science, Taipei Medical University, Taipei, Taiwan
J Cell Biochem 82:537-48. 2001.... - Rutinoside at C7 attenuates the apoptosis-inducing activity of flavonoidsYen Chou Chen
Graduate Institute of Pharmacognosy, Taipei Medical University, 250 Wu Hsing Street, Taipei, Taiwan, ROC
Biochem Pharmacol 66:1139-50. 2003..Our experiments provide the first evidence to suggest that rutinoside in flavonoids prevents the induction of apoptosis, and that activation of the traditional caspase-3 cascade participates in HT- and NE-induced apoptosis... - Prostaglandin D(2) and J(2) induce apoptosis in human leukemia cells via activation of the caspase 3 cascade and production of reactive oxygen speciesYen Chou Chen
Graduate Institute of Pharmacognosy, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
Biochim Biophys Acta 1743:291-304. 2005..However, neither GW9662 nor BADGE showed any protective effect on PGD(2)- and PGJ(2)-induced apoptosis. A differential apoptotic effect of PGs through ROS production, followed by activation of the caspase 3 cascade, was demonstrated... - Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species productionYen Chou Chen
Graduate Institute of Pharmacognosy Science, Taipei Medical University, 250 Wu Hsing Street, Taipei, Taiwan
Biochem Pharmacol 64:1713-24. 2002..Our experiments provide evidence that emodin is an effective apoptosis inducer in HL-60 cells through activation of the caspase 3 cascade, but that it is independent of ROS production... - Baicalein inhibition of oxidative-stress-induced apoptosis via modulation of ERKs activation and induction of HO-1 gene expression in rat glioma cells C6Yen Chou Chen
Graduate Institute of Pharmacognosy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan
Toxicol Appl Pharmacol 216:263-73. 2006..These data indicate that BE possesses abilities to inhibit ROS-mediated cytotoxic effects through modulation of ERKs activation and induction of HO-1 protein expression. The role of HO-1 in ROS-scavenging activity of BE is proposed... - Nitric oxide and prostaglandin E2 participate in lipopolysaccharide/interferon-gamma-induced heme oxygenase 1 and prevent RAW264.7 macrophages from UV-irradiation-induced cell deathYen Chou Chen
Graduate Institute of Pharmacognosy Science, Taipei Medical University, Taiwan
J Cell Biochem 86:331-9. 2002..These results demonstrated that inflammatory molecules NO and PGE(2) were potent inducers of HO-1 gene, and protected cells from UV-irradiation-induced cell death through HO-1 induction... - Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1Yen Chou Chen
Graduate Institute of Pharmacognosy Science, Taipei Medical University, 250 Wu Hsing Street, Taipei, Taiwan
Arch Toxicol 76:351-9. 2002.... - Flavone inhibition of tumor growth via apoptosis in vitro and in vivoYen Chou Chen
Graduate Institute of Pharmacognosy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan
Int J Oncol 25:661-70. 2004..These data provide evidence to suggest that flavone is an effective agent to induce apoptosis in colorectal carcinoma cells in vitro and in vivo; activation of caspase 3, ROS production, and increasing p21 protein are involved... - Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expressionHui Yi Lin
Graduate Institute of Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan
Biochim Biophys Acta 1773:1073-86. 2007..The notion of induction of HO-1 gene expression through a ROS-dependent manner suppressing H(2)O(2)-induced cell death is identified in the present study... - IGF-I plus E2 induces proliferation via activation of ROS-dependent ERKs and JNKs in human breast carcinoma cellsCheng Wei Lin
Graduate Institute of Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan
J Cell Physiol 212:666-74. 2007..The structure-related inhibition of E2/IGF-I-induced proliferative events by flavonoids is elucidated... - Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cellsChing Huai Ko
Graduate Institute of Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan
Int J Cancer 121:1670-9. 2007..Results of the present study provide the first evidences demonstrating the in vitro and in vivo antitumor effects of GOS via an ROS-dependent mitochondrial apoptosis in colorectal carcinoma... - Anti-inflammatory effect of heme oxygenase 1: glycosylation and nitric oxide inhibition in macrophagesHui Yi Lin
Graduate Institute of Pharmaceutical Sciences, School of Pharmacy, Taipei Medical University, Taipei, Taiwan
J Cell Physiol 202:579-90. 2005.... - 12-O-tetradecanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCalpha/ERK/NF-kappaB-dependent MMP-9 expressionCheng Wei Lin
Graduate Institute of Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan
J Cell Physiol 225:472-81. 2010..Application of flavonoids to prevent the migration/invasion of glioblastoma cells through blocking PKCalpha/ERK/NF-kappaB activation is first demonstrated herein... - Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonucleaseWoan Rouh Lee
Institute of Medical Sciences, School of Medicine, Taipei Medical University, 250 Wu-Hsing Street, ROC, Taipei, Taiwan
Biochem Pharmacol 63:225-36. 2002.... - Cytotoxic effects of metal protoporphyrins in glioblastoma cells: roles of albumin, reactive oxygen species, and heme oxygenase-1Jyh Ming Chow
Section of Hematology Oncology, Department of Internal Medicine, Taipei Municipal Wan Fang Hospital, Taipei Medical University, Taiwan
Toxicol Lett 177:97-107. 2008..Effect of serum and BSA on the cytotoxicity of metal protoporphyrins in glioma cells is first demonstrated in the present study, and the roles of ROS, MAPKs, and HO-1 were elucidated... - Hydroxylation at C4' or C6 is essential for apoptosis-inducing activity of flavanone through activation of the caspase-3 cascade and production of reactive oxygen speciesChing Huai Ko
Graduate Institute of Pharmaceutical Sciences, School of Pharmacy, Taipei Medical University, Taipei, Taiwan
Free Radic Biol Med 36:897-910. 2004..This suggests that hydroxylation at C4' or C6 is important to the apoptosis-inducing activities of flavanone through ROS production, and that activation of the caspase-3 cascade, downstream of caspase-9 activation, is involved... - Differential apoptotic effect of wogonin and nor-wogonin via stimulation of ROS production in human leukemia cellsJyh Ming Chow
Section of Hematology Oncology, Department of Internal Medicine, Taipei Municipal Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
J Cell Biochem 103:1394-404. 2008..Evidence to support a distinct structure-activity relationship in apoptosis induction of flavonoids is provided for the first time in this study... - Imatinib mesylate induction of ROS-dependent apoptosis in melanoma B16F0 cellsShao Ping Chang
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
J Dermatol Sci 62:183-91. 2011.... - Vitamin K3-2,3-epoxide induction of apoptosis with activation of ROS-dependent ERK and JNK protein phosphorylation in human glioma cellsJender Wu
Department of Medicinal Chemistry, School of Pharmacy, Taipei Medical University, Taipei, Taiwan
Chem Biol Interact 193:3-11. 2011..Our findings demonstrate that 2,3-epoxide substitution significantly potentiates the apoptotic effect of vitamin K3 via stimulating ROS production, which may be useful in the chemotherapy of glioblastoma cells... - Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE(2) activationWen Ta Chiu
Department of Neurosurgery, Taipei Medical University Shuang Ho Hospital, Taipei, Taiwan
Neurobiol Dis 37:118-29. 2010.... - Structurally related antitumor effects of flavanones in vitro and in vivo: involvement of caspase 3 activation, p21 gene expression, and reactive oxygen species productionShing-Chuan Shen
Graduate Institute of Pharmacognosy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan
Toxicol Appl Pharmacol 197:84-95. 2004..These results revealed in vitro, ex vivo, and in vivo antitumor activities of 2'-OH flavanone via apoptosis induction, and indicates that 2'-OH flavanone is an active compound worthy of development for cancer chemotherapy... - Zinc protoporphyrin inhibition of lipopolysaccharide-, lipoteichoic acid-, and peptidoglycan-induced nitric oxide production through stimulating iNOS protein ubiquitinationJyh Ming Chow
Section of Hematology Oncology, Department of Internal Medicine, Taipei Municipal Wan Fang Hospital, Taipei Medical University, Taipei 110, Taiwan
Toxicol Appl Pharmacol 237:357-65. 2009..Data of the present study provide the first evidence to support ZnPP effectively inhibiting inflammatory iNOS/NO production through activation of protein ubiquitination in a HO-1-independent manner in macrophages... - Heme oxygenase-1 inhibits breast cancer invasion via suppressing the expression of matrix metalloproteinase-9Cheng Wei Lin
Graduate Institute of Pharmacy, School of Pharmacy, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan, Republic of China
Mol Cancer Ther 7:1195-206. 2008..The beneficial role of HO-1 in blocking tumor invasion was first identified in this study... - Reactive oxygen species-dependent HSP90 protein cleavage participates in arsenical As(+3)- and MMA(+3)-induced apoptosis through inhibition of telomerase activity via JNK activationShing Chuan Shen
Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
Toxicol Appl Pharmacol 229:239-51. 2008.... - Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cellsCheng Wei Lin
Graduate Institute of Pharmacy, Taipei Medical University, Taipei 110, Taiwan
Carcinogenesis 29:1807-15. 2008..The antitumor invasion and migration effects of breast carcinoma cells induced by QUE with the structure-activity relationship analysis were identified... - Lipopolysaccharide enhancement of 12-o-tetradecanoylphorbol 13-acetate-mediated transformation in rat glioma C6, accompanied by induction of inducible nitric oxide synthaseTong-Jong Chen
Department of Pathology and Laboratory Medicine, Shin Kong Wu Ho-Su Memorial Hospital, No. 95, Wen-Chung Road, Taipei, Taiwan
Toxicol Lett 147:1-13. 2004.... - Reciprocal activation of macrophages and breast carcinoma cells by nitric oxide and colony-stimulating factor-1Cheng Wei Lin
Graduate Institute of Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan
Carcinogenesis 31:2039-48. 2010..The reciprocal activation of breast cancer and macrophages via NO-CSF-1 is first elucidated herein... - Cobalt protoporphyrin inhibition of lipopolysaccharide or lipoteichoic acid-induced nitric oxide production via blocking c-Jun N-terminal kinase activation and nitric oxide enzyme activityHui Yi Lin
Graduate Institute of Medical Sciences, Taipei Medical University, Taipei 110, Taiwan
Chem Biol Interact 180:202-10. 2009..CoPP effectively suppressing LPS- and LTA-induced iNOS/NO production through blocking JNK activation and iNOS enzyme activity via a HO-1 independent manner is first demonstrated herein... - Mechanism of heme oxygenase-1 gene induction by quercetin in rat aortic smooth muscle cellsHui Chen Lin
Department of Ophthalmology, Shin Kong Wu Ho Su Memorial Hospital, Taipei Medical University, Taiwan
Pharmacology 71:107-12. 2004..The level of quercetin-induced HO-1 expression was attenuated by SB202190 (a p38MAPK inhibitor). Taken together from the data in this study, we suggest that quercetin induced HO-1 expression, at least in part, through p38MAPK... - Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase 3 cascadeShing-Chuan Shen
Department of Dermatology, School of Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, Taiwan
J Cell Biochem 89:1044-55. 2003..Our experiments provide evidence to indicate that the addition of rutinose or rhamnose attenuates the apoptosis-inducing activity of QUE, and that the caspase 3 cascade but not free radical production is involved... - Binding of a venom Lys-49 phospholipase A(2) to LPS and suppression of its effects on mouse macrophagesShu Huei Tsai
Department of Orthopaedics and Traumatology, School of Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan
Toxicon 50:914-22. 2007..These findings provide unprecedented evidence that a low dose of K49-PLA possesses potent anti-inflammatory and antibacterial properties, which raises the prospect of a new therapeutic approach against sepsis... - 12-o-Tetradecanoylphorbol 13-acetate prevents baicalein-induced apoptosis via activation of protein kinase C and JNKs in human leukemia cellsJyh-Ming Chow
Section of Hematology-Oncology, Department of Internal Medicine, Taipei Municipal Wan-Fang Hospital, Taipei Medical University, Taipei, Taiwan
Apoptosis 11:1999-2011. 2006..This suggests that activation of PKC and JNKs participate in TPA's prevention of BE-induced apoptosis via suppressing mitochondrial dysfunction in HL-60 cells... - Inhibition of lipopolysaccharide-induced nitric oxide production by flavonoids in RAW264.7 macrophages involves heme oxygenase-1Hui-Yi Lin
Graduate Institute of Pharmaceutical Sciences, School of Pharmacy, Taipei Medical University, Taipei, Taiwan ROC
Biochem Pharmacol 66:1821-32. 2003..A combination of HO-1 inducers (i.e. hemin) and flavonoids might be an effective strategy for the suppression of LPS-induced NO production... - Inhibition of inflammatory nitric oxide production and epidermis damages by Saccharomycopsis Ferment FiltrateHsiou Hsin Tsai
Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan
J Dermatol Sci 42:249-57. 2006..Yeast extracts have been shown to perform anti-inflammatory and cytoprotective activities. However, the effects of yeast extracts on lipopolysaccharide (LPS)-induced nitric oxide (NO) production and epidermal damages are still unclear... - Inhibition of HSP90-dependent telomerase activity in amyloid ?-induced apoptosis of cerebral endothelial cellsWen Ta Chiu
Department of Neurosurgery, Taipei Municipal Wan Fang Hospital and Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan
J Cell Physiol 226:2041-51. 2011..The data of the present study firstly demonstrates that telomerase inhibition contributes to the apoptosis induction of A? in CECs... - Myricetin inhibits matrix metalloproteinase 2 protein expression and enzyme activity in colorectal carcinoma cellsChing-Huai Ko
Graduate Institute of Pharmaceutical Sciences, School of Pharmacy, 250 Wu-Hsing Street, Taipei, Taiwan
Mol Cancer Ther 4:281-90. 2005..The blockade involved suppression of PKC translocation, ERK phosphorylation, and c-Jun protein expression... - 3-OH flavone inhibition of epidermal growth factor-induced proliferaton through blocking prostaglandin E2 productionShing-Chuan Shen
Department of Dermatology, School of Medicine, Taipei Medical University, Taipei, Taiwan, Republic of China
Int J Cancer 108:502-10. 2004.... - Quercetin inhibition of ROS-dependent and -independent apoptosis in rat glioma C6 cellsTong-Jong Chen
Department of Pathology and Laboratory Medicine, Shin Kong Wu Ho-Su Memorial Hospital, No.95, Wen-Chung Road, Taipei, Taiwan
Toxicology 223:113-26. 2006..Taken together, the results of this study suggest that QUE exhibits an inhibitory effect on both ROS-dependent and -independent cell death, and induction of HO-1 protein expression is involved... - Flavanones structure-related inhibition on TPA-induced tumor promotion through suppression of extracellular signal-regulated protein kinases: involvement of prostaglandin E2 in anti-promotive processChing-Huai Ko
Graduate Institute of Pharmaceutical Sciences, School of Pharmacy, Taipei Medical University, Taipei, Taiwan
J Cell Physiol 193:93-102. 2002..We proposed that blocking TPA-induced intracellular signaling responses might be involved in the anti-promotive mechanism of flavanones... - Mitochondrial-dependent, reactive oxygen species-independent apoptosis by myricetin: roles of protein kinase C, cytochrome c, and caspase cascadeChing Huai Ko
Graduate Institute of Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan
Biochem Pharmacol 69:913-27. 2005.... - The role of COX-2/PGE(2) in gossypol-induced apoptosis of colorectal carcinoma cellsChih Chiang Chien
Division of Nephrology, Chi Mei Medical Center, Tainan, Taiwan Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
J Cell Physiol 227:3128-37. 2012..J. Cell. Physiol. 227: 3128-3137, 2012. © 2011 Wiley Periodicals, Inc... - Quercetin, but not rutin and quercitrin, prevention of H2O2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophagesJyh-Ming Chow
Section of Hematology-Oncology, Department of Internal Medicine, Taipei Municipal Wan-Fang Hospital, Taipei Medical University, Taiwan
Biochem Pharmacol 69:1839-51. 2005..Differential anti-apoptotic effect between QE and its glycosides RUT and QI via distinct HO-1 protein induction was also delineated... - Nicotine enhancement of lipopolysaccharide/interferon-gamma-induced cytotoxicity with elevating nitric oxide productionYen-Chou Chen
Graduate Institute of Pharmacognosy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan
Toxicol Lett 153:191-200. 2004..A cross-talk between inflammation and smoking was proposed in the present study... - Mitochondria-mediated caspase-independent apoptosis induced by cadmium in normal human lung cellsChwen Ming Shih
Department of Biochemistry, School of Medicine, Taipei Medical University, Taipei, Taiwan, ROC
J Cell Biochem 89:335-47. 2003..In summary, this study demonstrated for the first time that cadmium induced a caspase-independent apoptotic pathway through mitochondria-mediated AIF translocation into the nucleus... - The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cellsAn Ming Wang
Institute of Biopharmaceutical Sciences, School of Medicine, National Yang Ming University, Taipei, Taiwan
J Cell Biochem 106:682-92. 2009..Taken together, this system could be beneficial for screening of drugs with potential to treat Notch signal pathway-associated diseases... - Biochemical alteration in cerebrospinal fluid precedes behavioral deficits in Parkinsonian rats induced by 6-hydroxydopamineJia Wei Lin
Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei 110, Taiwan
Surg Neurol 72:S55-65; discussion S65. 2009..In this study, we tested the hypothesis that biochemical changes in CSF precede behavioral deficits in Parkinsonian animals... - Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophagesGuan Cheng Huang
Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan
Int Immunopharmacol 7:1054-63. 2007..These data suggest that OHs at both C5 and C7 are essential for NO inhibition of flavonoids, and OCH(3) at C8 may contribute to this activity, and suppression of JNKs-c-Jun activation is involved...