Research Topics
Genomes and Genes | Shu Chun TengSummaryAffiliation: National Taiwan University Country: Taiwan Publications
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Detail Information
Publications
Induction of global stress response in Saccharomyces cerevisiae cells lacking telomeraseShu Chun Teng
Department of Microbiology, National Taiwan University College of Medicine, Taipei, 10018, Taiwan
Biochem Biophys Res Commun 291:714-21. 2002..The expression of telomere-proximal genes was also analyzed. The possibility of induction of a program to cope with cellular senescence and active telomere-telomere recombination is discussed...- Importin KPNA2, NBS1, DNA repair and tumorigenesisShu Chun Teng
Department of Microbiology, College of Medicine, National Taiwan University, No 1 Sec 1 Jen Ai Road, Taipei 10063, Taiwan
J Mol Histol 37:293-9. 2006..This review focuses on recent experimental evidences demonstrating how NBS1 is translocated into the nucleus by an importin KPNA2 which mediates NBS1 subcellular localization and the functions of the NBS1 complex in tumorigenesis... - Recruitment of Rad51 and Rad52 to short telomeres triggers a Mec1-mediated hypersensitivity to double-stranded DNA breaks in senescent budding yeastYi Hsuan Lin
Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
PLoS ONE 4:e8224. 2009..These results suggested that the sensitive phenotype may be attributed to the sequestration of repair proteins to compromised telomeres, thus limiting the repair capacity at bona fide DSB sites... - The telomerase-recruitment domain of the telomere binding protein Cdc13 is regulated by Mec1p/Tel1p-dependent phosphorylationShun Fu Tseng
Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
Nucleic Acids Res 34:6327-36. 2006..These results demonstrate the telomerase recruitment domain of Cdc13p as an important new telomere-specific target of Mec1p/Tel1p... - Overexpression of NBS1 contributes to transformation through the activation of phosphatidylinositol 3-kinase/AktYen Chung Chen
Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei, Taiwan
J Biol Chem 280:32505-11. 2005..These results indicate that overexpression of NBS1 is an oncogenic event that contributes to transformation through the activation of PI3-kinase/Akt... - Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1Shun Fu Tseng
Department of Microbiology, College of Medicine, National Taiwan University, No 1, Section 1, Jen Ai Road, Taipei 10018, Taiwan
J Biol Chem 280:39594-600. 2005..Collectively, our results strongly suggest that an interaction with KPNA2 contributes to nuclear localization and multiple tumor suppression functions of the NBS1 complex... - Krüppel-like transcription factor 4 contributes to maintenance of telomerase activity in stem cellsChui Wei Wong
Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
Stem Cells 28:1510-7. 2010..Therefore, our findings demonstrate that hTERT is one of the major targets of KLF4 in cancer and stem cells to maintain long-term proliferation potential... - c-Myc directly regulates the transcription of the NBS1 gene involved in DNA double-strand break repairYu Chi Chiang
Department of Medical Genetics, College of Medicine, National Taiwan University, Taipei 100, Taiwan
J Biol Chem 278:19286-91. 2003..These results indicate that NBS1 is a direct transcriptional target of c-Myc and links the function of c-Myc to the regulation of DNA DSB repair pathway operating during DNA replication... - Involvement of topoisomerase III in telomere-telomere recombinationHung Ji Tsai
Department of Microbiology, College of Medicine, National Taiwan University, No 1, Sec 1, Jen Ai Road, Taipei 10018, Taiwan
J Biol Chem 281:13717-23. 2006..Altogether, the present results suggest a potential role for hTOP3alpha in dissociating telomeric structures in telomerase-deficient cells, providing therapeutic implications in human tumors... - Extrachromosomal telomeric circles contribute to Rad52-, Rad50-, and polymerase delta-mediated telomere-telomere recombination in Saccharomyces cerevisiaeChi Ying Lin
Department of Microbiology, National Taiwan University College of Medicine, Taipei 10018, Taiwan
Eukaryot Cell 4:327-36. 2005..These results imply that telomeres can use looped-out telomeric rings to promote telomere-telomere recombination in telomerase-deficient Saccharomyces cerevisiae... - Proofreading activity of DNA polymerase Pol2 mediates 3'-end processing during nonhomologous end joining in yeastShun Fu Tseng
Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
PLoS Genet 4:e1000060. 2008..Indeed, a mutation in the 3'-5' exonuclease domain of Pol2 dramatically reduces the frequency of end joins formed with initial 3' flaps. Thus, Pol2 performs a key 3' end-processing step in NHEJ... - Involvement of replicative polymerases, Tel1p, Mec1p, Cdc13p, and the Ku complex in telomere-telomere recombinationYun-Luen Tsai
Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China
Mol Cell Biol 22:5679-87. 2002.... - Direct interaction between Utp8p and Utp9p contributes to rRNA processing in budding yeastYu Ching Huang
Department of Microbiology, National Taiwan University, Taipei, Taiwan
Biochem Biophys Res Commun 393:297-302. 2010..Together, our data support a model where Utp8p and Utp9p must interact directly and functionally in the U3-containing SSU processome for optimal rRNA biosynthesis to occur in budding yeast... - Sumoylation of the BLM ortholog, Sgs1, promotes telomere-telomere recombination in budding yeastChia Yin Lu
Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
Nucleic Acids Res 38:488-98. 2010..We suggest that sumoylation of different domains of RecQ DNA helicases from different organisms contributes to conserved roles in regulating telomeric recombination... - Intragenic transcription of a noncoding RNA modulates expression of ASP3 in budding yeastYu Ching Huang
Department of Microbiology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan
RNA 16:2085-93. 2010..Our results show for the first time that intragenic noncoding transcription promotes gene expression... - Phosphorylation of telomeric repeat binding factor 1 (TRF1) by Akt causes telomere shorteningYen Chung Chen
Institutes of Biochemistry and Molecular Biology, National Yang Ming University, Taipei, Taiwan
Cancer Invest 27:24-8. 2009..Overexpression of Akt decreased telomere length in a HTC cell line. These results indicate that Akt plays an important role in telomere length regulation, contributing to genomic instability and tumorigenesis... - Rapid Cdc13 turnover and telomere length homeostasis are controlled by Cdk1-mediated phosphorylation of Cdc13Shun Fu Tseng
Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
Nucleic Acids Res 37:3602-11. 2009..Together these results demonstrate that Cdk1 phosphorylates the telomerase recruitment domain of Cdc13, thereby preserves optimal function and expression level of Cdc13 for precise telomere replication and cell cycle progression... - Interaction between HSP60 and beta-catenin promotes metastasisYa Ping Tsai
Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei, Taiwan
Carcinogenesis 30:1049-57. 2009..Coexpression of HSP60 and nuclear beta-catenin predicts a worse prognosis of metastatic head and neck cancer patients. These results implicate a novel role of HSP60 in metastasis... - Inhibition of estradiol-induced mammary proliferation by dibenzoylmethane through the E2-ER-ERE-dependent pathwayChuan-Chuan Lin
Department of Food Science, China Institute of Technology, and National Taiwan University Hospital, Taipei, Taiwan
Carcinogenesis 27:131-6. 2006..Taken together, our results strongly suggest that DBM plays an inhibitory role in E2-induced proliferations, which establishes DBM as a model molecule for studying the antiestrogenic drugs... - Telomere configuration influences the choice of telomere maintenance pathwaysWan-Ying Wen
Department of Microbiology, College of Medicine, National Taiwan University, Taipei 100, Taiwan, ROC
Biochem Biophys Res Commun 343:459-66. 2006..Altogether, our results suggest that both protein factors and substrate availability contribute to the choice among telomere replication pathways in yeast... - Activation of phosphoinositide 3-kinase by the NBS1 DNA repair protein through a novel activation motifYen Chung Chen
Institute of Biochemistry and Molecular Biology, National Yang Ming University, No 155, Li Nong St, Sec 2, Peitou, Taipei 112, Taiwan
J Mol Med (Berl) 86:401-12. 2008..These results demonstrate that NBS1 can function as an adaptor/activator of p110alpha PI 3-kinase through a novel activation motif, consistent with its possible role in cell transformation and tumorigenesis... - Est1p as a cell cycle-regulated activator of telomere-bound telomeraseAndrew K P Taggart
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
Science 297:1023-6. 2002..These findings suggest a model in which Est1p binds telomeres late in S phase and interacts with Cdc13p to convert inactive, telomere-bound Est2p to an active form... - Increased NBS1 expression is a marker of aggressive head and neck cancer and overexpression of NBS1 contributes to transformationMuh Hwa Yang
Institute of Clinical Medicine, National Yang Ming University, No 155 Li Nong Street Sec 2, Peitou, Taipei 112, Taiwan
Clin Cancer Res 12:507-15. 2006..We showed previously that c-MYC directly activates the expression of the DNA double-strand break repair gene NBS1, and NBS1 overexpression contributes to transformation. Here, we investigate the role of NBS1 overexpression in HNSCC... - Direct regulation of TWIST by HIF-1alpha promotes metastasisMuh Hwa Yang
Institutes of Biochemistry and Molecular Biology, National Yang Ming University, No 155, Sec 2, Li Niong Street, Peitou, Taipei 112, Taiwan
Nat Cell Biol 10:295-305. 2008..These results provide evidence of a key signalling pathway involving HIF-1alpha and TWIST that promotes metastasis in response to intratumoural hypoxia...