Research Topics
| David R BellSummaryAffiliation: World Health Organization Country: Switzerland Publications
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Detail Information
Publications
Conditional regulation of the human CYP4X1 and CYP4Z1 genesUzen Savas
Division of Biochemistry, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
Arch Biochem Biophys 436:377-85. 2005..These results demonstrate selective tissue expression and implicate PPARalpha in CYP4X1 regulation, and the glucocorticoid and progesterone receptors in CYP4Z1 gene activation...
Ensuring quality and access for malaria diagnosis: how can it be achieved?David Bell
Malaria, other Vector borne and Parasitic Diseases, World Health Organization Regional Office for the Western Pacific, P O Box 2932, Manila, Philippines
Nat Rev Microbiol 4:682-95. 2006....
Evaluation of rapid diagnostic tests: malariaDavid Bell
Malaria, and other Vector-borne and Parasitic Diseases, World Health Organization-Regional Office for the Western Pacific, PO Box 2932, Manila, Philippines
Nat Rev Microbiol 4:S34-8. 2006
Evaluation of the intra- and inter-specific genetic variability of Plasmodium lactate dehydrogenaseArthur M Talman
Unité d Epidémiologie Moléculaire, Institut Pasteur in Cambodia 5 Boulevard Monivong BP983, Phnom Penh, Kingdom of Cambodia
Malar J 6:140. 2007..However a characterization of the efficiency of these tests and the proteins they detect is needed to maximize RDT sensitivity...
Improving community health worker use of malaria rapid diagnostic tests in Zambia: package instructions, job aid and job aid-plus-trainingSteven A Harvey
University Research Co, LLC, 7200 Wisconsin Ave, Suite 600, Bethesda, MD 20814, USA
Malar J 7:160. 2008....
An assessment of various blood collection and transfer methods used for malaria rapid diagnostic testsJennifer Luchavez
Research Institute for Tropical Medicine, Filinvest Compound, Alabang, Muntinlupa, Philippines
Malar J 6:149. 2007..Four blood collection and transfer devices commonly used for malaria rapid diagnostic tests (RDTs) were assessed for their consistency, accuracy and ease of use in the hands of laboratory technicians and village health workers...
False-positive results of a Plasmodium falciparum histidine-rich protein 2-detecting malaria rapid diagnostic test due to high sensitivity in a community with fluctuating low parasite densityDavid R Bell
Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Am J Trop Med Hyg 73:199-203. 2005....
Malaria risk: estimation of the malaria burdenDavid R Bell
Malaria, Other Vector borne and Parasitic Diseases Unit, World Health Organization Regional Office for the Western Pacific, PO Box 2932, Manila, Philippines
Nature 437:E3-4; discussion E4-5. 2005....
Making malaria testing relevant: beyond test purchaseDavid Bell
Malaria, other Vector borne and Parasitic Diseases, World Health Organization, Regional Office for the Western Pacific, UN Avenue, Ermita, P O Box 2932, Manila, The Philippines
Trans R Soc Trop Med Hyg 102:1064-6. 2008..If this is to occur, a re-think is required of the way many malaria programmes are funded and run...
Ensuring quality and access for malaria diagnosis: how can it be achieved?David Bell
Malaria, and other Vector borne and Parasitic Diseases, World Health Organization Regional Office for the Western Pacific, P O Box 2932, Manila, Philippines
Nat Rev Microbiol 4:S7-20. 2006....
Global sequence variation in the histidine-rich proteins 2 and 3 of Plasmodium falciparum: implications for the performance of malaria rapid diagnostic testsJoanne Baker
Department of Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane, Australia
Malar J 9:129. 2010..This is of particular concern for Plasmodium falciparum histidine-rich protein 2 (PfHRP2)-detecting RDTs since PfHRP2 has been reported to be highly variable in isolates of the Asia-Pacific region...
Malaria trends and challenges in the Greater Mekong SubregionCharles Delacollette
WHO Mekong Malaria Programme, Bangkok, Thailand
Southeast Asian J Trop Med Public Health 40:674-91. 2009..Strengthening networking between research institutions and non-government organizations will increase knowledge-based decision and action...
Estimating trends in the burden of malaria at country levelRichard E Cibulskis
Global Malaria Program, World Health Organization, 20 Avenue Appia, Geneva, Switzerland
Am J Trop Med Hyg 77:133-7. 2007....
Assessing the genetic diversity of the aldolase genes of Plasmodium falciparum and Plasmodium vivax and its potential effect on performance of aldolase-detecting rapid diagnostic testsNelson Lee
The Australian Centre for International and Tropical Health, Brisbane, Australia
J Clin Microbiol 44:4547-9. 2006..vivax aldolases by sequencing the coding genes from parasites of various origins. The results show that aldolases are highly conserved, indicating that antigenic diversity is not a cause of variable RDT sensitivity...
Genetic diversity of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) and its effect on the performance of PfHRP2-based rapid diagnostic testsJoanne Baker
Department of Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane, Australia
J Infect Dis 192:870-7. 2005..These findings provide an alternative explanation for the variable sensitivity in field tests of malaria RDTs that is not due to the quality of the RDTs...
Malaria rapid diagnostic tests in tropical climates: the need for a cool chainPernille Jorgensen
World Health Organization-Regional Office for the Western Pacific, Manila, The Philippines
Am J Trop Med Hyg 74:750-4. 2006..These results emphasize the need for good logistical planning during the introduction of point-of-care tests in tropical countries and the importance of considering the stability of diagnostic tests during procurement...
Amino acid mutations in Plasmodium vivax DHFR and DHPS from several geographical regions and susceptibility to antifolate drugsAlyson Auliff
Department of Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane, QLD, Australia
Am J Trop Med Hyg 75:617-21. 2006..Parasites with the S58R/S117N dhfr allelic type showed an MIC level for pyrimethamine and cycloguanil comparable to that previously reported, but were susceptible to WR99210...
Effect of sequence variation in Plasmodium falciparum histidine- rich protein 2 on binding of specific monoclonal antibodies: Implications for rapid diagnostic tests for malariaNelson Lee
Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research and School of Population Health, University of Queensland, Queensland, Australia
J Clin Microbiol 44:2773-8. 2006..These findings support the role of sequence variation as an explanation for variations in the performance of HRP2-based RDTs and point toward possible approaches to improve their diagnostic sensitivities...
The Australian Cancer Anaemia Survey: a snapshot of anaemia in adult patients with cancerTara Seshadri
Peter MacCallum Centre, Melbourne, Vic
Med J Aust 182:453-7. 2005..CONCLUSIONS: Anaemia is prevalent among Australian patients with cancer managed in hospital oncology units. Its management varies between tumour types. Many patients do not receive treatment for their anaemia...
