F X Vollenweider

Summary

Affiliation: University of Zurich
Country: Switzerland

Publications

  1. ncbi The effects of the preferential 5-HT2A agonist psilocybin on prepulse inhibition of startle in healthy human volunteers depend on interstimulus interval
    Franz X Vollenweider
    University Hospital of Psychiatry, Neuropsychopharmacology and Brain Imaging and Heffter Research Center, Lenggstrasse 31, CH 8032 Zurich, Switzerland
    Neuropsychopharmacology 32:1876-87. 2007
  2. ncbi Clozapine enhances prepulse inhibition in healthy humans with low but not with high prepulse inhibition levels
    Franz X Vollenweider
    University Hospital of Psychiatry, Clinical Research, Zurich, Switzerland
    Biol Psychiatry 60:597-603. 2006
  3. ncbi MDMA affects both error-rate dependent and independent aspects of decision-making in a two-choice prediction task
    Franz X Vollenweider
    University Hospital of Psychiatry and Heffter Research Center, University of Zurich, Zurich, Switzerland
    J Psychopharmacol 19:366-74. 2005
  4. ncbi [Hallucinogens, amphetamines and entactogens]
    F X Vollenweider
    Psychiatrische Universitätsklinik Zürich, Klinische Forschung, Lenggstrasse 31, CH 8029 Zurich
    Ther Umsch 60:323-8. 2003
  5. ncbi Acute psychological and neurophysiological effects of MDMA in humans
    Franz X Vollenweider
    Privatdozent of Psychiatry, University of Zurich, Psychiatric University Hospital Zurich, Clinical Research Unit and Heffter Research Center, Zurich, Switzerland
    J Psychoactive Drugs 34:171-84. 2002
  6. ncbi A systems model of altered consciousness: integrating natural and drug-induced psychoses
    F X Vollenweider
    Psychiatric University Hospital Zurich, Zurich, Switzerland
    Brain Res Bull 56:495-507. 2001
  7. ncbi Effects of (S)-ketamine on striatal dopamine: a [11C]raclopride PET study of a model psychosis in humans
    F X Vollenweider
    Psychiatric University Hospital Zurich, Research Department, Switzerland
    J Psychiatr Res 34:35-43. 2000
  8. ncbi Effects of high amphetamine dose on mood and cerebral glucose metabolism in normal volunteers using positron emission tomography (PET)
    F X Vollenweider
    Research Department, Psychiatric University Hospital Zurich, Switzerland
    Psychiatry Res 83:149-62. 1998
  9. ncbi Metabolic hyperfrontality and psychopathology in the ketamine model of psychosis using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG)
    F X Vollenweider
    Research Department, Psychiatric University Hospital of Zurich, Switzerland
    Eur Neuropsychopharmacol 7:9-24. 1997
  10. ncbi Opposite effects of 3,4-methylenedioxymethamphetamine (MDMA) on sensorimotor gating in rats versus healthy humans
    F X Vollenweider
    Psychiatric University Hospital Zurich, Research Department, Switzerland
    Psychopharmacology (Berl) 143:365-72. 1999

Detail Information

Publications51

  1. ncbi The effects of the preferential 5-HT2A agonist psilocybin on prepulse inhibition of startle in healthy human volunteers depend on interstimulus interval
    Franz X Vollenweider
    University Hospital of Psychiatry, Neuropsychopharmacology and Brain Imaging and Heffter Research Center, Lenggstrasse 31, CH 8032 Zurich, Switzerland
    Neuropsychopharmacology 32:1876-87. 2007
    ....
  2. ncbi Clozapine enhances prepulse inhibition in healthy humans with low but not with high prepulse inhibition levels
    Franz X Vollenweider
    University Hospital of Psychiatry, Clinical Research, Zurich, Switzerland
    Biol Psychiatry 60:597-603. 2006
    ..Atypical antipsychotics have been assessed for normalization effects on deficient sensory gating as indexed by prepulse inhibition (PPI) in schizophrenics with generally positive, although somewhat conflicting, results...
  3. ncbi MDMA affects both error-rate dependent and independent aspects of decision-making in a two-choice prediction task
    Franz X Vollenweider
    University Hospital of Psychiatry and Heffter Research Center, University of Zurich, Zurich, Switzerland
    J Psychopharmacol 19:366-74. 2005
    ..These results support the hypothesis that acute administration of MDMA affects success-related response selection during decision-making...
  4. ncbi [Hallucinogens, amphetamines and entactogens]
    F X Vollenweider
    Psychiatrische Universitätsklinik Zürich, Klinische Forschung, Lenggstrasse 31, CH 8029 Zurich
    Ther Umsch 60:323-8. 2003
    ..The present contribution summarizes the psychological and somatic effects of hallucinogens, amphetamines, and entactogens...
  5. ncbi Acute psychological and neurophysiological effects of MDMA in humans
    Franz X Vollenweider
    Privatdozent of Psychiatry, University of Zurich, Psychiatric University Hospital Zurich, Clinical Research Unit and Heffter Research Center, Zurich, Switzerland
    J Psychoactive Drugs 34:171-84. 2002
    ..The present contribution summarizes the acute effect of MDMA on psychological and cognitive measures, information processing, and regional brain activity in healthy human volunteers...
  6. ncbi A systems model of altered consciousness: integrating natural and drug-induced psychoses
    F X Vollenweider
    Psychiatric University Hospital Zurich, Zurich, Switzerland
    Brain Res Bull 56:495-507. 2001
    ....
  7. ncbi Effects of (S)-ketamine on striatal dopamine: a [11C]raclopride PET study of a model psychosis in humans
    F X Vollenweider
    Psychiatric University Hospital Zurich, Research Department, Switzerland
    J Psychiatr Res 34:35-43. 2000
    ..These results provide evidence that the glutamatergic NMDA receptor may contribute to psychotic symptom formation via modulation of the DA system...
  8. ncbi Effects of high amphetamine dose on mood and cerebral glucose metabolism in normal volunteers using positron emission tomography (PET)
    F X Vollenweider
    Research Department, Psychiatric University Hospital Zurich, Switzerland
    Psychiatry Res 83:149-62. 1998
    ....
  9. ncbi Metabolic hyperfrontality and psychopathology in the ketamine model of psychosis using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG)
    F X Vollenweider
    Research Department, Psychiatric University Hospital of Zurich, Switzerland
    Eur Neuropsychopharmacol 7:9-24. 1997
    ....
  10. ncbi Opposite effects of 3,4-methylenedioxymethamphetamine (MDMA) on sensorimotor gating in rats versus healthy humans
    F X Vollenweider
    Psychiatric University Hospital Zurich, Research Department, Switzerland
    Psychopharmacology (Berl) 143:365-72. 1999
    ..This phenomenon provides an operational measure of sensorimotor gating that has been found to be reduced in patients with schizophrenia and rats treated with serotonin agonists or serotonin releasers...
  11. ncbi Acute psychological and physiological effects of MDMA ("Ecstasy") after haloperidol pretreatment in healthy humans
    M E Liechti
    University Hospital of Psychiatry Zurich, Research Unit, P O Box 68, CH 8029, Zurich, Switzerland
    Eur Neuropsychopharmacol 10:289-95. 2000
    ..Results are consistent with a partial dopaminergic mediation of the euphoriant effects of MDMA. In contrast, dopamine does not seem to contribute to the physiological effects of MDMA, indicating a role for serotonin and norepinephrine...
  12. ncbi Psychological and physiological effects of MDMA ("Ecstasy") after pretreatment with the 5-HT(2) antagonist ketanserin in healthy humans
    M E Liechti
    University Hospital of Psychiatry Zurich, P O Box 68, CH 8029, Zurich, Switzerland
    Neuropsychopharmacology 23:396-404. 2000
    ..Body temperature was lower under MDMA plus ketanserin compared to MDMA alone. The results suggest a contributing role for 5-HT(2) receptors in the action of MDMA in humans...
  13. ncbi Haloperidol differentially modulates prepulse inhibition and p50 suppression in healthy humans stratified for low and high gating levels
    Philipp A Csomor
    University Hospital of Psychiatry Zurich, Experimental Psychopathology and Brain Imaging, Zurich, Switzerland
    Neuropsychopharmacology 33:497-512. 2008
    ..Furthermore, the results suggest a relation between sensorimotor gating and working memory performance...
  14. ncbi Investigation of serotonin-1A receptor function in the human psychopharmacology of MDMA
    F Hasler
    Department of Clinical Research, Heffter Research Center, University Hospital of Psychiatry, Zurich, Switzerland
    J Psychopharmacol 23:923-35. 2009
    ..Our findings suggest that MDMA differentially affects higher cognitive functions, but does not support the hypothesis from animal studies, that some of the MDMA effects are causally mediated through action at the 5-HT1A receptor system...
  15. ncbi Sensorimotor gating and attentional set-shifting are improved by the mu-opioid receptor agonist morphine in healthy human volunteers
    Boris B Quednow
    University Hospital of Psychiatry, Experimental Psychopathology and Brain Imaging, University of Zurich, Switzerland
    Int J Neuropsychopharmacol 11:655-69. 2008
    ....
  16. ncbi Decision-making dysregulation in first-episode schizophrenia
    Katja Cattapan-Ludewig
    University Hospital of Psychiatry, University of Bern, Bern, Switzerland
    J Nerv Ment Dis 196:157-60. 2008
    ..These results indicate that behavioral abnormalities during the two-choice prediction task are already present during the early stages of the illness...
  17. ncbi No difference in brain activation during cognitive performance between ecstasy (3,4-methylenedioxymethamphetamine) users and control subjects: a [H2(15)O]-positron emission tomography study
    A Gamma
    Research Unit, University Hospital of Psychiatry, Zurich, Switzerland
    J Clin Psychopharmacol 21:66-71. 2001
    ..However, this study cannot exclude the possibility that the observed differences are preexisting rather than a result of Ecstasy use...
  18. ncbi Acute psychological effects of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") are attenuated by the serotonin uptake inhibitor citalopram
    M E Liechti
    Psychiatric University Hospital Zürich Research Department, P O Box 68, CH 8029, Zurich, Switzerland
    Neuropsychopharmacology 22:513-21. 2000
    ..This finding suggests that the psychological effects of MDMA are mediated via action at the 5-HT uptake site to increase 5-HT release through the carrier, as expected from animal studies...
  19. ncbi Localization of MDMA-induced brain activity in healthy volunteers using low resolution brain electromagnetic tomography (LORETA)
    E Frei
    University Hospital of Psychiatry, Zurich, Switzerland
    Hum Brain Mapp 14:152-65. 2001
    ....
  20. ncbi Prepulse inhibition deficits in patients with panic disorder
    S Ludewig
    Psychiatric University Hospital Zurich, Department of Clinical Research, Zurich, Switzerland
    Depress Anxiety 15:55-60. 2002
    ..The correlation between high trait anxiety and deficient PPI supports the hypothesis that sensorimotor gating abnormalities are an enduring feature of subjects with PD...
  21. ncbi On the influence of baseline startle reactivity on the indexation of prepulse inhibition
    Philipp A Csomor
    Psychiatric University Hospital Zurich, Zurich, Switzerland
    Behav Neurosci 122:885-900. 2008
    ....
  22. ncbi P50 suppression, prepulse inhibition, and startle reactivity in the same patient cohort suffering from posttraumatic stress disorder
    Dominique H Holstein
    Psychiatric University Hospital Zurich, Zurich, Switzerland
    J Affect Disord 126:188-97. 2010
    ..However, findings are inconsistent, and potential relationships to symptomatology remain unclear...
  23. ncbi Mismatch negativity predicts psychotic experiences induced by NMDA receptor antagonist in healthy volunteers
    Daniel Umbricht
    Psychiatric University Hospital Zurich, Department of Psychiatric Research, Zurich, Switzerland
    Biol Psychiatry 51:400-6. 2002
    ..MMN generation appears to index the functional state of NMDAR-mediated neurotransmission even in subjects who do not demonstrate any psychopathology...
  24. ncbi On the feasibility to detect and to quantify prepulse-elicited reaction in prepulse inhibition of the acoustic startle reflex in humans
    Philipp A Csomor
    Psychiatric University Hospital Zurich, Lenggstrasse 31, CH-8029 Zurich, Switzerland
    Behav Brain Res 162:256-63. 2005
    ..This provides an additional measure of theoretical and potentially clinical relevance to PPI, and it ought to be included in future studies in patients as well as healthy subjects...
  25. ncbi The serotonin uptake inhibitor citalopram reduces acute cardiovascular and vegetative effects of 3,4-methylenedioxymethamphetamine ('Ecstasy') in healthy volunteers
    M E Liechti
    University Hospital of Psychiatry Zurich, Switzerland
    J Psychopharmacol 14:269-74. 2000
    ..These findings suggest that physiological effects of MDMA in humans are partially due to an interaction of MDMA with the serotonin carrier and a subsequent release of serotonin...
  26. ncbi Gender differences in the subjective effects of MDMA
    M E Liechti
    University Hospital of Psychiatry Zurich, Switzerland
    Psychopharmacology (Berl) 154:161-8. 2001
    ..5-HT is known to play an important role in mood and anxiety disorders, for which there is a female preponderance. To date, there are no systematic data on gender differences in the subjective effects of MDMA...
  27. ncbi Ketamine-induced deficits in auditory and visual context-dependent processing in healthy volunteers: implications for models of cognitive deficits in schizophrenia
    D Umbricht
    Psychiatric University Hospital, Department of Research, PO Box 68, Zurich 8029, Switzerland
    Arch Gen Psychiatry 57:1139-47. 2000
    ....
  28. ncbi Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose-effect study
    Felix Hasler
    Heffter Research Center, Psychiatric University Hospital Zurich, Lenggstrasse 31, 8029 Zurich, Switzerland
    Psychopharmacology (Berl) 172:145-56. 2004
    ..Pharmacological challenge with the 5-HT(2A) agonist psilocybin (PY) is useful in studying the neurobiological basis of cognition and consciousness...
  29. ncbi The monotonic dependency of prepulse inhibition of the acoustic startle reflex on the intensity of the startle-eliciting stimulus
    Philipp A Csomor
    Psychiatric University Hospital Zurich, Lenggstrasse 31, CH 8029 Zurich, Switzerland
    Behav Brain Res 174:143-50. 2006
    ....
  30. ncbi The P3 in 'ecstasy' polydrug users during response inhibition and execution
    Alex Gamma
    University Hospital of Psychiatry, Research Unit, Lenggstr. 31, 8029 Zurich, Switzerland
    J Psychopharmacol 19:504-12. 2005
    ....
  31. ncbi Effects of the 5-HT2A agonist psilocybin on mismatch negativity generation and AX-continuous performance task: implications for the neuropharmacology of cognitive deficits in schizophrenia
    Daniel Umbricht
    Psychiatric University Hospital of Zurich Department of Research, Switzerland
    Neuropsychopharmacology 28:170-81. 2003
    ..Comparable deficits in schizophrenia may result from independent dysfunctions of 5-HT(2A) and NMDAR-related neurotransmission...
  32. ncbi Effects of typical and atypical antipsychotics on prepulse inhibition and latent inhibition in chronic schizophrenia
    Lorenz Leumann
    Artificial Intelligence Laboratory, University of Zurich, Switzerland
    Biol Psychiatry 52:729-39. 2002
    ..Because it is crucial to understand why there are considerable differences between the two paradigms and between human and animal studies, research should focus more strongly on comparative approaches...
  33. ncbi Renal excretion profiles of psilocin following oral administration of psilocybin: a controlled study in man
    Felix Hasler
    Heffter Research Center, Psychiatric University Hospital Zurich, Lenggstrasse 31, CH 8029 Zurich, Switzerland
    J Pharm Biomed Anal 30:331-9. 2002
    ..We conclude that in humans PI is partially excreted as PI-O-glucuronide and that enzymatic hydrolysis extends the time of detectability for PI in urine samples...
  34. ncbi Effects of psilocybin on time perception and temporal control of behaviour in humans
    Marc Wittmann
    Generation Research Programme, Human Science Centre, Ludwig Maximilian University Munich, Bad Tölz, Germany, and Heffter Research Centre, University Hospital of Psychiatry, Zurich, Switzerland
    J Psychopharmacol 21:50-64. 2007
    ..We speculate that psilocybin's selective disruption of longer intervals is likely to be a product of interactions with cognitive dimensions of temporal processing -presumably via 5-HT2A receptor stimulation...
  35. ncbi Psychometric evaluation of the altered states of consciousness rating scale (OAV)
    Erich Studerus
    Neuropsychopharmacology and Brain Imaging and Heffter Research Center, University Hospital of Psychiatry Zurich, Zurich, Switzerland
    PLoS ONE 5:e12412. 2010
    ....
  36. ncbi GMP-compliant radiosynthesis of [18F]altanserin and human plasma metabolite studies
    F Hasler
    University Hospital of Psychiatry, Heffter Research Center, Zurich, Switzerland
    Appl Radiat Isot 67:598-601. 2009
    ..We conclude that metabolite analysis for correction of individual plasma input functions used in tracer modeling is not necessary for [(18)F]altanserin studies involving psilocybin or dexfenfluramine treatment...
  37. ncbi Decision-making strategies by panic disorder subjects are more sensitive to errors
    Stephan Ludewig
    Psychiatric University Hospital Zurich, Lenggstrasse 31, CH-8029 Zurich, Switzerland
    J Affect Disord 76:183-9. 2003
    ..CONCLUSIONS: Panic disorder subjects show uniformly high response sequence unpredictability in the presence of low error-rates, which is consistent with continued search for an optimal response strategy even when the error-rate is low...
  38. ncbi The neurobiology of psychedelic drugs: implications for the treatment of mood disorders
    Franz X Vollenweider
    Neuropsychopharmacology and Brain Imaging Research Unit, University Hospital of Psychiatry, Zurich, Switzerland
    Nat Rev Neurosci 11:642-51. 2010
    ..These findings raise the possibility that research into psychedelics might identify novel therapeutic mechanisms and approaches that are based on glutamate-driven neuroplasticity...
  39. ncbi Potential antipsychotic properties of central cannabinoid (CB1) receptor antagonists
    Patrik Roser
    Research Group Clinical and Experimental Psychopathology, Department of General and Social Psychiatry ZH West, Psychiatric University Hospital Zurich, Zurich, Switzerland
    World J Biol Psychiatry 11:208-19. 2010
    ..In this review, both preclinical and clinical studies investigating the potential antipsychotic effects of both CBD and SR141716 are presented together with the possible underlying mechanisms of action...
  40. ncbi Comparison of simultaneously recorded [H2(15)O]-PET and LORETA during cognitive and pharmacological activation
    Alex Gamma
    Research Unit, University Hospital of Psychiatry, Zurich, Switzerland
    Hum Brain Mapp 22:83-96. 2004
    ..EEG-LORETA. In general, correspondences, to the extent they were found, were dependent on experimental condition, brain region, and EEG frequency...
  41. ncbi Using psilocybin to investigate the relationship between attention, working memory, and the serotonin 1A and 2A receptors
    Olivia L Carter
    University of Queensland, Australia
    J Cogn Neurosci 17:1497-508. 2005
    ..The clinical relevance of these results is also discussed...
  42. ncbi Stability of the acoustic startle reflex, prepulse inhibition, and habituation in schizophrenia
    Katja Ludewig
    Department of Research, Psychiatric Services of Aargau Canton, P.O. Box, CH-5201 Brugg, Switzerland
    Schizophr Res 55:129-37. 2002
    ..This PPI deficit was evident in all three sessions. These results indicate that PPI is a stable neurobehavioral measure in chronic schizophrenic patients in the absence of changes in clinical state...
  43. ncbi Behavioural dysregulation of decision-making in deficit but not nondeficit schizophrenia patients
    Katja Ludewig
    Psychiatric Services of Aargau Canton, Department of Research, Zürcherstrasse, P O Box 298, 5201 Brugg, Switzerland
    Psychiatry Res 119:293-306. 2003
    ..Moreover, in deficit patients, the previous choice was more predictive of the current response. Therefore, the two-choice prediction task may be useful in differentiating between deficit and nondeficit schizophrenia...
  44. ncbi Deficits in prepulse inhibition and habituation in never-medicated, first-episode schizophrenia
    Katja Ludewig
    Department of Research, Psychiatric Services of Aargau Canton, Brugg, Switzerland
    Biol Psychiatry 54:121-8. 2003
    ..CONCLUSIONS: In combination with other studies, these findings indicate that PPI and habituation may be sensitive intermediate phenotypic markers for information-processing deficits in schizophrenic patients...
  45. ncbi Psilocybin impairs high-level but not low-level motion perception
    Olivia L Carter
    Vision Touch and Hearing Research Center, School of Biomedical Sciences, University of Queensland, Australia
    Neuroreport 15:1947-51. 2004
    ....
  46. ncbi Modulating the rate and rhythmicity of perceptual rivalry alternations with the mixed 5-HT2A and 5-HT1A agonist psilocybin
    Olivia L Carter
    Vision Touch and Hearing Research Center, School of Biomedical Science, University of Queensland, Australia
    Neuropsychopharmacology 30:1154-62. 2005
    ..This study suggests the involvement of serotonergic pathways in binocular rivalry and supports the previously proposed role of a brainstem oscillator in perceptual rivalry alternations and symptoms of psychosis...
  47. ncbi Rapid visual information processing in schizophrenic patients: the impact of cognitive load and duration of stimulus presentation. A pilot study
    Katja Cattapan-Ludewig
    Department of Research, Psychiatric Services of Aargau, Brugg, Switzerland
    Neuropsychobiology 52:130-4. 2005
    ..This finding supports the hypothesis that patients have an impaired ability to coactivate different cognitive performances; thus the results favor the theory of impaired functional connectivity in schizophrenia...
  48. ncbi Psilocybin links binocular rivalry switch rate to attention and subjective arousal levels in humans
    Olivia L Carter
    Vision Touch and Hearing Research Center, School of Biomedical Science, University of Queensland, Brisbane, Australia
    Psychopharmacology (Berl) 195:415-24. 2007
    ..Previous studies have suggested that a slow rate of perceptual switching may be associated with clinical and drug-induced psychosis...
  49. ncbi Effects of varied doses of psilocybin on time interval reproduction in human subjects
    Jiri Wackermann
    Department of Empirical and Analytical Psychophysics, Institute for Frontier Areas of Psychology and Mental Health, Wilhelmstrasse 3a, D 79098 Freiburg i Br, Germany
    Neurosci Lett 435:51-5. 2008
    ..These findings are tentatively linked to qualitative alterations of subjective time in altered states of consciousness...
  50. ncbi The acoustic startle reflex and its modulation: effects of age and gender in humans
    Katja Ludewig
    Psychiatric Services of Aargau Canton, Department of Research, PO Box 298, CH-5201, Brugg, Switzerland
    Biol Psychol 63:311-23. 2003
    ..The results demonstrated that PPI and startle are reliable measures of sensory information processing in both genders and that startle magnitude and habituation are age-dependent measures...
  51. ncbi Information-processing deficits and cognitive dysfunction in panic disorder
    Stephan Ludewig
    Department of Research, Psychiatric Services of Aargau Canton, Brugg, Switzerland
    J Psychiatry Neurosci 30:37-43. 2005
    ....