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Genomes and GenesSpecies | C TosoSummaryAffiliation: University Hospital Country: Switzerland Publications
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Publications
Protein kinase C inhibitor, AEB-071, acts complementarily with cyclosporine to prevent islet rejection in ratsShaheed Merani
Department of Surgery, Surgical Medical Research Institute, University of Alberta, Edmonton, AB, Canada
Transplantation 87:59-65. 2009..The present study investigated the effect of AEB on rat islet allotransplantation alone or in combination with CTLA4-Ig, mycophenolate mofetil, or cyclosporine A (CsA)...- Appendectomy during the third trimester of pregnancy in a 27-year old patient: case report of a "near miss" complicationThomas Holzer
Abdominal and Transplant Surgery, University Hospitals of Geneva, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Patient Saf Surg 5:11. 2011..In case of unclear pre-operative diagnosis, a laparoscopy should be conducted even during the third trimester with a Mc Burney conversion when the diagnosis of appendicitis is confirmed... - The role of macrophage migration inhibitory factor on glucose metabolism and diabetesC Toso
University of Alberta, Edmonton, AB, Canada
Diabetologia 51:1937-46. 2008..The present review summarises our current knowledge, based on clinical and research data, on the impact of MIF on both physiological and pathological aspects of glucose metabolism... - The impact of sirolimus on hepatocyte proliferation after living donor liver transplantationChristian Toso
Department of Surgery, Section of Hepatobiliary, Pancreatic and Transplant Surgery, University of Alberta Hospital, Edmonton, AB, Canada
Clin Transplant 24:695-700. 2010..There is a lack of data on the use of sirolimus after partial liver transplantation, especially regarding its impact on post-transplant regeneration... - Histologic graft assessment after clinical islet transplantationChristian Toso
Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada
Transplantation 88:1286-93. 2009..An accurate monitoring would help understanding the fate of islet grafts after transplantation... - Liraglutide, a long-acting human glucagon-like peptide 1 analogue, improves human islet survival in cultureChristian Toso
Clinical Islet Transplant Program, Department of Surgery, University of Alberta, Edmonton, AB, Canada
Transpl Int 23:259-65. 2010..Overall, these data demonstrate the beneficial effect of liraglutide on cultured human islets, preserving islet mass. They support the design of clinical studies looking at the effect of liraglutide in clinical islet transplantation... - Assessment of 18F-FDG-leukocyte imaging to monitor rejection after pancreatic islet transplantationC Toso
Cell Isolation and Transplantation Center, Clinic for Visceral and Transplant Surgery, University Hospital, Geneva, Switzerland
Transplant Proc 38:3033-4. 2006..We sought to investigate the feasibility of 18F-FDG-leukocyte imaging to detect islet rejection... - Positron-emission tomography imaging of early events after transplantation of islets of LangerhansChristian Toso
Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
Transplantation 79:353-5. 2005..Ex vivo labeling of islets and imaging of posttransplant early events were feasible. Islets engrafted exclusively in the liver. No islet loss could be demonstrated 6 hours after transplantation... - Intussusception as a cause of bowel obstruction in adultsChristian Toso
Clinic of Abdominal and Transplant Surgery, University Hospital, Rue Micheli du Crest 24, CH 1211 Geneva 14, Switzerland
Swiss Med Wkly 135:87-90. 2005..Due to its unspecific presentation, intussusception is often diagnosed with delay in adults... - The estimated number of patients with hepatocellular carcinoma selected for liver transplantation using expanded selection criteriaChristian Toso
Section of Hepatobiliary, Pancreatic and Transplant Surgery, University of Alberta, Edmonton, AB, Canada
Transpl Int 22:869-75. 2009..This data will assist Centers and policy agencies in predicting the need for resources linked to an expansion of criteria... - Reassessing selection criteria prior to liver transplantation for hepatocellular carcinoma utilizing the Scientific Registry of Transplant Recipients databaseChristian Toso
Section of Hepatobiliary, Pancreatic, and Transplant Surgery, University of Alberta, Edmonton, Canada
Hepatology 49:832-8. 2009..A composite patient selection score combining TTV and AFP was the most effective of all tested staging criteria for the prediction of posttransplant patient survival for candidates with HCC... - Management of hepatocellular adenoma: solitary-uncomplicated, multiple and ruptured tumorsChristian Toso
Abdominal and Transplant Surgery, University Hospital, 24, Rue Micheli du Crest, 1211 Geneva 14, Switzerland
World J Gastroenterol 11:5691-5. 2005..While hepatocellular adenomas (HAs) have often been studied as a unique entity, we aimed to better define current management of the various forms of HAs... - Effect of microcapsule composition and short-term immunosuppression on intraportal biocompatibilityChristian Toso
Centre d isolement et de transplantation cellulaire, Service de Chirurgie Viscerale, Hopital Universitaire, 4, Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
Cell Transplant 14:159-67. 2005..Biocompatibility after intraportal infusion was best for barium-alginate microbeads and poorest for polycation-containing microcapsules. Short- and long-term overgrowth could be significantly reduced by short-term immunosuppression... - The role of macrophage migration inhibitory factor in mouse islet transplantationChristian Toso
Islet Transplant Program, Alberta Diabetes Institute, University of Alberta, Edmonton AB, Canada
Transplantation 86:1361-9. 2008..Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine produced by many tissues including pancreatic beta-cells... - Clinical magnetic resonance imaging of pancreatic islet grafts after iron nanoparticle labelingC Toso
Cell Isolation and Transplantation Center, Geneva University Hospitals, Geneva, Switzerland
Am J Transplant 8:701-6. 2008..Altogether, this study demonstrates the feasibility and safety of MRI-based islet graft monitoring in clinical practice. Iron overload (spontaneous or induced) represents the major obstacle to the technique... - Intra-portal injection of 400- microm microcapsules in a large-animal modelChristian Toso
Division d Investigations Chirurgicales, Clinique de Chirurgie Digestive et Unité de Transplantation, Hopital Universitaire, 24 Rue Micheli du Crest, 1211 Geneva, Switzerland
Transpl Int 16:405-10. 2003..Hemodynamic, biological and radiological results are similar to those observed in clinical free-islet transplantation... - Kidney-pancreas transplantation in a long-term non-progressor HIV-infected recipientChristian Toso
Transplantation Unit, Visceral and Transplant Surgery, University Hospitals, Geneva, Switzerland
Am J Transplant 3:631-3. 2003..HAART is not required, thus sparing drug interactions and their unique immunological features, such as CCR5 mutation, might prevent rejection. This subgroup of HIV patients should be offered less restricted access to transplantation... - Hepatocellular adenoma and polycystic ovary syndromeChristian Toso
Clinique et Policlinique de Chirurgie Digestive, Departement de Chirurgie, Hôpitaux Universitaires Genève, Rue Michelidu Crest, 24 CH 1211, Geneve
Liver Int 23:35-7. 2003..In view of this complication, we recommend a close screening of patients with such hormonal imbalance, especially those who are treated with high doses of hormones, with repeated liver tests and ultrasonographies... - Sirolimus-based immunosuppression is associated with increased survival after liver transplantation for hepatocellular carcinomaChristian Toso
Section of Hepatobiliary, Pancreatic and Transplant Surgery, University of Alberta, Edmonton, Canada
Hepatology 51:1237-43. 2010..Conclusion: According to these data, sirolimus-based immunosuppression has unique posttransplant effects on HCC patients that lead to improved survival... - Liver transplantation for hepatocellular carcinoma: five steps to prevent recurrenceC Toso
Abdonimal and Transplant Surgery, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
Am J Transplant 11:2031-5. 2011.... - Quality of life after islet transplant: impact of the number of islet infusions and metabolic outcomeChristian Toso
Clinical Islet Transplant Program, University of Alberta, Edmonton, Alberta, Canada
Transplantation 84:664-6. 2007..01). Fear of hypoglycemia correlated with the occurrence of hypoglycemia (r=0.47, P=0.01), and even more so with blood glucose stability (r=0.56, P=0.0007) and insulin requirement (r=0.69, P=0.000002)... - The place of downstaging for hepatocellular carcinomaChristian Toso
Transplantation Unit, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
J Hepatol 52:930-6. 2010..The present review discusses which treatments and strategies are available for downstaging HCC on the basis of the published literature... - Detecting rejection after mouse Islet transplantation utilizing islet protein-stimulated ELISPOTChristian Toso
Transplant Unit, Department of Surgery, University of Geneva Hospitals, Switzerland
Cell Transplant 20:955-62. 2011..Overall, allogeneic rejection was associated to a transient increase in the reactivity of splenocytes against islet proteins. Such a strategy has the potential to improve islet graft monitoring in human and should be further explored... - Short-term immunosuppression reduces fibrotic cellular infiltration around barium-M-alginate microbeads injected intraportallyZ Mathe
Cell Isolation and Transplantation Center, Geneva University Hospitals, Geneva, Switzerland
Transplant Proc 36:1199-200. 2004..6 +/- 2.0. CONCLUSION: Combination of highly purified alginate with short-term immunosuppression reduces fibrotic overgrowth around microbeads injected intraportally... - Sequential kidney/islet transplantation: efficacy and safety assessment of a steroid-free immunosuppression protocolC Toso
Cell Isolation and Transplantation Center, Division of Visceral and Transplant Surgery, Geneva University Hospitals, Geneva, Switzerland
Am J Transplant 6:1049-58. 2006..The net harm versus benefit has not yet been established and will require further studies with larger numbers of enrolled subjects... - Impact of a sirolimus/tacrolimus-based immunosuppressive regimen on kidney function after islet transplantationA Andres
Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
Transplant Proc 37:1326-7. 2005..The presence of low creatinine clearance, albuminuria, and long-established kidney graft were associated with poorer outcomes... - Phylogenetic disparity influences the predominance of direct over indirect pathway of antigen presentation in islet xenotransplantationA Andres
Surgical Research Unit, Department of Surgery, University Hospital Geneva, Geneva, Switzerland
Transplant Proc 37:463-5. 2005..Both direct and indirect antigen presentation are involved in rejection of discordant xenogeneic islets. Macrophage depletion or inhibition should be considered as therapeutic tool for discordant islet xenotransplantation... - Human islet allotransplantation with Basiliximab in type I diabetic patients with end-stage renal failureJ Oberholzer
Division of Surgical Research, Clinic of Digestive and Transplant Surgery, Department of Surgery, University Hospital of Geneva, Geneva, Switzerland
Transplant Proc 34:823-5. 2002 - Isolation of adult porcine islets of LangerhansC Toso
Division of Surgical Research, Clinic for Digestive and Transplant Surgery, University Hospital, Geneva, Switzerland
Cell Transplant 9:297-305. 2000..This review article is intended to collate published information on adult pig islet isolation to provide the reader with a clear overview of the relevant issues in this field, and to detail the current state of the art... - Factors affecting human islet of Langerhans isolation yieldsC Toso
Division of Surgical Research, Department of Surgery, University Hospital, University of Geneva, Switzerland
Transplant Proc 34:826-7. 2002 - Beta cell replacement for the treatment of diabetesJ Oberholzer
Department of Surgery, University Hospital, Geneva, Switzerland
Ann N Y Acad Sci 944:373-87. 2001..In this review we discuss the various key steps in islet transplantation and offer perspectives for future developments in the replacement of insulin-producing beta cells for the treatment of type I diabetes... - Liraglutide, a long-acting human glucagon-like peptide 1 analog, improves glucose homeostasis in marginal mass islet transplantation in miceS Merani
Surgical Medical Research Institute, University of Alberta, Edmonton, Alberta, Canada
Endocrinology 149:4322-8. 2008..Overall, our data show that liraglutide has a beneficial impact on the engraftment and function of syngeneic islet transplants in mice, when administered continuously starting on the day of transplant... - Transplantation of islets of Langerhans: new developmentsT Berney
Department of Surgery, University Hospital of Geneva, 24 Rue Micheli du Crest, CH 1211 Geneva 14, Switzerland
Swiss Med Wkly 131:671-80. 2001.... - Islet of Langerhans allogeneic transplantation at the University of Geneva in the steroid free era in islet after kidney and simultaneous islet-kidney transplantationsT Berney
Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
Transplant Proc 36:1121-2. 2004..We report a single-center experience of islet allogeneic transplantation in islet after kidney (IAK) and simultaneous islet-kidney (SIK) type 1 diabetic recipients using a steroid-free immunosuppressive regimen... - Detection of insulin mRNA in the peripheral blood after human islet transplantion predicts deterioration of metabolic controlT Berney
Division of Visceral and Transplant Surgery, Geneva University Hospitals, Geneva, Switzerland
Am J Transplant 6:1704-11. 2006..These data suggest that insulin mRNA detection in the peripheral blood is a promising method for the prediction of islet graft damage... - A novel method for quantitative monitoring of transplanted islets of langerhans by positive contrast magnetic resonance imagingL A Crowe
Department of Radiology Cell Isolation and Transplant Center, Department of Surgery, University of Geneva School of Medicine and Geneva University Hospitals, Geneva, Switzerland
Am J Transplant 11:1158-68. 2011..This imaging protocol reliably quantifies transplanted islet mass and has high translational potential to clinical studies of transplanted pancreatic islets... - Microbial surveillance during human pancreatic islet isolationP Bucher
Cell Isolation and Transplantation Center, Geneva University Hospitals, Geneva, Switzerland
Transplant Proc 36:1147-8. 2004..Significant contaminants present when beginning islet isolation become undetectable by the conclusion of isolation. Diminishing the bio-burden by pancreas decontamination reduces the risk of contamination of the final islet preparation... - Optimal implantation site for pancreatic islet transplantationS Merani
Surgical Medical Research Institute, University of Alberta, Edmonton, Canada
Br J Surg 95:1449-61. 2008..About half of the islets introduced into the liver die during or shortly after transplantation. Although many patients achieve insulin independence after portal vein infusion of islets, in the long term most resume insulin injections... - Insulin-heparin infusions peritransplant substantially improve single-donor clinical islet transplant successAngela Koh
1 Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada 2 Division of Clinical Immunology, Department of Oncology, Radiology and Clinical Immunology, The Rudbeck Laboratory, Uppsala University, Uppsala, Sweden
Transplantation 89:465-71. 2010..The ability to achieve insulin independence with a single donor is an important goal in clinical islet transplantation due to the limited organ supply... - AEB-071 has minimal impact on onset of autoimmune diabetes in NOD miceS Merani
Alberta Diabetes Institute, University of Alberta, Edmonton, Canada
Autoimmunity 42:242-8. 2009..AEB, a T-cell-targeted immunosuppressive strategy, is only sufficient as a monothereapy to modestly delay onset of autoimmune disease in the NOD mouse... - Monitoring of the islet graftT Berney
Cell Isolation and Transplantation Center, Division of Visceral and Transplant Surgery, Geneva University Hospitals, Geneva, Switzerland
Diabetes Metab 32:503-12. 2006..Progress is likely to arise in the fields of immune monitoring, molecular monitoring and islet imaging, notably thanks to magnetic resonance (MR) or positron emission tomography (PET) technologies... - Supplemental islet infusions restore insulin independence after graft dysfunction in islet transplant recipientsAngela Koh
Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada
Transplantation 89:361-5. 2010..However, improving islet transplant outcomes could explain the success of SII. We aimed to determine the effect on islet graft function and insulin independence of SII using these new protocols, without the use of exenatide... - Impact of HLA matching on the outcome of simultaneous pancreas-kidney transplantationThierry Berney
Division of Visceral and Transplantation Surgery, Geneva University Hospitals, Switzerland
Nephrol Dial Transplant 20:ii48-53, ii62. 2005..CONCLUSIONS: There was no evidence that HLA matching was associated with improved kidney or pancreas survival. However, a higher rate of acute rejection was observed with poor HLA match, which may impact long-term survival... - De novo sirolimus-based immunosuppression after liver transplantation for hepatocellular carcinoma: long-term outcomes and side effectsChristian Toso
Department of Surgery, Section of Hepatobiliary, Pancreatic and Transplant Surgery, University of Alberta, Edmonton, Canada
Transplantation 83:1162-8. 2007..We report long-term outcomes and side effects after transplantation for hepatocellular carcinoma (HCC) using de novo, sirolimus-based immunosuppression (IS)... - Impairment of renal function after islet transplant alone or islet-after-kidney transplantation using a sirolimus/tacrolimus-based immunosuppressive regimenAxel Andres
Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
Transpl Int 18:1226-30. 2005..Although a specific etiology was not identified, some subsets of patients presented a higher risk for decline of kidney function. Low creatinin clearance, albuminuria and long-established kidney graft were associated with poorer outcome... - Total tumor volume predicts risk of recurrence following liver transplantation in patients with hepatocellular carcinomaChristian Toso
Section of Hepatobiliary, Pancreatic, and Transplant Surgery, University of Alberta, Edmonton, Canada
Liver Transpl 14:1107-15. 2008.... - Left lobe splitting and full right-full left splitting: study of the portal anatomy on corrosion casts and on autopsy liversP Majno
Transplantation Unit, Department of Surgery, University Hospitals, Geneva, Switzerland
Transplant Proc 34:769-70. 2002 - Molecular detection of circulating beta-cells after islet transplantationBeate Ritz-Laser
Diabetes Unit, Department of Internal Medecine, University Hospital Geneva, Geneva, Switzerland
Diabetes 51:557-61. 2002..This test may allow better estimation of islet cell loss and identification of factors involved in islet graft injury... - Microbial surveillance during human pancreatic islet isolationPascal Bucher
Laboratory for Cell Isolation and Transplantation, Clinic for Visceral and Transplant Surgery, Geneva University Hospital, Geneva, Switzerland
Transpl Int 18:584-9. 2005..Most microorganisms are eliminated during islet isolation, and de novo contaminations during islet isolation are rare. Pancreas decontamination reduces the risk of infection of the final islet preparation... - Immunomodulation by blockade of the TRANCE co-stimulatory pathway in murine allogeneic islet transplantationAnne Wojtusciszyn
Cell Isolation and Transplantation Center, University of Geneva School of Medicine, Geneva, Switzerland
Transpl Int 22:931-9. 2009..TRANCE-targeting may be an effective strategy for the prolongation of allogeneic islet graft survival, thanks to its inhibitory effects on co-stimulatory signals and macrophage recruitment... - Caspase inhibitor therapy synergizes with costimulation blockade to promote indefinite islet allograft survivalJuliet A Emamaullee
Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
Diabetes 59:1469-77. 2010..Costimulation blockade has emerged as a selective nontoxic maintenance therapy in transplantation. However, these drugs must be combined with other immunomodulatory agents to ensure long-term graft survival... - Macrophage migration inhibitory factor deficiency leads to age-dependent impairment of glucose homeostasis in miceVeronique Serre-Beinier
Surgical Research Unit, Department of Surgery Department of Surgery, Cell Isolation and Transplantation Center, Geneva University Hospitals and University of Geneva, 1211 Geneva 4, Switzerland
J Endocrinol 206:297-306. 2010..In conclusion, this mouse model provides evidence for the role of MIF in the control of glucose homeostasis... - Influence of donor age on islet isolation and transplantation outcomeNadja Niclauss
Department of Surgery, Cell Isolation and Transplantation Center, Geneva, Switzerland
Transplantation 91:360-6. 2011..It has been suggested that the age of human organ donors might influence islet isolation and transplantation outcome in a negative way due to a decrease of in vivo function in islets isolated from older donors... - The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in miceJuliet A Emamaullee
Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
Diabetes 57:1556-66. 2008..EP1013 (N-benzyloxycabonyl-Val Asp-fluoromethyl ketone [zVD-FMK]), is a broad-spectrum caspase selective inhibitor with no observed toxicity in rodents... - Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation in the absence of GAD and IA-2 autoantibodiesM Assalino
Division of Transplantation, Geneva University Hospitals and University of Geneva, School of Medicine, Geneva, Switzerland
Am J Transplant 12:492-5. 2012..This observation indicates unequivocally that pancreas graft can be lost to recurrence of type 1 diabetes in the absence of rejection. GAD-65 and IA-2 autoantibodies are not reliable markers of autoimmunity recurrence... - Macrophage depletion prolongs discordant but not concordant islet xenograft survivalAxel Andres
Surgical Research Unit, Department of Surgery, University Hospital Geneva, Geneva, Switzerland
Transplantation 79:543-9. 2005..Both direct and indirect antigen presentation are involved in rejection of discordant xenogeneic islets. Macrophage depletion should only be considered as therapeutic tool for discordant islet xenotransplantation... - Inhibition of Th17 cells regulates autoimmune diabetes in NOD miceJuliet A Emamaullee
Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
Diabetes 58:1302-11. 2009..CONCLUSIONS: These studies suggest that Th17 cells are involved in the pathogenesis of autoimmune diabetes. Further development of Th17-targeted therapeutic agents may be of benefit in this disease... - ABO-incompatible liver transplantation for critically ill adult patientsChristian Toso
Department of Surgery, Section of Hepatobiliary, Pancreatic and Transplant Surgery, University of Alberta, Edmonton, Canada
Transpl Int 20:675-81. 2007..Our results suggest that ABO-incompatible transplants should be viewed as an important therapeutic option in adult patients with acute liver failure awaiting an emergency procedure... - Eculizumab in acute recurrence of thrombotic microangiopathy after renal transplantationK Hadaya
Division of Nephrology, University Hospital and Medical School, Geneva, Switzerland
Am J Transplant 11:2523-7. 2011..This case illustrates the benefit of eculizumab therapy in a fulminant recurrence of TMA after kidney transplantation, resistant to classical therapy... - The management of splenic artery aneurysm in patients awaiting liver transplantationS Asthana
Hepatobiliary and Transplant Unit, University of Alberta Hospital, Edmonton, AB, Canada
Clin Transplant 24:691-4. 2010..We discuss the presentation and management options, with elective and emergent presentation of SAA in patients with end-stage liver disease... - Porcine marginal mass islet autografts resist metabolic failure over time and are enhanced by early treatment with liraglutideJuliet A Emamaullee
Department of Surgery, University of Alberta, Edmonton, Alberta, Canada T6G 2E1
Endocrinology 150:2145-52. 2009..These results are discrepant with previous large animal studies and suggest that porcine islets may be resistant to metabolic failure... - Role of imaging in clinical islet transplantationGavin Low
Department of Radiology and Diagnostic Imaging and Department of Surgery, University of Alberta Hospital, 2A2 41 Walter Mackenzie Center, 8440 112 Street, Edmonton, AB, Canada T6G2B7
Radiographics 30:353-66. 2010..Because of the success of islet transplantation and its increasing availability worldwide, familiarity with the role of imaging is important... - Vascular endothelial growth factor expression in hepatic epithelioid hemangioendothelioma: Implications for treatment and surgical managementJuliet A Emamaullee
Department of Surgery, University of Alberta, Edmonton, AB Canada AB T6G 2E1
Liver Transpl 16:191-7. 2010.... - Potential impact of in situ liver splitting on the number of available graftsChristian Toso
Transplantation Unit, Clinic of Digestive and Transplantation Surgery, University Hospitals, Geneva, Switzerland
Transplantation 74:222-6. 2002..A wider use of the technique could reduce the patient's time on the waiting list and the need for living-donor procedures, and should be encouraged... - Logistics and transplant coordination activity in the GRAGIL Swiss-French multicenter network of islet transplantationMarie-Claude Kempf
Department of Surgery, Geneva University Hospitals, Geneva, Switzerland
Transplantation 79:1200-5. 2005..CONCLUSIONS.: A high rate of pancreas offers, successful isolation, and islet transplantation can be achieved in multicenter networks such as GRAGIL. Such an approach can expand both the donor pool and the recipient population... - Effect of different induction strategies on effector, regulatory and memory lymphocyte sub-populations in clinical islet transplantationChristian Toso
Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
Transpl Int 22:182-91. 2009.... - Are stem cells a cure for diabetes?Michael D McCall
Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
Clin Sci (Lond) 118:87-97. 2010..We also consider some of the limitations of stem cell therapy and the potential complications that may develop with their use... - Expression and secretion of alpha1-proteinase inhibitor are regulated by proinflammatory cytokines in human pancreatic islet cellsDomenico Bosco
Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals, Switzerland
Diabetologia 48:1523-33. 2005..The aims of this study were to assess the islet cell types that produce alpha1-PI, to determine whether alpha1-PI is actually secreted by islet cells, and to assess how its production and/or secretion are regulated... - In vivo study of HCV in mice with chimeric human liversNorman M Kneteman
Department of Surgery Faculty of Medicine and Oral Health Sciences, University of Alberta, Edmonton, Canada
Methods Mol Biol 510:383-99. 2009..This chapter reviews development, validation, and early application of a mouse model with a chimeric human liver... - FLIP switches Fas-mediated glucose signaling in human pancreatic beta cells from apoptosis to cell replicationKathrin Maedler
Divisions of Endocrinology and Diabetes and Clinical Immunology, University Hospital, Zurich CH 8091, Switzerland
Proc Natl Acad Sci U S A 99:8236-41. 2002..The present data provide evidence for expression of FLIP in the human beta cell and suggest a novel approach to prevent and treat diabetes by switching Fas signaling from apoptosis to proliferation... - Factors affecting hepatocyte isolation, engraftment, and replication in an in vivo modelToshiyasu Kawahara
Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
Liver Transpl 16:974-82. 2010.... - Prostaglandin E(1) protects human liver sinusoidal endothelial cell from apoptosis induced by hypoxia reoxygenationHong Yang
Division of Investigative Surgery, Department of Surgery, University Hospital, University of Geneva, Geneva, Switzerland
Microvasc Res 64:94-103. 2002..These results indicate that the protection of LSECs from apoptosis by PGE(1) in hepatic ischemia-reperfusion injury is mediated by inhibiting inducible NO synthase and MMP release... - Costimulatory blockade with belatacept in clinical and experimental transplantation - a reviewJuliet Emamaullee
University of Alberta, Surgery, 5 126 HRIF East, Shapiro Lab, Edmonton, Alberta T6G2E1, Canada
Expert Opin Biol Ther 9:789-96. 2009..However, long-term follow-up has revealed that these agents are associated with troublesome side effects and chronic toxicity, contributing to graft loss and death... - Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocytesGang Mai
Surgical Research Unit, Department of Surgery, University Hospital Geneva, Switzerland
Xenotransplantation 12:457-64. 2005.... - Reduction of blood glucose variability in type 1 diabetic patients treated by pancreatic islet transplantation: interest of continuous glucose monitoringLaurence Kessler
Department of Endocrinology, University Hospital, Strasbourg, France
Diabetes Care 25:2256-62. 2002..To compare the glycemic profiles of patients with type 1 diabetes treated with either an implantable insulin pump or pancreas or islet transplantation by the means of the continuous glucose monitoring system (CGMS; Minimed, Sylmar, CA)... - Insulin independence after conversion to tacrolimus and sirolimus-based immunosuppression in islet-kidney recipientsChristian Toso
Transplantation 76:1133-4. 2003 - Islet transplantation in a recipient presenting the factor V Leiden mutationAxel Andres
Transplantation 79:1771-2; author reply 1773. 2005 - Acquired and reversible Pelger-Huët anomaly of polymorphonuclear neutrophils in three transplant patients receiving mycophenolate mofetil therapyLars M Asmis
Division of Hematology, Geneva University Hospital, Switzerland lars asmis2jhmi edu
Am J Hematol 73:244-8. 2003..In the other two patients, the left shift disappeared after dose reduction. In these latter two patients, a form of desensitization to the effect of MMF on neutro- phils was observed following re-augmentation of MMF dose...