Research Topics
| T SmithSummaryAffiliation: University of Basel Country: Switzerland Publications
| Collaborators
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Detail Information
Publications
Dynamics of multiple Plasmodium falciparum infections in infants in a highly endemic area of TanzaniaT Smith
Swiss Tropical Institute, Basel, Switzerland
Trans R Soc Trop Med Hyg 93:35-9. 1999....- Associations of peak shifts in age--prevalence for human malarias with bednet coverageT Smith
Papua New Guinea Institute of Medical Research, P O Box 378, Madang, Papua New Guinea
Trans R Soc Trop Med Hyg 95:1-6. 2001..vivax. It is concluded that short-term variations in inoculation rate are not important determinants of parasite prevalence in this population... - Premunition in Plasmodium falciparum infection: insights from the epidemiology of multiple infectionsT Smith
Swiss Tropical Institute, Basel, Switzerland
Trans R Soc Trop Med Hyg 93:59-64. 1999..This has important implications for our understanding of immunity against P. falciparum, its ecological niche, and the epidemiological impact of interventions against it... - Effect of insecticide-treated bed nets on the dynamics of multiple Plasmodium falciparum infectionsT Smith
Swiss Tropical Institute, Basel, Switzerland
Trans R Soc Trop Med Hyg 93:53-7. 1999..This suggests that, in areas of high P. falciparum endemicity, ITNs have little effect on the establishment of chronic malaria infection... - Age dependence of the multiplicity of Plasmodium falciparum infections and of other malariological indices in an area of high endemicityT Smith
Swiss Tropical Institute, Basel, Switzerland
Trans R Soc Trop Med Hyg 93:15-20. 1999..There was a significant correlation between parasite density and multiplicity of infection in infants and young children (1-2 years of age) but not in older individuals... - The epidemiology of malaria in the Wosera area, East Sepik Province, Papua New Guinea, in preparation for vaccine trials. II. Mortality and morbidityB Genton
Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea
Ann Trop Med Parasitol 89:377-90. 1995.... - Multiple Plasmodium falciparum infections in Tanzanian infantsI Felger
Swiss Tropical Institute, Basel, Switzerland
Trans R Soc Trop Med Hyg 93:29-34. 1999..The findings help in the understanding of infection dynamics, premunition, and development of semi-immunity in malaria... - A prospective study of Plasmodium falciparum multiplicity of infection and morbidity in Tanzanian childrenL Henning
Swiss Tropical Institute, Socinstrasse 57, P.O. Box, CH-4002, Basel, Switzerland
Trans R Soc Trop Med Hyg 98:687-94. 2004..These results provide further evidence that relationships between asymptomatic malaria infections and clinical malaria change with cumulative exposure... - Consequences of multiple infection with Plasmodium falciparum in an area of high endemicityT Smith
Swiss Tropical Institute, Basel, Switzerland
Parassitologia 41:247-50. 1999..The normal situation for P. falciparum is one in which the host is partially immune, and competition between parasite genotypes in this situation is not expected to result in selection for virulence... - The epidemiology of malaria in the Wosera area, East Sepik Province, Papua New Guinea, in preparation for vaccine trials. I. Malariometric indices and immunityB Genton
Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea
Ann Trop Med Parasitol 89:359-76. 1995..Identification of significant temporal and local variations in malaria endemicity is important for the design and evaluation of intervention studies, including field trials of an antimalarial vaccine... - Area effects of bednet use in a malaria-endemic area in Papua New GuineaJ L Hii
Guinea Institute of Medical Research, P O Box 378, Madang, Papua New Guinea
Trans R Soc Trop Med Hyg 95:7-13. 2001..This finding highlights the importance of local vector ecology for outcomes of bednet programmes and suggests that area effects of untreated bednets should be reassessed in other settings... - Malaria infection and morbidity in infants in relation to genetic polymorphisms in TanzaniaH A Stirnadel
Swiss Tropical Institute, Basel
Trop Med Int Health 4:187-93. 1999.... - Malaria mapping using transmission models: application to survey data from MaliA Gemperli
Biostatistics and Basic Epidemiology Group, Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
Am J Epidemiol 163:289-97. 2006..The approach makes more efficient use of the available data than do previous malaria mapping methods, and it produces highly plausible maps of malaria distribution... - Prospective risk of morbidity in relation to malaria infection in an area of high endemicity of multiple species of PlasmodiumT Smith
Swiss Tropical Institute, Basel
Am J Trop Med Hyg 64:262-7. 2001..Covariate adjustment had considerable effects on estimated relationships between species, and confounding variables may account for many differences among reports of inter-species interactions in human malaria... - Estimation of the sequestered parasite load in severe malaria patients using both host and parasite markersL B Ochola
Swiss Tropical Institute, Socinstrasse 57, Postfach, CH-4002, Basel, Switzerland
Parasitology 131:449-58. 2005..Longitudinal analyses are needed that allow for the clearance rates of the marker molecules and for variations between hosts in the history of parasitaemia... - Age and seasonal variation in the transition rates and detectability of Plasmodium falciparum malariaW Sama
Department of Public Health and Epidemiology, Swiss Tropical Institute, Socinstrasse 57, Postfach CH 4002, Basel, Switzerland
Parasitology 132:13-21. 2006..The best fitting models had no age dependence in infection or clearance rates, suggesting that acquired immunity mainly affects detectability... - Bayesian modelling of geostatistical malaria risk dataL Gosoniu
Swiss Tropical Institute, Basel, Switzerland
Geospat Health 1:127-39. 2006..Results indicate that the stationarity assumption is important because it influences the significance of environmental factors and the corresponding malaria risk maps... - Spatial patterns of child growth in Papua New Guinea and their relation to environment, diet, socio-economic status and subsistence activitiesI Mueller
Swiss Tropical Institute, Basel
Ann Hum Biol 28:263-80. 2001..This indicates that nutritional interventions in PNG should aim at promoting the consumption of such high energy and high protein foods as well as strengthening the general economic base of rural populations... - Distribution of survival times of deliberate Plasmodium falciparum infections in tertiary syphilis patientsW Sama
Department of Public Health and Epidemiology, Swiss Tropical Institute, Socinstrasse 57, Postfach CH 4002, Basel, Switzerland
Trans R Soc Trop Med Hyg 100:811-6. 2006..It is desirable to know the correct distribution because its shape profoundly influences the length of monitoring needed in an intervention programme for eliminating or reducing malaria... - Bayesian age-stage modelling of Plasmodium falciparum sequestered parasite loads in severe malaria patientsT Smith
Swiss Tropical Institute, Socinstrasse 57, Postfach, CH 4002, Basel, Switzerland
Parasitology 129:289-99. 2004..The resulting models should prove a useful tool for cross-validating biochemical approaches for estimating the sequestered load... - Towards a comprehensive simulation model of malaria epidemiology and controlT Smith
Swiss Tropical Institute, Socinstrasse 57, PO Box, CH 4002 Basel, Switzerland
Parasitology 135:1507-16. 2008..The project thus provides a general platform for comparing, fitting, and evaluating different model structures, and for quantitative prediction of effects of different interventions and integrated control programmes... - Relationships between the outcome of Plasmodium falciparum infection and the intensity of transmission in AfricaT Smith
Swiss Tropical Institute, Basel, Switzerland
Am J Trop Med Hyg 71:80-6. 2004..The effects of transmission reduction on mortality rates in older age groups are also uncertain. However, it is clear that reduction of exposure during infancy is not reflected in increased mortality at older ages... - Mosquito nets for the elderly?T Smith
Papua New Guinea Institute of Medical Research, Maprik, Papua New Guinea
Trans R Soc Trop Med Hyg 96:37-8. 2002..There may be substantial benefits of malaria transmission reduction for older people, that have been overlooked in public health programmes and burden of disease calculations... - Assessing the public health importance of Schistosoma mansoni in different endemic areas: attributable fraction estimates as an approachH Guyatt
Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
Am J Trop Med Hyg 53:660-7. 1995..japonicum. Attributable fraction estimates for these three schistosome species in different endemic areas would greatly aid in the assessment of the health burden of this parasite and the effectiveness of control programs... - Spatial patterns of infant mortality in Mali: the effect of malaria endemicityA Gemperli
Swiss Tropical Institute, Basel, Switzerland
Am J Epidemiol 159:64-72. 2004..However, at points very remote from those sampled, it is important to consider prediction error... - Antimicrobial prophylaxis to prevent surgical site infections in a rural sub-Saharan hospitalJ Fehr
Department of Medicine and Diagnostics, Swiss Tropical Institute, Basel, Switzerland
Clin Microbiol Infect 12:1224-7. 2006..Staphylococcus aureus (36%), Escherichia coli (5%) and enterococci (4%) were the pathogens isolated most commonly from SSIs... - Heritability of gastrointestinal nematode faecal egg counts in West African village N'Dama cattle and its relation to ageJ Zinsstag
Swiss Tropical Institute, PO Box, Socinstrasse 7, CH 4002, Basle, Switzerland
Vet Parasitol 89:71-8. 2000.... - Molecular epidemiology of Plasmodium falciparum infections among asymptomatic inhabitants of a holoendemic malarious area in northern GhanaS Owusu-Agyei
Navrongo Health Research Centre, Navrongo, Ghana
Trop Med Int Health 7:421-8. 2002.... - The spatial distribution of Anopheles gambiae sensu stricto and An. arabiensis (Diptera: Culicidae) in MaliN Sogoba
Malaria Research and Training Center, Faculte de Medecine, Pharmacie et Odontostomatologie, Université de Bamako, Mali
Geospat Health 1:213-22. 2007..gambiae s.s. in Mali, the maps provide valuable information for vector control. They may also be useful for planning future implementation of malaria control by genetically manipulated mosquitoes... - Towards empirical description of malaria seasonality in southern Africa: the example of ZimbabweM L H Mabaso
Malaria Research Programme, Medical Research Council, Durban, South Africa
Trop Med Int Health 10:909-18. 2005..There is a need for seasonality models that predict quantitative variation in transmission between months... - Spatial effects of the social marketing of insecticide-treated nets on malaria morbidityS Abdulla
Ifakara Health Research and Development Centre IHRDC, Ifakara, Tanzania
Trop Med Int Health 10:11-8. 2005..The use of untreated nets had neither coverage nor short distance effects. More efforts should be made to ensure high coverage in ITNs programmes to achieve maximum benefit... - Survival and sequelae of meningococcal meningitis in GhanaA Hodgson
Navrongo Health Research Centre, Ghana
Int J Epidemiol 30:1440-6. 2001..There is a sizeable burden of depressive disorders secondary to meningitis which should be identified and looked after appropriately... - Mortality in a seven-and-a-half-year follow-up of a trial of insecticide-treated mosquito nets in GhanaF N Binka
Navrongo Health Research Centre, P.O. Box 114, Navrongo, Ghana
Trans R Soc Trop Med Hyg 96:597-9. 2002..These results should further encourage the use of ITNs as a malaria control tool in areas of high endemicity of Plasmodium falciparum... - Analgesia in the intensive care unit. Pharmacologic and pharmacokinetic considerationsE J Nickel
Department of Pharmaceutical Care, University of Iowa Hospitals and Clinics, Iowa City 52242, USA
Crit Care Nurs Clin North Am 13:207-19. 2001..Employing these principles optimizes the use of medications in the management of the complex physiologic response to pain... - Survey of Johne's disease in imported animals in the Republic of IrelandT Smith
Central Veterinary Research Laboratory, Abbotstown, Castleknock, Dublin, Ireland
Vet Rec 150:634-6. 2002 - Effect of helmet wear on the incidence of head/face and cervical spine injuries in young skiers and snowboardersA J Macnab
Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
Inj Prev 8:324-7. 2002.... - Prevalence of Toxoplasma gondii in dogs from Colombia, South America and genetic characterization of T. gondii isolatesJ P Dubey
United States Department of Agriculture, Agricultural Research Service, Animal and Natural Resources Institute, Animal Parasitic Diseases Laboratory, Building 1001, Beltsville, MD 20705 2350, USA
Vet Parasitol 145:45-50. 2007..A new allele denoted u-3 at PK1 locus was identified in three isolates. This result supports previous findings that T. gondii population is highly diverse in Colombia... - Farm residence and exposures and the risk of allergic diseases in New Zealand childrenK Wickens
Wellington Asthma Research Group, University of Otago, Wellington South, New Zealand
Allergy 57:1171-9. 2002..4, 95% CI 0.2-0.8); and pigs with SPT positivity (OR = 0.2, 95% CI 0.1-0.9). CONCLUSIONS: Despite finding a protective effect of early-life animal exposures, we found a greater prevalence of allergic disease on farms... - Genetic and metabolic predictors of chemosensitivity in oligodendroglial neoplasmsC Walker
JK Douglas Laboratories, Clatterbridge Hospital, Bebington, Wirral, UK
Br J Cancer 95:1424-31. 2006..In this initial study, (201)Tl and (18)F-FDG uptake did not predict response to PCV, but may be associated with poor survival following therapy irrespective of genotype. This may be clinically useful warranting further study... - Effects of hormone replacement therapy on olfactory sensitivity: cross-sectional and longitudinal studiesL F Hughes
Center for Alzheimer Disease and Related Disorders, Department of Surgery, Division of Otolaryngology, Neurology, Southern Illinois University School of Medicine, PO Box 19643, Springfield, Illinois 62794-9643, USA
Climacteric 5:140-50. 2002..CONCLUSION: Although prophylactic HRT has been suggested to be associated with improved olfactory function, we find that its use in healthy postmenopausal women does not enhance performance in a wide range of olfactory tasks... - Clinical use of genotype to predict chemosensitivity in oligodendroglial tumorsC Walker
J K Douglas Laboratories, Clatterbridge Hospital, Bebington, Wirral, UK
Neurology 66:1661-7. 2006..The -1p/-19q genotype has been associated with prolonged survival and chemosensitivity in oligodendroglial neoplasms, but the predictive and prognostic significance of genotype in the routine clinic is not established... - Genetic susceptibility to benzene and shortened gestation: evidence of gene-environment interactionX Wang
Department of Pediatrics, Boston University School of Medicine and Boston Medical Center, MA 02118, USA
Am J Epidemiol 152:693-700. 2000..This study provides evidence of gene-environment interaction and supports further assessment of the role of genetic susceptibility in the evaluation of reproductive toxins... - Evaluation of clarithromycin resistance and cagA and vacA genotyping of Helicobacter pylori strains from the west of Ireland using line probe assaysK A Ryan
National Diagnostics Centre, BioResearch Ireland, National University of Ireland, Galway, Ireland
J Clin Microbiol 39:1978-80. 2001..pylori strains with vacA midregion genotype m1, 29 (58%) carried strains that were m2, 1 (2%) was infected by a strain that was positive for both m1 and m2, and 7 (14%) carried strains that could not be typed... - Renal hyperfiltration in type 2 diabetes: effect of age-related decline in glomerular filtration rateE Premaratne
Endocrinology Unit, Department of Medicine, University of Melbourne, Austin Health, Melbourne, Vic, Australia
Diabetologia 48:2486-93. 2005..We sought to characterise the effect of the age-related decline of GFR on hyperfiltration in type 2 diabetes and to identify clinical characteristics associated with hyperfiltration... - AA2500 testosterone gel normalizes androgen levels in aging males with improvements in body composition and sexual functionC Steidle
Northeast Indiana Research, Fort Wayne, Indiana 46825, USA
J Clin Endocrinol Metab 88:2673-81. 2003..Testosterone gel was well tolerated; however, the testosterone patch resulted in a high rate of application site reactions. Overall, AA2500 is an effective, well tolerated treatment for hypogonadism... - Risk factors for meningococcal meningitis in northern GhanaA Hodgson
Navrongo Health Research Centre, Ministry of Health, Ghana
Trans R Soc Trop Med Hyg 95:477-80. 2001..If wood-burning stoves cannot be avoided, kitchens should be made larger with improved ventilation. Meningitis cases should be nursed in well-ventilated rooms and the number of people sharing a room with a case kept at a minimum... - The reliability of diagnostic techniques in the diagnosis and management of malaria in the absence of a gold standardL B Ochola
Centre for Geographic Medicine Research, KEMRI, Kilifi, Kenya
Lancet Infect Dis 6:582-8. 2006..Microscopy still remains more reliable in detecting non-falciparum infections...